scholarly journals Recommended parameters for hepatocyte isolation-a review

2020 ◽  
Vol 6 (12) ◽  
pp. 537
Author(s):  
Sushrutha C. S. ◽  
Sandhya K. ◽  
Savitha Karalwad ◽  
Elango E. M.
Keyword(s):  
Human Hepatocytes ◽  
Critical Factors ◽  
Whole Process ◽  
Metabolic Capability ◽  
Pharmacological Studies ◽  
Hepatocyte Isolation ◽  
Increasing Demand ◽  
Critical Limits ◽  
Liver Cell Transplantation ◽  
The Ideal

<p>There is an increasing demand for primary human hepatocytes for toxico-pharmacological studies and for exploring their role in liver cell transplantation. During the whole process of isolation, culture and cryopreservation hepatocytes are subjected to various stress. All these factors will lead to the impairment in the metabolic capability of the hepatocytes post isolation. Hepatocyte isolation is an expensive and resource driven procedure. Thus, it is important to consider all the factors before we subject the specimen for isolation of cells. By considering the factors that influence hepatocyte isolation, hepatocytes of good quality can be obtained. With recommendations on the ideal parameters for isolation being made the researcher shall have a knowledge on what critical factors need to be taken care of during hepatocyte isolation. There will be an opportunity to modify critical factors if possible, during the procurement of specimen by working in tandem with the clinicians. The specimen which shall be deemed un fit when two or more factors have exceeded the critical limits can be rejected.</p>

scholarly journals CMMI and Ideal in Software Process Improvement

2020 ◽  
Vol 17 ◽  
Keyword(s):  
Customer Satisfaction ◽  
Best Practices ◽  
Software Development ◽  
Process Improvement ◽  
Software Process ◽  
Software Process Improvement ◽  
Critical Factors ◽  
Development Processes ◽  
The Ideal

Different models and standards have been developed with the purpose of improving software development processes and obtaining quality products and achieving customer satisfaction. Despite the efforts that organizations make, they do not always achieve these results. In this article we present the results of the implementation of best practices established by the CMMI model using the IDEAL and SCAMPI B methodology. The results show that applying best practices helps organizations to improve their processes, minimize the number of defects and increase customer satisfaction. Likewise, the critical factors that were considered and aspects to be considered in the deployment of processes are presented.

Strategies and Therapies for Wound Healing: A Review

2021 ◽  
Vol 22 ◽  
Author(s):  
Hitesh Chopra ◽  
Sandeep Kumar ◽  
Inderbir Singh
Keyword(s):  
Wound Healing ◽  
Growth Factors ◽  
Wound Dressings ◽  
Gaseous Exchange ◽  
Critical Factors ◽  
Enzymatic Cascades ◽  
Moist Environment ◽  
Human Use ◽  
Ending Process ◽  
The Ideal

: Wound healing is the complex and a never-ending process that involves numerous mediators, enzymatic cascades that are directly or indirectly involved in the mechanism. So, it becomes necessary to closely examine critical factors such as gaseous exchange, a moist environment, anti-microbial activity, and exudation liquids' absorption while designing wound dressings. There is a heap of wound dressings available for human use, but they all are way apart from the ideal dressing. Use of biopolymers may be a solution to tackle the difficulties such as combining with growth factors and cells that can trigger the wound healing. This article reviews such therapies for wound healing application.

