scholarly journals Integration of Proteomics and Metabonomics in Exploring the Protecting Mechanism of Gushukang Capsule in Osteoporosis Rats

2021 ◽  
Author(s):  
Ruohui LIN ◽  
Bingying XIE ◽  
Lihua XIE ◽  
Jirong GE ◽  
Shengqiang Li
Keyword(s):  
Metabolic Pathway ◽  
Pearson Correlation ◽  
Nucleotide Metabolism ◽  
Treatment Of Osteoporosis ◽  
Beta Alanine ◽  
Differential Proteins ◽  
Chinese Patent ◽  
The Common ◽  
Underlying Mechanisms ◽  
Pearson Correlation Matrix

Abstract Background Gushukang (GSK) capsule is a Chinese patent medicine for the treatment of osteoporosis (OP). It has been widely used in clinics. However, the specific mechanism and target of GSK in the treatment of osteoporosis is not clear, which needs further study. Methods Metabolomics (GC/MS) and proteomics (TMT-LC-MC/MC) together with bioinformatics (KEGG pathway enrichment), correlation analysis (pearson correlation matrix) and joint pathway analysis (Metabo Analyst) were employed to discover the underlying mechanisms of GSK. Results The regulations of differential proteins Cant1, Gstz1, Aldh3b1, Bid and Slc1a3 in the common metabolic pathway of differential proteins and metabolites between GSK/OP and OP/SHAM were corrected in GSK group. The regulations of 12 metabolites (Tyramine、Thymidine、Deoxycytidine、Cytosine、L-Aspartate and so on) were differential in the common enrichment metabolic pathway between GSK /OVX and OVX/SHAM. Differential proteins and metabolites jointly regulate 11 metabolic pathways, such as purine metabolism, pyrimidine metabolism, histidine metabolism, beta-Alanine metabolism and so on. Conclusion GSK may protect bone metabolism in osteoporosis rats by affecting nucleotide metabolism, amino acid metabolism and immune system.

scholarly journals Patient and Therapist In-Session Cortisol as Predictor of Post-Session Patient Reported Affect

2021 ◽  
Vol 11 (11) ◽  
pp. 1483
Author(s):  
Eyal Levi ◽  
Susanne Fischer ◽  
Hadar Fisher ◽  
Roee Admon ◽  
Sigal Zilcha-Mano
Keyword(s):  
Positive Affect ◽  
Stress Hormone ◽  
Major Depressive ◽  
Retrospective Reports ◽  
The Social ◽  
Patient Reported ◽  
Before And After ◽  
The Common ◽  
Underlying Mechanisms

The importance of the role of affect in psychotherapy for major depressive disorder (MDD) is well established, but the common use of self-reported measures may limit our understanding of its underlying mechanisms. A promising predictor of patient affect is the stress hormone cortisol. To date, no studies have studied in-session changes in cortisol in psychotherapy for MDD. We investigated whether an increase in patient cortisol over the course of a session correlated with higher negative and lower positive affect. Given previous findings on healthy individuals on the contagious nature of stress, an additional aim was to examine whether these relationships are moderated by therapist cortisol. To this end, 40 dyads (including 6 therapists) provided saliva samples before and after four pre-specified sessions (616 samples). After each session, the patients provided retrospective reports of in-session affect. We found no association between patient cortisol and affect. However, increases in patient cortisol predicted negative affect when the therapists exhibited decreases in cortisol, and increases in patient cortisol predicted positive affect when the therapists showed increases. Our study provides initial evidence for the importance of the social context in the cortisol–affect relationship in MDD.

Writing Styles of Abstracts in Occupational Therapy Journals

1985 ◽  
Vol 48 (8) ◽  
pp. 244-246 ◽  
Author(s):  
Ashok Chandani
Keyword(s):  
Operating System ◽  
British Journal ◽  
Occupational Therapy ◽  
Canadian Journal ◽  
Correlation Matrix ◽  
Pearson Correlation ◽  
Negative Relationship ◽  
Formula One ◽  
Unix Operating System ◽  
Pearson Correlation Matrix

The readability grades of abstracts randomly selected from the American Journal of Occupational Therapy, the Australian Occupational Therapy Journal, the British Journal of Occupational Therapy, and the Canadian Journal of Occupational Therapy were studied through the program Style of the Unix operating system (computer). The formulae for readability grades used were the Kincaid formula, the automated readability index, the Coleman-Liau formula, and the Flesch formula. One-way analysis of variance was found to be significant (p<0.05) between the British and Australian journals in all four formulae. Based on samples of abstracts, the results indicated that the British journal is the easiest and the Australian journal is the most difficult to read of all four journals. A Pearson correlation matrix revealed a significant positive and negative relationship between some of the 12 variables in each journal.

scholarly journals Bariatric Surgery: Remission of Inflammation, Cardiometabolic Benefits, and Common Adverse Effects

