scholarly journals Study of oral glucosamine, methylsulfonylmethane and their combination in osteoarthritis of the knee

2021 ◽  
Vol 10 (1) ◽  
pp. 225
Author(s):  
Shashikala Eda
Keyword(s):  
Clinical History ◽  
Study Groups ◽  
Control Group ◽  
Osteoarthritis Of The Knee ◽  
Womac Pain ◽  
X Rays ◽  
Joint Disorder ◽  
Physical Functions ◽  
Male Patients ◽  
Anti Inflammatory

Background: Osteoarthritis (OA) of the knee is the most common degenerative joint disorder that results in disability and increased morbidity. Conventional treatment of OA with non-steroidal anti-inflammatory drugs (NSAIDs) often leads to serious adverse side effects that may increase morbidity and mortality. Glucosamine and Methylsulfonylmethane (MSM) have anti-inflammatory and analgesic properties which may supplement NSAIDs. Hence this study was aimed to determine the effectiveness and safety of these drugs in the management of knee OAMethods: 76 (63.33%) female and 44 (36.67%) male patients of OA of the knees were divided equally into four groups depending upon the therapy with Glucosamine or MSM or their combination (study groups) or none of them (control group) for 12 weeks. After the written consent, a detail Clinical History& Examination, Biochemical investigations, X-rays of chest and knees and ECG were done. The outcome of the treatment was assessed by Western Ontario and McMaster University Osteoarthritis (WOMAC) Index and for any adverse drug effects.Results: After 12 weeks of study there was significant decrease in mean WOMAC pain scores (27.29-39.13) and total aggregate scores (23.53-37.14%) in study groups (p<0.01-p<0.001) as compared to control group (14.28 % and 8.82% respectively). Besides the relief of pain and improvement in physical functions were superior in patients treated with combination therapy. Conclusions: This study showed Glucosamine & MSM are effective in the management of OA of knee and are safe health supplement to NSAIDs while their combination was more superior and effective. 

A Blinded Randomised Trial of Acupuncture (Manual and Electroacupuncture) Compared with a Non-Penetrating Sham for the Symptoms of Osteoarthritis of the Knee

2008 ◽  
Vol 26 (2) ◽  
pp. 69-78 ◽  
Author(s):  
Ronald W Jubb ◽  
Emad S Tukmachi ◽  
Peter W Jones ◽  
Emma Dempsey ◽  
Lynn Waterhouse ◽  
...  
Keyword(s):  
Randomised Trial ◽  
Symptomatic Improvement ◽  
Sham Acupuncture ◽  
Mean Difference ◽  
Acupuncture Group ◽  
Control Group ◽  
Acupuncture Points ◽  
Osteoarthritis Of The Knee ◽  
Womac Pain ◽  
Treatment Comparison

Objectives To compare the effect of acupuncture (manual and electroacupuncture) with that of a non-penetrating sham (‘placebo’ needle) in patients with osteoarthritic knee pain and disability who are blind to the treatment allocation. Methods Acupuncture naive patients with symptomatic and radiological evidence of osteoarthritis of the knee were randomly allocated to a course of either acupuncture or non-penetrating sham acupuncture using a sheathed ‘placebo’ needle system. Acupuncture points for pain and stiffness were selected according to acupuncture theory for treating Bi syndrome. Both manual and electrical stimulation were used. Response was assessed using the WOMAC index for osteoarthritis of the knee, self reported pain scale, the EuroQol score and plasma β-endorphin. The effectiveness of blinding was assessed. Results There were 34 patients in each group. The primary end point was the change in WOMAC pain score after the course of treatment. Comparison between the two treatment groups found a significantly greater improvement with acupuncture (mean difference 60, 95% CI 5 to 116, P=0.035) than with sham. Within the acupuncture group there was a significant improvement in pain (baseline 294, mean change 95, 95% CI 60 to 130, P<0.001) which was not seen by those who had sham acupuncture (baseline 261, mean change 35, 95% CI-10 to 80, P=0.12). Similar effects within group, but not between groups, were seen with the secondary end points of WOMAC stiffness, WOMAC function, and self reported pain. One month after treatment the between group pain difference had been lost (mean difference 46; 95% CI −9 to 100, P=0.10) although the acupuncture group was still benefiting compared to baseline (mean difference 59; 95% CI 16 to 102, P=0.009). The EuroQol score, a generic measure of health related quality of life, was not altered by the treatments. A minority of patients correctly guessed their treatment group (41% in the acupuncture group and 44% in the control group). Plasma β-endorphin levels were not affected by either treatment. Conclusions Acupuncture gives symptomatic improvement for patients with osteoarthritis of the knee, and is significantly superior to non-penetrating sham acupuncture. The study did not confirm earlier reports of release of plasma β-endorphin during acupuncture.

