scholarly journals PROMOTIVE FACTORS DURING ADOLESCENCE: ARE THERE CHANGES IN IMPACT AND PREVALENCE DURING ADOLESCENCE AND HOW DOES THIS RELATE TO RISK FACTORS?

2011 ◽  
Vol 2 (1/2) ◽  
pp. 119 ◽  
Author(s):  
Claudia Van der Put ◽  
Peter Van der Laan ◽  
Geert-Jam Stams ◽  
Maja Deković ◽  
Machteld Hoeve
Keyword(s):  
Risk Factors ◽  
Sex Differences ◽  
Clinical Practice ◽  
Early Intervention ◽  
Criminal Offense ◽  
Promotive Factors ◽  
Older Adolescents ◽  
The Impact ◽  
Age And Sex

<p>In this study we compared the impact of promotive and risk factors on 18-month recidivism during adolescence. <em>We measured bipolar factors (factors with risk and promotive effects being the ends of the same continuum) for 13,613 American juveniles who had committed a criminal offense. For most of the factors </em>no significant differences were found between the impact of the promotive and risk ends. Interventions aimed at increasing promotive factors may therefore be potentially just as effective as interventions aimed at decreasing risks. The importance of both promotive and risk factors was found to be significantly higher for younger than for older adolescents in almost every domain, which emphasizes the importance of early intervention. Furthermore, age and sex differences were found in the impact and prevalence of promotive and risk factors.<em> </em>The discussion focuses on implications for clinical practice.</p>

Age and sex differences of risk factors of activity limitations in Japanese older adults

2015 ◽  
Vol 16 (6) ◽  
pp. 670-678 ◽  
Author(s):  
Takafumi Monma ◽  
Fumi Takeda ◽  
Haruko Noguchi ◽  
Nanako Tamiya
Keyword(s):  
Risk Factors ◽  
Older Adults ◽  
Sex Differences ◽  
Activity Limitations ◽  
Japanese Older Adults ◽  
Age And Sex

Sex similarities and differences in risk factors for recurrence of major depression

2017 ◽  
Vol 48 (10) ◽  
pp. 1685-1693 ◽  
Author(s):  
Hanna M. van Loo ◽  
Steven H. Aggen ◽  
Charles O. Gardner ◽  
Kenneth S. Kendler
Keyword(s):  
Risk Factors ◽  
Sex Differences ◽  
Family History ◽  
Major Depression ◽  
Prediction Models ◽  
Population Sample ◽  
Disease Onset ◽  
Risk Factors For Recurrence ◽  
Males And Females ◽  
The Impact

AbstractBackgroundMajor depression (MD) occurs about twice as often in women as in men, but it is unclear whether sex differences subsist after disease onset. This study aims to elucidate potential sex differences in rates and risk factors for MD recurrence, in order to improve prediction of course of illness and understanding of its underlying mechanisms.MethodsWe used prospective data from a general population sample (n = 653) that experienced a recent episode of MD. A diverse set of potential risk factors for recurrence of MD was analyzed using Cox models subject to elastic net regularization for males and females separately. Accuracy of the prediction models was tested in same-sex and opposite-sex test data. Additionally, interactions between sex and each of the risk factors were investigated to identify potential sex differences.ResultsRecurrence rates and the impact of most risk factors were similar for men and women. For both sexes, prediction models were highly multifactorial including risk factors such as comorbid anxiety, early traumas, and family history. Some subtle sex differences were detected: for men, prediction models included more risk factors concerning characteristics of the depressive episode and family history of MD and generalized anxiety, whereas for women, models included more risk factors concerning early and recent adverse life events and socioeconomic problems.ConclusionsNo prominent sex differences in risk factors for recurrence of MD were found, potentially indicating similar disease maintaining mechanisms for both sexes. Course of MD is a multifactorial phenomenon for both males and females.

scholarly journals Risk factors and incidence over time for lower extremity amputations in people with type 1 diabetes: an observational cohort study of 46,088 patients from the Swedish National Diabetes Registry

