scholarly journals APPLICATION OF GENETIC METHODS OF RESEARCH IN CLINICAL DENTISTRY

2021 ◽  
Vol 17 (2) ◽  
pp. 43-49
Author(s):  
Viktoriya Miroshnichenko ◽  
Mark Varshavchik ◽  
Alena Rudenko
Keyword(s):  
Clinical Signs ◽  
The Body ◽  
Negative Effects ◽  
Genetic Tests ◽  
Genetic Characteristics ◽  
Financial Investments ◽  
Rehabilitation Period ◽  
Probable Gene ◽  
Dental Diseases

Subject. The prevalence of dental diseases worldwide comes between 67% and 98% at an older age, regardless of gender. Many chronic dental processes take place with intoxication of the body. Thereby they cause significant health problems, disrupting the quality of life. They entail large financial investments both from the person and the state. Doctor’s prognosis and understanding on the possible development of the disease in the patient either completely helps to prevent it or facilitates its course, helping to recover and accelerate the rehabilitation period. Genetic tests are an extremely promising and modern solution to this prognosis. Knowledge of genetic characteristics allows dentists to determine the medical tactics, helps to build a plan of recommendations for the patient's lifestyle and the schedule of preventive examinations. In dentistry genetic tests determine the quality of the innate inflammatory immune response to the introduction of pathogenic flora. Such tests allow to find out the features of the regenerative processes in the body and the quality of the detoxification system. Thus, they help to predict a more aggressive and faster course of the disease. Purpose. The aim of the work is to study the relevance and possibility of using genetic testing in dentistry. It describes the most modern methods. The present study shows the function and interpretation of the effect of the most probable gene polymorphisms on clinical signs of dental diseases. Materials and methods. The analysis of 40 sources of domestic and foreign literature on the possibilities and availability of modern test systems in dentistry has been carried out. The information on possible associations of genetic predisposition to the most common dental diseases and conditions has been highlighted, summarized and analyzed. Conclusion. Having previously obtained the results of the patient's genetic characteristics of the metabolism of mineral and vitamin substances, confirmation of the propensity for excessive bacterial growth and other genetic characteristics, the doctor will be able to build a plan of preventive measures to preserve the patient's health or, if necessary, will prepare the patient for treatment to minimize negative effects.

Opposing Vitalism and Embracing Hospice: How a Theology of the Sabbath Can Inform End-of-Life Care

2021 ◽  
Author(s):  
Sarah K Sawicki
Keyword(s):  
End Of Life ◽  
End Of Life Care ◽  
Hospice Care ◽  
Modern Medicine ◽  
The Body ◽  
Care Plan ◽  
Life Care ◽  
Negative Effects ◽  
Whole Person

Abstract Medicine often views hospice care as “giving up,” which results in a reduced quality of end-of-life care for many patients. By integrating a theology of the Sabbath with modern medicine, hospice becomes a sacred and valuable way to honor the dying patient in a comprehensive and holistic way. A theology of Sabbath as “Sacredness in Time” can provide the foundation for a shift in understanding hospice as a legitimate care plan, which shifts the focus from controlling and manipulating space for the body, to rest and enjoyment of time for the whole person. First, I explore vitalism and its negative effects on the institution of hospice. Second, I address the main misconceptions and biases surrounding hospice in order to establish hospice as an appropriate option for the terminally ill. Finally, I argue for a shift away from sacredness in space (as seen in vitalism) to sacredness in time.

Pre-clinical study of complex phyto-sorbents on the basis of makley and chitozan

2020 ◽  
Vol 1 ◽  
pp. 52-56
Author(s):  
V.A. Baryshev ◽  
◽  
O.S. Popova ◽  
Keyword(s):  
Quality Of Life ◽  
Antimicrobial Activity ◽  
Animal Husbandry ◽  
The Body ◽  
Agricultural Products ◽  
Negative Effects ◽  
Subacute Toxicity ◽  
Poultry Farming

