scholarly journals Effect of Carica papaya leaf extract (CPLE) on thrombocytopenia among dengue patients of tertiary care hospital, Chitradurga, India

2018 ◽  
Vol 5 (4) ◽  
pp. 974
Author(s):  
Vijeth S. B. ◽  
Mohamed Murtuza Kauser ◽  
Vijayalaxmi Mangasuli ◽  
Vagesh Kumar S. R. ◽  
Suba Sree ◽  
...  
Keyword(s):  
Hospital Stay ◽  
Leaf Extract ◽  
Carica Papaya ◽  
Tertiary Care ◽  
Specific Treatment ◽  
Public Health Problem ◽  
Study Group ◽  
Care Hospital ◽  
Platelet Counts ◽  
Significant Difference

Background: Dengue is a global public health problem and thrombocytopenia associated with it is a serious complication for which there is no specific treatment available. This study was done to assess the effect of Carica papaya Leaf Extract (CPLE) on thrombocytopenia associated with Dengue and to study other clinical parameters of dengue.Methods: A longitudinal study conducted in Department of General Medicine, BMCH, Chitradurga, from September 2017 to March 2018. All the participants were randomized into two groups by simple randomization by lot method. Study group was given Carica papaya Leaf Extract (CPLE) and routine supportive treatment for other group. The patients were followed from the day of admission till their discharge from hospital. The platelet counts and other baseline hematological investigations, duration of hospital stay in both the groups were compared statistically by unpaired t-test.Results: There were total 127 males and 73 females. Age groups were comparable in both the groups. Most common presenting complaints were fever (100%) followed by headache (85%), myalgia (81.4%), fatigue (75%), arthralgia (65%). On admission baseline investigations were done and mean levels of both groups were compared. It was found that there was only significant difference of mean RBC levels (p=0.045). When followed up with daily platelet counts of both the groups, it was seen that there was increase in platelet counts in study group compared to placebo group and on third day there was significant difference between both (p=0.002). It was also found that discharge rate is earlier in study group than placebo group.Conclusions: Carica papaya leaf extract accelerates the increase in platelet count and reduces the hospital stay. So, it can be used as supplementary drug to reduce complications.

scholarly journals Drug utilization study in dengue infection in a tertiary care hospital

2019 ◽  
Vol 8 (3) ◽  
pp. 569
Author(s):  
Smita Bhandare ◽  
Santoshkumar R. Jeevangi
Keyword(s):  
Drug Utilization ◽  
Leaf Extract ◽  
Tertiary Care Hospital ◽  
Dengue Infection ◽  
Tertiary Care ◽  
Specific Treatment ◽  
Public Health Problem ◽  
Rational Approach ◽  
Care Hospital ◽  
Utilization Pattern

Background: Dengue fever (DF) is a serious public health problem, gaining global attention because of its morbidity and mortality. Less studies on Drug utilization pattern of DF in India. The present study was undertaken to analyze Drug utilization pattern of dengue infection in a tertiary care hospital.Methods: A prospective cross-sectional study was conducted for a period of 2 months in a tertiary care hospital and the data was analyzed by using various drug use indicators.Results: A total of 52 prescriptions were analyzed. Male and female were (46.16%, 53.84%), A total of 330 drugs were prescribed. 86 (26.06%) antibiotics, 70 (21.21%) antipyretics, 51 (15.46%) antacids, 19 (5.76%) multivitamins, 52 (15.76%) anti-emetics and 52 (15.76%) papaya leaf extract was prescribed. 84 (25.46%) oral and 246 (74.54%) injectable drugs. IV-fluids given to all patients. 10 (19.24%) were given blood transfusion. 6.17 drugs per prescription. 96% drugs were prescribed by brand names. High DDD for drugs like diclofenac (184), doxycycline (115), metronidazole (2.5), pantoprazole (161.5), rabeprazole (34.6), ondansetron (200) was observed.Conclusions: Most commonly used drugs are antipyretics, antibiotics, antacids, antiemetic, papaya leaf extract. As the incidence of DF is increasing with epidemics, demand for specific treatment guidelines is in great need. Early recognition of the disease, with a rational approach in case management leads good clinical outcome.

