scholarly journals Review on Ethnomedicinal uses of Memory Boosting Herb, Butterfly Pea, Clitoria ternatea

2015 ◽  
Vol 15 (2) ◽  
pp. 71 ◽  
Author(s):  
Piya Kosai ◽  
Kanjana Sirisidthi ◽  
Kanitta Jiraungkoorskul ◽  
Wannee Jiraungkoorskul
Keyword(s):  
Wide Spectrum ◽  
Biological Effects ◽  
Pharmacological Activities ◽  
Medicinal Uses ◽  
Clitoria Ternatea ◽  
Wide Range ◽  
Butterfly Pea ◽  
Anti Fungal ◽  
Anticonvulsant Activities ◽  
Ethnomedicinal Uses

<em>Clitoria ternatea</em> (Family: Fabaceae) is one of the traditional medicinal plants used as “Shanka Pushpi” an Ayurvedic medicine used to boost or enhance neurological health. The plant contains alkaloid, flavonoid, taraxerol, taraxerone, triterpenoid and anthocyanin as active chemicals that bring about its biological effects. Its extracts possess a wide range of pharmacological activities including antibacterial, anti-diabetic, anti-diarrheal, anti-fungal, anti-helmintic, anti-inflammatory, antimicrobial, antioxidant, and antipyretic activities, hypolipidemia, immunomodulatory, and wound healing. This review is an attempt to compile information on various ethno medicinal uses of memory boosting herb, butterfly pea, <em>Clitoria ternatea</em>. <strong>Conclusion</strong>: It has a wide spectrum of neuro pharmacological benefits such as nootropic, anti-depressant, anti-stress, anxiolytic, and anticonvulsant activities.

Phytochemical and pharmacological aspects of Nothapodytes nimmoniana. An overview

2013 ◽  
Vol 59 (1) ◽  
pp. 53-66 ◽  
Author(s):  
Nazeerullah Khan ◽  
Ennus Tajuddin Tamboli ◽  
V.K. Sharma ◽  
Sunil Kumar
Keyword(s):  
Wide Spectrum ◽  
Pharmacological Activities ◽  
Nothapodytes Nimmoniana ◽  
Jammu And Kashmir ◽  
Medicinal Uses ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Anti Fungal ◽  
Anti Hiv ◽  
Important Medicinal Plant

Summary Nothapodytes nimmoniana (J. Graham) (Icacinaceae), commonly known as Amruta is found in India particularly in Maharashtra, Goa, Kerala, Assam, Jammu and Kashmir as well as Tamilnadu areas. It is an important medicinal plant, the major source of a potent alkaloid, namely camptothecin, of a wide spectrum of pharmacological activities like anti-cancer, anti-HIV, antimalarial, antibacterial, anti-oxidant, anti-inflammatory, anti-fungal and also applied in the treatment of anaemia. Camptothecin is still not synthesized, therefore, its production entirely depends on natural sources. N. nimmoniana is one such plant which yields contain camptothecin in significantly high amount. The plant is gaining international recognition due to its diversified medicinal uses. It is subjected to excessive harvest. It has been categorized as a vulnerable and endangered plant. The present review encompasses the phytochemical, analytical, pharmacological, biotechnological, and other specific aspects of N. nimmoniana.

Ethnomedicinal uses, Phytochemistry and Pharmacological Aspects of the Genus Berberis Linn: A Comprehensive Review

2020 ◽  
Vol 23 ◽  
Author(s):  
Roohi Mohi-ud-din ◽  
Reyaz Hassan Mir ◽  
Prince Ahad Mir ◽  
Saeema Farooq ◽  
Syed Naiem Raza ◽  
...  
Keyword(s):  
Chemical Constituents ◽  
Pharmacological Activities ◽  
Traditional Use ◽  
Comprehensive Review ◽  
Wide Range ◽  
Anti Cancer ◽  
Comprehensive Survey ◽  
Ethnomedicinal Uses