The aim of our research was to assess the toxicity of complex phytosorbents based on maklea cordate and chitosan. Evaluation of antimicrobial activity in vitro was carried out according to the General Pharmacopoeia Monograph (the method is described in the Pharmacopoeia (OFS.1.2.4.0010.15), three types of phytosorption complex were used as the material for the study. Phytosorbents were included in samples 1–3. In addition to sorbents, sample No. 1, oil of oregano and thyme containing carvacrol (with proven antimicrobial activity in previous experi-ments) was added, compound Macleaya cor-data was added to compound No. 2, and chi-tosan was added to compound No. 3-components of samples 1. Нe study of the toxicity of the studied parameters was stud-ied according to the guidelines [5]. The haz-ard class of the studied drugs was deter-mined according to GOST 12.1.007-76. Ac-cording to experiments, drugs can be classi-fied as low-hazard substances. Assessment of acute and subacute toxicity proved the absence of negative effects of both drugs on the body of laboratory ani-mals, at a dose twice and four times the rec-ommended therapeutic, which is 6000 mg / goal. and 12000 mg / goal., Do not cause toxic effects and death of animals. And the introduction of complexes with chitosan and macklea, at a dose of 6000 mg / goal. within 28 days, positively affects the body of labor-atory rats. That allows research to determine the effectiveness, including on productive animals. Factors that determine the relevance of the development of highly effective phytobi-otics and their use in animal husbandry and poultry farming should also include the high profitability of the production of environ-mentally friendly agricultural products and the task of improving the quality of life of the population.

scholarly journals Compulsive Disorder in Border Collie bitch

2019 ◽  
Vol 47 ◽  
Author(s):  
Isabel Rodriges Rosado ◽  
Juliana Gonzaga Da Silva ◽  
Dilmas Mendes De Freitas ◽  
Aline Silva Dos Reis ◽  
Julia Perinotto Picelli ◽  
...  
Keyword(s):  
Repetitive Behavior ◽  
Clinical Signs ◽  
Clinical Manifestations ◽  
Repetitive Behaviors ◽  
Duration Of Treatment ◽  
Presumptive Diagnosis ◽  
Genetic Characteristics ◽  
Compulsive Disorder ◽  
Compulsive Disorders

Background: Compulsive disorders are excessive and repetitive behaviors that jeopardize the quality of life of both animal and tutor. It generally affects dogs between 6 and 36 months of age, and its etiology is associated to stress, anxiety and genetic predisposition. Clinical manifestations are the usual behaviors of the dog, but overly and inappropriately done. Diagnosis is based on a history of repetitive behavior, and on clinical and complementary exams to discard other diseases. The aim of this study is to report a case of compulsive disorder in a female Border Collie dog, including diagnostic and therapeutic approaches.Case: A 5-month-old, female, Border Collie dog was presented to Uberaba’s Veterinary Hospital (HVU) owing to a chasing shadows behavior that started as a playtime activity but intensified to the point of becoming a repetitive and excessive act, followed by self-trauma and excessive barking. Clinical examination showed lesions in nasal planum region. No alterations were observed on neurological examination apart from the chasing of shadows that also happened in the consultation room. Therefore, since there were no other findings on clinical and neurological exams, and since the manifestation occurred as a response to environmental stimuli (presence of shadows), it was established a presumptive diagnosis of compulsive disorder. Treatment with trazodone chlorhydrate was performed, and it was indicated ovariohysterectomy, a follow-up with a professional behaviorist and trainer and environment modifications.  After a fortnight, it was observed a discreet improvement of the clinical signs, hence a second anxiolytic, clomipramine, was added to the treatment. Approximately 3 months after the beggining of therapy, there was improvement of the animal’s clinical picture, being calmer and most days ignoring the shadows.Discussion: Compulsive disorders are described as exaggerated and repetitive behaviors that jeopardize the animal’s interaction with its environment and with its tutor. The animal of this report showed repetitive behavior of chasing shadows, with claw abrasion and self-inflicted nasal lesions caused by leaping and biting on the surfaces where the shadows were projecting. Additionally, during the manifestation of the behavior, the animal barked excessively, which compromised the quality of the tutors’ lives. The patient was a Border Collie female dog, though there are no descriptions of this type of behavior in this breed. The starting age of this patient’s manifestations is consistent with previous reports, which observed it more frequently in animals with 6 to 36 months of age. The absence of alterations on clinical and neurological exams that could indicate maladies in other systems, in addition to a detailed anamnesis and assessment of videos of the animal recorded in his domicile, enabled the diagnosis of compulsive disorder. Ovariohysterectomy was done with the purpose of reducing the previously mentioned behavior. Drug therapy in addition to behavior training were efficient to promote significant improvement, although the duration of treatment is a long-term one, as described by other authors. Further studies are necessary for enlightenment of compulsive disorder’s physiopathology in dogs, and to investigate and identify the causes, such as environmental factors and genetic characteristics, that trigger these behaviors.

