scholarly journals Association between serum magnesium and obesity in postmenopausal women

2018 ◽  
Vol 6 (9) ◽  
pp. 3156
Author(s):  
Alka Yadav ◽  
Madhuri Gupta ◽  
R. C. Gupta
Keyword(s):  
Postmenopausal Women ◽  
Magnesium Deficiency ◽  
Serum Magnesium ◽  
Venous Blood ◽  
Cross Sectional Study ◽  
Magnesium Concentration ◽  
Control Group ◽  
Excess Body Weight ◽  
Cross Sectional ◽  
Dietary History

Background: Obesity is a complex, multifactorial condition in which excess body weight may put a female at risk of serious health problems such as hypertension, dyslipidemia, diabetes mellitus and cardiovascular diseases. Magnesium deficiency is reported to be associated with obesity in children and adolescents. An inverse relationship has been reported between serum magnesium and estrogen levels in women. It is not known whether magnesium deficiency may have a role in genesis of obesity in women after menopause. Therefore, the present study was planned to compare serum magnesium levels in obese and non-obese postmenopausal women and to find out the relationship, if any, between serum magnesium levels and obesity.Methods: This cross-sectional study was conducted in the department of Biochemistry at National Institute of Medical Sciences and Research, Jaipur, Rajasthan on fifty subjects over a period of six months. Twenty-five obese postmenopausal women (BMI ≥ 30) having their final menstrual period at least one year prior to the study were taken as the study group and twenty-five non-obese (BMI ≤ 22.9) post-menopausal women were taken as control group. All subjects were asked to give detailed dietary history using Food Frequency Questionnaire (FFQ). Venous blood samples were collected after an overnight fast for estimation of serum total magnesium in all subjects.Results: Obese postmenopausal women had significantly higher weight (78.36±0.064kg) and BMI (32.68±1.7kg/mt2) compared to non-obese postmenopausal women (wt. 54.72±4.80kg and BMI 21.75±1.68kg/mt2). The mean±SD serum magnesium concentration found in the obese postmenopausal women was 1.40±0.45mg/dl as compared to 2.03±0.49 mg/dl in the non-obese group. Pearson’s correlation analysis showed a significant (r = -0.9) negative correlation between BMI and serum magnesium in postmenopausal women.Conclusions: Serum magnesium was lower in obese postmenopausal women as compared to that in non-obese postmenopausal women. Serum magnesium was negatively correlated with BMI. Magnesium supplementation may be useful in prevention of obesity after menopause.

Can Cytokines be used as an Activation Marker in Rheumatoid Arthritis?

2020 ◽  
Vol 20 ◽  
Author(s):  
Fatih Öner Kaya ◽  
Yeşim Ceylaner ◽  
Belkız Öngen İpek ◽  
Zeynep Güneş Özünal ◽  
Gülbüz Sezgin ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Healthy Volunteers ◽  
Venous Blood ◽  
Cross Sectional Study ◽  
Joint Disease ◽  
Control Group ◽  
Cross Sectional ◽  
Positive Correlation ◽  
Das 28 ◽  
Tnf Α

Aims: The etiopathogenesis of Rheumatoid Arthritis (RA) is not clearly understood. However, the role of the cytokines takes an important part in this mechanism. We aimed to bring a new approach to the concept of 'remission' in patients with RA. Background: RA is a chronic, autoimmune, inflammatory disease that involves small joints in the form of symmetrical polyarthritis and progresses with exacerbations and remissions. Pain, swelling, tenderness and morning stiffness are typical of the joints involved. Although it is approached as a primary joint disease, a wide variety of extra-articular involvements may also occur. It is an interesting pathophysiological process, the exact cause of which is still unknown, with many environmental, genetic and potentially undiscovered possible factors in a chaotic manner. Objective: In this cross-sectional study, sedimentation rate (ESR), C- Reactive protein (CRP), Tumor necrosis factor (TNF)-α, soluble-TNF-α receptor (TNF-R), Interleukin (IL)-1B and IL-10 were measured in three groups which were healthy volunteers, patients with RA in the active period, and patients with RA in remission. Disease activity score-28 (DAS-28) was calculated in active RA and RA in remission. Methods: This study included 20 healthy volunteers, 20 remission patients with RA and 20 active RA patients. Venous blood samples were collected from patients in both healthy and RA groups. Results: RA group consisted 43 (71.6%) female and 17 (28.4%) male. Control group consisted 11 (55%) female and 9 (45%) male. TNF-R was significantly high only in the active group according to the healthy group (p=0.002). IL-10 was significantly high in active RA according to RA in remission (p=0.03). DAS-28 was significantly high in active RA according to RA in remission (p=0.001). In the active RA group, ESR and TNF-R had a positive correlation (r:0.442; p=0.048). In the active RA group, there was also a positive correlation between TNF-R and CRP (r:0.621; p=0,003). Both healthy and active RA group had significant positive correlation between ESR and CRP (r: 0.481; p=0.032 and r: 0,697; p=0,001 respectively). Conclusion: TNF-R can be the main pathophysiological factor and a marker showing activation. TNF-R can be very important in revealing the effect of TNF on the disease and the value of this effect in the treatment and ensuring the follow-up of the disease with CRP instead of ESR in activation.

