scholarly journals Application of Multiblock Analysis on Small Metabolomic Multi-Tissue Dataset

2020 ◽  
Author(s):  
Frida Torell ◽  
Tomas Skotare ◽  
Johan Trygg
Keyword(s):  
Data Integration ◽  
Biological Properties ◽  
Analysis Method ◽  
Single Model ◽  
Integration Methods ◽  
Using Data ◽  
The Stability

Data integration has been proven to provide valuable information. The information extracted using data integration in the form of multiblock analysis can pinpoint both common and unique trends in the different blocks. When working with small multiblock datasets the number of possible integration methods is drastically reduced. To investigate the application of multiblock analysis in cases where one has few number of samples, we studied a small metabolomic multiblock dataset containing six blocks (i.e. tissue types), only including common metabolites. We used a single model multiblock analysis method called Joint and unique multiblock analysis (JUMBA) and compare it to a commonly used method, concatenated PCA. These methods were used to detect trends in the dataset and identify underlying factors responsible for metabolic variations. Using JUMBA, we were able to interpret the extracted components and link them to relevant biological properties. JUMBA shows how the observations are related to one another, the stability of these relationships and to what extent each of the blocks contribute to the components. These results indicate that multiblock methods can be useful even with a small number of samples.

scholarly journals Application of Multiblock Analysis on Small Metabolomic Multi-Tissue Dataset

Metabolites ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. 295
Author(s):  
Frida Torell ◽  
Tomas Skotare ◽  
Johan Trygg
Keyword(s):  
Principal Component Analysis ◽  
Data Integration ◽  
Statistical Power ◽  
Principal Component ◽  
Biological Properties ◽  
Analysis Method ◽  
Single Model ◽  
Integration Methods ◽  
Using Data ◽  
The Stability

Data integration has been proven to provide valuable information. The information extracted using data integration in the form of multiblock analysis can pinpoint both common and unique trends in the different blocks. When working with small multiblock datasets the number of possible integration methods is drastically reduced. To investigate the application of multiblock analysis in cases where one has a few number of samples and a lack of statistical power, we studied a small metabolomic multiblock dataset containing six blocks (i.e., tissue types), only including common metabolites. We used a single model multiblock analysis method called the joint and unique multiblock analysis (JUMBA) and compared it to a commonly used method, concatenated principal component analysis (PCA). These methods were used to detect trends in the dataset and identify underlying factors responsible for metabolic variations. Using JUMBA, we were able to interpret the extracted components and link them to relevant biological properties. JUMBA shows how the observations are related to one another, the stability of these relationships, and to what extent each of the blocks contribute to the components. These results indicate that multiblock methods can be useful even with a small number of samples.

ESTIMATION OF TECHNICAL, SPECIALIZED AND ECONOMIC EFFICIENCY OF CULTIVATED POTATO VARIETIES USING DATA ENVELOPE ANALYSIS METHOD (DEA) IN IRAQ FOR SPRING LUG 2018

2020 ◽  
pp. 119-131
Keyword(s):  
Technical Efficiency ◽  
Economic Efficiency ◽  
Potato Crop ◽  
Economic Status ◽  
Analysis Method ◽  
Envelope Analysis ◽  
Variable Capacity ◽  
Data Envelope Analysis ◽  
Using Data ◽  
The Stability

Research highlights the importance of potato crop, which occupies a prominent food and economic status in food security besides rice, wheat and corn at the local and global level. Despite the expansion of the cultivation of potato crop in Iraq in general and Ameriyah district in particular However, potato productivity remains substandard, this may be due to a lack of knowledge of the most efficient varieties and not to use productive resources at the levels at which technical, specialized and economic efficiency is achieved. Therefore, the aim of the research is to determine the technical, specialized and economic efficiency according to the cultivated seed category. The data envelope analysis (DEA) method was used to estimate technical, specialized and economic efficiency, assuming constant and variable capacity returns. As a result of the study, the Safrana variety achieved the highest average technical efficiency according to the stability of the yield and capacity efficiency in addition to achieving the highest average specialized and economic efficiency, The Lapadia variety achieved the highest average technical efficiency, assuming that capacity returns have changed. Therefore, we recommend the adoption of items that achieve higher efficiency and the need to redistribute the elements of production better and Achieving the optimum levels at which technical, specialized and economic efficiency is achieved and saving what has been wasted.

scholarly journals The Role of Employment Protection during an Exogenous Shock to an Economy