Background: Genus Berberis (family Berberidaceae), which contains about 650 species and 17 genera worldwide, has been used in folklore and various traditional medicine systems. Berberis Linn. is the most established group among genera with around 450-500 species across the world. This comprehensive review will not only help researchers for further evaluation but also provide substantial information for future exploitation of species to develop novel herbal formulations. Objective: The present review is focussed to summarize and collect the updated review of information of Genus Berberis species reported to date regarding their ethnomedicinal information, chemical constituents, traditional/folklore use, and reported pharmacological activities on more than 40 species of Berberis. Conclusion: A comprehensive survey of the literature reveals that various species of the genus possess various phytoconstituents mainly alkaloids, flavonoid based compounds isolated from different parts of a plant with a wide range of pharmacological activities. So far, many pharmacological activities like anti-cancer, anti-hyperlipidemic, hepatoprotective, immunomodulatory, anti-inflammatory both in vitro & in vivo and clinical study of different extracts/isolated compounds of different species of Berberis have been reported, proving their importance as a medicinal plant and claiming their traditional use.

Phytochemical, Pharmacological Activities and Ayurvedic Significances of Magical Plant Mimosa pudica Linn

2020 ◽  
Vol 17 ◽  
Author(s):  
Vijay Kumar
Keyword(s):  
Therapeutic Potential ◽  
Wide Spectrum ◽  
Chemical Constituents ◽  
Future Research ◽  
Mimosa Pudica ◽  
Pharmacological Activities ◽  
Medicinal Uses ◽  
Traditional Medicines ◽  
Crude Extracts ◽  
Anti Cancer

: Mimosa pudica Linn is an integrated part of Traditional Medicines Systems of India, China, Africa, Korea and America. It has been used from centuries in traditional medicines to cure different diseases like fever, diabetes, constipation, jaundice, ulcers, biliousness, and dyspepsia. It is an important ingredient of wide class of herbal formulations. To assess the scientific evidence for therapeutic potential of Mimosa pudica Linn and to identify the gaps for future research. The available information on the ethno-medicinal uses, phytochemistry, pharmacology and toxicology of Mimosa pudica Linn was collected via a library and electronic searches in Sci-Finder, Pub-Med, Science Direct, Google Scholar for the period, 1990 to 2020. In traditional medicinal systems, variety of ethno-medicinal applications of Mimosa pudica Linn has been noticed. Phytochemical investigation has resulted in identification of 40 well known chemical constituents, among which alkaloids, phenols and flavionoids are the predominant groups. The crude extracts and isolates have exhibited a wide spectrum of in vitro and in vivo pharmacological activities including anti-cancer, anti-inflammation, osteoporosis, neurological disorders, hypertension etc.. To quantify the Mimosa pudica Linn and its formulations, analytical techniques like HPLC and HPTLC has shown dominancy with good range of recovery and detection limit. Mimosa pudica Linn is the well-known herb since an ancient time. The pharmacological results supported some of the applications of Mimosa pudica Linn in traditional medicine systems. Perhaps, the predominance of alkaloids, phenols and flavionoids are responsible for the pharmacological activities the crude extracts and isolates of Mimosa pudica Linn. Further, there is need to isolate and evaluate the active chemical constituents of Mimosa pudica Linn having significant medicinal values. In future, it is important to study the exact mechanism associated with the phytochemicals of Mimosa pudica Linn especially on anti-cancer activities. Notably, toxicity studies on Mimosa pudica Linn are limited which are to be explored in future for the safe application of Mimosa pudica Linn and its formulations.