Diabetologia ◽  
2021 ◽  
Author(s):  
Sara Hallström ◽  
Ann-Marie Svensson ◽  
Aldina Pivodic ◽  
Arndís F. Ólafsdóttir ◽  
Magnus Löndahl ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 1 Diabetes ◽  
Lower Extremity ◽  
Renal Dysfunction ◽  
Diabetes Registry ◽  
Male Sex ◽  
The Impact ◽  
Over Time ◽  
Age And Sex

Abstract Aims/hypothesis The aim of this work was to study the incidence over time of lower extremity amputations and determine variables associated with increased risk of amputations in people with type 1 diabetes. Methods Individuals with type 1 diabetes registered in the Swedish National Diabetes Registry with no previous amputation from 1 January 1998 and followed to 2 October 2019 were included. Time-updated Cox regression and gradient of risk per SD were used to evaluate the impact of risk factors on the incidence of amputation. Age- and sex-adjusted incidences were estimated over time. Results Of 46,088 people with type 1 diabetes with no previous amputation (mean age 32.5 years [SD 14.5], 25,354 [55%] male sex), 1519 (3.3%) underwent amputation. Median follow-up was 12.4 years. The standardised incidence for any amputation in 1998–2001 was 2.84 (95% CI 2.32, 3.36) per 1000 person-years and decreased to 1.64 (95% CI 1.38, 1.90) per 1000 person-years in 2017–2019. The incidence for minor and major amputations showed a similar pattern. Hyperglycaemia and renal dysfunction were the strongest risk factors for amputation, followed by older age, male sex, cardiovascular comorbidities, smoking and hypertension. Glycaemic control and age- and sex-adjusted renal function improved during the corresponding time period as amputations decreased. Conclusions/interpretation The incidence of amputation and of the most prominent risk factors for amputation, including renal dysfunction and hyperglycaemia, has improved considerably during recent years for people with type 1 diabetes. This finding has important implications for quality of life, health economics and prognosis regarding CVD, indicating a trend shift in the treatment of type 1 diabetes. Graphical abstract

scholarly journals Sex differences in incidence and mortality of bloodstream infections. Results from the population-based HUNT study in Norway

2021 ◽  
Author(s):  
Randi Marie Mohus ◽  
Lise T. Gustad ◽  
Anne Sofie Furberg ◽  
Martine Kjølberg Moen ◽  
Kristin Vardheim Liyanarachi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Sex Differences ◽  
Large Population ◽  
Bloodstream Infections ◽  
Hdl Cholesterol ◽  
Health Behaviours ◽  
Population Based ◽  
Incidence And Mortality ◽  
The Impact ◽  
First Time

AbstractObjectiveTo examine the effect of sex on risk of bloodstream infections (BSI) and BSI mortality and to assess to what extent known risk factors for BSI mediate this association in the general population.ParticipantsThe prospective, population-based HUNT2 Survey (1995-97) in Norway invited 93,898 inhabitants ≥20 years in the Nord-Trøndelag region, whereof 65,237 (69.5%) participated. 46.8% of the participants were men.ExposuresSex and potential mediators between sex and BSI; health behaviours (smoking, alcohol consumption), education attainment, cardiovascular risk factors (systolic blood pressure, non-HDL cholesterol, body mass index) and previous or current comorbidities.Main outcome measuresSex differences in risk of first-time BSI, BSI mortality (death within first 30 days after a BSI), BSI caused by the most frequent bacteria, and the impact of known BSI risk factors as mediators.ResultsWe documented a first-time BSI for 1,840 (2.9%) participants (51.3% men) during a median follow-up of 14.8 years. Of these, 396 (0.6%) died (56.6% men). Men had 41% higher risk of any first-time BSI (95% confidence interval (CI), 28 to 54%) than women. An estimated 34% of the excess risk of BSI in men was mediated by known BSI risk factors. The hazard ratio (HR) with 95% CI for BSI due to S. aureus was 2.09 (1.28 to 2.54), S. pneumoniae 1.36 (1.05 to 1.76), and E. coli 0.97 (0.84 to 1.13) in men vs women. BSI related mortality was higher in men compared to women with HR 1.87 (1.53 to 2.28).ConclusionsThis large population-based study show that men have higher risk of BSI than women. One-third of this effect was mediated by known risk factors for BSI. This raises important questions regarding sex specific approaches to reduce the burden of BSI.

scholarly journals Age and Sex Differences in Acute and Osteoarthritis-Like Pain Responses in Rats