scholarly journals Workers’ quality of working life and privatisation: Insights from a developing country

2021 ◽  
Vol 18 (4) ◽  
pp. 231-238
Author(s):  
Mehadi Mamun
Keyword(s):  
Trade Unions ◽  
Working Life ◽  
The Body ◽  
Negative Effects ◽  
Quality Of Working Life ◽  
Face To Face ◽  
Left Behind ◽  
The Impact

Privatisation affects tens of thousands of workers in Bangladesh, though most research has focused on the relationships between privatisation and profitability of this developing country’s privatisation programmes. This study, therefore, is an attempt to shed light on workers who are very vulnerable and examines the impact of privatisation on workers’ quality of working life. Employing document analysis and semi-structured face-to-face interviews with privatised and state-owned organisations’ workers in Bangladesh, this study finds that workers’ compensation, job security, access to trade unions, and leave entitlements in most privatised case study organisations are less than their counterparts in comparable state-owned organisations. These findings aim at contributing to the body of research by empirically investigating the impact of privatisation on workers who are left behind and possess important implications for the privatisation programmes in Bangladesh as it informs that there is a need to reassess the privatisation programmes through greater awareness of the negative effects of privatisation on workers and renew efforts to develop an approach that is sensitive to the Bangladeshi context.

DETECTION OF METABOLIC DISORDERS IN HIGH PRODUCTIVE COWS

2021 ◽  
Vol 1 (1) ◽  
pp. 127-133
Keyword(s):  
Metabolic Disorders ◽  
Clinical Signs ◽  
The Body ◽  
Metabolic Processes ◽  
Clinical Indicators ◽  
Animal Development ◽  
Healthy State ◽  
Normal Composition ◽  
Quality Of Milk

ANNOTATION The productivity of cows is closely related to the level of metabolism in animals. At different stages of animal development, the intensity of metabolic processes varies significantly. The study of the mechanisms of such changes can significantly help in the regulation of metabolic processes, increase the productivity and quality of milk. In the course of research, the causes of metabolic disorders in highly productive Simmental cows were studied. Using clinical indicators of urine, milk, dispensary examination of cows and statistical analysis made by us, the frequency of occurrence of clinical signs characterizing metabolic disorders in animals was established. Of the 40 animals studied, 11 heads (28 %) showed a healthy state of the body, 9 heads (22 %) showed weak rumination, in turn, 10 heads (25 %) showed a decrease in appetite, 2 heads (5 %) showed udder edema, and 8 heads (20 %) showed general depression of the body. During the veterinary and sanitary evaluation of milk according to the main indicators, changes were detected in animals with metabolic disorders, which leads to a decrease in the quality of milk and dairy products. The most important condition for obtaining milk with a normal composition and properties is a balanced feeding of cows in all elements. Incomplete provision of animals with the necessary nutrients and energy contributes to a decrease not only in milk yield, but also to a change in the amount and ratio of milk components, which reduces biological characteristics and technological indicators.

scholarly journals Use of semi-leafless peas (Pisum sativum L) with enzyme addition in diets for broilers

2016 ◽  
Vol 25 (2) ◽  
Author(s):  
Erja Koivunen ◽  
Eija Talvio ◽  
Eija Valkonen ◽  
Tuomo Tupasela ◽  
Petra Tuunainen ◽  
...  
Keyword(s):  
Body Weight ◽  
Body Weight Gain ◽  
The Body ◽  
Feed Conversion ◽  
Negative Effects ◽  
Broiler Performance ◽  
Organoleptic Quality ◽  
Enzyme Cocktail ◽  
Entire Experiment