The anti-inflammatory effects of erythromycin, clarithromycin, azithromycin and roxithromycin on histamine-induced otitis media with effusion in guinea pigs

2018 ◽  
Vol 132 (7) ◽  
pp. 579-583 ◽  
Author(s):  
B Ersoy ◽  
B Aktan ◽  
K Kilic ◽  
M S Sakat ◽  
S Sipal
Keyword(s):  
Otitis Media ◽  
Middle Ear ◽  
Guinea Pigs ◽  
Otitis Media With Effusion ◽  
Study Groups ◽  
Control Group ◽  
Middle Ear Mucosa ◽  
Anti Inflammatory ◽  
The Right ◽  
Better Than

AbstractBackgroundOtitis media with effusion is a clinical manifestation characterised by inflammation of middle-ear mucosa. This study investigated the therapeutic effect of erythromycin, clarithromycin, azithromycin and roxithromycin on a histamine-induced animal model of otitis media with effusion.MethodsThe animals were divided into five groups, receiving erythromycin, clarithromycin, azithromycin, roxithromycin or saline solution. The guinea pigs in the study groups received erythromycin (40 mg/kg/day), clarithromycin (15 mg/kg/day), azithromycin (10 mg/kg/day) or roxithromycin (10 mg/kg/day) for 3 days by gastric tube. Four hours after the end of the administration, histamine solution was injected into the right middle ear.ResultsThe lowest neutrophil density value obtained using stereological techniques was in the azithromycin group (0.86 ± 0.25 × 10−5/μm3), while the highest value was observed in the control group (6.68 ± 3.12 × 10−5/μm3). The anti-inflammatory properties of clarithromycin, azithromycin and roxithromycin were similar to one another, but better than that of erythromycin.ConclusionThe use of macrolide antibiotics is recommended, as they show antibacterial and anti-inflammatory efficacy in otitis media with effusion.

scholarly journals Platelet-rich plasma injection is more effective than hyaluronic acid in the treatment of knee osteoarthritis

2014 ◽  
Vol 2 (12_suppl4) ◽  
pp. 2325967114S0024
Author(s):  
Esteban Holguin
Keyword(s):  
Hyaluronic Acid ◽  
Platelet Rich Plasma ◽  
Low Cost ◽  
Study Groups ◽  
Womac Score ◽  
Pain Scale ◽  
Control Group ◽  
Osteoarthritis Of The Knee ◽  
Clear Result

Objectives: To determine and compare the effects of autologous platelet rich plasma (PRP) and hyaluronic acid (HA) for the treatment of osteoarthritis of the knee. Methods: This prospective study included 150 patients affected by severe osteoarthritis of the knee. Gonarthrosis was graded using the Kellgren-Lawrence and Albhack radiographic classification scale. 150 patients were randomized into 2 study groups .In the PRP group (n=55) three intraarticular injection were applied andthe control group (n=55) received 3 intra-articular injections of high molecular weight HA. An unblinded physician performed infiltration once a week for 3 weeks into the knee affected by clinically relevant gonarthrosis (in both groups). All patients were evaluated with the Western Ontario and McMaster (WOMAC) score and visual pain scale before the infiltration and at 3, 6, and 12 months after the first injection. Results: No severe adverse events was observed. Statistically significant better results in the WOMAC score and visual pain scale was determined in PRP group than HA group at 3 months and 6 months follow up. The cost of the application for the PRP group was lower than that of the HA group.At 12 months' of follow-up, PRP and HA treatments offered similar results. Conclusion: The results of this study have shown the application of autologousPRP to be a safe, effective and low-cost method for treating OA tan HA. However, further studies are required for a more clear result