Cucurbitacins as Anticancer Agents: A Patent Review

2019 ◽  
Vol 14 (2) ◽  
pp. 133-143 ◽  
Author(s):  
Hidayat Hussain ◽  
Ivan R. Green ◽  
Muhammad Saleem ◽  
Khanzadi F. Khattak ◽  
Muhammad Irshad ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Wide Spectrum ◽  
Biological Effects ◽  
Therapeutic Effects ◽  
Cytotoxic Effects ◽  
Natural Sources ◽  
Oh Groups ◽  
Drug Candidates ◽  
The Past ◽  
Wide Range

Background: Cucurbitacins belong to a group of tetracyclic triterpenoids that display a wide range of biological effects. In the past, numerous cucurbitacins have been isolated from natural sources and many active compounds have been synthesized using the privileged scaffold in order to enhance its cytotoxic effects. Objective: his review covers patents on the therapeutic effects of natural cucurbitacins and their synthetic analogs published during the past decade. By far, the majority of patents published are related to cancer and Structure-Activity Relationships (SAR) of these compounds are included to lend gravitas to this important class of natural products. Methods: The date about the published patents was downloaded via online open access patent databases. Results: Cucurbitacins display significant cytotoxic properties, in particular cucurbitacins B and D which possess very potent effects towards a number of cancer cells. Numerous cucurbitacins isolated from natural sources have been derivatized through chemical modification at the C(2)-OH and C(25)- OH groups. Most importantly, an acyl ester of the C(25)-OH and, iso-propyl, n-propyl and ethyl ether groups of the C(2)-OH demonstrated the most increased cytotoxic activity. Conclusion: The significant cytotoxic effects of natural and semi-synthetic cucurbitacins make them attractive as new drug candidates. Moreover, cucurbitacins have the capability to form conjugates with other anticancer drugs which will synergistically enhance their anticancer effects. The authors believe that in order to get lead compounds, there should be a greater focus on the synthesis of homodimers, heterodimers, and halo derivatives of cucurbitacins. In the opinion of the authors the analysis of the published patents on the cucurbitacins indicates that these compounds can be developed into a regimen to treat a wide spectrum of cancers.

Chemical constituents, ethnomedicinal uses, pharmacology, and toxicity of Dysphania ambrosioides (L.) Mosyakin & Clemants, formerly Chenopodium ambrosioides L.

2021 ◽  
Vol 11 ◽  
Author(s):  
Boniface Pone Kamdem ◽  
Eutrophe Le Doux Kamto ◽  
Hugues Kamdem Paumo ◽  
Lebogang Maureen Katata-Seru ◽  
Dieudonné Emmanuel Pegnyemb ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Chemical Constituents ◽  
Literature Information ◽  
Pharmacological Activities ◽  
In Vivo Experiments ◽  
Wide Range ◽  
Recent Developments ◽  
Available Information ◽  
Ethnomedicinal Uses

Background: Dysphania ambrosioides (L.) Mosyakin & Clemants is an aromatic herb native to South America, but also distributed widely throughout Africa and Europe. This plant is traditionally used to treat various ailments including, pain and swellings, flu, parasitic diseases, and as analgesic, antipyretic, and wound healing. Phytochemical analyses of D. ambrosioides revealed the presence of terpenoids, flavonoids, coumarins, fatty acids and miscellaneous compounds among others, which might be responsible for its modern pharmacological actions. Objective: The present work summarizes recent developments on phytochemistry, ethnomedicinal use, pharmacology, and toxicity of D. ambrosioides. A critical assessment of the literature information of D. ambrosioides is also presented. Methods: The available information on D. ambrosioides was collected through libraries and electronic databases [Scifinder, ACS, Scielo, Science direct, Pubmed (National Library of Medicine), Wiley, Springer, PROTA, Web of Science, Google Web, Yahoo search and Google scholar] from respective inception until january 2021. Results: More than 150 compounds, including terpenoids, flavonoids, coumarins, fatty acids, and miscellaneous compounds etc.. were identified from D. ambrosioides. D. ambrosioides exhibited a wide range of pharmacological activities, including antimalarial, anti-inflammatory, antiparasitic, anticancer, insecticidal, antigiardial, among others. Metal nanoparticles synthesized from D. ambrosioides extracts presented enhanced pharmacological activities as compared to the crude plant extracts counterparts. Conclusion: D. ambrosioides is a promising medicinal plant, however, more in vivo experiments, cytotoxicity tests, and mechanisms of actions of its extracts and compounds are recommended to transubstantiate the ethnomedicinal claims of this plant into scientific rationale-based information.

