scholarly journals Granulomatous dermatosis: histopathological study in a tertiary care hospital

2017 ◽  
Vol 5 (9) ◽  
pp. 3869
Author(s):  
Teerthanath Srinivas ◽  
Hariprasad S.
Keyword(s):  
Clinical Data ◽  
Histopathological Examination ◽  
Periodic Acid ◽  
Tertiary Care ◽  
Histological Finding ◽  
Histopathological Study ◽  
Care Hospital ◽  
Diagnostic Challenge ◽  
Morphological Pattern ◽  
Periodic Acid Schiff

Background: Granulomatous dermatosis shares the histological finding of granuloma formation; it is usually formed because of the persistence of a non-degradable product of active hypersensitivity. The identical histological picture may be produced by several causes, which pose a diagnostic challenge to dermatopathologist, Present study aims at classifying cutaneous granulomatous dermatosis based on the morphology and aetiology of granulomas, and to highlight its significance for specific clinical diagnosis.Methods: A retrospective analysis of skin biopsy was done and cases of cutaneous granulomatous lesions diagnosed on histopathological examination were retrieved for a period of 8 years. Clinical data and diagnosis were retrieved from hospital records. Hematoxylin and eosin stained paraffin sections were reviewed. The morphological pattern of granuloma was classified into sarcoidal, necrotizing, necrobiotic and suppurative granulomas and further aetiological evaluation for the granulomatous dermatosis were done using various special stains like Periodic Acid Schiff stain, Fite-Farraco stain, Gomori methenamine silver stain and acid-fast bacilli stain.Results: A total of 228 cases of cutaneous granulomatous lesion were retrieved; out of these 93cases (40.79%) were sarcoidal granuloma type, 83cases (36.40%) were of suppurative granulomas, 29 cases (12.72%) were of necrobiotic granulomas, 20 cases (8.77%) were necrotizing granuloma and 3 cases (1.32%) had granulomatous dermatitis with vasculitis. Infective aetiology was the commonest cause for granulomatous dermatosis (57.89%), mainly by leprosy, tuberculosis and various fungal infection.Conclusions: Granulomatous dermatosis has significant overlap in histopathological picture of various granulomatous reactions. Morphology alone is seldom specific and cannot be used as diagnostic tool. It is better understood based adequate clinical data, morphology of granuloma, special stains and laboratory workup in arriving at a etiology specific diagnosis for definitive clinical management.

scholarly journals Vascular malformations of central nervous system: A series from tertiary care hospital in South India

2016 ◽  
Vol 07 (02) ◽  
pp. 262-268
Author(s):  
Sudhir Babu Karri ◽  
Megha S. Uppin ◽  
A. Rajesh ◽  
K. Ashish ◽  
Suchanda Bhattacharjee ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Vascular Malformations ◽  
Demographic Data ◽  
Periodic Acid ◽  
Tertiary Care ◽  
Care Hospital ◽  
Periodic Acid Schiff ◽  
Radiological Features ◽  
Risk Of Hemorrhage

ABSTRACT Aims and Objectives: To describe clinicopathological features of surgically resected vascular malformations (VMs) of central nervous system (CNS). Materials and Methods: Histologically diagnosed cases of VMs of CNS during April 2010–April 2014 were included. Demographic data, clinical and radiological features were obtained. Hematoxylin and eosin slides were reviewed along with Verhoeff-Van Gieson (VVG), Masson’s trichrome, periodic acid-Schiff, and Perls’ stains. Morphologically, cavernomas and arteriovenous malformations (AVMs) were distinguished on the basis of vessel wall features on VVG and intervening glial parenchyma. Results: Fifty cases were diagnosed as VMs of CNS with an age range of 14–62 years. These included 36 cavernomas, 12 AVMs, 2 mixed capillary-cavernous angiomas. Most of the cavernoma patients (15/36) presented with seizures, whereas AVM patients (8/12) had a headache as the dominant symptom. Twenty-nine patients were reliably diagnosed on radiological features. Microscopic evidence of hemorrhage was seen in 24/36 cavernomas and 6/12 AVMs, as opposed to radiologic evidence of 10 and 4, respectively. Reactive gliosis was seen in 16 cavernomas. Conclusions: Histological features are important for classifying the VMs of CNS as there are no specific clinical and radiological features. Type of VM has a bearing on management, prognosis, and risk of hemorrhage.