Benchmarking of TQM: the case of Hikma Pharmaceuticals company

2015 ◽  
Vol 22 (3) ◽  
pp. 488-504 ◽  
Author(s):  
Rateb J Sweis ◽  
Hala Jamal Al-Ghawi ◽  
Noor Abdel-Aziz AlSaleh ◽  
Zu'bi M.F Al-Zu'bi ◽  
Bader Y Obeidat
Keyword(s):  
Quality Management ◽  
Management System ◽  
Quality Management System ◽  
Cost Effective ◽  
Current Status ◽  
Total Quality ◽  
Critical Factors ◽  
Content Type ◽  
Internal Benchmarking ◽  
The Ideal

Purpose – The purpose of this paper is to gain a better understanding of internal benchmarking through the evaluation of quality management in two quality departments (Quality Assurance (QA) and Quality Control (QC)) in a pharmaceutical company by utilizing total quality index (TQI). Design/methodology/approach – In order to achieve the above-mentioned purpose a structured questionnaire was used to assess the gap between the ideal and current status of the quality management system. The mean differences between the current and ideal states for the eight critical factors were compared for the two departments using t-test. Findings – There is difference in the actual and ideal scores on three out of eight critical factors between the QA and QC departments. Practical implications – The internal benchmarking process which was applied in this case study can be applied in other pharmaceutical companies in order to improve the status of the quality management system and achieve competitive advantage. Originality/value – Benchmarking of total quality management (TQM) can improve the performance of organizations. The benchmarking tool used in this study TQI is an information technology-supported tool that helps managers assess a TQM program by enabling the cost-effective measurement of key organizational processes. TQI measures the ideal and actual quality management along eight critical factors synthesized by Saraph et al. (1989).

scholarly journals Study on Bohai sea ice based on MODIS data

2018 ◽  
Vol 53 ◽  
pp. 03038
Author(s):  
Zhou ye ◽  
Fan Zhaopeng
Keyword(s):  
Sea Ice ◽  
Bohai Sea ◽  
Ice Age ◽  
Landsat Data ◽  
Color Processing ◽  
Modis Data ◽  
Whole Process ◽  
Pseudo Color ◽  
Ice Model ◽  
The Ideal

Based on MODIS L1B data, we identify information of sea ice area, peripheral line and density, and also use Landsat data with higher resolution to verify the results obtained from MODIS data. Using pseudo color processing technology is more intuitive and more clear to show the various information of the Bohai sea. The whole process of sea ice information extraction is described in detail from MODIS data downloads to image processing and analysis. The selected data basically cover the entire process from the initial ice age, the peak ice age to the final ice age. The ideal results are obtained, and it also shows that the MODIS satellite data is feasible to monitor sea ice, which provides a reference for the establishment of monitoring sea ice model.

scholarly journals Diagnosis of machine tool with using Renishaw ball-bar system

2018 ◽  
Vol 157 ◽  
pp. 01006 ◽  
Author(s):  
Robert Čep ◽  
Šárka Malotová ◽  
Jiří Kratochvíl ◽  
Dana Stančeková ◽  
Andrej Czán ◽  
...  
Keyword(s):  
Machine Tool ◽  
Direct Method ◽  
International Standards ◽  
Cnc Milling ◽  
Whole Process ◽  
Cnc Milling Machine ◽  
Measurement Principle ◽  
Method Of Measurement ◽  
The Ideal

The article deals with accuracy of machine tools. The aim was to determine the accuracy with which already operates used machine – HAAS CNC Milling machine MiniMill. For evaluation of accuracy of the machine tool was used Renishaw QC20-W Ballbar system, which has the Department of Machining, Assembly and Engineering Metrology of VŠB – TUO. The theoretical part describes the measurement principle using a telescopic Ballbar system. The principle of measurement is the comparison of the actual deviation from the ideal circle which is programmed. Experimental part is focused on the diagnosis of the whole process by the direct method of measurement during changing feed rate. Specifically, the determination of circularity deviation at machine tool was in accordance with international standards, e.g. ISO 230-4.

scholarly journals Rekonstruksi Kebijakan Tanah Eks Kerajaan Di Indonesia Berbasis Nilai Keadilan Sosial (Studi Kasus Tanah Eks Kerajaan Di Bali)