scholarly journals Butterfly Pea (Clitoria ternatea L.: Fabaceae) and Its Morphological Variations in Bali

2021 ◽  
Vol 6 (2) ◽  
pp. 63013
Author(s):  
I Wayan Suarna ◽  
I Made Saka Wijaya
Keyword(s):  
Ornamental Plants ◽  
Morphological Characterization ◽  
Primary Data ◽  
Natural Food ◽  
Herbaceous Plant ◽  
Clitoria Ternatea ◽  
Morphological Variations ◽  
Perennial Herbaceous Plant ◽  
Wide Range ◽  
Butterfly Pea

Butterfly pea (Clitoria ternatea L.) is an important perennial herbaceous plant with a range of uses as ornamental plants, fodder crops, medicine, and sources of natural food colorant and antioxidants. The leaves and pods are commonly used as a source of protein in fodder, while the flowers are usually dried and processed as a high antioxidant-containing tea. The blue variant of butterfly pea was the most commonly used variety, although there are quite diverse butterfly pea varieties. The present study aimed to observe the morphological variations among the 26 butterfly pea accessions that originated from a wide range of areas in Bali. The explorative method was used to obtain diverse specimens (accessions) of butterfly pea in Bali, and subsequently, morphological characterization of the accessions was performed. The primary data of morphological traits that were recorded included stems, leaves, flower structures, flower colors, pods, and seeds. The data were analyzed descriptively to determine the morphological variations between accessions. The results showed three major morphological variations: (i) the colour of the flower (corolla), (ii) the corolla structure, and (iii) the stamen structure. The colour of corolla has four variations: white, mauve, light blue, and dark blue; while the corolla structure has two variations: normal and multiple layered corollas. The stamen character showed a correlation with the structure of the corolla. The normal corolla has diadelphous stamens, while the multiple layered corollas have solitary stamens. These morphological variations are the genetic richness of Indonesia’s biodiversity and should be protected and conserved.

scholarly journals Tinjauan manfaat bunga telang (clitoria ternatea l.) bagi kesehatan manusia

2020 ◽  
Vol 1 (2) ◽  
pp. 63-85
Author(s):  
Abdullah Muzi Marpaung
Keyword(s):  
Clinical Trial ◽  
Fatty Acids ◽  
Human Health ◽  
Functional Activity ◽  
Functional Food ◽  
Clitoria Ternatea ◽  
Flower Extract ◽  
Wide Range ◽  
Butterfly Pea ◽  
Positive Effect

All part of the butterfly pea (Clitoria ternatea) plant reported having a various positive effect on human health. The blue petal, in particular, shows a wide range of functional activity including as an antioxidant, antidiabetic, antiobesity, anticancer, anti-inflammatory, and antibiotic. The hydrophilic phase of butterfly pea flower extract contains flavonol glycosides, anthocyanins, flavones, flavonols, phenolic acids, and cyclotides. Meanwhile, the terpenoids, alkaloids, and fatty acids were found in the lipophilic phase of butterfly pea flower extract. The proven health benefits and the wide range of the type of bioactive compounds promote butterfly pea flower as the source of functional food and nutraceuticals. However, a series of intensive research, including the clinical trial, is still needed.

Ethnomedicinal Uses, Phytochemistry and Pharmacology of Carica papaya Plant: A Compendious Review

2019 ◽  
Vol 16 (5) ◽  
pp. 463-480 ◽  
Author(s):  
Manpreet Kaur ◽  
Naveen Chandra Talniya ◽  
Seema Sahrawat ◽  
Arvind Kumar ◽  
Elena E. Stashenko
Keyword(s):  
Carica Papaya ◽  
Therapeutic Potential ◽  
Industrial Applications ◽  
Present Review ◽  
Future Research ◽  
Pharmacological Activities ◽  
Traditional System ◽  
Wide Range ◽  
Microbial Infections ◽  
Ethnomedicinal Uses