scholarly journals The Role of TNF-α induced MSCs on Suppressive Inflammation by Increasing TGF-β and IL-10

2018 ◽  
Vol 6 (10) ◽  
pp. 1779-1783 ◽  
Author(s):  
Agung Putra ◽  
Fatkhan Baitul Ridwan ◽  
Allisha Irwaniyanti Putridewi ◽  
Azizah Retno Kustiyah ◽  
Ken Wirastuti ◽  
...  
Keyword(s):  
Study Groups ◽  
Significant Negative Correlation ◽  
Control Group ◽  
Control Group Design ◽  
Tnf Α ◽  
Post Test ◽  
Anti Inflammatory ◽  
Suppressive Phenotype ◽  
Inflammatory Milieu ◽  
Inflammatory Molecules

BACKGROUND: Mesenchymal stem cells (MSCs) may serve as immunoregulators by producing various anti-inflammatory molecules. Under sufficient level of TNF-α, MSCs become activated and adopt immune-suppressive phenotype (MSCs type-2) by releasing various anti-inflammatory molecule including TGF-β and IL-10. However, the ability of MSC itself to produce IL-10 under TNF-α stimulation and the correlation of TGF-β production of MSCs to IL-10 level remains to be elucidated. AIM: In this study, MSCs were activated with various TNF-α doses to determine the increase of IL-10 and TGF-β level as well as its correlation. MATERIAL AND METHODS: This study used post-test only control group design, by using 3 study groups, consist of 1 control (C) and 2 treatments (T) (TNF-α = 5 and 10 ng/mL) with triplicate induced in MSC for 24 hours, then the levels of IL-10 and TGF-β were measured by using ELISA assay. RESULTS: The results of this study showed a significant increase of TGF-β and IL-10 levels (p < 0.05) at TNF-α 5 and 10 ng/mL dose of TNF-α. Moreover, there was a significant negative correlation between TGF-β and IL-10 level on 5 and 10 ng/mL dose TNF-α treatment. CONCLUSION: Based on our study, we conclude that the 5 ng/mL dose of TNF-α is a sufficient dose for MSCs to suppress the inflammatory milieu. The higher increase of TGF beta is due to the controlled inflammation by IL-10.

scholarly journals EVALUATION OF INTERLEUKIN-10 LEVELS IN THE PLASMA OF PATIENTS WITH VARIOUS STAGES OF TUBERCULOSIS

2015 ◽  
Vol 88 (2) ◽  
pp. 164-167 ◽  
Author(s):  
Pacifique Ndishimye ◽  
Fouad Seghrouchni ◽  
Bianka Domokos ◽  
Olga Soritau ◽  
Abderrahim Sadak ◽  
...  
Keyword(s):  
Inflammatory Cytokines ◽  
Interleukin 10 ◽  
Vital Role ◽  
Control Group ◽  
Clear Understanding ◽  
X Rays ◽  
Abnormal Chest ◽  
Anti Inflammatory ◽  
Tuberculosis Therapy ◽  
And Control