scholarly journals Serum Magnesium Levels among Pregnant Women with and without Complications: A Cross-sectional Study

2020 ◽  
Author(s):  
Santhini Gopalakrishnan Sethulekshmi ◽  
S Sumathy ◽  
Banani Dutta
Keyword(s):  
Pregnant Women ◽  
Magnesium Deficiency ◽  
Serum Magnesium ◽  
First Trimester ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Significant Difference ◽  
History Of ◽  
Student’S T

Introduction: Pregnancy is a period that is characterised by remarkable physiological changes which are needed to support the growing fetus. Micronutrients play a crucial role in the maintenance of pregnancy. Among the micronutrients, magnesium has got ample amount of clinical relevance to pregnancy. Magnesium deficiency has been associated with reproductive risk during pregnancy such as anaemia, pre-eclampsia, eclampsia, fetal growth retardation, preterm labour, low intrauterine growth rate and leg cramps. Aim: To find out whether there was significant difference in the magnesium levels among pregnant women with and without pregnancy related complications and also to find out whether the magnesium levels differed significantly among the three trimesters. Materials and Methods: This was a cross-sectional study done among 240 pregnant patients from different trimesters attending the Obstetrics and Gynaecology Outpatient Department. Out of them 164 women had complications like pre-eclampsia, Gestational Diabetes Mellitus, leg cramps and history of abortions. Demographic details were obtained from all the women. BMI was calculated for each subject using the formula BMI=weight(kg)/height(m2). Haemoglobin was assessed in all samples using cyanmethaemoglobin method. Magnesium levels were analysed in the all samples using automated analyser in the Biochemistry laboratory. Student’s t-test was used to compare the levels of magnesium among the groups with and without complications. ANOVA test was used to compare the three trimesters. Results: The pregnant women were divided into three groups based on the different trimesters in which the samples were taken. Magnesium levels among the women in the first trimester were (2.96±0.83) second trimester (2.99±1.48) and third trimester (3.05±1.48) respectively. Women with previous abortions were found to have less magnesium levels (2.71) compared to women without a history of abortion (3.11) and value was found to be statistically significant (p<0.007) and magnesium levels among vegetarians (2.45) were lower than non vegetarians (3.08) and it was found to be statistical significant (p<0.013). There was no significant difference in the magnesium levels among pregnant women with complications and those without complications. Conclusion: The study shows the importance of maintaining the magnesium levels among pregnant women. There was no difference in the magnesium levels among the three trimesters. Study also points out the influence of parity, diet and occupation of pregnant women on the levels of magnesium.

scholarly journals Correlation between Serum Magnesium and Lactate Levels at the Time of ICU Admission and Early Phase of Sepsis

2019 ◽  
Author(s):  
Amin Assarian ◽  
Afsaneh Noormandi ◽  
Hossein Khalili ◽  
Mostafa Mohammadi ◽  
Alireza Abdollahi
Keyword(s):  
Serum Magnesium ◽  
Lactate Concentration ◽  
Cross Sectional Study ◽  
Serum Lactate ◽  
The Body ◽  
Magnesium Concentration ◽  
Apache Ii Score ◽  
Cross Sectional ◽  
Icu Stay ◽  
Parametric Data