2011 ◽  
Vol 11 (2) ◽  
pp. 1850225 ◽  
Author(s):  
Miki Malul ◽  
Mosi Rosenboim ◽  
Tal Shavit ◽  
Shlomo Yedidia Tarba
Keyword(s):  
Economic Crisis ◽  
Employment Protection ◽  
Exogenous Shock ◽  
Unemployment Rates ◽  
World Crisis ◽  
Automatic Stabilizer ◽  
Medium Level ◽  
Using Data ◽  
The Stability

This paper explores the role of employment protection when powerful external crises reduce demand for products. We first present a theoretical framework that shows that employment protection has a U-shaped effect on abnormal unemployment during a negative exogenous shock to an economy. Using data from the 33 OECD countries, we analyze how the level of employment protection affected the stability of unemployment rates during the recent global economic crisis. The results suggest that countries with an intermediate level of employment protection will have more stable unemployment rates during a world crisis. The policy implication of our paper is that countries should seek a medium level of employment protection that may act as an automatic stabilizer of the economy on the macro level.

scholarly journals Anthocyanins Recovered from Agri-Food By-Products Using Innovative Processes: Trends, Challenges, and Perspectives for Their Application in Food Systems

Molecules ◽  
2021 ◽  
Vol 26 (9) ◽  
pp. 2632
Author(s):  
Henrique Silvano Arruda ◽  
Eric Keven Silva ◽  
Nayara Macêdo Peixoto Araujo ◽  
Gustavo Araujo Pereira ◽  
Glaucia Maria Pastore ◽  
...  
Keyword(s):  
Food Systems ◽  
Food Industry ◽  
Biological Properties ◽  
Extraction Techniques ◽  
Naturally Occurring ◽  
Current Review ◽  
Natural Colorants ◽  
Conventional Extraction ◽  
The Stability ◽  
By Products

Anthocyanins are naturally occurring phytochemicals that have attracted growing interest from consumers and the food industry due to their multiple biological properties and technological applications. Nevertheless, conventional extraction techniques based on thermal technologies can compromise both the recovery and stability of anthocyanins, reducing their global yield and/or limiting their application in food systems. The current review provides an overview of the main innovative processes (e.g., pulsed electric field, microwave, and ultrasound) used to recover anthocyanins from agri-food waste/by-products and the mechanisms involved in anthocyanin extraction and their impacts on the stability of these compounds. Moreover, trends and perspectives of anthocyanins’ applications in food systems, such as antioxidants, natural colorants, preservatives, and active and smart packaging components, are addressed. Challenges behind anthocyanin implementation in food systems are displayed and potential solutions to overcome these drawbacks are proposed.

scholarly journals Analysis of Mercury in Skin Lightening Cream by Microwave Plasma Atomic Emission Spectroscopy (MP-AES)

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3130
Author(s):  
Hardoko I. Qudus ◽  
Purwadi Purwadi ◽  
Iis Holilah ◽  
Sutopo Hadi
Keyword(s):  
Emission Spectroscopy ◽  
Microwave Plasma ◽  
Atomic Emission ◽  
Atomic Emission Spectroscopy ◽  
Solution Stability ◽  
Analysis Method ◽  
Plasma Atomic Emission ◽  
Relative Standard ◽  
The Stability ◽  
Skin Lightening

This research aimed at developing an analysis method, which was optimized and validated to determine the content of mercury in skin lightening cream discovered in the market in Bandar Lampung, Indonesia, through the use of microwave plasma atomic emission spectroscopy (MP-AES). The optimization on the analysis method was conducted on pump rate, viewing position, and reductant concentration in order to obtain the highest mercury emission intensity, while the solution stability was optimized to know the stability of mercury in the solution. The result showed that the method developed had precision with a relative standard deviation of 2.67%, recovery value of 92.78%, and linearity with an r value of 0.993, respectively. The sensitivity of the instrument detection had a limit of analysis method detection and quantification of 0.59 and 1.98 µg/L, respectively. The results of the test of the lightening cream (8 of 16 samples) positively contained mercury in the range of 422.61–44,960.79 ng/g. Therefore the method of analysis developed may be used for routine analysis of chemicals in any cosmetics products.

