scholarly journals Analysis of Differences of Serum Thromboxane B2 Level after Taking Acetosal in Acute Thrombotic Stroke with Diabetes Mellitus and Non-Diabetes Mellitus

2018 ◽  
Vol 54 (1) ◽  
pp. 53
Author(s):  
Nur Hadiyanti ◽  
Didik Hasmono ◽  
Mohammad Saiful Islam
Keyword(s):  
Diabetes Mellitus ◽  
Thrombus Formation ◽  
Mean Value ◽  
Diabetic Group ◽  
Diabetic Patients ◽  
Stroke Patients ◽  
Before And After ◽  
Potent Agonist ◽  
The Mean ◽  
Txb2 Level

Endothelial dysfunction and vascular injuries are the early processes in thrombogenesis leading to thrombotic stroke. These processes trigger platelet activation characterized by synthesis of Thromboxane A2, potent agonist in platelet aggregation. Acetosal (ASA) 100 mg usually given to thrombotic stroke patients exerts its pharmacological effect by inhibition of TxA2 synthesis, thus could prevent thrombus formation. Diabetes mellitus (DM) as risk factor of thrombotic stroke exhibits an increase in TxA2 synthesis. It is not known whether ASA 100 mg could inhibit TxA2 adequately in diabetic patients. This study aimed to analyze the differences of serum TxA2 level, which was measured by serum TxB2 level as stabile metabolite of TxA2, after taking ASA 100 mg in diabetic and non-diabetic thrombotic stroke patients. This prospective observational study was held in Neurology Department of Dr. Soetomo Hospital, Surabaya. Total 27 patients, consisted of 15 patients with DM and 12 patients with non-DM were enrolled. Serum TxB2 was measured before and after 5-7 days 100 mg ASA 100 administration. Mean value of serum TxB2 level before and after taking ASA was 16.43 ± 16.08 ng/mL and 2.93 ± 1.83 ng/mL in diabetic and 27.36 ± 21.04 ng/mL and 5.36 ± 4.06 ng/mL in non-diabetic group. Mean reduction of serum TxB2 level in diabetic and non-diabetic group was 13.49 ± 15.9 ng/mL and 22.00 ± 21.65 ng/mL. There were significant differences in serum TxB2 level after taking ASA 100 mg in diabetic and non-diabetic group but the mean reduction of serum TxB2 level were not significantly different.

scholarly journals Clinical profile of tuberculosis with diabetes mellitus

2021 ◽  
Vol 9 (6) ◽  
pp. 1692
Author(s):  
Pooja Gautam ◽  
Neelima Sharma ◽  
Bishal Gautam ◽  
Preksha Sharma ◽  
Neha Sharma
Keyword(s):  
Diabetes Mellitus ◽  
Pulmonary Tuberculosis ◽  
General Medicine ◽  
Good Evidence ◽  
Diabetic Group ◽  
Sputum Smear ◽  
Diabetic Patients ◽  
Significant Difference ◽  
The Mean ◽  
A Prospective Study

Background: There is now good evidence that people with diabetes mellitus (DM) have 2–3 times the risk of developing active tuberculosis (TB) compared with those who do not have DM. The aim of the study was to analyze typical / atypical presentation of pulmonary tuberculosis with diabetes mellitus.Methods: This study was carried out in the Department of Respiratory Medicine and General Medicine, SAIMS, Indore during the period of July 2012 to June 2014. A prospective study including 100 microscopically proven cases of sputum smear positive pulmonary tuberculosis. Among these, 50 are diabetic patients with sputum positive tuberculosis and 50 are non-diabetic patients with sputum positive tuberculosis.Results: The mean age in diabetic group was 51.92±9.96 years. The mean age in non-diabetic group was 39.58±15.19 years. In the diabetic group, there were 38 (76.00%) male and 12 (24.00%) females, while in the non-diabetic group there were 40 (80.00%) males and 10 (20.00%) females. Fever, cough and weakness were the three most common symptoms seen in patients with tuberculosis in both the groups.Conclusions: There was a preponderance of male in both the groups over the female patients. There is no significant difference in the symptoms in both the groups.

scholarly journals Salivary Amylase as Potential Biochemical Marker in Diabetes Mellitus

