scholarly journals ANALGETICACTIVITY TEST OF ETHANOL EXTRACT OFTAMARIND LEAVES (TamarindusIndica L.) TO MALEMICE OF SWISS STRAIN

2018 ◽  
Vol 1 (1) ◽  
pp. 34-38
Author(s):  
Sri Saptuti Wahyuningsih
Keyword(s):  
Emotional Experience ◽  
Ethanol Extract ◽  
Male Mice ◽  
Optimal Activity ◽  
Normality Test ◽  
Cumulative Amount ◽  
Kolmogorov Smirnov ◽  
Analysis Of Results ◽  
Post Hoc ◽  
Swiss Strain

Tamarind is a medicinal plant that has benefits as an antiseptic, antipyretic and analgetic (anti-pain). Pain is an unpleasant sensory and emotional experience due to actual or potential damage.The purpose thisstudy to determine the optimal analgetic and dosage activity of tamarind leaf ethanol extract on male mice swiss strain induced by acetic acid. The method used is analysis of results by observing the amount of stretching of mice every five minutes for an hour. The cumulative amount of stretching in mice to calculate the analgetic activity was obtained from the amount of stretching of mice induced by acetid acid intraperitoneally within 30 minutes after orally induced. Statistical analgetic data using kolmogorov-smirnov normality test, test of homogenity of variances followed by Anova test and post hoc tests using SPSS 24.0 for windows. Percentanalgesic activity of ethanol extract of leaves tamarind dosage 5%, 10%, 20%wererespectively (9,81 ± 2,24)%, (24,68 ± 2,10)% and (36,39 ± 3,06)%. Ethanol extract of leaves tamarind dosage 20% provide the most optimal activity analgesic

scholarly journals EFEKTIVITAS ANALGETIK EKSTRAK ETANOL AKAR ALANG-ALANG (Imperata cylindrica (L) Beauv ) PADA MENCIT PUTIH JANTAN

2020 ◽  
Vol 2 (2) ◽  
pp. 97-101
Author(s):  
Dewi Kartika ◽  
Veronika Yuliyani Gultom ◽  
Andelila Suprianti Sitompul
Keyword(s):  
Emotional Experience ◽  
Ethanol Extract ◽  
Imperata Cylindrica ◽  
Test Method ◽  
Phytochemical Screening ◽  
Male Mice ◽  
Relieve Pain ◽  
Infra Red ◽  
Therapeutic Doses ◽  
Plantar Test

Pain is an unpleasant sensory and emotional experience due to tissue damage, either actual or potential or described in the form of damage. Provision of therapeutic doses of analgesics relieve pain or suppress. Plants Imperata cylindrica L. Beauv empirically used as traditional medicine. The purpose of this study to know the analgetic effect of root ethanol extract of alang-alangImperata cylindrica L. Beauv. This study was done by infra red (IR) plantar test method with a wavelength of 96 nm. Twenty male mice were divided into 4 groups. Three groups were given ethanol extract of Imperata cylindrica L. Beauv branches at a doses of 15 mg/kg bb, 30 mg/kg bb 60 mg/kg bb and one group was given 0,5% CMC Na (control) orally. After that, the time (second) hold infra red induction of pain every 10 minutes to 60 minutes. The data obtained were processed using one-way analysis of variance (ANOVA) and followed test the level of 95%. The results of phytochemical screening  Imperata cylindrica L. Beauv is alkaloid, flavonoid, and steroid/triterpenoid. Ethanol extract Imperata cylindrica L. Beauv dose of 15 mg/kg bb average  induction able to withstand pain of 12,86; 14,34; 15,44; 19,2; 17,52; 15,42 second, the dose of 30 mg/kg bb 13,6; 17,08; 19,82; 18,44; 16,9; 16,48 second, and a dose of 60 mg/kg bb 16,96; 18,9; 18,94; 22,14; 18,0; 17,26 second. Pain is an unpleasant sensory and emotional experience due to tissue damage, either actual or potential or described in the form of damage. Provision of therapeutic doses of analgesics relieve pain or suppress. Plants Imperata cylindrica L. Beauv empirically used as traditional medicine. The purpose of this study to know the analgetic effect of root ethanol extract of alang-alangImperata cylindrica L. Beauv. This study was done by infra red (IR) plantar test method with a wavelength of 96 nm. Twenty male mice were divided into 4 groups. Three groups were given ethanol extract of Imperata cylindrica L. Beauv branches at a doses of 15 mg/kg bb, 30 mg/kg bb 60 mg/kg bb and one group was given 0,5% CMC Na (control) orally. After that, the time (second) hold infra red induction of pain every 10 minutes to 60 minutes. The data obtained were processed using one-way analysis of variance (ANOVA) and followed test the level of 95%. The results of phytochemical screening  Imperata cylindrica L. Beauv is alkaloid, flavonoid, and steroid/triterpenoid. Ethanol extract Imperata cylindrica L. Beauv dose of 15 mg/kg bb average  induction able to withstand pain of 12,86; 14,34; 15,44; 19,2; 17,52; 15,42 second, the dose of 30 mg/kg bb 13,6; 17,08; 19,82; 18,44; 16,9; 16,48 second, and a dose of 60 mg/kg bb 16,96; 18,9; 18,94; 22,14; 18,0; 17,26 second.