Mycobacterium tuberculosis (Mtb) infection remains one of the world’s major causes of illness and mortality. A clear understanding of the host defense against Mtb is imperatively needed for the control of this epidemic. When tuberculosis (TB) infection occurs, a variety of pro and anti-inflammatory cytokines play a vital role in the pathogenesis of this disease. Interleukin-10 (IL-10) is one of the most important anti-inflammatory cytokines reported to suppress the protective immune response against tuberculosis.The aim of the present study was to evaluate the association of plasma IL-10 levels with various disease stages of TB and the possible effects of treatment on these levels. A group of 30 patients with active pulmonary TB and a control group of 21 healthy individuals were enrolled in this study. The levels of IL-10 were measured before, during, and after treatment using commercially available enzyme-linked immune-sorbent assay (ELISA). Data were analyzed using GraphPad Prism version 5.0.The results showed that the levels of IL-10 had significant differences between the TB and control groups (p<0.05). The patients with abnormal chest X-Ray findings had higher IL-10 levels when compared to patients with normal X-Rays (p=0.03). A subgroup of 18 patients were followed during the treatment and the mean plasma concentration of IL-10 in patients before therapy was higher than in patients at 3 months of therapy and in patients after 6 months of therapy (p=0.01). However, the IL-10 level remained significantly higher in patients at the end of treatment compared with controls.These findings could be used in follow-up as clinical biomarker of the success of tuberculosis therapy.

scholarly journals Metabolic Syndrome and Selective Inflammatory Markers in Psoriatic Patients

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Simona Vachatova ◽  
Ctirad Andrys ◽  
Jan Krejsek ◽  
Miloslav Salavec ◽  
Karel Ettler ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Cardiovascular Risk ◽  
Inflammatory Markers ◽  
Subclinical Atherosclerosis ◽  
Serum Markers ◽  
Control Group ◽  
Male Patients ◽  
Anti Inflammatory

The presented article studies the role of selected inflammatory and anti-inflammatory serum markers of psoriatic patients in the pathogenesis of metabolic syndrome (MS) and psoriasis. The study is based on the comparison between the group of psoriatic patients (74) and the control group (65). We found significantly higher BMI (p<0.05) and diastolic blood pressure (p<0.05) in the psoriatic patients. The values of waist circumference and BMI were significantly higher (p<0.05) in the male patients compared to the men in the control group. The analysis revealed significantly higher CRP (p<0.001), Lp-PLA2 (p<0.001), leptin (p<0.01), and resistin (p<0.01) levels in the psoriatic patients. Significantly higher levels of CRP (p<0.01), Lp-PLA2 (p<0.001), leptin (p<0.01), and resistin (p<0.05) were found in the patients with MS compared to the controls with MS. The level of adiponectin was significantly lower (p<0.01) in the patients with MS. Finally, we found significantly higher level of Lp-PLA2 (p<0.001) in the group of patients without MS compared to the controls without MS. In conclusion, observed inflammatory and anti-inflammatory markers (CRP, adiponectin, leptin, resistin, and Lp-PLA2) are involved in both pathogenesis of MS and pathogenesis of psoriasis. The level of Lp-PLA2 indicates the presence of subclinical atherosclerosis (cardiovascular risk) in psoriatic patients.

scholarly journals A community-centric multi-disciplinary education program with the 8-section brocade Tai Chi therapy for patients with osteoarthritis of the knee – a pilot study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Kevin Ki-Wai Ho ◽  
Gerald Pong ◽  
Queena Wai-Chin Poon ◽  
Jojo Yan-Yan Kwok ◽  
Wai-Wang Chau ◽  
...  
Keyword(s):  
Education Program ◽  
Tai Chi ◽  
Program Effectiveness ◽  
Dropout Rate ◽  
Activity Level ◽  
Control Group ◽  
Osteoarthritis Of The Knee ◽  
Womac Pain ◽  
Knee Oa ◽  
Tai Chi Exercise