2016 ◽  
Vol 02 (01) ◽  
pp. 019-022
Author(s):  
B Satish ◽  
Prashant Kumar ◽  
S Avanti ◽  
Shruti Singh
Keyword(s):  
Diabetes Mellitus ◽  
Type I Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Mean Value ◽  
Diabetic Patients ◽  
Amylase Level ◽  
Type I ◽  
Salivary Amylase ◽  
Significant Difference ◽  
The Mean

Abstract Introduction: Diabetes mellitus has emerged as a major global health problem. Diagnosing and monitoring diabetes is the best way for its prevention, thus reducing the burden of disease. As saliva is easily available and accessible when compared with serum, salivary biomarkers have gained importance in recent years and, therefore, can be helpful in diagnosing the disease. Aims: The purpose of this study was to estimate the salivary amylase level in patients with types I and II diabetes mellitus and to correlate these findings with those of nondiabetic individuals in order to ascertain its value as a biochemical indicator for diagnosing and monitoring the patients. Materials and methods: Three groups of patients were selected for the present study. Group A: 20 nondiabetic, healthy individuals; group B: 20 type I diabetes mellitus patients; group C: 20 type II diabetes mellitus patients. Fasting and postprandial unstimulated saliva samples were collected and subjected for analysis of salivary amylase. Estimation of salivary amylase was determined by direct substrate method. Results: The mean fasting salivary amylase level for types I and II diabetic and nondiabetic individuals was 245.60, 239.10, and 149 U/dL respectively, whereas the mean postprandial salivary amylase was 257.35, 246.15, and 154.2 U/dL respectively. The mean value of variables was compared using Student's t test and one-way analysis of variance test. Conclusion: The mean salivary amylase level was significantly increased in both types I and II diabetic individuals as compared with healthy nondiabetic subjects (p < 0.05). However, there was no significant difference in the mean of types I and II diabetic patients.

scholarly journals Comparative study of clinical profile of patients with stroke in diabetic and non-diabetic patients admitted to SIMS Shivamogga

2020 ◽  
Vol 8 (1) ◽  
pp. 67
Author(s):  
P. Eshwarappa ◽  
R. A. Kumar Naveen ◽  
M. Rangantha ◽  
G. K. Kumar Ranjith
Keyword(s):  
Past History ◽  
Study Groups ◽  
Diabetic Group ◽  
Clinical Profile ◽  
Diabetic Patients ◽  
Medical Sciences ◽  
Stroke Patients ◽  
Male Population ◽  
History Of ◽  
The Mean

Background: Diabetes mellitus is one of the major risk factor for stroke. Stroke in diabetic patients is different from stroke in non-diabetics in many aspects. This study was carried out to with the aim to compare the clinical profile of patients with diabetic non-diabetic stroke, and its outcome. The objective of the study was to compare the clinical profile of stroke in diabetics and non-diabetics.Methods: The present study is a prospective case control observational study, carried out at Shivamogga Institute of Medical Sciences, Shivamogga. 100 patients with stroke were enrolled (out of which 50 patients were diabetic or found to have diabetes during hospital stay, and 50 were non-diabetic stroke patients). Other risk factors, clinical presentation and the pattern of stroke were evaluated.Results: The mean age in diabetic stroke patients was 56±9.93. and in non-diabetic stroke patients was 59.92±13.26. Percentage of male population in both groups were higher. Stroke patients in both study groups presented with history of motor weakness as their most common presenting complaint. 69% of diabetic patients had past history of hypertension compared to 21% in non-diabetic group. The mean blood sugar on admission was higher in diabetic group (221.87±76.16) compared with in non-diabetic group (133.12±44.68). Diabetic patients had greater percentage of ischemic stroke (65%) as compared to non-diabetic patients (33%). Hemorrhages were less in diabetic stroke patients (35%) as compared to non-diabetics (67%).Conclusions: Stroke in diabetic patients has a specific clinical pattern and a poor prognosis, which emphasizes the need for early diagnosis and treatment of every case of diabetes.

scholarly journals TO STUDY THE EFFECT OF YOGA ON BLOOD SUGAR PROFILE IN DIABETICS TYPE-2 PATIENTS

2019 ◽  
Vol 3 (7) ◽  
Author(s):  
Dr. B S Gupta ◽  
Dr. Yogesh Singh
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Mean Value ◽  
T Test ◽  
Diabetic Patients ◽  
The Mean ◽  
The Difference

