scholarly journals Study on impact of protein energy malnutrition on development in children

2019 ◽  
Vol 6 (6) ◽  
pp. 2566
Author(s):  
Dhara Patel ◽  
Greeshma Issac
Keyword(s):  
Protein Energy Malnutrition ◽  
Fine Motor ◽  
Maximum Effect ◽  
P Value ◽  
Normal Children ◽  
Social Domain ◽  
Gross Motor ◽  
Protein Energy ◽  
Grade 3 ◽  
The Impact

Background: Majority of the children in India who live below the poverty line in an environment of deprivation and starvation have physical and developmental retardation. The Objective of this study to study the impact and comparison of protein energy malnutrition on the development with normal children.Methods: This was a hospital based cross sectional study in which total 128 cases of protein energy malnutrition and 30 normal children were enrolled from nutritional rehabilitation center and in patients wards. The study population comprised of children less than 5 years of age, having weight for height/length ≤3 SD, with visible wasting, or bipedal oedema, with mid arm circumference <11.5 cm were assessed for their development in all four domains using Denver II developmental Screening Test (DDST-II).Results: The gross motor milestones are affected in 62.5% with grade4 PEM & 42.85% with grade 3, the fine motor component is affected more in grade 4 with other domains less affected, no significant relation of language delay with PEM was observed in this study, 40% of children with grade 4 PEM shows delay in social domain while 18.18% of the patients with grade 3 PEM show delay in social domain. No patients with grade 1 or grade 2 PEM showed delay in social domain. All four domains are affected in PEM with a maximum effect in gross motor, but the difference does not seem to be significant as the p value is 0.3 i.e.  >0.05 which is insignificant.Conclusions: My study on the effect of protein energy malnutrition on development proves that there in increasing delay in all the domains of development with increasing grade of malnutrition. Early detection of malnutrition in community can cause early intervention and increase the productivity of nation.

scholarly journals 3423 Poorer Outcomes Among Septic Patients with Protein Energy Malnutrition

2019 ◽  
Vol 3 (s1) ◽  
pp. 124-124
Author(s):  
Adeyinka Charles Adejumo ◽  
Olalekan Akanbi ◽  
Lydie Pani
Keyword(s):  
Clinical Outcomes ◽  
Primary Care Physicians ◽  
Protein Energy Malnutrition ◽  
Community Dwelling ◽  
P Value ◽  
Protein Energy ◽  
Propensity Matching ◽  
Study Population ◽  
Clinical Conditions ◽  
The Impact

OBJECTIVES/SPECIFIC AIMS: Protein Energy Malnutrition (PEM) could compromise the body’s defense systems resulting in sepsis, which further depletes calorie stores. Among hospitalized patients, we investigate 1) the relationship between PEM and sepsis, 2) the impact of PEM on trends in mortality from sepsis, and 3) the influence of PEM on clinical outcomes of sepsis. METHODS/STUDY POPULATION: Using the 2014 Healthcare Cost and Utilization Project - Nationwide Inpatient Sample (NIS) patient’s discharge records, we identified patients with sepsis, PEM, and other clinical conditions with ICD-9-CM codes. After stratifying sepsis into two: uncomplicated (without shock) and complicated (with shock), we estimated the adjusted odds (aOR) of developing sepsis (total, uncomplicated and complicated) with PEM. Then, we selected hospitalizations with sepsis from 2007-2014 years of the HCUP-NIS, and calculated the trend in mortality from sepsis, stratified by PEM status, as an effect modifier. Finally, we matched PEM to no PEM (1:1) using a greedy algorithm-based propensity methodology and estimated the effect of having mortality, complicated sepsis and 10 other clinical outcomes and healthcare utilization (SAS 9.4). RESULTS/ANTICIPATED RESULTS: PEM was associated with higher odds for sepsis (aOR:3.97[3.89-4.05]), and complicated vs. uncomplicated sepsis (1.74[1.67-1.81]). Although mortality in sepsis has been trending down from 2007-2014 (−1.19%/year, p-trend<0.0001), the decrease was less pronounced among those with PEM vs. no-PEM (−0.86%/year vs. −1.29%/year, p-value < 0.0001). After propensity matching, PEM was associated with higher mortality (1.35[1.32-1.37]), cost ($160,724[159,517-161,940] vs. $86,650[85,931-87,375]), length of stay (14.76[14.68-14.84] vs. 8.49[8.45-8.56] days), and worse outcomes in general. DISCUSSION/SIGNIFICANCE OF IMPACT: PEM is a risk factor of sepsis and associated with poorer outcomes among septic patients. A concerted effort involving primary care physicians, nutritionists, nurses in identifying, preventing, and treatment of PEM in the community-dwelling individuals before hospitalization might mitigate against these devastating outcomes.