scholarly journals Prostatic lesions: Histopathological study in a tertiary care hospital

2018 ◽  
Vol 4 (1) ◽  
pp. 12-19
Author(s):  
S. Bhatta ◽  
S. Hirachan
Keyword(s):  
Histopathological Examination ◽  
Benign Lesion ◽  
Tertiary Care ◽  
Histopathological Study ◽  
P Value ◽  
Care Hospital ◽  
Significant Difference ◽  
Nodular Hyperplasia ◽  
Malignant Lesions ◽  
The Mean

Background: Prostatic lesions like Nodular hyperplasia of prostate, inflammation and carcinoma are common causes of morbidity and mortality in males. The incidence of these lesions increases with age. This study was conducted with the objective of evaluating histopathological pattern of prostatic lesions.Methods: This was a retrospective study conducted at KIST Medical College from Jan 2014 to Jan 2018. The study included ninety six prostatic specimens received in department of pathology. Hematoxylin and Eosin stained slides were retrieved and reviewed. The specimens and slides were analyzed according to type of specimen, age of patient, histopathological pattern and final diagnosis. Results were analyzed using Statistical Package for Social Science (SPSS, version 21) for Windows. Independent t test was used to correlate the mean age between patients with benign and malignant lesions. P value less than 0.05 was considered as statistically significant.Results: The most common benign lesion was nodular hyperplasia of prostate 86(89.58%). Malignant lesions comprised 8 (8.34%) cases of all prostatic lesions. All the cases of prostate carcinoma were adenocarcinoma. The most frequent Gleason score was 9. Mean age for benign and malignant lesions were 69.6 ± 8.1 years and 72.9 ± 5.2 years respectively. There was no significant difference in the mean age between patients with benign and malignant lesions (p value 0.27).Conclusion: Benign lesions of prostate are more common than malignant lesions. Histopathological examination of prostate specimens have important role in diagnosing various benign and malignant lesions, especially to rule out incidental carcinoma.JMMIHS.2018;4(1):12-19

scholarly journals HISTOPATHOLOGICAL STUDY OF BENIGN AND MALIGNANT LESIONS OF UTERUS AND CERVIX IN HYSTERECTOMY SPECIMENS

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Shikha Raghuwanshi ◽  
Dharmendra Singh Bhadouria ◽  
Surendra Raghuwanshi ◽  
Arun Saxena ◽  
S.K. Nema
Keyword(s):  
Histopathological Examination ◽  
Tertiary Care ◽  
Common Finding ◽  
Histopathological Study ◽  
Histopathological Diagnosis ◽  
Care Hospital ◽  
Fibroid Uterus ◽  
Malignant Lesions ◽  
Chronic Cervicitis ◽  
Insight Into

Background: The present study was aimed to obtain insight into the varied histopathological patterns of lesions of uterus and cervix in hysterectomy specimens and their age-wise distribution in Index MedicalCollege, Hospital and Research Center. Methodology: This was anobservational study conducted on 100 cases of hysterectomy specimens received at tertiary care hospital Indore. All the specimen was subjected to detailed gross and histopathological examination. Results: Mean age of patients was 44.78±8.64 years. The most common age group was 41-50yrs (42%). Maximum cases were diagnosed as AUB/ DUB/Menorrhagia (31%) followed by fibroid uterus (28%). Uterus was bulky in 70%, cut sections revealed single fibroid in majority i.e. 39% cases and endometrium was in proliferative phase (early 12%, mid 30%, late 19%). Most common histopathological diagnosis of uterus was leiomyoma in 39% cases whereas chronic nonspecific cervicitis (47%) was most common histological diagnosis of cervix. Intramural leiomyoma were most common and were associated with degenerative changes in 33 cases. Hyaline degeneration was observed in maximum cases. Conclusion: The most common indication for hysterectomies in our institution is excessive uterine bleeding. Fibroid uterus as the cause of bleeding is the most common pathology for which hysterectomy is performed. Chronic cervicitis is the most common finding and Adenomyosis continued to be missed preoperatively and diagnosed postoperatively on histopathological examination. Every hysterectomy specimen should be subjected to histopathological examination to confirm various pathological lesions. Keywords: Leiomyoma, histopathology, spectrum, uterus, cervix, hysterectomy