Advanced Geosteering using Data Integration on XRF/XRD, Gas Analysis and LWD data to Optimize Well Placement

2021 ◽  
Author(s):  
J. Dashti ◽  
B. Al-Ajmi ◽  
H. Sabri ◽  
B. Al-Adsani ◽  
H. Farwan ◽  
...  
Keyword(s):  
Data Integration ◽  
Gas Analysis ◽  
Well Placement ◽  
Using Data

Updated outcomes for patients with completely resected pulmonary recurrent osteosarcoma: A report from the Children’s Oncology Group.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 10023-10023
Author(s):  
Alexander J. Chou ◽  
Mark D. Krailo ◽  
Ruxu Han ◽  
Allen Buxton ◽  
Damon R. Reed ◽  
...  
Keyword(s):  
Disease Control ◽  
Oncology Group ◽  
Specific Patient ◽  
Efficacy Analysis ◽  
Investigational Agent ◽  
Phase 2 Trial ◽  
Select Group ◽  
Using Data ◽  
The Stability ◽  
Histological Confirmation

10023 Background: Amongst patients with recurrent osteosarcoma (OS), those with resectable pulmonary-only relapse appear to have the best outcomes. Prior analysis of patients with completely resected recurrent OS enrolled on a Children’s Oncology Group (COG) Phase 2 trial AOST0221, which studied the efficacy of inhaled GMCSF, showed a 12- month disease control rate (DCR12) of only 20% (95% CI, 10 – 34%). DCR12 based on this analysis was used as the historical benchmark for efficacy analysis in two recently completed trials, AOST1321 (completely resected cohort only) and AOST1421. We analyzed the stability of the DCR12 benchmark using data from these contemporary studies. Methods: Patients were eligible for AOST1321 if they had undergone resection of all sites of recurrent or refractory OS within 30 days of enrollment and for AOST1421 if they had lung only recurrent OS completely resected within 4 weeks of enrollment. AOST1321 evaluated denosumab while AOST1421 evaluated dinutuximab. Patients with refractory disease, extrapulmonary recurrence or without histological confirmation of relapse were excluded from this analysis. DCR12 was defined as having at least stable disease 12 months after the start of protocol therapy. We report the DCR12 observed on AOST1321, AOST1421 and AOST0221. Results: One hundred and twenty-eight evaluable patients with completely resected recurrent OS were enrolled on AOST0221 (N=49), AOST1321 (N=38) and AOST1421 (N=41). One hundred and one patients were included in this analysis (AOST0221: 37, AOST 1321: 25, AOST1421:39). DCR12 was 14 % (95% CI, 5% – 26%) for AOST0221, 24% (95%CI 10-42%) for AOST1321, and 31% (95% CI, 17% - 45%) for AOST1421. Risk for disease progression did not differ across the 3 included studies. DCR12 for all three studies combined was 23% (95% CI, 15% – 31%). Conclusions: Prognosis for recurrent OS remains dismal, even for those with resectable pulmonary-only disease. Although not statistically significant, dinutuximab may have activity in a select group of relapsed OS patients; combination studies using dinutuximab are planned. The previously described benchmark of disease control at 12 months remained relatively consistent in recent studies for those patients who have resectable pulmonary-only relapse. Therefore, DCR12 remains a useful outcome measure in fully resected OS with lung only metastases. Analyses are ongoing to better define the appropriate threshold to define investigational agent activity in this specific patient population.

scholarly journals KEARIFAN LOKAL DALAM PEMBANGUNAN KOMPLEKS CANDI GUNUNG KAWI

2017 ◽  
Vol 29 (2) ◽  
pp. 105
Author(s):  
A.A Gde Bagus ◽  
Hedwi Prihatmoko
Keyword(s):  
Data Integration ◽  
Qualitative Approach ◽  
Narrative Text ◽  
Archaeological Remains ◽  
Literature Study ◽  
Environmental Preservation ◽  
Material Resources ◽  
Using Data ◽  
Preservation Value

Gunung Kawi Temple is one of the most monumental archaeological remains in Bali originating from the 10th to 11th century. This study aims to determine the values of local wisdom of ancient Balinese society related to the construction and presence of Gunung Kawi Temple. Data were collected through literature study and observation. Analysis was conducted through qualitative approach using data integration and explanation based on theory. Explanation is presented in narrative text. The results of this study indicate that the construction using the concept of cliff temple is an adaptation in addressing the limitations of geography and material resources. This adaptation is a form of ancient Balinese society local wisdom. This local wisdom is also reflected on the environmental preservation value which is related to the function of Gunung Kawi Temple as a religious sacred building. Keywords: gunung kawi, cliff temple, local wisdom, adaptation, enviromental preservation. Kompleks Candi Gunung Kawi merupakan salah satu tinggalan arkeologi paling monumental di Bali yang berasal dari abad ke-10 sampai 11 Masehi. Kajian ini bertujuan untuk mengetahui nilainilai kearifan lokal masyarakat Bali Kuno yang terkait dengan pembangunan dan keberadaan Kompleks Candi Gunung Kawi. Pengumpulan data dilakukan melalui studi kepustakaan dan observasi. Analisis dilakukan melalui pendekatan kualitatif dengan pengintegrasian data dan memaparkan simpulan-simpulan berdasarkan teori. Pembahasan kemudian disajikan dalam bentuk teks naratif. Hasil kajian ini menunjukkan bahwa pembangunan dengan konsep candi tebing merupakan bentuk adaptasi dalam menyikapi keterbatasan geografi dan sumber bahan baku. Adaptasi tersebut merupakan salah satu wujud kearifan lokal masyarakat Bali Kuno. Kearifan lokal tercermin juga dari nilai pelestarian lingkungan yang terkait dengan fungsi Kompleks Candi Gunung Kawi sebagai bangunan suci keagamaan. 