Background: Diabetes mellitus is a syndrome complex characterized by impaired carbohydrate, protein and fat metabolism. Methods: Prospective study was conducted on 100 type 2 diabetes mellitus patients and 100 normal healthy persons. Cases were recruited from a yoga centre. Control subjects were selected from diabetic patients attending hospital. Alcoholic or smoker subjects were excluded. Results: The mean value of blood glucose level of subjects was 136.4±9.42 mg/dl and that of controls was 183.2±9.16 mg/dl.  The difference between the mean value of fasting blood glucose level determined by unpaired  ‘t’ test was statistically highly significant (p=<0001). The mean value of blood glucose level of subjects was 6.32±1.35 % and that of controls was 7.46±1.41%.  The difference between the mean value of HB1Ac level determined by unpaired  ‘t’ test was statistically highly significant (p=<0001). Conclusion: Yoga can be used as an alternate therapy to reduce the blood glucose level along with the drug therapy. Keywords: Yoga, Diabetics, Drugs.

scholarly journals How is NLR and PLR affected in Type 2 diabetes mellitus compared to healthy population?

2020 ◽  
Vol 7 (2) ◽  
pp. 405-408
Author(s):  
Yavuz Dik
Keyword(s):  
Diabetes Mellitus ◽  
Significant Relationship ◽  
Diabetic Group ◽  
Diabetic Patients ◽  
Healthy Population ◽  
Healthy Individuals ◽  
Healthy Group ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
The Mean

Objective: Diabetes Mellitus (DM); has become an important public health problem in Turkey and in the world. In this study, we aimed to investigate the effect of neutrophil / lymphocyte ratio and platelet / lymphocyte ratio in diabetic patients compared to healthy population in terms of cost effectiveness. Material and Methods: A control group consisting of 82 diabetics and 85 healthy individuals who applied to the internal medicine outpatient clinic between January 2019 and November 2019 were included in the study. The patients were divided into two groups as those with diabetes and healthy individuals. Files were scanned retrospectively and hemoglobin, mean platelet volume (MPV), glycosylated hemoglobin (HbA1c), hematocrit counts (hct), neutrophil and lymphocyte counts, and neutrophil-lymphocyte ratio (NLR), platelet count (plt), platelet lymphocyte ratio (NLR) PLR) has been recorded. Results: We retrospectively compared the demographic and laboratory parameters of the healthy group and the diabetic patients (82 patients and 85 healthy). The mean age of the diabetic group was 55.9 years, while the mean age of the healthy group was 37.5. Mean NLR was 2.4 and 2.1 in diabetic and healthy groups, respectively. NLR value was higher in diabetic group compared to healthy group and there was no statistically significant difference (p = 0.07). MPV values in diabetic group and healthy group were 8.53 and 8.51, respectively, and there was no significant relationship between them (p = 0.81). PLR value was 145.9 and 146.7 in diabetic group and healthy group, respectively, and we did not find any significant relationship (p = 0.97). Discussion: As a result; In our study, when we evaluated the diabetic group within the diabetic group and the healthy group, we could not find a statistically significant relationship between the groups in terms of hematological parameters.

scholarly journals IL-2, IFN-?³ and anti-HBs based Immune Responses to Hepatitis B Vaccine in Type 2 Diabetic Patients

2016 ◽  
Vol 17 (1) ◽  
pp. 8-11
Author(s):  
Ashesh Kumar Chowdhury ◽  
Sujal Kumar Bokshi ◽  
Zeenat Farzana Rahman ◽  
Md Abu Taher ◽  
Subhagata Choudhury
Keyword(s):  
Hepatitis B ◽  
Immune Responses ◽  
Mean Value ◽  
Hepatitis B Vaccine ◽  
Diabetic Group ◽  
Diabetic Patients ◽  
The Mean ◽  
The Difference ◽  
Type 2 Diabetic