Risk factors for oral mucositis (OM) in multiple myeloma (MM) patients receiving high-dose melphalan (Mel) prior to autologous stem cell transplantation (SCT).

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e19565-e19565
Author(s):  
Bhavana Bhatnagar ◽  
Olga G. Goloubeva ◽  
Steven Gilmore ◽  
Arnold Hoffman ◽  
Kathleen Ruehle ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hospital Stay ◽  
Oral Intake ◽  
Length Of Hospital Stay ◽  
High Serum ◽  
P Value ◽  
High Dose ◽  
Grade 3 ◽  
High Dose Melphalan ◽  
The Impact

e19565 Background: OM is a common complication of high-dose melphalan in MM patients (pts). Proposed risk factors for OM in SCT include: low albumin and high serum creatinine (Cr) levels, both were evaluated in MM patients undergoing Mel/ASCT. (Grazziutti, ML, Bone Marrow Transplant 2006). Methods: This is a single center retrospective chart review of 214 sequentially treated MM pts who received Mel 200mg/m2 conditioning prior to SCT between January 2005-September 2011. Data collected included: demographics, Hgb, Cr, C-reactive protein and albumin on the day of SCT, length of hospital stay. OM assessment was graded as follows: Grade 1, no OM; Grade 2, mild OM; the pts maintained adequate oral intake; Grade 3, decreased oral intake and/or use of oral narcotics; Grade 4, severe OM needing intravenous narcotics. Results: The table below describes pt characteristics grouped by OM grade. Overall, 56 pts (27%) had grade 3/4 OM. Multivariate analysis of variance revealed no statistically significant correlation between OM grade and Hgb, Cr, albumin, CRP; the overall test’s p value = 0.55. There were no racial or gender differences with regard to grade of mucositis, the p-values range are 0.75 and 0.31, respectively (likelihood ratio chi-square test). Most interestingly, OM did not impact length of hospital stay. Conclusions: We did not establish any predictive risk factors for OM as previously described. Analysis of the impact of OM on MM response and event and overall survival will be presented. Studies of Mel pharmacogenetics may provide insight to patients' predisposition to OM. [Table: see text]

Regorafenib (REG) in progressive metastatic colorectal cancer (mCRC): Analysis of age subgroups in the phase III CORRECT trial.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. 3636-3636 ◽  
Author(s):  
Eric van Cutsem ◽  
Alberto Sobrero ◽  
Salvatore Siena ◽  
Alfredo Falcone ◽  
Marc Ychou ◽  
...  
Keyword(s):  
Progression Free Survival ◽  
Phase Iii ◽  
P Value ◽  
Correct Trial ◽  
Multikinase Inhibitor ◽  
Once Daily ◽  
Grade 3 ◽  
Dose Modifications ◽  
The Impact ◽  
To Receive

