scholarly journals THE SPECIFIC FEATURES OF FLUORESCEIN ANGIOGRAPHY OF THE RETINA IN THE CHILDREN OF DIFFERENT AGE AND THE POSSIBLE COMPLICATIONS OF ITS APPLICATION

2017 ◽  
Vol 12 (2) ◽  
pp. 82-86
Author(s):  
Nikolai Anatol’evich Zaitcev
Keyword(s):  
General Anesthesia ◽  
Premature Infants ◽  
Intravenous Administration ◽  
Age Groups ◽  
Oral Intake ◽  
Fluorescence Angiography ◽  
Sodium Fluorescein ◽  
Premature Babies ◽  
Fluorescein Solution ◽  
Two Age Groups

Purpose. The objective of the present study was the further adaptation of the fluorescence angiography technique for the examination of the children of different ages and the evaluation of the nature, severity, and frequency of complications likely to develop in the course of such examination as a result of intravenous administration of sodium fluorescein and its intake. Material and methods. A total of 957 children at the age varying between 1.5 months and 16 years were divided into two age groups. The first group consisted of 204 (21.3%) children under the age of 1.5 months and up to 5 years including premature babies in whom fluorescence retinal angiography was performed under general anesthesia with the use of the specially developed and improved methodology. The second group was comprised of 753 (78.7%) children at the age between 6 and 16 years. To 649 of these children (86.2%), the dye was injected intravenously whereas to 104 (13.8%) of them sodium fluorescein was given per os. Results. We have developed and further improved the method for fluorescence angiography in the children of various ages including premature infants. The fluorescence angiography of the fundus of the eye in the children at the age from 1.5 months and up to 16 years resulted in the complications of varying severity in 5.2% of the patients. Mild complications in the form of nausea or vomiting accounted for 3.8% of their total number. The moderately severe complications (1.0%) manifested themselves as the development of the collaptoid state or urticaria. The severe complications (0.2%) were apparent as bronchospasm and laryngospasm. No complications whatever were documented in the children after the oral intake of a 10% sodium fluorescein solution. Conclusion. The intravenous fluorescence angiography is a fairly safe method for the examination of the fundus of the eye in the children, however it can be accompanied in rare cases (3.8%) by the complications the majority of which (75%) are mild disorders. Both intravenous administration of sodium fluorescein under general anesthesia and its oral intake can be regarded as safe interventions.

Concordance of Glucose-Based and of HbA1c-Based Diagnoses of Diabetes in Patients with Peripheral Artery Disease—A Comparison between Two Age Groups

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1522-P
Author(s):  
CHRISTOPH H. SAELY ◽  
ALEXANDER VONBANK ◽  
CHRISTINE HEINZLE ◽  
DANIELA ZANOLIN ◽  
BARBARA LARCHER ◽  
...  
Keyword(s):  
Peripheral Artery Disease ◽  
Age Groups ◽  
Peripheral Artery ◽  
Artery Disease ◽  
Two Age Groups

Foundation for the Prevention and Pathological Aspects of Diseases of the Mucous Membranes of the Oral Cavity (Review)

2020 ◽  
Vol 3 (6) ◽  
pp. 8-11
Author(s):  
Bakaev Zh. N.
Keyword(s):  
Oral Cavity ◽  
Rural Women ◽  
Rural Areas ◽  
Southern China ◽  
Age Groups ◽  
Urban Residents ◽  
Volgograd Region ◽  
Mucous Membranes ◽  
The Russian Federation ◽  
Two Age Groups

According to the authors, the prevalence of SOPR diseases is from 3 to 20%.In a study of 1573 residents of southern China in two age groups who use tobacco and alcohol, the incidence of SOPR was higher among men living in rural areas compared to urban residents. Among women aged 35-44 years, the incidence was higher in urban women, and in the 65-77-year-old group in rural women. In the course of studies in Brazil, among 335 patients older than 60 years, 646 diseases of the SOPR were identified. Similar results were obtained in the analysis of SOPR diseases in the Volgograd region of the Russian Federation

Internet Sex discourse and porn viewing by Arab adolescents: The overt and the covert and its impact on their sexual education and behavior (Preprint)

2018 ◽  
Author(s):  
Anat Gesser-Edelsburg ◽  
Munawar Abed Elhadi
Keyword(s):  
Age Groups ◽  
Sexual Education ◽  
The Internet ◽  
Traditional Values ◽  
Sexual Discourse ◽  
Cultural Taboos ◽  
Internet Sex ◽  
And Behavior ◽  
Depth Interviews ◽  
Two Age Groups