2019 ◽  
Vol 75 (8) ◽  
pp. 1465-1472 ◽  
Author(s):  
Jin Y Ro ◽  
Youping Zhang ◽  
Christina Tricou ◽  
Dan Yang ◽  
Joyce T da Silva ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Sex Differences ◽  
Knee Joint ◽  
Weight Bearing ◽  
Female Rats ◽  
Peak Reduction ◽  
Chronic Pain Conditions ◽  
The Impact ◽  
Age And Sex ◽  
Pain Responses

Abstract In this study, we investigated age and sex differences in acute and chronic pain in rats. Groups of young (3–6 months) and aged (20–24 months) male and female Fischer 344 rats were used to assess basal thermal and mechanical thresholds, capsaicin-induced acute nocifensive responses and c-Fos expression in the spinal cord, and monoiodoacetate (MIA)-induced knee osteoarthritis (OA)-like pain responses. There was a significant sex, but not age, effect on thermal threshold on the hindpaw and mechanical threshold on the knee joint. No significant age and sex differences in capsaicin-induced nocifensive and c-Fos responses were observed. MIA induced a greater peak reduction of weight-bearing responses in aged males than young rats. Aged females developed the most profound weight-bearing deficit. With knee joint sensitivity as a primary outcome measure, MIA induced more pronounced and longer-lasting hyperalgesia in older rats, with aged female rats showing the worst effect. These data suggest that age may not have significant effect on acute nociceptive processing, but it significantly impacts OA-like pain, making aged rats, especially females, more vulnerable to chronic pain conditions. These preclinical models should provide important tools to investigate basic mechanisms underlying the impact of age and sex in chronic pain conditions.

Sex differences in genetic and environmental risk factors for irrational fears and phobias

2002 ◽  
Vol 32 (2) ◽  
pp. 209-217 ◽  
Author(s):  
K. S. KENDLER ◽  
K. C. JACOBSON ◽  
J. MYERS ◽  
C. A. PRESCOTT
Keyword(s):  
Risk Factors ◽  
Sex Differences ◽  
Genetic Risk ◽  
Threshold Model ◽  
Twin Studies ◽  
Genetic Effects ◽  
Males And Females ◽  
The Impact ◽  
Best Fit ◽  
Twin Resemblance

Background. For irrational fears and their associated phobias, epidemiological studies suggest sex differences in prevalence and twin studies report significant genetic effects. How does sex impact on the familial transmission of liability to fears and phobias?Methods. In personal interviews with over 3000 complete pairs (of whom 1058 were opposite-sex dizygotic pairs), ascertained from a population-based registry, we assessed the lifetime prevalence of five phobias and their associated irrational fears analysed using a multiple threshold model. Twin resemblance was assessed by polychoric correlations and biometrical model-fitting incorporating sex-specific effects.Results. For agoraphobia, situational and blood/injury fear/phobia, the best fit model suggested equal heritability in males and females and genetic correlations between the sexes of less than +0·50. For animal fear/phobias by contrast, the best fit model suggested equal heritability in males and females and a genetic correlation of unity. No evidence was found for an impact of family environment on liability to these fears or phobias. For social phobias, twin resemblance in males was explained by genetic factors and in females by familial–environmental factors.Conclusion. The impact of sex on genetic risk may differ meaningfully across phobia subtypes. Sex-specific genetic risk factors may exist for agoraphobia, social, situational and blood-injury phobias but not for animal fear/phobia. These results should be interpreted in the context of the limited power of twin studies, even with large sample sizes, to resolve sex-specific genetic effects.

scholarly journals Impact of comorbidity burden on mortality in patients with COVID-19 using the Korean health insurance database

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Soo Ick Cho ◽  
Susie Yoon ◽  
Ho-Jin Lee
Keyword(s):  
Risk Factors ◽  
Health Insurance ◽  
Roc Curve ◽  
Significant Risk ◽  
Curve Analysis ◽  
Roc Curve Analysis ◽  
Comorbidity Burden ◽  
Comorbidity Index ◽  
The Impact ◽  
Age And Sex