2019 ◽  
Vol 5 (2) ◽  
pp. 195-207
Author(s):  
Iga Gangga Santi Dewi
Keyword(s):  
Land Rights ◽  
The State ◽  
Land Policy ◽  
Land Acquisition ◽  
Whole Process ◽  
The People ◽  
Private Rights ◽  
New Construction ◽  
Land Policies ◽  
The Ideal

Abstract: The phenomenon of substantive injustice related to the kingdom land policy of in the Dictum IV letter A of the UUPA which states that “The rights and authorities of the land and water of the Swapraja or former Swapraja (kingdom) which still exist at the time of entry into force of this law are removed and transferred to the State”, is an injustice felt by former kingdom, considering that land rights are private rights that cannot be taken arbitrarily. This happened also because there was no proper compensation for the loss of the rights of their comfort in life due to arbitrary land acquisition by the state. Land Office must be a progressiveminded office which is able to interpret which laws need to be applied to realize substantial justice and which laws already contain justice. The ideal new construction of the concept of justice in former kingdom land policies based on progressive law is nothing but to realize substantial justice. The whole process of the operation of the legal implementation instrument (Land Office) must be verifiable into the factors of justice, welfare, concern for the people and others, all of which has been contained in the values   of Pancasila. Intisari: Fenomena ketidakadilan substantif terkait kebijakan tanah eks kerajaan dalam Diktum IV huruf A UUPA bahwa “Hak-hak dan wewenang-wewenang atas bumi dan air dari Swapraja atau bekas Swapraja (kerajaan) yang masih ada pada waktu mulai berlakunya undang-undang ini hapus dan beralih kepada Negara”, merupakan ketidakadilan yang dirasakan oleh pihak eks kerajaan mengingat hak atas tanah adalah hak pribadi yang tidak boleh diambil sewenang-wenang. Hal ini terjadi juga karena tidak diberikannya ganti rugi yang layak atas kehilangan hak-hak kenyamanan kehidupan mereka akibat pengambilalihan tanah secara sewenang-wenang oleh negara.  Kantor Pertanahan harus berpikiran progresif yang mampu menafsirkan mana hukum yang perlu diterapkan untuk mewujudkan keadilan substansial dan mana hukum yang sebenarnya sudah mengandung keadilan. Konstruksi baru yang ideal yaitu  konsep keadilan dalam kebijakan tanah eks kerajaan berbasis hukum progresif, tidak lain adalah untuk mewujudkan keadilan substansial. Seluruh proses bekerjanya instrumen pelaksana hukum (Kantor Pertanahan) tersebut harus bisa diverifikasi ke dalam faktor-faktor keadilan, kesejahteraan, kepedulian kepada rakyat, yang kesemuanya itu telah terkandung dalam nilai-nilai Pancasila. 

scholarly journals Detection of serum bone alkaline phosphatase in 77 adolescents

2017 ◽  
Vol 1 (1) ◽  
Author(s):  
Dingping Shi ◽  
Dafang Wang ◽  
Yonggang Zheng
Keyword(s):  
Alkaline Phosphatase ◽  
Bone Growth ◽  
Bone Development ◽  
Bone Mineralization ◽  
Bone Alkaline Phosphatase ◽  
Bone Change ◽  
Growing Period ◽  
Whole Process ◽  
Second Peak ◽  
The Ideal

In the fast growing period of adolescent children, bone growth and bone mineralization are extremely active. Adulthood is the second peak of bone development, adolescent appropriate calcium intake into the ideal bone peak to achieve an important role. It is important to clear whether or not bone mineralization and to early intervene. Bone alkaline phosphatase (BALP) is the most correct indicator to reflect the whole process of bone change[2], we detected BALPon 177 cases of adolescents in 2007 to, evaluate the measuring meaning.