3636 Background: In the CORRECT phase III trial, the multikinase inhibitor REG demonstrated significant improvement in overall survival (OS) and progression-free survival vs placebo (Pla) in patients (pts) with mCRC whose disease progressed on other standard therapies. The most frequent REG-related grade ≥3 adverse events (AEs) of interest were hand–foot skin reaction (HFSR), fatigue, diarrhea, hypertension, and rash/desquamation. We explored whether the impact of REG in pts aged ≥65 years differed from that in younger patients. Methods: Pts with mCRC progressing following all other available therapies were randomized 2:1 to receive REG 160 mg once daily (n=505) or Pla (n=255) for the first 3 weeks of each 4-week cycle. The dose could be modified to manage AEs. The primary endpoint was OS. We report efficacy, safety, and dosing data from REG recipients by age. Results: The REG treatment group included 309 pts <65 years (307 evaluable for safety) and 196 pts ≥65 years (193 evaluable for safety). The OS hazard ratio (REG/Pla) was 0.72 (95% confidence interval [CI] 0.56–0.91) in pts <65 years and 0.86 (95% CI 0.61–1.19) in pts ≥65 years (interaction p-value = 0.405). Median OS was 6.7 vs 5 months for REG vs Pla in pts <65 years, and 6.0 vs 5.6 months, respectively, in pts ≥65 years. Most pts experienced drug-related AEs (<65 years: 93.8%; ≥65 years: 91.7%). The rates of grade ≥3 REG-related AEs of interest and dose modifications are shown in the Table. In pts <65 years vs ≥65 years, median (interquartile range [IQR]) duration of REG was 7.6 weeks (6.6–15.4) vs 7.1 weeks (5.1–17.2), median (IQR) daily REG dose was 160.0 mg (134.6–160.0) vs 160.0 mg (137.5–160.0), and median (IQR) proportion of planned REG dose was 83.3% (65.7–100.0) vs 78.6% (66.7–100.0), respectively. Conclusions: In the CORRECT trial, REG demonstrated an OS benefit in pts <65 years and ≥65 years. Safety and tolerability of REG appeared to be similar in both age subgroups. Clinical trial information: NCT01103323. [Table: see text]

scholarly journals PENGETAHUAN IBU TENTANG PERKEMBANGAN ANAK DENGAN PERKEMBANGAN MOTORIK KASAR DAN HALUS PADA ANAK USIA 4 – 5 TAHUN

2019 ◽  
Vol 12 (4) ◽  
pp. 253-264
Author(s):  
Desi Kumalasari ◽  
Desi Setia Wati
Keyword(s):  
Motor Skills ◽  
Growth And Development ◽  
Skills Development ◽  
Fine Motor ◽  
P Value ◽  
Fine Motor Skills ◽  
Cross Sectional ◽  
Gross Motor ◽  
Gross Motor Skills ◽  
Children's Development