The aim was to study the effects of dietary pea inclusion and the addition of Avizyme 1200 -enzyme cocktail on broiler performance, intestinal viscosity and organoleptic quality of meat. The experimental design was a 4 × 2 factorial, the factors being dietary pea inclusion (0, 150, 300 and 450 g kg-1) in the diets fed from day 9 to day 38 and the addition of Avizyme 1200 enzyme cocktail including amylase, protease and xylanase during the entire experiment. The growth of birds improved (p ≤ 0.018) with pea inclusion in a cubic manner. Feed conversion ratio (FCR) of the birds fed on unsupplemented diets improved along pea inclusion, while pea inclusion impaired the FCR on the birds on enzyme cocktail supplemented diets (p ≤ 0.006). The use of the enzyme cocktail improved the body weight, body weight gain and FCR of the broilers and decreased intestinal viscosity (p < 0.001). The organoleptic quality of meat was similar among treatments (p > 0.05). In conclusion, 450 g kg-1 peas can be used in the broiler grower diets without negative effects on the bird performance. The use of enzyme cocktail improves bird performance.

METHOD FOR DETERMINING THE DEGREE OF GINGIVAL INFLAMMATION IN THE UPPER AND LOWER JAW USING THE PMA INDEX IN CHRONIC GENERALIZED PERIODONTITIS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS COMPLICATED BY PARTIAL SECONDARY ADENTIA

2021 ◽  
pp. 96-101
Author(s):  
Наталия Александровна Полушкина ◽  
Наталия Владимировна Чиркова ◽  
Жанна Владимировна Вечеркина ◽  
Елена Александровна Лещева ◽  
Кристина Павловна Кубышкина
Keyword(s):  
Periodontal Diseases ◽  
Dental Health ◽  
Age Groups ◽  
The Elderly ◽  
The Body ◽  
Periodontal Inflammation ◽  
Urgent Task ◽  
Dental Diseases ◽  
Dental Apparatus

Особое место в структуре стоматологической заболеваемости занимает патология пародонтального комплекса, в частности - хронический генерализованный пародонтит, который по данным ВОЗ находится на втором месте по частоте распространения среди всех стоматологических заболеваний, уступая лишь кариесу. Первые признаки воспаления пародонта начинают проявляться уже в молодые годы, а к пожилому периоду - распространенность заболеваний пародонта достигает значений, стремящихся к 100%. Решение проблемы своевременной диагностики, профилактики и лечения патологии пародонта по-прежнему является актуальнейшей задачей современной стоматологии. Генерализованный пародонтит - это не только очаг хронической инфекции и источник сенсибилизации организма, но также ведущая причина потери зубов (особенно в старших возрастных группах), приводящая к серьезным деструктивным последствиям, дезорганизующим зубочелюстной аппарат. Данный факт способен серьезным образом повлиять на качество жизни человека, делая пародонтологическую проблему не только медицинской, но и социальной. Несмотря на очевидную актуальность данного вопроса, а также большой интерес к научным исследованиям в области пародонтологии, стоит признать, что уровень стоматологического здоровья, а также оказания пародонтологической помощи, в том числе пожилому населению - далеки от идеала. Во многом это объясняется сложностью этиологии и патогенеза заболеваний пародонта, а также, нередко, отсутствием комплексного понимания данной патологии при ее терапии A special place in the structure of dental morbidity is occupied by the pathology of the periodontal complex, in particular, chronic generalized periodontitis, which, according to the WHO, is in second place in terms of prevalence among all dental diseases, second only to caries. The first signs of periodontal inflammation begin to appear already in the young years, and by the old age the prevalence of periodontal diseases reaches values tending to 100%. Solving the problem of timely diagnosis, prevention and treatment of periodontal pathology is still the most urgent task of modern dentistry. Generalized periodontitis is not only a source of chronic infection and a source of sensitization of the body, but also a leading cause of tooth loss (especially in older age groups), leading to serious destructive consequences that disorganize the dental apparatus. This fact can seriously affect the quality of life, making periodontal problems not only medical, but also social. Despite the obvious relevance of this issue, as well as the great interest in scientific research in the field of periodontology, it is worth recognizing that the level of dental health, as well as the provision of periodontal care, including the elderly population, is far from ideal. This is largely due to the complexity of the etiology and pathogenesis of periodontal diseases, as well as, often, the lack of a comprehensive understanding of this pathology during its therapy

scholarly journals “Just Like Someone Without Mental Illness, Only More So”: Normalizing Beliefs and their Buffering Effects on Psychiatric Symptoms