Role of FNA and Special Stains in Rapid Cytopathological Diagnosis of Pulmonary Nocardiosis

2018 ◽  
Vol 62 (3) ◽  
pp. 178-182 ◽  
Author(s):  
Ridhi Sood ◽  
Ruchita Tyagi ◽  
Pavneet Kaur Selhi ◽  
Gursheen Kaur ◽  
Harpreet Kaur ◽  
...  
Keyword(s):  
Fungal Infections ◽  
Periodic Acid ◽  
Tertiary Care ◽  
Opportunistic Pathogen ◽  
Clinical Findings ◽  
Accurate Diagnosis ◽  
Care Hospital ◽  
Periodic Acid Schiff ◽  
Pulmonary Nocardiosis ◽  
Inflammatory Infiltrates

Background: Nocardia, a gram-positive aerobic bacillus of the Actinomycetales family, is a significant opportunistic pathogen in immunocompromised individuals. Clinical and radiological features of pulmonary nocardiosis are nonspecific and can be misdiagnosed as tuberculosis, pneumocystis, staphylococcal or fungal infections, or as malignancy. Aspiration cytology with special stains is a quick and effective approach for accurate diagnosis. Materials and Methods: We present 7 cases of pulmonary nocardiosis, admitted to the pathology department in a tertiary-care hospital in Punjab. Clinical findings, immune status, laboratory tests, chest radiographs, and computed tomography scans were reviewed. Cytologically, special stains like 1% Ziehl-Neelsen (ZN), 20% ZN, periodic acid-Schiff (PAS), Grocott methenamine silver (GMS), and reticulin stains were studied along with May-Grünwald Giemsa, Papanicolaou, and hematoxylin and eosin. Results: All the patients were immunocompromised. The radiological changes were nonspecific. Cytomorphology showed acute and chronic inflammatory infiltrates with necrosis. None of the cases showed well-defined granulomas. GMS, modified 1% ZN and, Gordon and Sweet reticulin stains highlighted the delicate filamentous bacteria in all cases. PAS and 20% ZN stain for tuberculous bacilli were uniformly negative. Conclusion: FNAC can provide a quick and accurate diagnosis of nocardiosis and thereby facilitate timely medical management.

HISTOPATHOLOGICAL STUDY OF ENDOMETRIUM IN WOMEN WITH ABNORMAL UTERINE BLEEDING

2021 ◽  
pp. 30-33
Author(s):  
Bhakti D Deshmukh ◽  
Anuradha Malpani ◽  
Alka V Gosavi ◽  
Kalpana R Sulhyan ◽  
Rucha M Pimpalkhute
Keyword(s):  
Histopathological Examination ◽  
Tertiary Care ◽  
Abnormal Uterine Bleeding ◽  
Intraepithelial Neoplasia ◽  
Mucinous Carcinoma ◽  
Uterine Bleeding ◽  
Serous Carcinoma ◽  
Histopathological Study ◽  
Care Hospital ◽  
Age Group