AbstractWe aimed to investigate the impact of comorbidity burden on mortality in patients with coronavirus disease (COVID-19). We analyzed the COVID-19 data from the nationwide health insurance claims of South Korea. Data on demographic characteristics, comorbidities, and mortality records of patients with COVID-19 were extracted from the database. The odds ratios of mortality according to comorbidities in these patients with and without adjustment for age and sex were calculated. The predictive value of the original Charlson comorbidity index (CCI) and the age-adjusted CCI (ACCI) for mortality in these patients were investigated using the receiver operating characteristic (ROC) curve analysis. Among 7590 patients, 227 (3.0%) had died. After age and sex adjustment, hypertension, diabetes mellitus, congestive heart failure, dementia, chronic pulmonary disease, liver disease, renal disease, and cancer were significant risk factors for mortality. The ROC curve analysis showed that an ACCI threshold > 3.5 yielded the best cut-off point for predicting mortality (area under the ROC 0.92; 95% confidence interval 0.91–0.94). Our study revealed multiple risk factors for mortality in patients with COVID-19. The high predictive power of the ACCI for mortality in our results can support the importance of old age and comorbidities in the severity of COVID-19.

scholarly journals Sex differences in the predictors of recurrent atrial fibrillation after catheter ablation: insights from the Kansai Plus Atrial Fibrillation (KPAF) registry

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
N Tanaka ◽  
K Inoue ◽  
A Kobori ◽  
K Kazutai ◽  
T Morimoto ◽  
...  
Keyword(s):  
Risk Factors ◽  
Atrial Fibrillation ◽  
Sex Differences ◽  
Catheter Ablation ◽  
Large Scale ◽  
Funding Source ◽  
Recurrent Atrial Fibrillation ◽  
History Of ◽  
The Impact ◽  
Af Recurrence

Abstract Background The impact of sex differences on the clinical outcomes of radiofrequency catheter ablation (RFCA) of atrial fibrillation (AF) is controversial. We previously reported that females experienced more frequent AF recurrences than males after the index and last RFCA procedures. Purpose To identify the risk factors associated with recurrent AF in females and males after RFCA of AF. Methods We conducted a large-scale, prospective, multicenter, observational study (Kansai Plus Atrial Fibrillation Registry). We enrolled 5010 consecutive patients who underwent an initial RFCA of AF at 26 centers (64±10 years; 1369 [27.3%] females; non-paroxysmal AF, 35.7%). The median follow-up duration was 2.9 years. Results The incidence of AF recurrences after a single procedure was 43.3% in females and 39.0% in males. After a multivariate adjustment at baseline, the significant predictors of AF recurrence in females after the index RFCA were non-paroxysmal AF (hazard ration [HR],1.59; 95% confidence interval [CI],1.31–1.93, p&lt;0.0001), a history of AF ≥2 years (HR,1.47; 95% CI,1.24–1.74, p&lt;0.0001), coronary artery disease (HR,1.43; 95% CI,1.03–1.98, p=0.0035), and an estimated glomerular filtration rate (eGFR)&lt;60 mL/min/1.73m2 (HR,1.46; 95% CI,1.10–1.95, p=0.0086). On the other hand, significant predictors of AF recurrence in males after the index RFCA were non-paroxysmal AF (HR,1.54; 95% CI,1.37–1.73, p&lt;0.0001), a history of AF ≥2 years (HR,1.40; 95% CI,1.26–1.56, p&lt;0.0001), the number of antiarrhythmic drugs (HR,1.06; 95% CI,1.003–1.13, p=0.040), a left atrial diameter≥40mm (HR,1.13; 95% CI,1.007–1.27, p=0.038), and dilated cardiomyopathy (HR,1.55; 95% CI,1.07–2.26, p=0.021), however, an eGFR&lt;60 mL/min/1.73m2 was not associated with AF recurrence in males (HR, 1.00; 95% CI, 0.88–1.13, p=0.97). Conclusion The Kansai Plus Atrial Fibrillation Registry revealed a distinct sex difference in terms of the predictors of recurrent AF after RFCA. Non-Paroxysmal AF and a long history of AF were common risk factors both in females and males. However, renal dysfunction was a significant predictor of AF recurrence in females, while it was not a risk of recurrence in males. Funding Acknowledgement Type of funding source: Foundation. Main funding source(s): Research Institute for Production Development in Kyoto, Japan.

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