2018 ◽  
Vol 37 (1) ◽  
pp. 69-82
Author(s):  
Benjamin Buck ◽  
Neil Hester
Keyword(s):  
Quality Of Life ◽  
Protective Factor ◽  
Psychiatric Symptoms ◽  
Negative Effects ◽  
Genetic Characteristics ◽  
Online Study ◽  
Social Opportunities ◽  
Negative Effect ◽  
Study Participants

Self-stigma leads sufferers of psychiatric conditions to experience reduced self-efficacy and self-esteem as well as avoid treatment, employment, and social opportunities. There is a dearth of research on the mechanisms underlying individuals' ability to resist stigmatizing beliefs; furthermore, research has revealed limitations in current popular approaches to de-stigmatization, such as emphasizing the biological and genetic characteristics of symptoms. We propose normalization—the understanding of psychiatric phenomena as varying degrees of normative, understandable, and common experiences—as a cross-diagnostic protective factor against self-stigma. We recruited a sample of 137 online study participants to pilot an assessment of normalization, predicting that normalizing beliefs about psychiatric symptoms would positively influence quality of life, especially for those who report personal experience of symptoms. We found evidence for this prediction: belief that psychiatric symptoms were relatively common, buffered the negative effect of people's own psychiatric symptoms on quality of life. Cross-diagnostic symptom normalization may function as a protective factor against the negative effects of psychiatric symptoms and associated stigma.

scholarly journals A MODERN APPROACH TO THE TREATMENT OF PATIENTS WITH CLASS II DISTAL OCCLUSION OF THE 1ST SUBCLASS BY ENGLE

2019 ◽  
Vol 19 (1-2) ◽  
pp. 115-121
Author(s):  
A. A Dikova
Keyword(s):  
Orthodontic Treatment ◽  
Class Ii ◽  
The Body ◽  
Modern Approach ◽  
Second Molar ◽  
Additional Equipment ◽  
Dental Diseases ◽  
Upper Jaw ◽  
Distal Occlusion

Distal occlusion is a widespread dental anomaly among all dental diseases. Protrusion of the upper jaw incisors during distal occlusion is quite common. Orthodontic treatment is characterized by its high duration. In this regard, the issue of creating methods to reduce the time of orthodontic treatment of patients with distal occlusion Class II Engle subclass 1 and improve the quality of life of the patient is relevant. When treating patients with distal occlusion, it is necessary to create conditions for the distalization of the second molars of the upper jaw; therefore, it becomes necessary to use additional equipment at the initial stages of the active period of orthodontic treatment. The devices developed by the author allow the body to distalize the second molar of the upper jaw and stabilize its position in the process of orthodontic treatment.

Modern Approaches in the Fight Against Obesity

2021 ◽  
pp. 69-73
Author(s):  
E. Dubrovinskaya ◽  
N. Karpinskaya ◽  
A. Karpinskiy
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Diabetes Mellitus ◽  
Coronary Heart Disease ◽  
Heart Attack ◽  
Healthy Lifestyle ◽  
Diet Therapy ◽  
The Body ◽  
Negative Effects

In recent years, more and more people are obese, which often leads to the risk of developing arterial hypertension, coronary heart disease and atherosclerosis, as well as diabetes mellitus, and as a result of heart attack and stroke. The negative effects of obesity on the body are extremely diverse. Obesity is currently a global problem and requires the development of various approaches to combat it and promote a healthy lifestyle. Weight loss lowers the risk of developing comorbidities in obesity, so proper physical activity and diet therapy are important components for improving the quality of life and preventing overweight.

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