scholarly journals Uji Efek Analgetik Infusa Daun Beluntas (Pluchea indica L.) Pada Mencit Jantan Galur Swiss

2018 ◽  
Vol 7 (2) ◽  
pp. 61-67
Author(s):  
Sri S. Wahyuningsih ◽  
Linda Widyastuti
Keyword(s):  
Body Weight ◽  
Acetic Acid ◽  
Positive Control ◽  
Test Substance ◽  
Male Mice ◽  
Group Iii ◽  
Group I ◽  
Homogeneity Of Variance ◽  
Kolmogorov Smirnov ◽  
Swiss Strain

Beluntas leaves (Pluchea indica L.) have been known as analgetic reducer. The study about this research has been going on right now. The goal of this research is to study the analgesic effect of beluntas (P. indica) leaf infused into male mice of swiss strain. The method used is the stretching chemical stimuli using acetic acid as an inducer of pain. Healthy male mice of Swiss strain were divided into five groups, and each group consisted of 5 mice. Group I was given paracetamol at a dose of 65 mg/kg of body weight, group II were given distilled water , the group III-V were given beluntas leaf infuse in the variation of 10 %, 20 % and 40 %. Thirty minutes after test substance application, acetic acid of 100 mg/kg of body weight were given intraperitoneally in all groups and stretching of mice was observed every 5 minutes for 1 hour. The data was analyzed by using normality test of Kolmogorov-Smirnov; the  test of homogeneity of variance was analyzed by ANOVA and post hoc tests were to differenciate the percentage analgetic of every group. Statistical test showed normal distributed and homogeneous data; there are significant differences of percentage analgesic between paracetamol and beluntas leaf infuse of 10, 20, and 40 % (p < 0.05). There was significant differences between infuse of beluntas leaves with positive control (parasetamol) in mice. Key words: Analgetic, leave of beluntas (P. indica), infuse, mice.

POTENSI ANTIBAKTERI EKSTRAK ETANOL HERBA MENIRAN HIJAU (Phyllanthus niruri Linn.) DALAM MENGHAMBAT PERTUMBUHAN STAPHYLOCOCCUS AUREUS

2019 ◽  
pp. 144-150
Author(s):  
Vector Stephen Dewangga ◽  
Muhammad Taufiq Qurrohman
Keyword(s):  
Staphylococcus Aureus ◽  
Ethanol Extract ◽  
Inhibition Zone ◽  
Positive Control ◽  
Homogeneity Test ◽  
Phyllanthus Niruri ◽  
Kolmogorov Smirnov ◽  
Post Hoc ◽  
Negative Controls ◽  
Positive Controls