Background: As the fourth abundant electrolyte in the body, magnesium has critical roles in aerobic metabolism and regulation of the immune system. Few studies investigate the association between magnesium status of critically ill septic patients and lactate acidosis in the intensive care unit (ICU). In this study, serum magnesium level and lactate level were evaluated at both admission time and time of sepsis. Methods: This was a prospective, cross-sectional study conducted at general ICU of a tertiary referral teaching hospital. Hypomagnesemia was defined as a serum magnesium concentration of less than 1.7 mg/dL. Mann-Whitney test and independent-sample t-test were used to analyze nonparametric and parametric data, respectively. Results: Of 50 sepsis patients, 32 patients were normomagnesemic, and 18 were hypomagnesemic. Hypomagnesemic patients have significantly higher lactate serum level at the time of sepsis compared to normomagnesemic patients [2.32 (1.96-3.29) vs. 1.94 (1.80-2.15) mg/dl respectively, p<0.001]. There were significant differences between normomagnesemic and hypomagnesemic septic patients in Acute Physiology and Chronic Health Evaluation (APACHE) II score at sepsis time (9.44 ± 4.33 vs. 11.67 ± 3.83, p=0.46), and Sequential Organ Failure Assessment (SOFA) score [3 (3.00-5.00) vs. 4 (3.75-6.25), p=0.04]. Also, 28-day mortality because of sepsis (50% respectively, p<0.001), duration of mechanical ventilation [12.00 (4.00-14.25) days respectively, p<0.01] and ICU stay [14.00 (12.75-17.25) days respectively, p<0.01] were significantly higher in hypomagnesemic groups. Conclusion: Admission hypomagnesemia in sepsis patients may increase serum lactate concentration, duration of ventilation, duration of ICU stay and mortality.

Relationship between Serum Magnesium Concentration and Radiographic Knee Osteoarthritis

2015 ◽  
Vol 42 (7) ◽  
pp. 1231-1236 ◽  
Author(s):  
Chao Zeng ◽  
Jie Wei ◽  
Hui Li ◽  
Tuo Yang ◽  
Fang-Jie Zhang ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Serum Magnesium ◽  
Cross Sectional Study ◽  
Magnesium Concentration ◽  
Multivariable Model ◽  
Clear Trend ◽  
Cross Sectional ◽  
Knee Oa ◽  
Logistic Analysis ◽  
Radiographic Knee Osteoarthritis

Objective.To establish whether there is a relationship between serum magnesium (Mg) concentration and radiographic knee osteoarthritis (OA).Methods.There were 2855 subjects in this cross-sectional study. Serum Mg concentration was measured using the chemiluminescence method. Radiographic OA of the knee was defined as changes consistent with Kellgren-Lawrence (K-L) grade 2 on at least 1 side. Mg concentration was classified into 1 of 4 quartiles: ≤ 0.87, 0.88–0.91, 0.92–0.96, or ≥ 0.97 mmol/l. Multivariable logistic analysis was used to test the association between serum Mg and radiographic knee OA after adjustment for potentially confounding factors. The OR with 95% CI for the association between radiographic knee OA and serum Mg concentration were calculated for each quartile. The quartile with the lowest value was regarded as the reference category.Results.Significant association between serum Mg concentration and radiographic knee OA was observed in the model after adjustment for age, sex, and body mass index, as well as in the multivariable model. The multivariable-adjusted OR (95% CI) for radiographic knee OA in the second, third, and fourth serum Mg concentration quartiles were 0.90 (95% CI 0.71–1.13), 0.92 (95% CI 0.73–1.16), and 0.72 (95% CI 0.57–0.92), respectively, compared with the lowest (first) quartile. A clear trend (p for trend was 0.01) was observed. The relative odds of radiographic knee OA was decreased by 0.72 times in the fourth serum Mg quartile compared with the lowest quartile.Conclusion.Serum Mg concentration may have an inverse relationship with radiographic OA of the knee.

scholarly journals Similar hematological and biochemical parameters among periodontitis and control group subjects

2012 ◽  
Vol 06 (03) ◽  
pp. 287-294 ◽  
Author(s):  
Shobha Prakash ◽  
Kunaal Dhingra ◽  
Shanmuga Priya
Keyword(s):  
Biochemical Parameters ◽  
Complete Blood Count ◽  
Venous Blood ◽  
Study Groups ◽  
Cross Sectional Study ◽  
Control Group ◽  
Sectional Study ◽  
Cross Sectional ◽  
Hematological And Biochemical Parameters ◽  
And Control