scholarly journals Duration of Hospital Stay and Treatment Pattern among Patients Undergoing Common Operative Procedures at tertiary care hospital in Nepal

2019 ◽  
Vol 7 (2) ◽  
pp. 27-35
Author(s):  
Sanjay Chaudhary ◽  
Lokeshwar Chaurasia ◽  
Jitendra Kumar Singh
Keyword(s):  
Hospital Stay ◽  
Operative Procedure ◽  
Tertiary Care ◽  
Treatment Pattern ◽  
Operative Procedures ◽  
Care Hospital ◽  
Third Generation ◽  
Medical College ◽  
Duration Of Hospital Stay ◽  
Significant Difference

Background and Objectives: Appendectomy, cholecystectomy, fistulectomy, and herniotomy or herniorrhaphy are the most common surgical operations in Nepal. Despite the high prevalence and complexity of the patient population served by general and universal surgery services, little has been reported about the services, treatment procedures and outcomes. Therefore, the study is designed to investigate the duration of hospital stay, and treatment pattern among patients undergoing common surgical operative procedures at Janaki Medical College, Janakpur, Nepal. Material and methods: A prospective observational study was conducted among patients undergoing common surgical operative procedures at surgery department of Janaki Medical College (JMC) over a period of one year from January 2018 to December 2018. Patients of all age groups and gender undergoing surgical operative procedures; appendectomy, herniotomy cholecystectomy and fistulectomy were included in the study. The patients were assessed preoperatively, intra-operatively and postoperatively. Results: In a total of 325 patients, 11.1% of patients underwent fistulectomy, 14.5% underwent appendectomy, 35.4% underwent herniorrhaphy and 39.1% underwent cholecystectomy. Mean duration of stay at hospital for cholecystectomy was slightly higher (8.13±2.40 days) than other operating procedures: fistulectomy (5.44 ±1.48 days), appendectomy (7.40±2.00 days), and operative procedure of hernia (6.17±1.59 days). Most commonly used antibiotic for control of preoperative and post operative infection was third generation cephalosporin’s, ceftriaxone and cefixime. Conclusion: The study demonstrates longer duration of hospital stay for cholecystectomy as compared to other operating procedures like fistulectomy, appendectomy, herniorrhaphy, hernioplasty and herniotomy with significant difference by types of surgery. Most commonly used antibiotic for control of infection was third generation cephalosporin, ceftriaxone and cefixime.

ASSOCIATION OF HEMATOCRIT-PLATELET INDEX AND HEMATOCRIT SHIFT WITH WARNING SIGNS AND HOSPITAL STAY IN DENGUE PATIENTS AT A TERTIARY CARE HOSPITAL

2021 ◽  
Vol 71 (Suppl-1) ◽  
pp. S277-82
Author(s):  
Muhammad Fahd Bin Haider ◽  
Humaira Zafar ◽  
Syed Zubair Hussain Shah ◽  
Mobaila Akram ◽  
Kamran Malik ◽  
...  
Keyword(s):  
Hospital Stay ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Warning Signs ◽  
Care Hospital ◽  
Cross Sectional ◽  
Duration Of Stay ◽  
Platelet Indices ◽  
Significant Difference ◽  
Duration Of Hospitalization