Abstract Background Osteoarthritis (OA) of the knee is one of the most common chronic degenerative joint diseases, and a multi-disciplinary approach to educating patients with OA knee are effective in symptoms management. Tai Chi exercise is a novel approach to relieving knee OA symptoms. Combining both educational program and Tai Chi has not yet been explored. Methods Multi-disciplinary education program included a total of 4-week 2-h weekly talks delivered by different health professionals with live demonstrations. This was then followed by a 1-h Tai Chi class (Baduanjin). Results from IPAQ (Physical activity level), WOMAC (evaluate knee OA conditions), and SF-36v2 (quality of life) were collected at the first class of education program, 3 and 6 months after the end of Tai Chi class. CSQ-8 (program effectiveness) was administered on the last day of Tai Chi class. Results One hundred and twelve patients joined the program. The overall attendance was over 90% with close-to-zero dropout rate. Satisfaction scored high in 85% of patients. WOMAC pain scores (p = 0.04) and SF-36v2 emotional role (p = 0.02) were statistically decreasing (improving) at 6 months after the program. SF-36v2 physical role and mental health tended to improve with time. Conclusions Combining both multidisciplinary education program program and Tai Chi exercise for knee OA patients was proven feasible. This program received high satisfaction, high attendance and very low dropout rates without any adverse event. Patients’ pain and emotion were significantly improved. A large-scale randomized trial introducing a control group is recommended. Trial registration Registry: ClinicalTrials.gov Registration number: NCT04204213 Date of registration: 18/12/2019 (Retrospectively registered)

scholarly journals Comparative Study of Clinical and Radiological Outcomes of Unconstrained Bicondylar Total Knee Endoprostheses with Anti-allergic Coating

2011 ◽  
Vol 5 (1) ◽  
pp. 354-360 ◽  
Author(s):  
Philipp Bergschmidt ◽  
Rainer Bader ◽  
Susanne Finze ◽  
Christoph Schulze ◽  
Guenther Kundt ◽  
...  
Keyword(s):  
Comparative Study ◽  
Study Groups ◽  
Control Group ◽  
X Rays ◽  
Knee Prostheses ◽  
Postoperative Function ◽  
Sf 36 ◽  
Significant Difference ◽  
Total Knee ◽  
Retrospective Comparative Study

Background: Hypersensitivity reactions to implant materials have become more important in total knee replacement (TKR). The purpose of this retrospective comparative study was to evaluate the clinical and radiological outcomes of unconstrained bicondylar total knee prostheses with and without anti-allergic titanium(niobium)nitrite (Ti(Nb)N) coating. Methods: Twenty-four patients (25 TKRs) underwent a preoperative clinical evaluation and then a postoperative evaluation after 26.2 months in the allergy group treated with coated implants (n=13 implants) and after 24.5 months in the control group treated with uncoated implants but identical geometry (n=12) using HSS, WOMAC and SF-36 scores. Radiological evaluations were performed using standard anterior-posterior (a.p.) and lateral X-rays. Results: During follow-up two patients of the allergy group had to undergo revision surgery due to non-implant-related reasons. A comparative analysis of both study groups showed a significant difference in the HSS scores at both evaluation time points (MW test p≤0.050); these findings are remarkable since the control group had a significantly lower score preoperatively (54.0 vs 65.0 points) and a significantly higher score (82.5 vs 75.0 points) postoperatively. The preoperative and postoperative WOMAC and SF-36 scores were comparable in both groups (MW test p≥0.052), although the postoperative increase in the score for the allergy group was lower. The radiological results were comparable in both groups and were unlikely to influence the results. Conclusions: This clinical study demonstrates the restricted outcome in postoperative function and quality of life in the allergy group compared to the control group.

scholarly journals AflaB2® and osteoarthritis: a multicentric, observational, post-marketing surveillance study in Indian patients suffering from knee osteoarthritis

2020 ◽  
Vol 7 (1) ◽  
pp. 110
Author(s):  
Atul V. Jain ◽  
Karun A. Jain ◽  
N. Vijayaraghavan
Keyword(s):  
Oral Intake ◽  
Womac Pain ◽  
Baseline Score ◽  
Efficacy And Safety ◽  
Knee Oa ◽  
Post Marketing Surveillance ◽  
Joint Disorder ◽  
Post Marketing ◽  
Physical Functions ◽  
Immune Pathway