BACKGROUND –Abnormal uterine bleeding (AUB) is dened as a bleeding pattern that differs in frequency, duration and amount from a pattern observed during a normal menstrual cycle. The term dysfunctional uterine bleeding (DUB) is used to describe abnormal uterine bleeding for which no specic cause has been found. AUB is one of the most common gynaecological problems. This study was done to evaluate histological patterns of endometrium in women with abnormal uterine bleeding. AIMS AND OBJECTIVE – To study various histological patterns of endometrium in abnormal uterine bleeding and correlate it with age, parity and symptoms. MATERIAL AND METHODS –This is a retrospective study, conducted in the Department of Pathology, in a tertiary care hospital from 1st July 2016 to 30th June 2019. Total 718 specimens with AUB were included in the study from the age group of 21 to 95 years. The specimens received were hysterectomy (74.65 %), endometrial biopsies (21.45%), dilatation and curettage (2.79 %) and transcervical resection of endometrium (1.11 %). RESULTS –The patients with AUB were mainly from the age group 41-50 years with menorrhagia as the chief complaint. Most of the women with AUB were multiparous (84.54%). The most common pattern observed on histopathological examination was proliferative endometrium (49.86%) followed by atrophic endometrium (10.31%). Malignancy was found in 2.23% (Endometrioid carcinoma – 1.81%, serous carcinoma - 0.14% and mucinous carcinoma – 0.28%). Endometrial hyperplasia without atypia (23 cases, 3.20%) was more common than endometrial atypical hyperplasia (EAH) / endometrioid intraepithelial neoplasia {EIN} (4 cases, 0.56 %). Various other patterns of endometrium on histopathology were endometritis (6.82 %) followed by endometrial polyp (4.46 %). CONCLUSION – Histopathological examination of endometrium should be done generously in women presenting with abnormal uterine bleeding especially after the age of 40 years to rule out malignant pathology.

scholarly journals Histopathological Study of Endometrium in Infertility: Experience in A Tertiary Level Hospital

2018 ◽  
Vol 8 (2) ◽  
pp. 132-137
Author(s):  
Mousumi Ahmed ◽  
Nazma Afroze ◽  
Mahjabin Sabiha
Keyword(s):  
Endometrial Hyperplasia ◽  
Tertiary Care ◽  
Histopathological Study ◽  
Care Hospital ◽  
Secretory Phase ◽  
Secondary Infertility ◽  
Morphological Pattern ◽  
Infertile Women ◽  
Proliferative Phase ◽  
Primary Infertility

Background: Infertility refers to inability to achieve conception even after one year of unprotected coitus by a couple. It is a global health problem and affects 8-10% couple worldwide. Infertility can be primary or secondary and there are many causes of infertility involving both male and female partner. A wide range of investigations can be done to find out the causes of infertility. Endometrial biopsy or curettage or aspiration followed by histopathological study is a safe procedure. It not only shows the hormonal response of endometrium but also diagnose other endometrial pathology causing infertility. The study was performed to find out the morphological pattern of endometrium in infertile women in a tertiary care hospital to find out the causes of infertility and subsequent treatment of the patients.Methods: It was a cross sectional prospective study, conducted in the Department of Histopathology and Cytopathology in a tertiary care hospital in Dhaka for a period of two years from Jan 2015 to Dec 2016. It included 196 referred cases endometrial curettage or biopsy samples of infertile women, collected between days 21 to 23 of menstrual cycle. The endometrial samples obtained from patients suffering from diseases other than infertility were excluded from the study. Hematoxylin and Eosin (H&E) stained histopathological slides were prepared from the samples and examined under microscope. Reported results and relevant data were recorded in SPSS data collection sheet and statistical analysis was carried out.Results: A total of 196 cases of endometrial biopsy or curettage samples of both primary and secondary infertile women were studied. Age ranged from 20 years to 40 years with a mean age of 29.91±4.32years. 70.92% cases presented with primary infertility and 29.08% cases presented with secondary infertility. Proliferative phase/anovulation (41.33%) was found as the most common morphological pattern of endometrium in infertile women followed by secretory phase (40.30%). Endometrial hyperplasia, inadequate sample, nonspecific ednometritis and tuberculous endometritis were found in 10.72% , 6.12% , 6.12% and 0.51% cases respectively. In primary infertility, proliferative phase / anovulation (43.17%) was also the predominant pattern followed by secretory phase (37.40%) and endometrial hyperplasia (11.52%). Whereas, secretory phase( 47.37%) was the most common pattern of endometrium in secondary infertility, followed by proliferative phase (36.37%) and endometrial hyperplasia (8.77%). Primary infertility was most frequently presented in 26-30 years of age, whereas, secondary infertility was more prevalent in later age group.Conclusion: Histopathological study of endometrium gives us valuable information of endometrium in infertility. Morphological pattern of endometrium in our study was quite similar to other studies conducted in different countries with some variations. This study may help other studies in future to find out the cause of infertilityBirdem Med J 2018; 8(2): 132-137