Objective: To determine the relationship between hematocrit, platelet count, warning signs and duration ofhospitalization in indoor dengue patients. Study Design: Analytical, cross sectional study. Place and Duration of Study: Department of Medicine, Pakistan Air Force Hospital Islamabad and Departmentof Biochemistry and Molecular Biology, AM College, Rawalpindi, from Sep 2019 to Jun 2020. Methodology: A total of 100 indoor patients were recruited using convenience sampling. Their platelets, hema-tocrit and warning signs were recorded on arrival in the hospital. First two parameters were checked every day for the whole duration of stay in the hospital. The WHO standard treatment of dengue was given to the patients. Patient were divided into two groups based upon duration of hospitalization using cut-off of 3 days. Linear regression was used to analyze association of hematocrit-platelet index and hematocrit shift with presence of one or more warning signs and duration of hospital stay. Results: There was statistically significant difference in 3rd day Hematocrit Platelet Indices of patients with short and long hospital stay (p=0.003). 3rd day Hematocrit-platelet indices of patients with and without warning signs also showed statistically significant difference when compared with eachother (p=0.0001). It was stronger than Hematocrit Shift (p=0.82) and platelets considered alone. Conclusion: Day 3 Hematocrit Platelet Indexis more strongly associated with warning signs and duration of stay rather than hematocrit alone. It means both need to be taken into account while monitoring dengue patients. Hematocrit platelet index for severity and duration of hospitalization while Hematocrit shift for fluid therapy.

scholarly journals PARASITES IN HISTOPATHOLOGY: A TERTIARY CARE HOSPITAL EXPERIENCE

2021 ◽  
Vol 7 (3) ◽  
pp. 110-115
Author(s):  
Dr. Poovizhi Inbasekaran ◽  
◽  
Dr. Megala Chandrasekar ◽  
Dr. Thamilselvi Ramachandran ◽  
Dr. Anbu Lenin Kulandaivel ◽  
...  
Keyword(s):  
Tertiary Care ◽  
Specific Treatment ◽  
Public Health Problem ◽  
Tissue Response ◽  
Parasitic Infections ◽  
Major Public Health Problem ◽  
Hard Tick ◽  
Care Hospital ◽  
Tissue Sections ◽  
Immunocompromised State

Background: Parasitic infections are a major public health problem worldwide with one-quarter ofthe world’s population is suffering from it. Intestinal and extraintestinal parasitic infestations arerising in developing countries. There is a raise in the immunocompromised state in which tissueparasitic infestations are increasing which necessitates this type of study. Method: A retrospectivedescriptive study with data collected from histopathology register from January 2018 to December2020, all cases diagnosed as parasitic infestation with age, gender, location and histopathologicalevaluation with tissue response was analysed. Results: In the present study over 3 years 11parasitic infestations were identified. About 3(27.3%) cases of hydatid cyst, 5(45.5%) cases ofEnterobius vermicularis, 2 (18.2%) cases of cysticercosis and 1(9%) case of hard tick was identified.The most common age group affected was <25 years of age (54.5%). The most common parasitefound is Enterobius vermicularis in our study. Conclusion: A careful histopathological examinationto identify parasitic infestations in tissue sections will help to decrease morbidity and mortality byproviding specific treatment to the patient.

scholarly journals A comparative study of two layer versus three-layer repair of mediolateral episiotomy

2020 ◽  
Vol 9 (8) ◽  
pp. 3412
Author(s):  
Manasi V. Gaikwad ◽  
M. Vijaya Sree ◽  
Swapnil V. Bobde
Keyword(s):  
Hospital Stay ◽  
Operative Time ◽  
Tertiary Care ◽  
Obstetric Care ◽  
Wound Complications ◽  
Layer Versus ◽  
Care Hospital ◽  
Suture Materials ◽  
Mediolateral Episiotomy ◽  
Significant Difference

Background: Since majority of the women attending study hospital are belonging to lower socioeconomic strata and active involvement of paramedical staff in providing obstetric care, this study was undertaken to find the utility of a two-layer repair of mediolateral episiotomy and compare it with the standard method of closure in relation to its simplicity, cost-effectiveness and superiority if any, over the traditional three-layered repair of episiotomy.Methods: This was a prospective interventional study comparing 100 women who underwent two-layer closure with 100 women who underwent three-layer closure of episiotomy in a tertiary care hospital in Pune, India over a period of 2 years from October 2012 to October 2014. The parameters assessed were operative time, number of suture materials required, immediate post procedure pain and complications at follow-up. Qualitative and quantitative data was analysed using unpaired t-test, chi square test and Fisher exact test.Results: Both the groups were comparable in terms of hospital stay and wound complications such as oedema, dehiscence, hematoma, requirement of resuturing, cosmesis and long-term complications such as dyspareunia. However, two-layer repair required less operative time, lesser number of suture materials and decreased pain during hospital stay as there was statistically significant difference observed between the two groups.Conclusions: In this study experience, it can be concluded that two-layer repair of episiotomy is faster, with less post-operative pain and more cost effective. Hence it provides mother with better services.