KNOWLEDGE AMONG MOTHERS OF  PRESCHOOL CHILDREN IN MOTOR DEVELOPMENTBackground: Motorskill development is the development of physical movement control through coordinated central nerve and muscle activities. Motor skilldevelopment is divided into two, gross motor skills and fine motor skills. Gross motor skills involve large parts of the body, such as: walking, jumping, running and so on. Smaller groups of muscle movements are called fine motor skills, such as: writing, drawing, wearing scissors, and so on. One factor that influence children's development is mother's knowledge. Mothers who have good knowledge will tend to pay attention and stimulate their children’s development.Purpose: The purpose of this research is to determine the relations of mothers’ knowledge about children’s growth and development with gross and fine motor skills development of children aged 4-5 years old in Pesawaran Lampung Kindergarten in 2018.Methods: The design used in this research is analytic by using a cross sectional approach. The population in this research were all mothers with children aged 4-5 years old at Pesawaran Lampung Kindergarten, with a sample of 58 people, while sampling techniques were taken using the total population method. The analysis of the research uses univariate and bivariate analysis which use the chi-square test.Results: The results of this research are there is no relationship between mothers’ knowledge about children’s development and growth with gross motor skills development (p-value = 0.622) and fine motor skills development (p-value = 0.614) of children aged 4-5 years old at Pesawaran Lampung Kindergarten in 2018.Conclution: There is no relationship between maternal knowledge about the development of children with gross motoric and fine motor development of children 4-5 years in Pesawaran Lampung kindergarten in 2018. It is expected that parents can find sources information about the children’s growth and development, so parents can provide stimulation of children’s motor skills development.Latar Belakang: Menurut WHO (2014), diperkirakan 5-10% anak mengalami keterlambatan perkembangan. Diperkirakan sekitar 1–3% khusus pada anak dibawah usia 5 tahun di Indonesia mengalami keterlambatan perkembangan umum yang meliputi perkembangan motorik, bahasa, sosio–emosional, dan kognitif (Kemenkes, 2016). Perkembangan motorik merupakan perkembangan pengendalian gerakan jasmaniah melalui kegiatan pusat syaraf dan otot yang terkoordinasi.Perkembangan motorik terbagi menjadi dua yaitu motorik kasar dan motorik halus Salah satu faktor yang dapat mempengaruhi perkembangan anak adalah pengetahuan ibu. Ibu yang berpengetahuan baik maka akan cenderung untuk memperhatikan dan menstimulasi perkembangan anak terutama perkembangan anak.Tujuan: untuk mengetahui hubungan pengetahuan ibu tentang perkembangan anak dengan perkembangan motorik kasar dan halus anak usia 4-5 tahun di TK Pesawaran, Lampung tahun 2018.Metode: Desain yang digunakan dalam penelitian ini adalah analitik dengan menggunakan metode pendekatan cross sectional.  Populasi dalam penelitian ini adalah semua ibu dengan anak usia 4 – 5 tahun di TK  Pesawaran, Lampung dengan jumlah sampel sebanyak 58 orang, sedangkang teknik sampling yang diambil dengan menggunakan metode total populasi. Analisis yang digunakan univariat dan bivariat menggunakan uji chi-square.Hasil: penelitian ini menyatakan bahwa tidak ada hubungan antara pengetahuan ibu tentang perkembangan anak dengan perkembangan motorik kasar (nilai p-value 0,622) dan motorik halus (nilai p-value 0,614) anak usia 4-5 tahun di TK  Pesawaran, Lampung tahun 2018.Kesimpulan: Tidak ada hubungan pengetahuan ibu tentang perkembangan anak dengan perkembangan motorik kasar dan motorik halus anak usia 4-5 tahun di TK  Pesawaran, Lampung tahun 2018. Diaharapkan para orang tua dapat mencari sumber informasi tentang tumbuh kembang anak, sehingga orang tua mampu memberikan stimulasi perkembangan motorik anak.

scholarly journals KADAR TRIGLISERIDA DAN STATUS GIZI PADA KLIEN TUBERKULOSIS

2017 ◽  
Vol 5 (2) ◽  
pp. 101
Author(s):  
Noor Diani ◽  
Devi Rahmayanti
Keyword(s):  
Nutritional Status ◽  
Protein Energy Malnutrition ◽  
The Body ◽  
Nutrition Status ◽  
P Value ◽  
Cross Sectional ◽  
Protein Energy ◽  
Tnf Α ◽  
Relationship Of ◽  
The Relationship

