Comparative Ex Vivo Evaluation of Two Electronic Percussive Testing Devices Measuring the Stability of Dental Implants

2014 ◽  
Vol 85 (12) ◽  
pp. 1786-1791 ◽  
Author(s):  
Onur Geckili ◽  
Hakan Bilhan ◽  
Altug Cilingir ◽  
Caglar Bilmenoglu ◽  
Gokcen Ates ◽  
...  
Keyword(s):  
Dental Implants ◽  
Ex Vivo ◽  
The Stability

Parametric Optimization of Dental Implants

2020 ◽  
Vol 22 (4) ◽  
pp. 1061-1076
Author(s):  
Wafa Bensmain ◽  
Mohammed Benlebna ◽  
Boualem Serier ◽  
Bel Abbes ◽  
Bachir Bouiadjra
Keyword(s):  
Dental Implants ◽  
Clinical Success ◽  
Equivalent Stress ◽  
Radius Of Curvature ◽  
Geometrical Parameters ◽  
Neck Size ◽  
Biomechanical Behavior ◽  
Dynamic Charging ◽  
The Stability ◽  
Masticatory Process

AbstractOsseointegration is a fundamental phenomenon of dental implantology. It ensures the stability, the safety and the durability of dental implants and predictable clinical success in long-term. The geometric form of the implant is a defining parameter of osseointegration and implant-bone charge transfer. This is the essential constitutes of this study. In fact, we demonstrate using the finite elements method with tridimensional numerical computations, that the geometrical parameters of the implant conditionate the level and the repartition of the stresses, induced in the cortical bone and the spongy bone during the masticatory process, simulated here by dynamic charging. The effect of several parameters [size and conicity of the implant neck, size and radius of curvature of the implant apex] and the shape of the implant corps on the biomechanical behavior of the bone. The latest was analyzed in terms of variation of the equivalent stress induced in the bone. The purpose of this analysis was the developing of an implant form allowing stress relaxation, during the mastication process, in the living tissue.

scholarly journals The Bone Buttress Theory: The Effect of the Mechanical Loading of Bone on the Osseointegration of Dental Implants

Biology ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 12
Author(s):  
David Chavarri-Prado ◽  
Aritza Brizuela-Velasco ◽  
Ángel Álvarez-Arenal ◽  
Markel Dieguez-Pereira ◽  
Esteban Pérez-Pevida ◽  
...  
Keyword(s):  
Dental Implants ◽  
Mechanical Loading ◽  
Bone Growth ◽  
Bone Matrix ◽  
Test Group ◽  
Control Group ◽  
Group A ◽  
Bone To Implant Contact ◽  
The Stability ◽  
Group B

Objectives: To determine the effect of mechanical loading of bone on the stability and histomorphometric variables of the osseointegration of dental implants using an experimental test in an animal model. Materials and Methods: A total of 4 human implants were placed in both tibiae of 10 New Zealand rabbits (n = 40). A 6-week osseointegration was considered, and the rabbits were randomly assigned to two groups: Group A (Test group) included 5 rabbits that ran on a treadmill for 20 min daily during the osseointegration period; Group B (Controls) included the other 5 that were housed conventionally. The monitored variables were related to the primary and secondary stability of the dental implants (implant stability quotient—ISQ), vertical bone growth, bone to implant contact (BIC), area of regenerated bone and the percentage of immature matrix. Results: The results of the study show a greater vertical bone growth (Group A 1.26 ± 0.48 mm, Group B 0.32 ± 0.47 mm, p < 0.001), higher ISQ values (Group A 11.25 ± 6.10 ISQ, 15.73%; Group B 5.80 ± 5.97 ISQ, 7.99%, p = 0.006) and a higher BIC (Group A 19.37%, Group B 23.60%, p = 0.0058) for implants in the test group, with statistically significant differences. A higher percentage of immature bone matrix was observed for implants in the control group (20.68 ± 9.53) than those in the test group (15.38 ± 8.84) (p = 0.108). A larger area of regenerated bone was also observed for the test implants (Group A 280.50 ± 125.40 mm2, Group B 228.00 ± 141.40 mm2), but it was not statistically significant (p = 0.121). Conclusions: The mechanical loading of bone improves the stability and the histomorphometric variables of the osseointegration of dental implants.

scholarly journals Contemporary implantology - challenges, possibilities, limits

2008 ◽  
Vol 136 (Suppl. 2) ◽  
pp. 123-128 ◽  
Author(s):  
Vitomir Konstantinovic
Keyword(s):  
Bone Resorption ◽  
Dental Implants ◽  
Psychological Problems ◽  
Frequent Occurrence ◽  
Psychological Status ◽  
The Stability ◽  
Implant Loading