scholarly journals CARICA PAPAYA LEAF EXTRACT FOR TREATING THROMBOCYTOPENIA IN DENGUE FEVER- AN EXPERIENCE FROM A TERTIARY CARE CENTRE IN EASTERN PART OF INDIA

2021 ◽  
pp. 38-41
Author(s):  
Satish Kr. Prasad ◽  
Sameer Kr. Mehta ◽  
Ankit Poddar
Keyword(s):  
Platelet Count ◽  
Dengue Fever ◽  
Leaf Extract ◽  
Carica Papaya ◽  
Tertiary Care ◽  
Control Group ◽  
P Value ◽  
Case Group ◽  
Study Group ◽  
And Control

Background: Dengue fever is the most common arboviral mosquito-borne tropical disease of humans caused by the dengue virus. The incidence has increased many fold in India due to unplanned urbanization and migration of population to urban areas. Aim -To study if Carica papaya leaf extract will significantly increase the platelet count in cases of thrombocytopenia associated with Dengue fever. Materials and Methods- The case control study was conducted in the Department of Medicine of Tata Main Hospital,Jamshedpur.All participants were randomised into two groups, study group (n=50) and control group (50); the study group was given papaya leaf extract capsule of 1100 mg thrice daily for five days but the control group did not receive it. The basic supportive treatment of dengue fever was provided to both the groups. Results- On the first day,platelet count of study group and control group was (63.68 ± 16.88, 3 and 57.07 ± 17.46×10 respectively, p value=0.0573). The mean platelet count on Day 2, Day 3, Day 4 of CPC 3 3 3 administration (mean± S.D) was 80.34 ± 18.54×10 ,104.14 ± 20.42×10 ,135.08 ± 19.91×10 in the case group and 64.48 ± 3 3 3 17.02×10 ,77.02 ± 16.88×10 ,100.70 ± 18.33×10 in the control group respectively.The mean duration of stay in the study group was 4.6± 0.67 days and 6.76±1.54 days in the control group (p<0.01). Conclusion- Carica papaya leaves extract capsules offer a cheap and possibly effective treatment for increasing the platelet count in dengue

Uterine Exteriorization vs. In situ Repair of Cesarean Section: A Comparative Study at a Tertiary Care Hospital

2020 ◽  
Author(s):  
Reeta Kumari
Keyword(s):  
Cesarean Section ◽  
Hospital Stay ◽  
Abdominal Cavity ◽  
Tertiary Care ◽  
Elective Cesarean Section ◽  
Bowel Sound ◽  
Care Hospital ◽  
Uterine Incision ◽  
Significant Difference ◽  
Abdominal Repair

Background: Exteriorization, a valuable repair of uterus technique during cesarean section, requires removal of uterus temporarily from the abdominal cavity to repair the incision. The objective of this study was to compare the postoperative symptoms of intra-abdominal to extra-abdominal repair of the uterine incision during caesarean procedure. Methods: A quasi experimental study done in the Obstetrics and Gynecology unit of Ziauddin University Hospital, Kamari and Clifton Campus, Karachi from 1st January 2017 to 30th June 2017. A total of 190 patients were divided into two groups (95 patients in each). In group A Uterine incision was closed extra abdominally and in Group B the closure was done intra-abdominally. The rate of nausea, vomiting, hospital stay, wound infection, fever, returns of bowel sounds, blood loss, and uterine trauma was measured between the two groups. Statistical analyses were done by applying independent sample t-test and chi-square tests. Results: Exteriorization was better option above age 35 years and elective cesarean section(C/S) patients with less Intensity of pain and hospital stay (3 days) but the results were not statistically significant. Caesarean Section, hemoglobin both pre and post-operative, blood transfusion, the return of bowel sound after surgery, surgical site infection and uterine trauma between the two groups showed no significant difference. Conclusion: The postoperative management of Exteriorization was better compared to intra-abdominal repair but the results were not significant. Exteriorization is an easy, convenient and valid option without complications and can be used especially in cases where difficulty in visualization of uterine scar and hemostasis is at stake.