Penggunaan bahan alam semakin meningkat dan masih menjadi andalan di beberapa negara berkembang. Penelitian kali ini menggunakan ekstrak etanol dari herba Phyllanthus niruri Linn. Dalam usaha menghambat pertumbuhan Staphylococcus aureus. S. aureus merupakan salah satu mikroflora normal di wajah yang berperan dalam infeksi jerawat. Penelitian ini merupakan penelitian eksperimental menggunakan Rancangan Acak Lengkap dengan 7 perlakuan dan 5 ulangan. Perlakuan yang digunakan adalah pemberian ekstrak etanol herba P. niruri Linn. untuk konsentrasi 5%; 25%; 50%; 75%; 100%, pengenceran menggunakan pelarut DMSO 10%. Kontrol positif menggunakan ciprofloxacin, sedangkan kontrol negatif menggunakan DMSO 10%. Zona hambat yang diperoleh dianalisis menggunakan uji Kolmogorov–Smirnov dan uji homogenitas Levene. Apabila variansi data homogen, maka dilanjutkan analisis dengan Anova yang dilanjutkan dengan uji Post Hoc. Dari perhitungan kontrol negatif, variasi konsentrasi (5%, 25%, 50%, 75%, 100%) dan kontrol positif diperoleh rata-rata zona radikal berturut sebesar 6 mm; 7,46 mm; 7,52 mm; 7,6 mm; 8,52 mm; 8,98 mm; 31,08 mm. Semua variasi konsentrasi ekstrak etanol herba P. niruri Linn. mampu menghasilkan zona hambat radikal dengan zona hambat terbesar tetap dijumpai pada kontrol positif. Hal ini menunjukkan bahwa konsentrasi ekstrak etanol herba P. niruri Linn. yang semakin besar akan berbanding lurus dengan peningkatan aktivitas penghambatan, namun belum seoptimum kontrol positif.   The use of natural materials is increasing and is still a mainstay in several developing countries. This research was used ethanol extract from herb Phyllanthus niruri Linn. in an effort to inhibit the growth of Staphylococcus aureus. S. aureus is one of the normal microflora on the face that helps infection. This research is an experimental study used a completely randomized design with 7 preparations and 5 replications. The treatment used ethanol extract of P. niruri Linn herb. for a concentration of 5%; 25%; 50%; 75%; 100%, the dilution used 10% DMSO solvent. Positive controls used ciprofloxacin, while negative controls used DMSO 10%. The inhibition zone obtained was analyzed using the Kolmogorov-Smirnov test and the Levene homogeneity test. If the data variance is homogeneous, then the analysis is continued with ANOVA followed by the Post Hoc test. From the calculation of negative controls, various concentration (5%, 25%, 50%, 75%, 100%) and positive controls obtained an average radical zone of 6 mm; 7.46 mm; 7.52 mm; 7.6 mm; 8.52 mm; 8.98 mm; 31.08 mm. All variations in the concentration of ethanol extract of P. niruri Linn. herbs able to produce a radical inhibition zone with the largest inhibition zone still found in positive controls. This showed that the greater concentration of ethanol extract of P. niruri Linn. herb. will be directly proportional to the increase in inhibition activity, but not optimal as much as positive control.

scholarly journals Efek Pemberian Ekstrak Etanol Buah Adas (Foenicullum vulgare Mill.) terhadap Kadar Hormon Prolaktin Tikus Putih Betina Post Partum

2020 ◽  
Vol 17 (1) ◽  
pp. 1-8
Author(s):  
Ahwan Abdul ◽  
Fridah Wahyu Safitri ◽  
Rantika Purbowati
Keyword(s):  
Post Partum ◽  
Ethanol Extract ◽  
Female Rats ◽  
Control Group ◽  
Fruit Extract ◽  
Treatment Groups ◽  
Kolmogorov Smirnov ◽  
Post Hoc ◽  
Group 1 ◽  
Smirnov Test

Fennel plants are plants that have various traditional properties, such as facilitating breast milk or lactagogum. The aim of this research was to give ethanol extract of fennel fruit to increase the level of the hormone prolactin in lactating mice, so that the milk produced was increased. Subjects consisted of 12 postpartum female rats, divided into 1 control group (1% CMC Na) and 3 treatment groups (doses of 100, 500 and 1000 mg / Kg BW). Fennel fruit extract was given orally for each group for 14 days, after the treatment of blood samples were taken and centrifuged, the serum was read by Elisa Reader. The data obtained were analyzed using the Kolmogorov-Smirnov test, one-way ANAVA and Tukey's Multiple Comparison (post hoc test). Fennel fruit extract given from a dose of 100; 500 and 1000 mg / kg BW can significantly increase levels of the hormone prolactin (p 0.05) in nursing mice, respectively by 42.11; 44.26 and 43.83 ng / mL compared to controls (32.64 ng/mL).