Medicinal properties of papaya (Carica papaya Linn.) fruit and other parts are wellknown in the traditional system of medicine. Papaya plant originated in Central America and now grown in tropical areas of worldwide, most particularly in Africa and Asia. Studies validate that, papaya has several pharmacological activities, such as antioxidant, antiulcer, antibacterial, woundhealing, anti-inflammatory and anti-sickling, just to name a few. The present review article provides the explicit and updated information on botanical aspects, ethnomedicinal uses, phytochemistry and pharmacological activities of C. papaya plant in order to explore their therapeutic potential. This review conducted a systematic search on C. papaya through electronic database search (Google Scholar, PubMed, SciFinder, Scopus, Science Direct, and Web of Science) and a library search for articles published in peer-reviewed journals, until January of 2018. Constituents of papaya plant belongs to different chemical classes that include alkaloids, flavonoids, terpenoids, saponins, steroids, tannin, vitamins, quinones, minerals and others. Experimental evidence confirmed that these classes of compounds cure the microbial infections, diabetes, inflammatory, cytotoxic and liver disorders. Conclusively, the present review aimed to summarize the information of ethnomedicinal uses, phytochemistry and pharmacological activities to prevent and treat the wide range of diseases and disorders. The future research draws the attention of the researcher for intensive investigations relating to phytochemicals, pharmacological activities and industrial applications.

scholarly journals Unicellular Eukaryote as a Bio-cellular Model for Studying Effect Benzimidazole: Ultrastructural Analysis

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Karlen O Hovnanyan
Keyword(s):  
Mechanism Of Action ◽  
Wide Spectrum ◽  
Biological Effects ◽  
Unicellular Eukaryote ◽  
Electron Microscopic ◽  
Cystic Form ◽  
Ultrastructural Characterization ◽  
Wide Range ◽  
First Time ◽  
Derivatives Of

The search for new derivatives of benzoimidazole with an active center that have a wide range of biological effects (antifungal, antiflammatory, antibacterial, antiviral, antitumor, antidiabetic, etc.) is the subject of modern pharmaceutical science. To determine the mechanism of action of benzoimidazole, a search is underway for more. We have previously carried out the Ultrastructural characterization of various prokaryotes and protists, as well as the mechanism of action of antibiotics and chemical preparations on them. From a series of heterocyclic drugs, a drug with a wide spectrum of action was chosen as derivatives of benzimidazole and a model of a free-living unicellular eukaryote Endameba moshkovskii with a vegetative and cystic form. The purpose of this work is the nature of the action of drugs of the benzimidazole series and in the ultrastructural visualization of the mechanism of action of benzimidazole using electron microscopic and electron-cytochemical methods on the model of polyxenic cultures of unicellular eukaryotes Entamoeba moshkovskii. We have established for the first time the excising effect of benzimidazole and the functional-ultrastructural mechanism of the action of benzimidazole on entameoba cells. As a result, the ultrastructural and functional morphology of benzimidazole action in the process of excysting entamoeba was established.

scholarly journals TOXICOLOGICAL AND BIOLOGICAL CHARACTERISTICS OF NEW N-SUBSTITUTED AMINOAMIDES

2018 ◽  
pp. 46-49
Author(s):  
O. S. Kaldyrkaeva ◽  
E. V. Arzamastsev ◽  
E. Ya. Borisova ◽  
O. A. Terekhova ◽  
E. Yu. Afanasieva ◽  
...  
Keyword(s):  
Pharmacological Activity ◽  
Biological Effects ◽  
Biological Characteristics ◽  
Amino Groups ◽  
Pharmacological Activities ◽  
Wide Range ◽  
The Relationship

Functionally substituted amines containing amido and amino groups have a wide range of biological effects. Among them substances with various pharmacological activities were identified, and based on them a number of drugs were development. The paper presents toxicological characteristics of new substances and the relationship between the structure and pharmacological activity of aminoamides.

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