BACKGROUND Due to the religious proscription, it was found that Arab youths acquire information and view pornography secretly. The internet exposes them to contents that contradict religious and cultural taboos. There are few studies about viewing habits of sexual contents among Arab adolescents and about the way they discuss sexuality. OBJECTIVE to characterize the barriers and difficulties that prevent sexual discourse in Arab society and enable pornography viewing, according to the perceptions of adolescents and mothers. METHODS phenomological qualitative research methods, in-depth interviews with 40 participants. 20 Arab adolescents, sampled by two age groups: 14-16 and 16-18. In addition, 20 mothers of adolescents from both sexes were interviewed. RESULTS The findings indicate that mothers “turn a blind eye” to porn viewing and sexual activity by boys, versus a sweeping prohibition and denial of such behavior by girls. The boys reported viewing porn routinely, whereas girls denied doing so, but admitted that their girlfriends watched porn. The study also found that the boys have guilt feelings during and after the viewing as a result of the clash between modernity and traditional values. CONCLUSIONS It is necessary to find a way to encourage a significant sexual discourse to prevent the violent consequences of its absence in Arab society. A controlled, transparent and critical sexual discourse could help youth make more informed decisions concerning the search for sexual contents, porn viewing and sexual behavior.

scholarly journals A Reduced Dose Whole Virion Aluminum Adjuvanted Seasonal Influenza Vaccine Is Immunogenic, Safe, and Well Tolerated in Pediatric Patients

Viruses ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 500
Author(s):  
Zoltan Vajo ◽  
Gergely Balaton ◽  
Peter Vajo ◽  
Peter Torzsa
Keyword(s):  
Pediatric Patients ◽  
Geometric Mean ◽  
Age Groups ◽  
Aluminum Phosphate ◽  
Vaccine Virus ◽  
Serious Adverse Events ◽  
Reduced Dose ◽  
Viral Hemagglutinin ◽  
Virus Strains ◽  
Two Age Groups

Background: Data suggest that pediatric patients might react differently to influenza vaccination, both in terms of immunity and side effects. We have recently shown that using a whole virion vaccine with aluminum phosphate adjuvants, reduced dose vaccines containing 6 µg of viral hemagglutinin (HA) per strain are immunogenic, and well tolerated in adult and elderly patients. Here we show the results of a multicenter clinical trial of pediatric patients, using reduced doses of a new, whole virion, aluminum phosphate adjuvanted vaccine (FluArt, Budapest, Hungary). Methods: A total of 120 healthy volunteers were included in two age groups (3–11 years, receiving 3 µg of HA per strain, and 12–18 years, receiving 6 µg of HA per strain). We used hemagglutination inhibition testing to assess immunogenicity, based on EMA and FDA licensing criteria, including post/pre-vaccination geometric mean titer ratios, seroconversion and seropositivity rates. Safety and tolerability were assessed using CHMP guidelines. Results: All subjects entered the study and were vaccinated (ITT population). All 120 subjects attended the control visit on Day 21 (PP population). All immunogenicity licensing criteria were met in both age groups for all three vaccine virus strains. No serious adverse events were detected and the vaccine was well tolerated by both age groups. Discussion: Using a whole virion vaccine and aluminum phosphate adjuvants, a reduction in the amount of the viral hemmaglutinin is possible while maintaining immunogenicity, safety and tolerability in pediatric and adolescent patients.

scholarly journals How (not) to cross a boundary: Crosslinguistic influence in simultaneous bilingual children's event construal

2021 ◽  
pp. 1-13
Author(s):  
Helen Engemann
Keyword(s):  
Production Process ◽  
Age Groups ◽  
Boundary Crossing ◽  
Bilingual Children ◽  
Activation Patterns ◽  
Motion Event ◽  
Co Activation ◽  
Crosslinguistic Influence ◽  
Event Construal ◽  
Two Age Groups

Abstract Simultaneous bilingual children sometimes display crosslinguistic influence (CLI), widely attested in the domain of morphosyntax. It remains less clear whether CLI affects bilinguals’ event construal, what motivates its occurrence and directionality, and how developmentally persistent it is. The present study tested predictions generated by the structural overlap hypothesis and the co-activation account in the motion event domain. 96 English–French bilingual children of two age groups and 96 age-matched monolingual English and French controls were asked to describe animated videos displaying voluntary motion events. Semantic encoding in main verbs showed bidirectional CLI. Unidirectional CLI affected French path encoding in the verbal periphery and was predicted by the presence of boundary-crossing, despite the absence of structural overlap. Furthermore, CLI increased developmentally in the French data. It is argued that these findings reflect highly dynamic co-activation patterns sensitive to the requirements of the task and to language-specific challenges in the online production process.