<p><strong>Background:</strong> Osteoarthritis (OA) is one of the most debilitating chronic degenerative joint disorder characterized by pain, inflammation and stiffness of joints with wear and tear of the cartilage. Recent evidences suggest the involvement of the immune pathway in OA development. This study was conducted to evaluate the efficacy and safety of AflaB2<sup>®</sup> capsules containing Aflapin<sup>®</sup> and native collagen type II in knee OA patients.</p><p><strong>Methods:</strong> Total 40 knee OA subjects were enrolled at the out-patient department (OPD) of three different sites under supervision of physicians as per the inclusion and exclusion criteria of the study. Subjects were instructed to consume AflaB2<sup>® </sup>capsules once daily orally for three months. They were informed to visit the respective study center as per the schedule visits to assess and record the efficacy and safety.</p><p><strong>Results:</strong> AflaB2<sup>®</sup> treatment showed significant reduction in pain and stiffness with improvement in physical functions compared to the baseline. The reduction in pain score was observed from 2<sup>nd</sup> visit on visual analogue scale (VAS). The VAS score was reduced to 1.63±1.23 (p&lt;0.001) from its baseline score 6.0±1.04 at the end of the treatment. The WOMAC Total Score was reduced to 18.1±6.04 (p&lt;0.001) from its baseline score 74.4±8.07 at the end of the treatment. The improvement was observed in WOMAC pain, stiffness and physical functions score. No significant side-effect was reported with AflaB2<sup>®</sup> treatment throughout the study.</p><p><strong>Conclusions:</strong> The present study provides the evidence in support of the potential efficacy and excellent tolerability of oral intake of AflaB2<sup>®</sup> capsules in reducing OA symptoms.</p>

Computed Tomography-Based Patient-Specific Instrumentation Loses Accuracy with Significant Varus Preoperative Misalignment

2020 ◽  
Author(s):  
Vicente Jesús León-Muñoz ◽  
Mirian López-López ◽  
Alonso José Lisón-Almagro ◽  
Francisco Martínez-Martínez ◽  
Fernando Santonja-Medina
Keyword(s):  
Computed Tomography ◽  
Deformity Correction ◽  
Patient Specific ◽  
Control Group ◽  
X Rays ◽  
Varus Alignment ◽  
Patient Specific Instrumentation ◽  
Conventional Instrumentation ◽  
The Mean ◽  
Valgus Alignment

AbstractPatient-specific instrumentation (PSI) has been introduced to simplify and make total knee arthroplasty (TKA) surgery more precise, effective, and efficient. We performed this study to determine whether the postoperative coronal alignment is related to preoperative deformity when computed tomography (CT)-based PSI is used for TKA surgery, and how the PSI approach compares with deformity correction obtained with conventional instrumentation. We analyzed pre-and post-operative full length standing hip-knee-ankle (HKA) X-rays of the lower limb in both groups using a convention > 180 degrees for valgus alignment and < 180 degrees for varus alignment. For the PSI group, the mean (± SD) pre-operative HKA angle was 172.09 degrees varus (± 6.69 degrees) with a maximum varus alignment of 21.5 degrees (HKA 158.5) and a maximum valgus alignment of 14.0 degrees. The mean post-operative HKA was 179.43 degrees varus (± 2.32 degrees) with a maximum varus alignment of seven degrees and a maximum valgus alignment of six degrees. There has been a weak correlation among the values of the pre- and postoperative HKA angle. The adjusted odds ratio (aOR) of postoperative alignment outside the range of 180 ± 3 degrees was significantly higher with a preoperative varus misalignment of 15 degrees or more (aOR: 4.18; 95% confidence interval: 1.35–12.96; p = 0.013). In the control group (conventional instrumentation), this loss of accuracy occurs with preoperative misalignment of 10 degrees. Preoperative misalignment below 15 degrees appears to present minimal influence on postoperative alignment when a CT-based PSI system is used. The CT-based PSI tends to lose accuracy with preoperative varus misalignment over 15 degrees.

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