Background: The immune status is usually hampered in patients of diabetes mellitus. The global pandemic of diabetes principally involves type 2 diabetes. In diabetic patients higher prevalence of hepatitis B virus infection is also noted that leads to more severe complications. This study was conducted to determine the immune responses to hepatitis B vaccine in type 2 diabetic patients.Methods: In this study 33 diabetic patients were included as experimental group and 34 non diabetic healthy persons were included as control group. All the participants were vaccinated with hepatitis B vaccine following 0, 1, 6 months schedule. The vaccine responses in diabetic and non diabetic group were compared depending on seromarkers (anti-HBs titer, IL-2 and IFN-?) following vaccination.Results: The mean value of anti-HBs titer was lower in diabetic group (357.81 mIU/ml) than non diabetic group (621.24 mIU/ml) but the difference was not significant (p>0.05), the mean value of IFN-? was lower in diabetic group (0.1480 IU/ml) than non diabetic group (0.2788 IU/ml) and here the difference was significant (p<0.05), the mean value of serum IL-2 level was also lower in diabetic group (0.2611IU/ml) than non diabetic group (0.3691 IU/ml) but the difference was not significant (p>0.05).Conclusion: The study revealed no statistically significant variation in anti-HBs and IL-2 but a diminished IFN-? level as the immune response in diabetic patients after HBV infection.J MEDICINE January 2016; 17 (1) : 8-11

Perbedaan Pengetahuan Siswa Tentang Penyakit Hepatitis A Sebelum Dan Sesudah Penyuluhan Di MTsN 02 Bondowoso Tahun 2015

2017 ◽  
Vol 4 (2) ◽  
pp. 14
Author(s):  
Putri Megasari
Keyword(s):  
Hepatitis A ◽  
Hepatitis Virus ◽  
Sampling Technique ◽  
Mean Value ◽  
Test Design ◽  
The World ◽  
Before And After ◽  
Post Test ◽  
The Mean ◽  
Paired T Test

Hepatitis has become a health problem in the world. The hepatitis virus infected many people. According to the teacher of MTsN 02 Bondowoso more than 20 students have hepatitis A viral infection. The purpose of this research was to know the differences of students' knowledge about hepatitis A before and after counseling in MTsN 02 Bondowoso 2015. This study used pre-experimental (pre-post test design). This study used stratified random sampling technique, 127 students from 270 sample involved this research,and 143 students was excluded. We used questionnaires to collect data. The results showed that the mean value of the students 'knowledge about hepatitis A before counseling in MTsN 02 Bondowoso 2015 was 83.96 with the lowest value of 37.5 and the highest value was 100. The mean value of the students' knowledge about hepatitis A after counseling in MTsN 02 Bondowoso 2015 was 93.21 with the lowest value waf 62.5 and the highest value was 100. Paired t test showed that t (-9.07) > t table (1.98), the null hypothesis (H0) was rejected. There was a difference between students' knowledge about hepatitis A before and after counseling in MTsN 02 Bondowoso 2015. This study showed that routine counseling by healthcare provider was important to prevent hepatitis A infection.; Keywords: counseling, knowledge of students, hepatitis

scholarly journals A preliminary study on diabetes self-management education and glycemic control among patients with diabetes mellitus

2019 ◽  
Vol 9 (9) ◽  
pp. 98 ◽  
Author(s):  
Kisokanth G. ◽  
Indrakumar J. ◽  
Prathapan S. ◽  
Joseph J. ◽  
Ilankoon I.M.P.S.
Keyword(s):  
Diabetes Mellitus ◽  
Glycemic Control ◽  
Management Education ◽  
Self Management ◽  
Rank Test ◽  
Diabetic Patients ◽  
Effective Measure ◽  
Before And After ◽  
Patients With Diabetes ◽  
Preliminary Study

This study was aimed to assess the effectiveness of diabetes self-management education (DSME) in the improvement of glycemic control among patients with type 2 Diabetes Mellitus (T2DM) in Batticaloa District, Sri Lanka. The study was a prospective interventional study and conducted as a preliminary study at medical clinic, Base hospital, Kaluwanchikudy, Batticaloa. Thirty patients with T2DM were included based on inclusion and exclusion criteria. A structured individual diabetes self-management education for 10 hours (one hour per week) was delivered to diabetic patients by the trained Nurse Health Educator. Glycosylate hemoglobin (HbA1c) was assessed as a main outcome measure and Fasting Blood Sugar (FBS), Body Mass Index (BMI) of each patient were also measured and recorded before and after the intervention. The respondent rate was 96.7% (n = 29). Majority of them were females (n = 25, 86.2%). A Wilcoxon signed rank test showed that DSME had a statistically significant reduction in HbA1c [8.60 (IQR 2.60) vs. 7.40 (IQR 2.10), p = .000] and FBS level [159.00 (IQR 77.50) vs. 134.00 (IQR 40.50), p = .002] at 3 months of intervention. The mean BMI at baseline was higher compared to 3 months of intervention [24.88 (SD ± 3.06) vs. 24.19 (SD ± 2.79)] which was statistically significant (p = .000). Majority of participants (n = 22, 75.9%) had improved their HbA1c level by ≥ 0.5% in 3 months. The diabetes self-management education is an effective measure in improving glycemic control and other clinical parameters among patients with T2DM. Thus, DSME needs to be implemented among clinic patients with T2DM for the better outcome and the preventions of complications.