Abstrak Tuberkulosis (TBC) mengakibatkan penurunan asupan dan malabsorbsi nutrien serta metabolisme tubuh berubah sehingga terjadi massa otot dan lemak menurun akibat mekanisme malnutrisi dari energi protein. Malnutrisi pada TBC berpengaruh terhadap prognosis dan tingkat kematian. Peningkatan produksi IFNl- γ dan IL-6, TNF α menghambat dari aktivitas Lipo Protein Lipase (LPL) dijaringan lemak. Enzim LPL berperan dalam proses bersihan trigliserida. Peningkatan ini meningkatkan trigliserida sehingga proses sintesis lemak menurun dan proses lipolisis lemak meningkat di jaringan. Tujuan penelitian ini menganalisis hubungan trigliserida dan status gizi pada klien TBC. Metode penelitian ini korelasi analitik dengan pendekatan cross-sectional, sampel 25 orang, dengan uji korelasi Pearson-Product Moment. Hasil penelitian status gizi dibawah normal 56%, normal 40% dan kelebihan berat badan 4%. Kadar Trigliserida normal 84%, trigliserida tinggi 16%. Kesimpulan ada hubungan antara kadar trigliserida dan status gizi yakni r hitung sebesar 0,5: r tabel = 0,396 sehingga r hitung > r tabel dengan korelasi positif.Kata Kunci : Trigliserida, Status Gizi, Tuberkulosis.AbstractTuberculosis(TB) resulting the decreasing of nutrient intake and malabsorbsi as well as changing the metabolism of the body. The wasthing are decreased protein energy. Malnutrition on TB affects the prognosis of the treatment and death rates. The increase TNF α will inhibit the enzyme activity of Lipoprotein Lipase (LPL) in the fat tissue. LPL enzyme plays a role in cleavage process of triglycerides. This research was to analyze the relationship of triglycerides and nutrition status on the client with tuberculosis. The design was cross-sectional approach. The respondents were gathered from 25 newly TB patients. The analyzed using Pearson Product-Moment correlation. The results showed 56% respondents undernutrition, and normal 40% and over nutrition 4%. Most triglyceride level of the respondent were normal (84). The concluded was a relationship between triglycerides and the nutritional status with a positive correlation ( P value 0,396).Keywords : Triglycerides, Nutritional Status, Tuberculosis

scholarly journals Serum albumin as predictor of post-operative morbidity and mortality

2017 ◽  
Vol 4 (3) ◽  
pp. 1078
Author(s):  
Latika Sharma ◽  
Poojan M. Purohit ◽  
Dharmendra Pipal ◽  
Saurabh Kothari ◽  
Harshit Srivastava ◽  
...  
Keyword(s):  
Serum Albumin ◽  
Protein Energy Malnutrition ◽  
Organ System ◽  
Morbidity And Mortality ◽  
Surgical Patients ◽  
P Value ◽  
Age Group ◽  
Operative Morbidity ◽  
Medical College ◽  
Protein Energy

Background: Protein energy malnutrition affects every organ system. So correct assessment of nutritional status is important as malnourishment is a risk factor for morbidity and morality in surgical patients. In our study, serum albumin has been taken as parameter for nutritional assessment.Methods: Study is conducted on 50 patients admitted in Department of General Surgery, Dr. Sampurnanand Medical College and associated Hospital, Jodhpur, Rajasthan, India for surgeries during January 2014-December 2015. Data was analyzed using Z-test and Fischer exact t-test and p value was calculated. P value <0.05 is considered statistically significant.Results: Patients with serum albumin <3gm/dl had more complications with maximum number of complications in age group of 41-60 year group. This finding was statistically significant.Conclusions: Low serum albumin patients has more post-operative complication than those with normal level and so is a good indicator of post-operative morbidity and mortality.

EFFECTIVENESS OF STRUCTURED NURSING INTERVENTION ON NUTRITIONAL STATUS OF UNDERFIVE CHILDREN, KNOWLEDGE AND PRACTICE OF MOTHERS REGARDING THE PREVENTION AND MANAGEMENT OF PROTEIN ENERGY MALNUTRITION IN SELECTED COASTAL VILLAGES OF KERALA.