Abstract TP224: Risk Factors for Stroke in Infective Endocarditis

Stroke ◽  
2013 ◽  
Vol 44 (suppl_1) ◽  
Author(s):  
Oguzhan Kursun ◽  
Mehmet A Topcuoglu ◽  
Hulya Karatas ◽  
Ferdinando S Buonanno ◽  
Aneesh B Singhal
Keyword(s):  
Risk Factors ◽  
Infective Endocarditis ◽  
Tertiary Care ◽  
Antibiotic Use ◽  
Care Hospital ◽  
Stroke Patients ◽  
Native Valve ◽  
Platelet Counts ◽  
Duke Criteria ◽  
Significant Difference

Background: Stroke is a common, serious complication of infective endocarditis (IE). We investigated risk factors for IE-associated cerebrovascular disease. Methods: We retrospectively reviewed data of all inpatients with discharge ICD-9 codes of IE admitted to our tertiary care hospital from 1980-2011. The diagnosis of IE was confirmed using the original Duke Criteria. Stroke was confirmed on CT or MRI. Results: Of 1151 hospitalizations (1083 adults), 277 (24%) included IE-related stroke (76% ischemic, 13% hemorrhagic, 10% both). Stroke patients had mean age 56 yrs, 63% male, 93% ’Definite IE’ per Duke Criteria, and 83% Native Valve infection. Organism types were Staph 40%, Strep 30% and Other 30%. Trans-esophageal echo was performed in 53% and MRI in 57%. The Stroke and Non-Stroke Groups showed no significant difference in age, sex, traditional cardiovascular risk factors (Htn, DM, lipids, AFib etc), and type of infectious organism. Patients with Stroke had a significantly higher frequency of multiple vegetations (20% vs 8%, p<0.001), cardiac abscess (16% vs 10%, p<0.01), cardiac surgery (37% vs 26%, p<0.01), sepsis (24% vs 14%, p<0.01) and DIC (9% vs 2%, p<0.01) and a tended to have higher rates of cardiac rupture (19% v 15%, p=0.08) and lower admission platelet counts (224 vs 249 thousand/cmm, p=0.11). The Ischemic Stroke sub-group showed similar high rates for these variables. Multivariate regression analysis showed IE-related stroke to be significantly predicted by the presence of sepsis (O.R. 3.6, 95%CI 1.8-7.0), congestive heart failure (O.R. 2.1, 95%CI 1.3-3.4), prosthetic valve IE (O.R. 2.3, 95%CI 1.13-4.4), and vegetations in aortic (OR 2.4, 95%CI 1.3-4.3) or mitral (OR 6.6, 95%CI 3.5-12.2) valves. Tricuspid vegetations (OR 0.3, 95%CI 0.1-0.7) and higher platelet counts (OR 0.99, 95%CI 0.99-1.0) had a protective effect. Age, Htn, DM, AFib, multiple vegetations, organism type, antibiotic use, and echo findings of cardiac abscess/rupture, did not predict stroke. Stroke patients had significantly worse outcomes with 22% deaths vs. 9% in non-stroke patients (p<0.001). Conclusion: This large 31-year retrospective study shows that potentially treatable conditions such as CHF and sepsis are associated with a higher rate of IE-related stroke.