Treatment of Surgically Induced Acute Liver Failure with Transplantation of Highly Differentiated Immortalized Human Hepatocytes

2000 ◽  
Vol 9 (5) ◽  
pp. 733-735 ◽  
Author(s):  
Naoya Kobayashi ◽  
Masahiro Miyazaki ◽  
Kenichi Fukaya ◽  
Yusuke Inoue ◽  
Masakiyo Sakaguchi ◽  
...  
Keyword(s):  
Simian Virus 40 ◽  
Hepatic Function ◽  
Simian Virus ◽  
T Antigen ◽  
Human Hepatocytes ◽  
Liver Functions ◽  
Hepatocyte Isolation ◽  
Human Livers ◽  
Surgically Induced ◽  
Intrasplenic Transplantation

Primary human hepatocytes are an ideal source of hepatic function in bioartficial liver (BAL), but the shortage of human livers available for hepatocyte isolation limits this modality. To resolve this issue, primary human fetal hepatocytes were immortalized using simian virus 40 large T antigen. One of the immortal cell lines, OUMS-29, showed highly differentiated liver functions. Intrasplenic transplantation of OUMS-29 cells protected 90% hepatectomized rats from hyperammonemia and significantly prolonged their survival. Essentially unlimited availability of OUMS-29 cells supports their clinical use for BAL treatment.

Commentary: Seventeenth-Century Venetian Opera as Fondamente nuove

2006 ◽  
Vol 36 (3) ◽  
pp. 411-417 ◽  
Author(s):  
Ellen Rosand
Keyword(s):  
Seventeenth Century ◽  
Publishing Industry ◽  
The Self ◽  
Self Image ◽  
The Arts ◽  
Multiple Levels ◽  
The Republic ◽  
Increasing Demand ◽  
The Many ◽  
The Ideal

Seventeenth-century Venice was the ideal center for the development of opera because of certain special conditions: regular demand from a broad and depend able audience of citizens and travelers alike, dependable financial backing from the many competing patrician families who constructed and operated theaters, a flourishing publishing industry that provided publicity, and a tradition in which the arts were designed specifically to enhance the self-image of the republic. These conditions combined to sustain a genre that appealed to its audience on multiple levels. The increasing demand for new works precipitated the development of new modes of production and communication, and the various musical and dramatic conventions that originated during this era have persisted to the present day.

scholarly journals The throat of Brazilian Agricole production: The breakdown of vertical silos

2021 ◽  
Vol 10 (8) ◽  
pp. e14510817253
Author(s):  
Karoline Carvalho Dornelas ◽  
Gypson Dutra Junqueira Ayres ◽  
Hygor Cesar Soares Rodrigues ◽  
Rafael Torres do Nascimento ◽  
José Pinheiro Lopes Neto ◽  
...  
Keyword(s):  
Friction Angle ◽  
Stored Products ◽  
Structural Components ◽  
Industrial Sites ◽  
Structural Failures ◽  
Increasing Demand ◽  
Alternative Solutions ◽  
Storage Units ◽  
Insufficient Knowledge ◽  
The Ideal

In the current world economical conjecture, the accentuated growth in Brazilian production and exportation in the Agro-Food industry sets the country as a central role in the field. Implementing storage units in Agricole properties and industrial sites constitutes a necessary premise to keep the country as a competitive member in the global scenery. The vertical silos present themselves as alternative solutions. However, a great sum of the existent silos does not match the ideal conditions of operation due to the insufficient knowledge of the pressure variations that happen in time and inner space, of the flow, and the variables that affect the behavior of the stored products. Such situations have contributed to accidents and breakdowns in silos. With this increasing demand for the storage capacity in silos, the full understanding of the structural functioning, failure prevention, and optimization of the structural components became of great importance. Thus, this work aimed to present some events that happened in the country in the last years and bring the main causes of structural failures, highlighting the failures that are directly related to the type of flow in the interior of the silo; wacky charging and/or discharging; change in the properties of the stored products (specified weight, actual inner friction angle, friction angle against the wall) and instability in the support columns. It follows that a great number of accidents in these structures could have been avoided or reduced with previous knowledge, from the silo designer and those responsible for the operation, about the most important occurrences in silos.

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