ABSTRACTObjectives: There are conflicting reports in the past literature documenting the tendency of anemia in patients with periodontitis. Hence, this study was undertaken to assess whether periodontitis may cause an anemic state, by evaluating and comparing the red blood cell count, levels of hemoglobin, hematocrit, erythrocyte sedimentation rate (ESR), serum iron and serum ferritin between subjects with and without periodontitis.Methods: In this cross-sectional study, 140 systemically healthy subjects of both sexes (mean age 46 years) were recruited as control group (50 subjects without periodontitis) and study groups comprising 30 patients each with mild, moderate and severe chronic generalized periodontitis. Periodontal parameters and orthopantamographs were taken for all the groups and then 5 mL venous blood samples were sent for complete blood count and biochemical analysis. Inter-group and intra-group comparisons were performed for all the assessed parametersResults: The periodontal parameters were significantly higher (P≤.05) in periodontitis patients. Except for the ESR, which was significantly higher (P=.03) in the mild periodontitis group than the control group, hematological and biochemical parameters were not significantly different (P>.05) among the study groups or between the control and study groups. This difference was not evident even among the male and female subjects of both control and study groups (P>.05).Conclusions: Within the limits of this cross-sectional study, it can be concluded that the presence and severity of periodontitis may not affect the hematological and biochemical parameters of an individual. Further long term studies are however encouraged to validate these findings. (Eur J Dent 2012;6:287-294)softening of enamel (erosion). In respect to the chemical variables tested, despite not statistically significant, the pH seems to have more influence on the erosive potential of these drinks. (Eur J Dent 2007;1:10-13)

Increased circulating cell-derived microparticle levels in deep infiltrating endometriosis patients with larger implants

2019 ◽  
Vol 11 (3) ◽  
pp. 137-145
Author(s):  
Jordina Munrós ◽  
Dolors Tàssies ◽  
Joan Carles Reverter ◽  
Francisco Carmona ◽  
María Ángeles Martínez-Zamora
Keyword(s):  
Venous Blood ◽  
Cross Sectional Study ◽  
Positive Control ◽  
Severe Form ◽  
Control Group ◽  
P Value ◽  
Deep Infiltrating Endometriosis ◽  
Cross Sectional ◽  
American Society ◽  
Infiltrating Endometriosis

Objective: Circulating cell-derived microparticles have been reported to be elevated in inflammatory and procoagulant conditions including deep infiltrating endometriosis. The objective of this pilot study was to investigate whether higher circulating cell-derived microparticle levels may be associated with specific clinical features and the extension or severity of deep infiltrating endometriosis. Methods: This is an observational analytical cross-sectional study, including three groups of patients undergoing gynecological surgery. The DIE group included 75 patients with deep infiltrating endometriosis, the control group (C group) consisted of 39 patients without endometriosis, and a positive control group was composed of 31 patients with ovarian endometriomas but not deep infiltrating endometriosis (OE group). Venous blood samples for circulating cell-derived microparticle determinations in plasma were obtained before surgery. The following variables were assessed: severe dysmenorrhea, dyspareunia, non-cyclic chronic pelvic pain, dyschezia, dysuria, hematuria, rectal bleeding, sterility, presence of ovarian endometrioma, adenomyosis, and adhesions, rASRM (revised American Society for Reproductive Medicine) stage, Enzian classification, number of sites affected, and the cumulative size of deep infiltrating endometrial implants. Results: Circulating cell-derived microparticle levels were statistically higher in the DIE group compared with the C group ( p-value = 0.001). None of the variables analyzed showed higher levels of circulating cell-derived microparticles in the DIE group, except for a significant positive correlation between the cumulative size of deep infiltrating endometrial lesions and circulating cell-derived microparticle levels ( r = 0.264, p = 0.022). Conclusion: Patients having deep infiltrating endometriosis with a larger cumulative size of endometriotic implants showed higher circulating cell-derived microparticle levels suggesting an increased inflammatory and/or hypercoagulable systemic status in this more severe form of the disease. Further research is needed to assess our findings and to explore the role of circulating cell-derived microparticles in the pathophysiology of deep infiltrating endometriosis.

scholarly journals PRETERM LABOUR

2018 ◽  
Vol 25 (09) ◽  
pp. 1342-1345
Author(s):  
Saima Ashraf ◽  
Shahida Parveen ◽  
Shahzad Alam
Keyword(s):  
Preterm Labour ◽  
Serum Magnesium ◽  
Venous Blood ◽  
Cross Sectional Study ◽  
Serum Magnesium Level ◽  
Amniotic Fluid Index ◽  
Singleton Pregnancy ◽  
Cross Sectional ◽  
History Of ◽  
Age Range