scholarly journals HISTOPATHOLOGICAL STUDY OF UTERINE LESIONS IN HYSTERECTOMY SPECIMENS IN A TERTIARY CARE HOSPITAL.

2020 ◽  
pp. 1-2
Author(s):  
Reddythota Sujeeva Swapna ◽  
V Siva Sankar Naik ◽  
C Bhavani ◽  
M Neeraja
Keyword(s):  
Histopathological Examination ◽  
Tertiary Care ◽  
Female Genital Tract ◽  
Total Abdominal Hysterectomy ◽  
Abdominal Hysterectomy ◽  
The Body ◽  
Histopathological Study ◽  
Histopathological Diagnosis ◽  
Care Hospital ◽  
Wide Range

Background: The Female Genital Tract is a hormone-responsive system to a degree unmatched by any other system in the body. The gross configuration of the uterus changes dramatically throughout life. It is a kind of 'Puppet on a string", thus manipulated throughout life by altering levels of ovarian hormones. Objective of the study: The present study is aimed at detailed histopathological evaluation of uterine lesions of hysterectomy specimens. Methodology: A total of 448 cases of hysterectomy specimens were received in the department of pathology GGH Ananthapur, for two years, were reviewed. The specimens were processed, and the histopathological diagnosis was studied. Result: Peak age group of hysterectomy was 40-49 years with 186 (41.51%) cases. The youngest patient was 21 years old, and the oldest was 75 years old. The most frequent type of hysterectomy done was total abdominal hysterectomy in 293 (65.4%) cases. Conclusion: Hysterectomy is the most common surgery performed in gynecological practice. A wide range of lesions were noted when hysterectomy specimens are subjected to histopathological examination.

scholarly journals Evaluation of genital tuberculosis as a cause of female infertility in a tertiary care hospital in North India

2018 ◽  
Vol 6 (1) ◽  
pp. 386
Author(s):  
Neelima Agarwal ◽  
Manisha Gupta ◽  
Alpana Agrawal
Keyword(s):  
Tertiary Care Hospital ◽  
Histopathological Examination ◽  
Early Stage ◽  
Tertiary Care ◽  
Endometrial Biopsy ◽  
Reproductive Age ◽  
North India ◽  
Care Hospital ◽  
Diagnostic Challenge ◽  
Genital Tuberculosis

Background: Female genital tuberculosis (FGTB) poses a great diagnostic challenge in women of reproductive age. It causes significant morbidity or short and long term sequelae, especially infertility. The disease often remains silent or may present with non-specific symptomatology. As a result, the prevalence of genital tuberculosis is largely underestimated. A high degree of suspicion aided by intensive investigations is important in the diagnosis of the disease, especially in its early stage, so that treatment may improve the prospects of cure before the tubes are damaged beyond recovery. Objectives were to find out the prevalence of genital tuberculosis in females presenting with infertility in a tertiary care hospital over a given period of time, and diagnostic comparison of endometrial tuberculosis by histopathological examination (HPE) and GeneXpert.Methods: The prospective observational study was conducted over one year duration. A total of 96 endometrial samples were collected from the women, satisfying the inclusion and exclusion criteria.Results: On HPE, out of 96 patients, proliferative endometrium (anovulatory) was found in 38 cases (39.6%), non-specific endometritis in 2 cases (2.08%) and 2 cases (2.08%) were found positive for tubercular endometritis. GeneXpert scored negative in our study.Conclusions: Endometrial biopsy shows not only the tuberculous endometritis, but also gives additional information about local factors of endometrium concerning non-specific and specific infections and anovulatory cycles. GeneXpert if positive on endometrial biopsy is a reliable test for FGTB and treatment can be started on its basis.

