GENE EBNA3C: TYPES OF INFECTION BY EBV (EBV1 and EBV2), CORRELATION WITH CLINICAL AND BIOCHEMICAL PARAMETERS (AST, ALT and GGT) IN INDIVIDUALS WITH INFECTIOUS MONONUCLEOSIS OF THE METROPOLITAN AREA OF BELÉM, PARÁ, IN THE PERIOD OF 2005-2016
Abstract Two types of EBV (EBV1 and 2) have been shown to infect humans. Detect the types of EBV that cause infectious mononucleosis and correlate these viral types with biochemical parameters (AST, ALT and GGT) on in the metropolitan region of Belém, 2005 to 2016. A total 76 cases of infectious mononucleosis, processed the Instituto Evandro Chagas, Ananindeua, Brazil. Evaluated by PCR used primers the region EBNA 3C. EBV1 infection was observed in 71.1% (54/76) of individuals, among whom those > 14 years constituted 66.7% (36/54), the average age was 23 years, and the number of women infected was higher (61.1% [33/54]) than that of men (38.9%[21/54]). The symptoms/clinical signs observed in infection by EBV1 were cervical lymphadenopathy in 64.8% (35/54), fever in 63% (34/54), headache and arthralgia in 20.3% (11/54), and exanthema in 18.5% (10/54). Infection by EBV2 was observed in only 17.1% (13/76) of cases. Co-infection by EBV1 and EBV2, most frequently showing symptoms of fever and cervical lymphadenopathy, occurred in 66.7 (6/9) and 55.6% (5/9) of individuals. EBV1 was predominant in 71% of clinical cases of infectious mononucleosis. Correlation of biochemical parameters in infection by EBV1, EBV2, and co-infection by EBV1/2 revealed a statistically significant difference in mean changes of EBV1 in individuals older than 14 years.