Objectives: To determine the frequency of hypomagnesaemia in women withpreterm labour. Study Design: Cross sectional study. Settings: Department of obstetrics &gynaecology Nishtar Hospital Multan. Duration of Study: From 10th November 2016 to 10th May2017. Subject and Methods: A total of 219 pregnant women with singleton pregnancy, pretermlabour and parity 1 – 4 were included in the study. Women with history of diabetes, hypertensionsmoking and polyhhydramnious amniotic fluid index (AFI)>25 cm on ultrasound were excluded.Venous blood was drawn from entire subjects to evaluate the serum magnesium level and sentimmediately to laboratory for analysis venous blood samples were obtained by venepunctureand collected in lithium heparin specimen bottles. Data was collected for hypomagnesaemia.Results: Age range in this study was from 20 to 40 years with mean age of 30.356±3.60 years,mean parity 1.936± 0.96, mean gravida 2.936 ± 0.96, mean gestational age 32.000±2.25weeks and mean BMI was 27.337 ± 1.67 kg/m2. Majority of the patients were from 20 – 30 years(51.1%). History of preterm delivery was 17.4%. Majority of patients belong to middle economicstatus (66.2%). Hypomagnesaemia was seen in 37.9% patients. Conclusion: it is concludedthat low serum magnesium (hypomagnesaemia) is associated with preterm onset of labour.Maternal hypomagnesaemia may be used as a predictor of preterm labour.

scholarly journals Association between serum magnesium concentration and metabolic syndrome, diabetes, hypertension and hyperuricaemia in knee osteoarthritis: a cross-sectional study in Hunan Province, China

BMJ Open ◽  
2018 ◽  
Vol 8 (9) ◽  
pp. e019159 ◽  
Author(s):  
Yilun Wang ◽  
Jie Wei ◽  
Chao Zeng ◽  
Tuo Yang ◽  
Hui Li ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Knee Osteoarthritis ◽  
Serum Magnesium ◽  
Cross Sectional Study ◽  
Hunan Province ◽  
Magnesium Concentration ◽  
Inverse Association ◽  
Sectional Study ◽  
Cross Sectional ◽  
Knee Oa

ObjectivesTo examine the associations between serum magnesium (Mg) concentration with the prevalence of metabolic syndrome (MetS), diabetes mellitus (DM), hypertension (HP) and hyperuricaemia (HU) in patients with radiographic knee osteoarthritis (OA).MethodsThe present study was conducted at the Health Management Center of Xiangya Hospital. Radiographic OA was evaluated for patients aged over 40 years with basic characteristics and blood biochemical assessment. Serum Mg concentration was measured using the chemiluminescence method. MetS, DM, HP and HU were diagnosed based on standard protocols. The associations between serum Mg concentration with MetS, DM, HP and HU were evaluated by conducting multivariable adjusted logistic regression.ResultsA total of 962 patients with radiographic knee OA were included. Compared with the lowest quintile, the multivariable adjusted ORs and related 95% CIs of DM were 0.40 (95% CI 0.23 to 0.70, p=0.001), 0.33 (95% CI 0.18 to 0.60, p<0.001), 0.27 (95% CI 0.14 to 0.52, p<0.001) and 0.22 (95% CI 0.11 to 0.44, p<0.001) in the second, third, fourth and highest quintiles of serum Mg, respectively (p for trend <0.001); the multivariable adjusted ORs of HU were 0.33 (95% CI 0.19 to 0.59, p<0.001), 0.52 (95% CI 0.30 to 0.91, p=0.022) and 0.39 (95% CI 0.22 to 0.70, p=0.001) in the third, fourth and highest quintiles of serum Mg, respectively (p for trend <0.001); and the multivariable adjusted ORs of MetS were 0.59 (95% CI 0.36 to 0.94, p=0.027) in the second and 0.56 (95% CI 0.34 to 0.93, p=0.024) in the highest quintiles of serum Mg. However, the inverse association between serum Mg and the prevalence of MetS was non-linear (p for trend=0.067). There was no significant association between serum Mg and HP in patients with OA.ConclusionsThe serum Mg concentration was inversely associated with the prevalence of MetS, DM and HU in patients with radiographic knee OA.Level of evidenceLevel III, cross-sectional study.

scholarly journals A comparative study of blood glucose and serum calcium levels in term IUGR neonates and normal neonates: a cross sectional study

2018 ◽  
Vol 5 (6) ◽  
pp. 2087
Author(s):  
Kavitha Konded ◽  
Bhavana Koppad
Keyword(s):  
Blood Glucose ◽  
Serum Calcium ◽  
Venous Blood ◽  
Cross Sectional Study ◽  
Primary Objective ◽  
Test Method ◽  
Control Group ◽  
Neurodevelopmental Outcomes ◽  
Cross Sectional ◽  
The Mean