2021 ◽  
pp. 57-59
Author(s):  
Lija R Nath
Keyword(s):  
Nutritional Status ◽  
Protein Energy Malnutrition ◽  
Nursing Intervention ◽  
P Value ◽  
Anthropometric Parameters ◽  
Knowledge Questionnaire ◽  
Protein Energy ◽  
Childhood Morbidity ◽  
Post Test ◽  
Knowledge And Practice

Malnutrition is not only an important cause of childhood morbidity and mortality, but leads also to permanent impairment of physical and possibly, of mental growth of those who survive. The study was carried out to nd out the effectiveness of structured nursing intervention on nutritional status of underve children, knowledge and practice of mothers regarding prevention and management of malnutrition in selected coastal villages of Kerala. Samples consisted of 122 underve children who were identied with different degrees of malnutrition and their mothers. Pre experimental study design was used. Anthropometric parameters (Weight, Height, MUAC) were checked. Structured knowledge questionnaire and practice check list were used to measure the knowledge and practice of mothers related to the prevention and management of malnutrition. All the measurements were carried out once before the Structured Nursing Intervention and three times after the intervention. Structured Nursing Intervention was found to be effective in improving the knowledge and practice of mothers related to prevention and management of malnutrition among underve children (p < 0.001). Percentage of grade I malnutrition reduced from 83.6% in pre test to 63.69% in post test III. Z test was carried out and it was concluded that Structured Nursing Intervention had signicant inuence on the nutritional status of underve children (Z = 3.33**, p value <0.01).

scholarly journals Impact of protein energy malnutrition on thyroid size in an iodine deficient population of Gujarat (India): Is it an aetiological factor for goiter?

2001 ◽  
pp. 11-17 ◽  
Author(s):  
SR Brahmbhatt ◽  
RM Brahmbhatt ◽  
SC Boyages
Keyword(s):  
Negative Correlation ◽  
Protein Energy Malnutrition ◽  
Linear Regression Analysis ◽  
Thyroid Volume ◽  
World Health ◽  
Aetiological Factor ◽  
Anthropometric Parameters ◽  
Thigh Circumference ◽  
Protein Energy ◽  
The Impact

OBJECTIVE: To assess the severity of protein energy malnutrition (PEM) in iodine deficient subjects and to assess the impact of PEM on thyroid size. METHODS: 1002 subjects (530 school-aged children and 472 adults) were assessed for PEM by direct anthropometric measurements of height, weight, triceps skinfold (TSF) thickness, mid upper arm circumference (MUAC) and thigh circumference (TC), and derived indices of body surface area (BSA), body mass index (BMI), and Z-scores for weight-for-age (WAZ), height-for-age (HAZ), and weight-for-height (WHZ). Severity of PEM was based on the World Health Organization (WHO) criteria and the threshold on the Waterlow classification. Thyroid size was measured by ultrasonography to determine the thyroid volume (TV). Linear regression analysis was performed between TV and anthropometric parameters. RESULTS: Children had severe PEM as evident from the WHO percentage prevalence of stunting (HAZ<-2SD)=64% (where <-2SD is the Z-score deficit), wasting (WHZ<-2SD)=43%, underweight (WAZ<-2SD)=82% and BMI<16 kg/m=90%. Waterlow classification showed that children were either stunted or wasted, or stunted and wasted, or stunted and obese. Nearly 100% (529/530) of the children had goiter as evidenced from enlarged TV-for-BSA when compared with the WHO reference. There was a weak but statistically significant (P<0.05) positive correlation between TV and BSA, weight, height, MUAC, TC and HAZ but a negative correlation between TV and WHZ, BMI and TSF (r=-0.1-0.2). Adults had PEM as evident from BMI<18.5 kg/m in 54% subjects. Median MUAC=22.7 cm reveals prolonged severe PEM. Eighty-two percent had enlarged TV (>20 ml). There was a significant (P=0.01) negative correlation between TV and MUAC. CONCLUSIONS: (i) The severity of acute (wasting) and chronic (stunting) PEM is very high in Gujarati children. They are stunted or wasted, or stunted and wasted, or stunted and obese. Gujarati adults are thin with low protein and fat reserves. (ii) Anthropometric parameters showed a significant (P<0.001) correlation (r=0.1-0.2) with thyroid size. (iii) Higher prevalence of goiter may be due to macro-nutrient malnutrition (PEM) in the face of micro-nutrient malnutrition (iodine deficiency disorders, IDD).

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