scholarly journals Quality of life of obstetrics fistula patients before and after surgical repair in the Jimma University Medical Center, Southwest Ethiopia

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Tilahun Fufa Debela ◽  
Zerihun Asefa Hordofa ◽  
Aster Berhe Aregawi ◽  
Demisew Amenu Sori
Keyword(s):  
Quality Of Life ◽  
Surgical Repair ◽  
Obstetric Fistula ◽  
Medical Center ◽  
Mean Value ◽  
Significant Difference ◽  
Before And After ◽  
The Mean ◽  
Jimma University

Abstract Background The consequences of obstetric fistula on affected women are more than the medical condition. It has extensive physical, psychological, social, and economic consequences on them. Obstetric fistula affects the entire health and entire life of women. Women suffering from obstetric fistula are often abandoned by her partner, relatives, and the community. This study aimed to determine the quality of life of obstetrics fistula patients before and after surgical repair. Methods Institutional-based prospective, before and after study design was conducted in the Jimma University Medical Center from November 1, 2019–October 30, 2020. A face-to-face interview was conducted with fistula patients who visited Jimma University Medical center, fistula clinic during the study period. All fistula patients were included in the study. Accordingly, 78 women who underwent surgical repair were interviewed. The means and the standard deviation were computed using conventional statistics formulas. The unpaired t-test was used to compare two independent means, and one-way analysis of variance (ANOVA) was used to compare the quality of life before repair and after a successful repair. Linear regression analysis was done for identifying determinants of quality of life. A P value of 0.05 will be considered statistical significance. Result The overall quality of life of women was 58.17 ± 7.2 before the surgical repair and 71.20 ± 10.79 after surgical repair. The result indicates there is a significant difference in the mean value of pre and post-operative (P < 0.001). The overall satisfaction of women with their health status before the surgical repair was 22.5 ± 1.30and it has increased to 53.0 ± .90after surgical repair. The physical health dimension score was 16.51 ± 5.27 before the surgical repair while it has increased to 21.77 ± 5.38 after the surgical repair. The score of the social domain before the surgical repair was 5.19 ± 1.34 and it has increased to 7.13 ± 3.67 after the surgical repair. The score of the environmental health domain was 17.41 ± 2.89 before the surgery while it also increased to 21.65 ± 4.04 after the surgical repair. The results have shown there was a significant difference in the mean values of pre and post-operatives in both social and environmental scores (P < 0.001). The score of the psychological health domain before the surgery was 19.06 ± 1.46 and it was increased to 19.84 ± 3.21 after the surgical repair. The result showed there is a significant difference in mean value pre and post-operative (P = 0.048), though it is a slight improvement compared to other domains. Conclusion The overall quality of life of the patient with fistula was improved after successful surgical repair. Although all domains of quality of life had shown significant improvement after successful surgical repair, the psychological domain showed slight improvement.

Nasal mucociliary clearance in patients with diabetes mellitus

1989 ◽  
Vol 103 (9) ◽  
pp. 853-855 ◽  
Author(s):  
W. L. Yue
Keyword(s):  
Diabetes Mellitus ◽  
Mucociliary Clearance ◽  
Mean Value ◽  
Nasal Disease ◽  
Patients With Diabetes ◽  
History Of ◽  
Insulin Dependent ◽  
Mucociliary Function ◽  
The Mean ◽  
Nasal Mucociliary Clearance

AbstractFifty insulin-dependent diabetics and 50 non-diabetics without a history of nasal disease have been studied for nasal problems including mucociliary function complicated by diabetes mellitus. For the diabetics, the mean value of nasal mucociliary clearance was considerably decreased and this was more often associated with dry noses but increased pH-values, both of which were higher than those for non-diabetics (p<0.05). As suggested in earlier literature, more aggressive nasal moistening therapy must be recommended for those patients presenting with these conditions in the light of systemic diabetic abnormalities.

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