scholarly journals Literacy Culture Development through Class Library at SDIT Salsabila 2 Klaseman Ngaglik Sleman

2019 ◽  
Vol 11 (2) ◽  
pp. 183-203
Author(s):  
Ahmad Safi'i
Keyword(s):  
Life Skills ◽  
Human Life ◽  
School Library ◽  
Field Research ◽  
Class Library ◽  
Reduction Techniques ◽  
The Government ◽  
Using Data ◽  
The Stability ◽  
Culture Development

Life skills are proven to be able to improve human civilization.  Improving literacy culture is one way to develop human life skills.  The National Literacy Movement/ Gerakan Literasi Nasional (GLN) initiated by the government is an effort to realize it.  SDIT Salsabila 2 Klaseman has a Class Literacy Movement/ Gerakan Literasi Kelas (GLK) program.  The limited space available is not a reason to discourage GLK.  This type of research was case study field research.  The institution studied was SDIT Salsabila 2 Klaseman.  The subjects consisted teachers, principals, students and parents.  Data was obtained by observation, interviews and documentation steps.  Analysis was performed by using data reduction techniques, data display, triangulation, and conclusion drawing/verification.  The data showed that the main purpose of GLK was to intensify the culture of school literacy, library revitalization, and maintain the stability of school library functions.  The technical implementation is by creating a class library in each class, fostering a sense of belonging to the class library, supplying books from the school library to the class library, providing educational playgrounds in the area of the class library, giving rewards for students who are diligent in reading, achievements are informed in public, and explore the student guardian support. The problems that arise are the lack of teacher exemplariness, lack of consistency, supply of books from school libraries is still small, and the system of re-education has not been orderly.

scholarly journals BUNDLE ADJUSTMENT-BASED STABILITY ANALYSIS METHOD WITH A CASE STUDY OF A DUAL FLUOROSCOPY IMAGING SYSTEM

2018 ◽  
Vol IV-2 ◽  
pp. 9-16 ◽  
Author(s):  
K. Al-Durgham ◽  
D. D. Lichti ◽  
I. Detchev ◽  
G. Kuntze ◽  
J. L. Ronsky
Keyword(s):  
Stability Analysis ◽  
Imaging System ◽  
Parameters Estimation ◽  
System Stability ◽  
Single Camera ◽  
Calibration Data ◽  
Analysis Method ◽  
Advantages And Disadvantages ◽  
Camera Imaging ◽  
The Stability

A fundamental task in photogrammetry is the temporal stability analysis of a camera/imaging-system’s calibration parameters. This is essential to validate the repeatability of the parameters’ estimation, to detect any behavioural changes in the camera/imaging system and to ensure precise photogrammetric products. Many stability analysis methods exist in the photogrammetric literature; each one has different methodological bases, and advantages and disadvantages. This paper presents a simple and rigorous stability analysis method that can be straightforwardly implemented for a single camera or an imaging system with multiple cameras. The basic collinearity model is used to capture differences between two calibration datasets, and to establish the stability analysis methodology. Geometric simulation is used as a tool to derive image and object space scenarios. Experiments were performed on real calibration datasets from a dual fluoroscopy (DF; X-ray-based) imaging system. The calibration data consisted of hundreds of images and thousands of image observations from six temporal points over a two-day period for a precise evaluation of the DF system stability. The stability of the DF system – for a single camera analysis – was found to be within a range of 0.01 to 0.66 mm in terms of 3D coordinates root-mean-square-error (RMSE), and 0.07 to 0.19 mm for dual cameras analysis. It is to the authors’ best knowledge that this work is the first to address the topic of DF stability analysis.

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