Effects of laser assisted hatching on IVF/ICSI cycles in two age groups

2012 ◽  
Vol 98 (3) ◽  
pp. S284
Author(s):  
B. Amorocho ◽  
G. Calderón ◽  
M. Mollá ◽  
D. Gumbao ◽  
J. Marcos ◽  
...  
Keyword(s):  
Age Groups ◽  
Assisted Hatching ◽  
Two Age Groups

Comparison of clinical characteristics of tuberculosis between two age groups at an Italian Tertiary Hospital

Infection ◽  
2015 ◽  
Vol 43 (3) ◽  
pp. 361-366 ◽  
Author(s):  
Elda Righi ◽  
Paola Della Siega ◽  
Maria Merelli ◽  
Nadia Castaldo ◽  
Anna Beltrame ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Age Groups ◽  
Tertiary Hospital ◽  
Two Age Groups

scholarly journals AB0876 THE BENEFIT AND SAFETY OF DIACEREIN IN AGED AND OBESE PATIENTS WITH SYMPTOMATIC KNEE OSTEOARTHRITIS: DATA FROM THE DISSCO CLINICAL STUDY

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1744.1-1744
Author(s):  
J. P. Pelletier ◽  
J. P. Raynauld ◽  
M. Dorais ◽  
P. Paiement ◽  
J. Martel-Pelletier
Keyword(s):  
Knee Osteoarthritis ◽  
Physical Function ◽  
Safety Profile ◽  
Age Groups ◽  
Womac Pain ◽  
Research Support ◽  
Symptomatic Knee Osteoarthritis ◽  
Symptomatic Knee ◽  
Time To Onset ◽  
Two Age Groups

Background:The DISSCO trial (6-month international, multicentre, double-blind, randomised study on the effect of diacerein vs celecoxib in symptomatic knee osteoarthritis [OA] patients) showed that diacerein had comparable efficacy to celecoxib at reducing the level of pain (WOMAC pain).Objectives:To assess the effect of age, body mass index (BMI), and gender on the efficacy/safety profile of diacerein following 6 months of treatment.Methods:Of the patients (n=380) that were randomised, 186 received treatment with 50 mg diacerein once daily for the first month and twice daily thereafter. This study was done on the intent-to-treat population (n=183). Efficacy outcome assessments which included absolute change in WOMAC pain (score 0-50) and function (score 0-170), and VAS (score 0-10) were analysed following stratification based on age (< 65 vs ≥ 65 years old) and BMI (< 30 vs ≥ 30 kg/m2) at time of randomisation. Treatment effects on continuous efficacy outcomes were performed using covariance analysis (ANCOVA). For gastrointestinal (GI) safety outcomes, the adverse events (AEs), including diarrhoea, soft faeces, abdominal pain and dyspepsia, and the time-to-onset from baseline were stratified according to age of patients at randomisation. Treatment-related GI AEs were also assessed according to the gender. The independent variables were treatment, stratification variable, interaction between both, and the outcome measure at baseline. Comparisons between groups were carried out using Chi-square.Results:No significant differences were found between the two age groups (<65 years old [n=105], ≥65 years old [n=78]) in the level of reduction in WOMAC pain (-10.3 ± 1.1, -8.6 ± 1.3, respectively; p=0.30), VAS (-2.3 ± 0.2, -2.2 ± 0.3, p=0.73) or improved physical function (-29.7 ± 3.7, -22.1 ± 4.2, p=0.18). The reported incidences of treatment-related GI AEs were also similar between the two age groups; more specifically for diarrhoea, incidence for patients <65 years old [n=12] 11.3% and for those ≥65 years old [n=7] 8.8% (p=0.63) with a mean time-to-onset (day 43 ± 49, 61 ±51, respectively; p=0.11). Moreover, gender had no influence on treatment-related GI AEs (p=0.42).In regard to treatment response of obese (n=101) vs. non-obese (n=82) patients in terms of pain reduction (WOMAC: -10.1 ± 1.2, -9.1 ± 1.1, respectively; p=0.58; VAS: -2.6 ± 0.3, -2.0 ± 0.3; p=0.15), or improved WOMAC physical function (-29.8 ± 4.2, -23.5 ± 3.8; p=0.26), there were also no significant differences.Conclusion:In symptomatic knee OA patients, the level of effectiveness and safety profile of treatment with diacerein were found not to be influenced by age, BMI or gender.Disclosure of Interests:Jean-Pierre Pelletier Shareholder of: ArthroLab Inc., Grant/research support from: TRB Chemedica, Speakers bureau: TRB Chemedica and Mylan, Jean-Pierre Raynauld Consultant of: ArthroLab Inc., Marc Dorais Consultant of: ArthroLab Inc., Patrice Paiement Employee of: ArthroLab Inc., Johanne Martel-Pelletier Shareholder of: ArthroLab Inc., Grant/research support from: TRB Chemedica