scholarly journals A histopathological study on cholecystectomy specimen in a tertiary care hospital

2020 ◽  
Vol 11 (SPL2) ◽  
pp. 161-164
Author(s):  
Volga Harikrishnan ◽  
Padmapriya B S ◽  
Chitra Srinivasan
Keyword(s):  
Malignant Tumors ◽  
Histopathological Examination ◽  
Tertiary Care ◽  
Chronic Cholecystitis ◽  
Histopathological Study ◽  
Main Function ◽  
Care Hospital ◽  
Female Ratio ◽  
Male Female Ratio ◽  
Macroscopic Findings

Gallbladder is a pear shaped organ and the main function of it is to store and concentrate the bile secreted by the liver and then deliver it into the intestine for digestion and absorption of fat. Congenital anomalies, inflammation, benign and malignant tumors can occur in the gallbladder. Cholecystectomy is one of the most commonly performed general surgery procedures. The principle aim of this study is to review the pathology results from gallbladder specimens sent for routine pathology with clinical parameters correlation. A retrospective study of 115cholecystectomy specimens for a period of 6 months in the year 2018 was carried out. All specimens subjected for histopathological examination and the clinical correlation was done. Commonest age group being 41-45 years (25%) with the male female ratio of 1:1.7. Most common lesions were Chronic calculouscholecystitis constituting 67 (58%) followed by chronic cholecystitis 24 cases (21%). Acute calculouscholecystits constitute 4 cases (3.5%), acute cholecystitis and acute or chronic cholecystitis constitutes 9 cases (8%).One case of adenomyoma (0.8%) and incidentally detected Gall bladder adenocarcinoma (0.8%) were diagnosed. Spectrum of lesions that affect the gallbladder necessitates the importance of histopathological examination of all cholecystectomy specimens with or without abnormal clinical, radiological and macroscopic findings.

scholarly journals Chronic Tonsillitis: A Recent Histopathological Study

2016 ◽  
Vol 8 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Wail Fayez Nasr ◽  
Samir S Sorour ◽  
Mohammed K Mobasher ◽  
Hesham R Abd El Aziz
Keyword(s):  
Histopathological Examination ◽  
Periodic Acid ◽  
Inflammatory Cells ◽  
University Hospital ◽  
Chronic Tonsillitis ◽  
Histopathological Study ◽  
Level Of Evidence ◽  
Periodic Acid Schiff ◽  
Level Ii ◽  
Hematoxylin And Eosin

ABSTRACT Objectives The aim of this study is to assess the incidence of tonsillomycosis in chronic tonsillitis on histopathological basis post-tonsillectomy in children. Study design Cohort study. Level of evidence Level II. Setting Ter tiary University Hospital, Department of Otorhinolaryngology. Materials and methods This study included 75 cases of children suffering from chronic tonsillitis (43 females and 32 males). On assessment of the clinical condition of the children with history taking, clinical examination, and preoperative investigation, post-tonsillectomy tonsils are placed in a separate container in 10% formol saline, and then are sent for histopathological examination using hematoxylin and eosin and periodic acid–Schiff (PAC). Results The obtained result had 31.3% of tonsils (47/150) with histopathological evidence of fungal invasion of tonsillar tissue with immune reaction and the presence of chronic inflammatory cells. After statistical analysis of the collected crude data, we found that results have come in accordance with previous studies. Conclusion Tonsillomycosis is a cause of chronic tonsillitis. Haphazard use of antibiotics and dental caries has a significant predisposing role in tonsillomycosis. Neutropenia can be considered as an indicator for tonsillomycosis. It is considerable in hypertrophic tonsils. How to cite this article Nasr WF, Sorour SS, Mobasher MK, Abd El Aziz HR. Chronic Tonsillitis: A Recent Histopathological Study. Int J Otorhinolaryngol Clin 2016;8(1):1-5.

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