Background: Hypoglycemia and hypocalcemia are common metabolic problems occurring in the newborn and have direct consequences in the early neonatal period, prompt identification and treatment prevents severe neurodevelopmental outcomes. The primary objective was to compare blood glucose and serum calcium levels in term Intrauterine growth restriction (IUGR) babies with term appropriate for age (AGA) babies and secondarily to compute number of term IUGR babies with hypoglycemia and hypocalcemia.Methods: Fifty term IUGR and 50 term AGA babies delivered at SDMCMSH, Dharwad during the study period of one year were included as cases and controls respectively after considering the inclusion and exclusion criteria. Two ml of peripheral venous blood was analyzed at 3 hours and 24 hours of life. Serum calcium was measured by calorimetric test method and blood glucose by auto analyzer. Statistical analysis was done using SPSS-17.Results: At 3 hours of birth, 24% of term IUGR and 4% of AGA neonates had hypoglycemia. The mean RBS of cases at 3rd hour was 61.36±23.56 mg/dl, significantly lower than control group (75.90±22.57mg/dl). The mean RBS among cases at 24 hours of life was 70.42±16.14 mg/dl compared to 78.84±15.90 mg/dl among controls. Both correlations were statistically significant. 8% cases had hypocalcemia at 3 hours and 6% had at 24 hours. The mean serum calcium level was lower in cases (8.50±1.40 mg/dl) than controls (8.63±1.14 mg/dl) at the 3rd hour of life and 24 hours of life [cases (8.42±1.07 mg/dl) versus controls (8.64±0.91 mg/dl)].Conclusions: Significantly lower blood glucose levels were identified in term IUGR neonates. This association was apparent at 3 hours of life. The measurement of serum calcium & glucose in IUGR babies could predict a poorer outcome in these patients. Identifying and treating these biochemical abnormalities can avoid short term as well as long term sequelae.

scholarly journals Vertebral Fracture Assessment in Postmenopausal Women With Postsurgical Hypoparathyroidism

2021 ◽  
Author(s):  
Cristiana Cipriani ◽  
Salvatore Minisola ◽  
John P Bilezikian ◽  
Davide Diacinti ◽  
Luciano Colangelo ◽  
...  
Keyword(s):  
Vertebral Fracture ◽  
Postmenopausal Women ◽  
Trabecular Bone Score ◽  
Cross Sectional Study ◽  
Qualitative Assessment ◽  
Vertebral Fracture Assessment ◽  
Control Group ◽  
Mineral Density ◽  
Cross Sectional ◽  
Fracture Assessment

Abstract Context Hypoparathyroidism is a rare endocrine disorder whose skeletal features include suppression of bone turnover and greater volume and width of the trabecular compartment. Few and inconsistent data are available on the prevalence of vertebral fractures (VF). Objective To evaluate the prevalence of VF assessed by vertebral fracture assessment (VFA) in postmenopausal women with chronic postsurgical hypoparathyroidism. Design Cross-sectional study Setting Ambulatory referral center. Patients or Other Participants Fifty postmenopausal women (mean age 65.4 ± 9 years) with chronic postsurgical hypoparathyroidism and 40 age-matched healthy postmenopausal women (mean age 64.2 ± 8.6). Main outcome measures Lumbar spine, femoral neck, and total hip bone mineral density were measured by dual X-ray absorptiometry (Hologic Inc., USA) in all subjects. Site-matched spine trabecular bone score was calculated by TBS iNsight (Medimaps, Switzerland). Assessment of VF was made by VFA (iDXA, Lunar GE, USA) using the semiquantitative method and the algorithm-based qualitative assessment. Results All-site BMD values were higher in the hypoparathyroid vs the control group. By VFA, we observed a 16% prevalence of VF in hypoparathyroid women vs 7.5% in control subjects. Among those with hypoparathyroidism who fractured, 5 (62.5%) had grade 1 wedge, 2 (25%) had grade 2 wedge, and 1 (12.5%) had grade 2 wedge and grade 2 biconcave VF. In the hypoparathyroid group, 57% with VFs and 32% without VFs had symptoms of hypoparathyroidism. Conclusion We demonstrate for the first time that in postmenopausal women with chronic postsurgical hypoparathyroidism, VFs are demonstrable by VFA despite normal BMD.

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