Analgesic Effectivty Of Nanoparticles Chitosan-Ethanol Leaf Extract Papaya (Carica Papaya L.) In White Male Mice (Mus Mucculus)

2017 ◽  
Vol 15 (2) ◽  
pp. 228
Author(s):  
Juliferd Gredi ◽  
Wintari Taurina ◽  
Mohamad Andrie
Keyword(s):  
Leaf Extract ◽  
Carica Papaya ◽  
White Male ◽  
Ethanol Extract ◽  
Test Method ◽  
Ionic Gelation ◽  
Male Mice ◽  
Writhing Test ◽  
Effi Ciency ◽  
Optimal Formula

Papaya leaves has been shown to have efficacy as an analgesic. Analgesic effect caused by the flavonoids in leaves of papaya. To enhance the analgesic effi cacy papaya into dosage formulatio of nanoparticles. The purpose of this research was to create and characterized nanoparticles from ethanol extract of papaya leaves then tested for effectiveness as an analgesic. This study used polymer chitosan and NaTPP to created nanoparticles through ionic gelation method and analgesic activity tested using writhing test method and statistical tested. Optimal formula of nanoparticles were produced at concentration of 0.2% chitosan, Na-TPP extract 0.1% and 4% with a ratio of 6: 1: 1. The nanoparticles was formed a size of 255.4 nm with polidispers index of 0.7, the zeta potential of + 11,1mV, the adsorption effi ciency by 87% and rounded morphology (spherical). Analgesic effectiveness tested by comparison between the groups ethanol extract of papaya and the groups nanoparticles of chitosan-ethanol extract papaya statistically using the T-test Independent. The results of this research indicate that there are statistically signifi cant differences (p <0.05). This results shows that the preparation nanoparticles of chitosan-ethanol extract papaya is more effective as an analgesic than the ethanol extract of papaya leaves.

Efek Ekstrak Etanol Kulit Petai (Parkia speciosa Hassk) Terhadap Penurunan Kadar Glukosa Darah Mencit Jantan

2018 ◽  
Vol 3 (1) ◽  
pp. 1
Author(s):  
Verawaty Verawaty ◽  
Dhea Claudia Novel
Keyword(s):  
Blood Glucose ◽  
Ethanol Extract ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Control Group ◽  
Male Mice ◽  
Glucose Levels ◽  
The Third ◽  
Blood Glucose Levels

<p>Penelitian ini bertujuan untuk melihat pengaruh pemberian ekstrak etanol kulit petai (Parkia speciosa Hassk) terhadap penurunan kadar glukosa darah mencit jantan yang diinduksi aloksan. Hewan percobaan dibagi atas 5 kelompok diantaranya kelompok kontrol negatif, kelompok kontrol positif,dosis I (280 mg/kgBB mencit), dosis II (560 mg/kg BB mencit), dosis III (840 mg/kg BB mencit). Penelitian dilakukan selama 21 hari. Persentase penurunan kadar glukosa darah mencit jantan setelah diberikan ekstrak etanol kulit petai pada hari ke-21 adalah dosis I (77,52 %) lebih besar dibandingkan dengan dosis II (69,5 %) dan dosis III (73,37 %). Data yang diperoleh dianalisis dengan uji Two Way Anova dengan program SPSS 17. Hasil penelitian ini menunjukkan bahwa pemberian ekstrak etanol kulit petai untuk tiga variasi dosis menyatakan perbedaan yang bermakna secara statistik terhadap penurunan kadar glukosa darah mencit jantan.</p><p><em>Petai (Parkia speciosa Hassk) has a compound β-sitosterol and stigmasterol that have efficacy to decreased blood glucose levels. This study aimed to determine the effect of ethanol extract of petai peel for decrease blood glucose levels of male mice induced by alloxan. Experimental animals were divided into 5 groups including negative control group, positive control group, the first dose (280 mg/kg in mice), the second dose (560 mg/kg in mice), the third dose (840 mg/kg in mice). The study was conducted for 21 days. After 21 days, the result found that the percentage of blood glucose levels after the male mice given the ethanol extract of petai peel was, the first dose (77.52%) biger than the second dose (69.5%) and the third dose (73.37%). The data obtained were analyzed by Two Way ANOVA using SPSS 17. The results showed that have signicantly difference between three dose variation of ethanol extract of petai peel in blood glucose levels.</em></p>