Association of Rugae Pattern with Skeletal Malocclusion in Orthodontic Patients Visiting Tertiary Care Hospital

2020 ◽  
Author(s):  
Sarwat Memon
Keyword(s):  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Class Iii ◽  
Chi Square ◽  
Cross Sectional ◽  
Skeletal Malocclusion ◽  
Palatal Rugae ◽  
Significant Difference ◽  
Orthodontic Patients

Background: The palatal rugae are special constructions that are inalterable in their position and pattern during the lifestyles of an individual. This imparts them an exceptional role in the forensic dentistry and may play potential role in malocclusion identification. This study was aimed to see association of rugae pattern with sagittal skeletal malocclusion in orthodontic patients visiting tertiary care hospital. Methods: This cross-sectional examination was completed on pretreatment records (lateral Cephalometric radiographs and maxillary dental casts) of 384 subjects at the orthodontic department of Ziauddin Dental Hospital, Karachi. The study duration was from January to July 2019. The samples were sub-divided into three sagittal skeletal groups based on ANB angle proposed by Steiner’s on lateral Cephalometric radiographs (Class I with ANB angle between 0° to 4°; Class II: ANB angle greater than 5°; Class III: ANB angle less than 0°). The shapes of three most-anterior primary rugae were then evaluated bilaterally using Kapali et al., Classification. Chi Square test was applied to find association of rugae pattern among sagittal skeletal malocclusions groups. Results: Circular and curved rugae shapes were the most prevalent in all skeletal malocclusions. The primary palatal rugae pattern was seen to be significantly different among three skeletal malocclusion groups (p<0.05). The right and left sided palatal rugae pattern showed significant difference in all three skeletal malocclusion groups (p<0.05). Conclusion: The present study showed no specific palatal rugae pattern associated with sagittal skeletal malocclusion. Further studies on larger sample and use of modern 3D technologies to scan the maxillary casts are required for results that are more precise.

Seroprevalence of anti-SARS-CoV-2 IgG antibodies in hospitalized patients at a tertiary referral center in North India (Preprint)

2020 ◽  
Author(s):  
Dr. Animesh Ray ◽  
Dr. Komal Singh ◽  
Souvick Chattopadhyay ◽  
Farha Mehdi ◽  
Dr. Gaurav Batra ◽  
...  
Keyword(s):  
Tertiary Care ◽  
Age Groups ◽  
Hospitalized Patients ◽  
North India ◽  
P Value ◽  
Care Hospital ◽  
Igg Antibodies ◽  
Igg Antibody ◽  
Increased Risk ◽  
Significant Difference

BACKGROUND Seroprevalence of IgG antibodies against SARS-CoV-2 is an important tool to estimate the true extent of infection in a population. However, seroprevalence studies have been scarce in South East Asia including India, which, as of now, carries the third largest burden of confirmed cases in the world. The present study aimed to estimate the seroprevalence of anti-SARS-CoV-2 IgG antibody among hospitalized patients at one of the largest government hospital in India OBJECTIVE The primary objective of this study is to estimate the seroprevalence of SARS-CoV-2 antibody among patients admitted to the Medicine ward and ICU METHODS This cross-sectional study, conducted at a tertiary care hospital in North India, recruited consecutive patients who were negative for SARS-CoV-2 by RT-PCR or CB-NAAT. Anti-SARS-CoV-2 IgG antibody levels targeting recombinant spike receptor-binding domain (RBD) protein of SARS CoV-2 were estimated in serum sample by the ELISA method RESULTS A total of 212 hospitalized patients were recruited in the study with mean age (±SD) of 41.2 (±15.4) years and 55% male population. Positive serology against SARS CoV-2 was detected in 19.8%patients(95% CI 14.7-25.8). Residency in Delhi conferred a higher frequency of seropositivity 26.5% (95% CI 19.3-34.7) as compared to that of other states 8% (95% CI 3.0-16.4) with p-value 0.001. No particular age groups or socio-economic strata showed a higher proportion of seropositivity CONCLUSIONS Around, one-fifth of hospitalized patients, who were not diagnosed with COVID-19 before, demonstrated seropositivity against SARS-CoV-2. While there was no significant difference in the different age groups and socio-economic classes; residence in Delhi was associated with increased risk (relative risk of 3.62, 95% CI 1.59-8.21)

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