The loss of teeth, which is a frequent occurrence, is followed by functional, aesthetic and psychological problems. Dentistry has very important role to enable adequate rehabilitation as soon as possible. Removable dentures or fixed bridges on dental implants are most modern and best mode of rehabilitation for the patient. The advantages of implant anchored tooth restorations compared with classical procedures are multiple. Among others, there is prevention of bone resorption, correction of the stability and retention of the restorations, elimination of the preparation of adjacent teeth, as well as the improvement of the patient?s psychological status. In order to achieve successful implantation, the following principles have to be taken into consideration: indications and contraindications; biocompatibility; osseointegration; the protocol of implant loading and the assessment of implant success. One of the biggest challenges is implantology under unfavourable anatomical conditions, as well as the implantation on irradiated tissue. However, these conditions are not absolute contraindications for implantation. The adequate choice of adequate implantological system enables successful implantation under different conditions.

scholarly journals Olive Oil Based Organogels for Effective Topical Delivery of Fluconazole: In-vitro Antifungal Study

2020 ◽  
pp. 29-36
Author(s):  
Mohammad Muqtader Ahmed ◽  
Farhat Fatima ◽  
Abdul Bari Mohammed
Keyword(s):  
Olive Oil ◽  
Ex Vivo ◽  
Similarity Index ◽  
Ex Vivo Permeation ◽  
Efficient Delivery ◽  
In Vitro Diffusion ◽  
Permeation Studies ◽  
The Stability ◽  
Hot Melt

The objective of the study was to formulate olive oil based organogels for the topical application of fluconazole (FLZ), to ensure the efficient delivery of the drug deeper in to the skin layers. Methods: Nine formulations developed by hot-melt method using olive oil, sorbitan monostearate (SMS) and FLZ. Prepared formulations characterized for macro evaluations, pH, spreadibility, viscosity, gel-sol transition, in-vitro diffusion study. Further optimized formulation evaluated for ex-vivo percutaneous permeation, in-vitro antifungal studies and stability studies by similarity index. Results: The results of evaluated parameters ensure the stability and effectiveness of the prepared olive oil based organogels. In-vitro diffusion studied reflects decrease in drug release with increase in surfactant concentration due to increase in viscosity. Moreover, ex-vivo permeation studies revealed that the permeation of FLZ was enhanced for optimized formulations (F6) as compared to the marketed gel formulation. Further, the optimized formulation exhibits the broad zone of inhibition against fungal strains in comparison to control and marketed product during in-vitro antifungal study. Conclusion: The olive oil based organogels formulation shown the enhanced permeation of FLZ from organogel network structure with good antifungal activity as compared to the marketed formulation. Henceforth, the FLZ organogel formulations could be used topically for the effective treatment of fungal infection.

scholarly journals Stability of dental implants with sandblasted and acid-etched (SLA) and modified (SLActive) surfaces during the osseointegration period

2021 ◽  
Vol 15 (4) ◽  
pp. 226-231
Author(s):  
Gulsum Sayin Ozel ◽  
Ozgur Inan ◽  
Asli Secilmis Acar ◽  
Gamze Alniacik Iyidogan ◽  
Dogan Dolanmaz ◽  
...  
Keyword(s):  
Dental Implants ◽  
Surface Properties ◽  
Resonance Frequency Analysis ◽  
Implant Stability ◽  
Osteoprogenitor Cells ◽  
Implant Placement ◽  
Modified Surfaces ◽  
Surface Measurements ◽  
The Stability ◽  
Over Time

Background. The surface properties of implants are effective factors for increasing the osseointegration and activity of osteoprogenitor cells. This study compared the stability of dental implants with sandblasted and acid-etched (SLA) and modified surfaces (SLActive) using the resonance frequency analysis (RFA). Methods. In a split-mouth design, 50 dental implants with either SLA surface properties (n=25) or modified (SLActive) surface properties (n=25) were placed in the mandibles of 12 patients with a bilateral posterior edentulous area. Implant stability was measured using RFA (Osstell) at implant placement time and every week for 1, 2, and 3 months before the conventional loading time. Results. One week following the implantation, implant stability increased from 70 to 77.67 for SLA and from 71.67 to 79 for SLActive (P<0.05). Stability improved each week except in the 4th week in SLActive surface measurements. No significant differences were observed between the groups at 2 and 3 months (P>0.05). Conclusions. For both implant surfaces, increased stability was observed over time, with no significant differences between the groups.

scholarly journals DEVELOPMENT AND EVALUATION OF MUCOADHESIVE NANOGEL OF NEVIRAPINE FOR VAGINAL APPLICATION

2019 ◽  
pp. 144-149
Author(s):  
Sheikh Sofiur Rahman ◽  
ABDUL BAQUEE AHMED
Keyword(s):  
Hiv Infection ◽  
Ex Vivo ◽  
Vaginal Fluid ◽  
Content Uniformity ◽  
Vaginal Mucosa ◽  
Salting Out ◽  
Zero Order Kinetics ◽  
The Stability ◽  
Ph Range