scholarly journals ASSOCIAÇÃO ENTRE O NÍVEL DE ATIVIDADE FÍSICA, ÍNDICE DE MASSA CORPORAL E AGILIDADE DE ESCOLARES

2021 ◽  
Vol 7 (15) ◽  
Author(s):  
Ana Regina Leão Ibiapina Moura ◽  
Jéssica Gonçalves da Silva ◽  
Jorge Luiz De Brito Gomes ◽  
Ferdinando Oliveira Carvalho ◽  
José Fernando Vila Nova de Moraes
Keyword(s):  
Kolmogorov Smirnov ◽  
Post Hoc

A pesquisa objetivou verificar a associação entre o nível de atividade física, o índice de massa corporal e a agilidade de adolescentes escolares da rede particular de ensino na cidade de Senhor do Bonfim/BA. Trata-se de um estudo de natureza transversal, com amostra de 75 alunos (35 meninas e 40 meninos), com idades entre 10 e 14 anos. A coleta de dados foi realizada por meio de medidas de massa corporal e estatura (para posterior cálculo do índice de massa corporal), questionário para estimativa de nível de atividade física semanal, e um teste de agilidade (teste do quadrado). A normalidade dos dados foi verificada usando o teste de Kolmogorov-Smirnov. Os dados foram analisados por meio do Teste-t de Student, ANOVA de uma entrada com post hoc de Bonferroni e Teste U de Mann-Whitney, considerando o nível de significância de p<0,05. Os resultados mostraram que os meninos obtiveram melhor agilidade e foram mais fisicamente ativos do que as meninas. Do total de participantes, 13 apresentaram sobrepeso, e 17 foram classificados como sedentários. Não houve diferenças na agilidade considerando a classificação do índice de massa corporal ou nível de atividade física. Conclui-se que meninos são mais ágeis e praticam mais atividade física do que meninas. Todavia, a agilidade não apresentou associação com o índice de massa corporal nem com o nível de atividade física

scholarly journals Efek Imunomodulator Ekstrak Etanol Spons Melophlus sarasinorum Terhadap Aktivitas Fagositosis Sel Makrofag Pada Mencit Jantan Balb/C

2019 ◽  
Vol 5 (2) ◽  
pp. 147-157
Author(s):  
Wahyuni Wahyuni ◽  
Muhammad Ilyas Yusuf ◽  
Fadhliyah Malik ◽  
Adryan Fristiohady Lubis ◽  
Astrid Indalifiany ◽  
...  
Keyword(s):  
Cell Activity ◽  
Ethanol Extract ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Control Group ◽  
Macrophage Cell ◽  
Macrophage Phagocytosis ◽  
Post Hoc ◽  
Phagocytosis Activity