EARLY FEEDING OF DEXTROSE AND SALINE SOLUTION TO PREMATURE INFANTS

PEDIATRICS ◽  
1960 ◽  
Vol 26 (5) ◽  
pp. 756-761
Author(s):  
William Allen Bauman
Keyword(s):  
Premature Infants ◽  
Saline Solution ◽  
Treated Group ◽  
Controlled Study ◽  
Early Feeding ◽  
Premature Babies ◽  
Hyaline Membranes ◽  
Average Intake ◽  
Feeding Trials ◽  
Physiologic Responses

Conflicting opinions concerning the optimum age at which to commence feeding premature infants have resulted in either early or late regimens. In order to test the hypothesis that the early administration of fluids to premature babies was beneficial, a controlled study of 50 newborn premature subjects was undertaken. Fluids consisting of 5% dextrose in 0.45% saline were started before the age of 6 hours by constant drip through a nasogastric plastic catheter in 24 subjects selected by a predesigned method using a table of random permutations. The average intake during the test period was 54.5 ml/kg/24 hours. The other 26 control subjects received no fluids until age 36 hours, when both groups were started on formula. There was no alteration of symptoms of respiratory distress in the group receiving early feedings. One-half of these subjects did not lose weight while being fed the dextrose and saline solution. They promptly lost weight, however, when regular milk feedings were commenced. The seven infants who died had similar pathologic findings. It was noted that three of the five in the fluid treated group also had pulmonary hyaline membranes. There were no hyaline membranes in the lungs of the two subjects deprived of water. From this study neither beneficial nor detrimental effects of early feeding could be demonstrated by use of the criteria of dyspnea or mortality. The question of when to start to feed premature babies is still unanswered. There is need for further feeding trials, in which associations among age of commencement, nature of substances fed and the consequent physiologic responses, can be observed.

HYPERGLYCEMIAAS AN INDEPENDENT RISK FACTOR FOR RETINOPATHY OF PREMATURITY (ROP): A COHORT STUDY

2021 ◽  
pp. 54-57
Author(s):  
Kali Shankar Das ◽  
Athokpam Poireiton ◽  
Niladri Sekhar Mandal ◽  
Samim Ahmed
Keyword(s):  
Risk Factor ◽  
Cohort Study ◽  
Blood Glucose ◽  
Premature Infants ◽  
Gestational Age ◽  
Independent Risk Factor ◽  
Logistic Regression Model ◽  
Bivariate Analysis ◽  
Premature Babies ◽  
Average Blood Glucose

OBJECTIVE: Retinopathy of prematurity (ROP) is a severe morbidity that can lead to blindness in premature babies. Neonatal hyperglycemia has been related to the growth of ROP in a variety of studies. However, there aren't many observational trials to show whether hyperglycemia is linked to ROP in the absence of other comorbidities. The aim of this research was to see if hyperglycemia in premature babies is linked to ROP in a different way. STUDY DESIGN: Premature infants (<1500 g or⩽ 32 weeks gestational age) were enrolled in a prospective longitudinal cohort study. All demographic, clinical and laboratory data were collected. Bedside whole-blood glucose concentration was measured every 8 hours daily for rst 7 , days of live. For any glucose reading <50 or>150 mg dl 1 serum sample was sent to the laboratory for conrmation. Hyperglycemia was dened as any blood glucose level⩾ 150 mg dl − 1. ROP patients were compared with non-ROP patients in a bivariate analysis. Variables signicantly associated with ROP were studied in a logistic regression model. RESULT:Atotal of 100 patients were enrolled with gestational age <32weeks and birth weight <1500g. Forty-eight patients (48%) were identied with hyperglycemia. On eye examination, 30 cases (30%) had ROP (19 with stage 1, 10 with stage 2 and 1 with stage 3). There were more cases of ROPin the hyperglycemia group compared with the euglycemia group (45.83% vs 15.38%, P = 0.007). Patients who developed ROP had signicantly higher maximum and average glucose concentrations when compared with non-ROP patients. Multiple factors have been associated with ROP on bivariate analysis, including gestational age, exposure to oxygen, respiratory support and poor weight gain. However, in a logistic regression model including all signicant variables, average blood glucose in the rst week of life was the factor independently associated with ROPwith an odds ratio of: 1.77 (95% condence interval: 1.08 to 2.86), P= 0.024 CONCLUSION: In a prospective cohort study of premature infants, elevated average blood glucose concentrations in the rst week of life is an independent risk factor associated with the development of ROP.

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