Objectives: The main objective of this study was to develop and evaluate Nevirapine nanoparticle loaded mucoadhesive gel (NVP-Np mucoadhesive gel) for vaginal application for the treatment of HIV infection.  Methods: NVP loaded nanoparticles were prepared by salting out method followed by incorporation in different gel bases to produce NVP-Np mucoadhesive gel The prepared gels were evaluated for their physicochemical parameters, rheological characteristics, mucoadhesion, in-vitro drug release and ex-vivo permeation of drug across porcine vaginal mucosa.  Results: The result of FT-IR and DSC study confirmed the absence of incompatibility of NVP with excipients used in the formulations. The particle size of the prepared NVP-Np was found to be 243.8 ± 3.15 nm, a polydispersity index (PI) of 0.787± 0.002 and zeta potential value -17.12 mV, which revealed the stability of nanoparticles. All the formulations showed good homogeneity, spreadability, physical appearance and content uniformity. The pH of the mucoadhesive gel formulations was in the range of 3.70 ± 0.03 to 4.56 ± 0.02, which lies in the normal pH range of the vaginal fluid.  The cumulative amounts permeated at 6 h were 832.23 ± 63.45 μg/cm2 , 592.13 ± 82.55 μg/cm2 and 941.32 ± 81.10 μg/cm2 from F1(1% Chitosan), F2(1% Carbopol 974P) and F3 (1% HPMC K100M )  respectively. A linear relationship [r2 > 0.9 (0.97 n 0.99)] was observed between the percentage cumulative amount permeated and time, indicating zero order kinetics. Conclusion: In conclusion, NVP-Np mucoadhesive gel was prepared successfully using salting out followed by a homogenization technique for vaginal application of NVP for the prophylaxis of HIV infection.

scholarly journals Development and Optimization of Proniosomal Gel Containing Etodolac: In-vitro, Ex-vivo and In-vivo Evaluation

2021 ◽  
Vol 62 (3) ◽  
pp. 290-304
Author(s):  
Moreshwar Patil ◽  
Prashant Pandit ◽  
Pavan Udavant ◽  
Sandeep Sonawane ◽  
Deepak Bhambere
Keyword(s):  
Drug Release ◽  
Zeta Potential ◽  
Ex Vivo ◽  
Entrapment Efficiency ◽  
In Vivo Evaluation ◽  
Vesicle Size ◽  
Skin Delivery ◽  
The Stability

Introduction: Etodolac is used in the treatment of acute pain and inflammation. It has low solubility because of high hydrophobicity and it is reported that upon oral administration shows gastric disturbances. This encourages the development of topical vesicular formulation. Method: In this work we used coacervation-phase separation method for the development of etodolac loaded vesicular system by using non-ionic surfactants, cholesterol and soya lecithin. Central composite design (rotatble) was used to optimize the concentrations of soy lecithin, surfactant and cholesterol. The prepared formulations were characterized by number of vesicles formed, vesicle size, zeta potential, entrapment efficiency, in-vitro permeation, ex-vivo permeation and anti-inflammatory study. Results: Etodolac was successfully entrapped in all formulations having efficiency in the range of 74.36% to 90.85%, which was more at 4 °C than room temperature. When hydrated with water; niosome in the range of 54 to 141 (per cubic mm) were spontaneously produced. The results of in-vitro diffusion study revealed that etodolac was released in the range of 71.86 to 97.16% over a period of 24 hrs. The average vesicle size of optimized formulation was found 211.9 nm with PDI of 0.5. The observed responses i.e. % encapsulation efficiency and drug release were 74.12 and 95.08 respectively. The zeta potential was -19.4mV revealed the stability of formulation which was further confirmed by no changes in drug content and drug release after stability studies. The % inhibition in paw volume was 40.52% and 43.61% for test and marketed proniosomal gel. Conclusion: Proniosomal gel formulation was stable and could enhance skin delivery of etodolac because of excellent permeation capability of vesicular system.

scholarly journals Biological Responses to the Transitional Area of Dental Implants: Material- and Structure-Dependent Responses of Peri-Implant Tissue to Abutments

Materials ◽  
2019 ◽  
Vol 13 (1) ◽  
pp. 72 ◽  
Author(s):  
Jung-Ju Kim ◽  
Jae-Hyun Lee ◽  
Jeong Chan Kim ◽  
Jun-Beom Lee ◽  
In-Sung Luke Yeo
Keyword(s):  
Soft Tissue ◽  
Internal Friction ◽  
Dental Implants ◽  
Relevant Literature ◽  
Positive Influence ◽  
Transitional Area ◽  
Microbial Invasion ◽  
Hard Tissues ◽  
The Stability ◽  
External Connections

The stability of peri-implant tissue is essential for the long-term success of dental implants. Although various types of implant connections are used, little is known about the effects of the physical mechanisms of dental implants on the stability of peri-implant tissue. This review summarizes the relevant literature to establish guidelines regarding the effects of connection type between abutments and implants in soft and hard tissues. Soft tissue seals can affect soft tissue around implants. In external connections, micromobility between the abutment and the hex component of the implant, resulting from machining tolerance, can destroy the soft tissue seal, potentially leading to microbial invasion. Internal friction connection implants induce strain on the surrounding bone via implant wall expansion that translates into masticatory force. This strain is advantageous because it increases the amount and quality of peri-implant bone. The comparison of internal and external connections, the two most commonly used connection types, reveals that internal friction has a positive influence on both soft and hard tissues.

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