Immunomodulator is an ingredient or drug that can modulate immune system functions and activities. This study was conducted to determine the effect of ethanol extract of Melophlus sarasinorum sponge on macrophage phagocytosis activity. Twenty four male mice balb/c were divided into six groups. The first group received 100 mg/kg of ethanol extract of Melophlus Sarasinorum sponge, the second group received 200 mg/kg of ethanol extract of Melophlus sarasinorum sponge, the third group received 300 mg/kg of ethanol extract of Melophlus Sarasinorum sponge and the fourth group received 400 mg/kg of ethanol extract of Melophlus Sarasinorum sponge. The positive control group received Phyllanthus niruri linn extract (Stimuno®) 0,13 mg/g and the negative control group received NaCMC 0,5%. The extract was orally administered from first day to seventh day. On the eighth day, each of the mice was injected Staphylococcus aureus bacteria (SA) 0.5 mL intraperitoneally. Macrophage cell activity is calculated from smears of peritoneal fluid of mice. Increased doses of ethanol extract of Melophlus sarasinorum sponge increase the amount of macrophage phagocytosis activity that are 25,25% (negative control), 61,5% (positive control), 55,75% (100 mg/kg), 60,75% (200 mg/kg), 62,25% (300 mg/kg) dan 66,25% (400 mg/kg). The results showed that the ethanol extract of Melophlus sarasinorum sponge has the potential as immunomodulator at a doses of 300 mg/kgBB and 400 mg/kg with no significantly different effectiveness with positive control in increasing macrophage cell phagocytosis activity based on the result of post-hoc statistical test of Tukey (sig.> 0,05).  

scholarly journals THE INFLUENCE OF SELF-EFFICACY ON STUDENTS' WORK READINESS

2021 ◽  
Vol 2 (2) ◽  
pp. 233-238
Author(s):  
Annisa Nur Fitriyana ◽  
Kurjono Kurjono ◽  
Budi Santoso
Keyword(s):  
Linear Regression ◽  
Self Efficacy ◽  
Quantitative Research ◽  
Analytical Techniques ◽  
Work Readiness ◽  
Simple Linear Regression ◽  
Normality Test ◽  
Kolmogorov Smirnov ◽  
11Th Grade ◽  
Smirnov Test

The purpose of this study was determine the effect of self efficacy on work readiness of vocational students. This research is quantitative research. The population in this study were all students of the 11th grade of the all department at SMK Al Ghazaly as many as 90 students. The population is limited less than 100, all subjects in this study were used as research samples This research use descriptive and verificative methods. The sample of the Analytical techniques used are simple linear regression. Normality test uses the Kolmogorov-smirnov test and simple linear regression. All data calculation using IBM SPSS v. 25 for Windows. The result showed that self efficacy effect toward work readiness The magnitude of the influence of self efficacy against the results of work readiness by 0,275 (27,5%) while the remaining 0,725 (72,5%) is affected by other factors.

scholarly journals Korelasi Antara Panjang Tulang Radius Dengan Tinggi Badan Pada Suku Batak di Universitas HKBP Nommensen Medan

2021 ◽  
Vol 6 (2) ◽  
pp. 36-39
Author(s):  
Genta Suci Anggitya Tobing ◽  
Saharnauli Janna Verawaty Simorangkir ◽  
Jenny Ria Sihombing
Keyword(s):  
Strong Correlation ◽  
Body Height ◽  
Sampling Technique ◽  
Bivariate Analysis ◽  
Cross Sectional ◽  
Normality Test ◽  
Kolmogorov Smirnov ◽  
Correlation Strength ◽  
Cross Sectional Design ◽  
Smirnov Test

Background: Dead victim and/ or found in unregocnized condition need to be identified. The identification of the unrecognized victim is carried out to prove that the skeleton is a human skeleton with ethnicity, race, sex, estimated age, height and special characteristics. Body height is a main characteristic which used as an identification process for various interests. Estimated body height can be measured based on long bones, which one of them is radius bone. Objective: This study aimed to determine the correlation between the length of the radius bone with body height of Bataknese student, lecturer, and staff at Universitas HKBP Nommensen Medan. Method: This research was an analytic study with cross-sectional design. The sample of this study was 72 students and employees of Universitas HKBP Nommensen Medan, consist of 27 Bataknese men and 45 Bataknese women who met the inclusion and exclusion criteria. Sampling technique was done by purposive sampling. Data analysis was done by univariate method to describe the characteristics of the subjects, normality test used the Kolmogorov-Smirnov test and bivariate analysis used the Pearson and Spearman tests to obtain the correlation between the radius bone length and body height. Results: The results of the study by sex, both men and women have a strong correlation value. Men have a correlation strength with r = 0.746 (p>0.05) and women have a correlation strength with r = 0.789 (p<0.05). Conclusion: There is a strong correlation between the length of the radius bone with body height of Bataknese students at Universitas HKBP Nommensen Medan.

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