2020 ◽  
Vol 4 (9) ◽  
Author(s):  
Fatimo Biobaku ◽  
Husam Ghanim ◽  
Scott V Monte ◽  
Joseph A Caruana ◽  
Paresh Dandona
Keyword(s):  
Bariatric Surgery ◽  
Weight Loss ◽  
Adverse Effects ◽  
Chronic Inflammation ◽  
Large Scale ◽  
Severe Obesity ◽  
Neurological Complications ◽  
The Common ◽  
Underlying Mechanisms ◽  
Remission Of Comorbidities

Abstract Obesity is associated with increased mortality as a result of several comorbidities which occur in tandem with the obese state. Chronic inflammation is well documented in obesity, and evidence from numerous studies support the notion that the increased inflammation in individuals with obesity accentuates the comorbidities seen in this condition. The remission of comorbidities such as metabolic, cardiovascular, and neurological complications occurs following bariatric procedures. Bariatric surgery significantly reduces mortality and results in remarkable weight loss and reversal in several obesity-related comorbidities. There is indisputable evidence that the resolution of inflammation that occurs after bariatric surgery mitigates some of these comorbidities. With the increasing use of bariatric surgery for the treatment of severe obesity, it is pivotal to elucidate the underlying mechanisms responsible for the notable improvements seen after the procedure. This review summarizes underlying mechanisms responsible for the remission of obesity-related abnormalities and discusses the common adverse effects of bariatric surgery. Well-stratified, large-scale studies are still needed for a proper evaluation of these underlying mechanisms.

scholarly journals The Effects ofAndrographis paniculataon Platelet Activity in Healthy Thai Volunteers

2018 ◽  
Vol 2018 ◽  
pp. 1-9
Author(s):  
Tichapa Sirikarin ◽  
Titchaporn Palo ◽  
Sirikul Chotewuttakorn ◽  
Weerawadee Chandranipapongse ◽  
Suveerawan Limsuvan ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Platelet Function ◽  
Bioactive Compound ◽  
Mrna Levels ◽  
Platelet Activity ◽  
Entire Study ◽  
The Common ◽  
Underlying Mechanisms ◽  
Cox 1

Background. Andrographis paniculata(AP) has been used in Thai traditional medicine to treat various infections, including the common cold and fever. Its bioactive compound, andrographolide, has shown antiplatelet activities in anin vitrostudy model. Since clinical studies of the effects of AP on the human platelet function have never been reported, we investigated its effect on platelet activity in ten healthy volunteers.Methods. Two grams of AP was taken 3 times within one day. The blood was withdrawn by venipuncture before and 2 and 24 hours after the AP administration to analyze the effects of AP on platelet aggregation, the expression of enzyme cyclooxygenase (COX) mRNA and protein, and TXB2, including P-selectin.Result. Even though there was no significant change in the studied parameters, this study exhibited patient-to-patient variability in platelet function. It was found that ADP-induced platelet aggregation tended to decrease after AP administration, while epinephrine-induced platelet aggregation in females tended to be higher than that in males for the entire study period. Moreover, COX-1 mRNA levels tended to decrease while P-selectin levels tended to rise after AP administration.Conclusion. These controversial results are possibly due to the multifactorial mechanisms of platelet aggregation as well as the multichemical composition of AP. Further study, probably at the molecular level, is needed to unveil the underlying mechanisms of action of AP.

scholarly journals MANAGEMENT OF ENDOCRINE DISEASE: Secondary osteoporosis: pathophysiology and management

2015 ◽  
Vol 173 (3) ◽  
pp. R131-R151 ◽  
Author(s):  
Faryal Mirza ◽  
Ernesto Canalis
Keyword(s):  
Bone Loss ◽  
Fragility Fractures ◽  
Low Bone Mass ◽  
Endocrine Disease ◽  
Skeletal Fragility ◽  
Increased Risk ◽  
Common Causes ◽  
The Common ◽  
Skeletal Disorder ◽  
Underlying Mechanisms

Osteoporosis is a skeletal disorder characterized by decreased mass and compromised bone strength predisposing to an increased risk of fractures. Although idiopathic osteoporosis is the most common form of osteoporosis, secondary factors may contribute to the bone loss and increased fracture risk in patients presenting with fragility fractures or osteoporosis. Several medical conditions and medications significantly increase the risk for bone loss and skeletal fragility. This review focuses on some of the common causes of osteoporosis, addressing the underlying mechanisms, diagnostic approach and treatment of low bone mass in the presence of these conditions.

Mathematical coupling of data: correction of a common error for linear calculations

1986 ◽  
Vol 60 (1) ◽  
pp. 335-343 ◽  
Author(s):  
L. F. Moreno ◽  
H. H. Stratton ◽  
J. C. Newell ◽  
P. J. Feustel
Keyword(s):  
Linear Regression ◽  
Regression Coefficient ◽  
Pearson Correlation ◽  
Pearson Correlation Coefficient ◽  
Linear Regression Coefficient ◽  
Common Error ◽  
The Common ◽  
The Relationship ◽  
Scientific Environment ◽  
Mathematical Coupling

The need frequently arises in the scientific environment to investigate the relationship between quantities that are calculated from a common set of directly measured variables. However, the presence of error in the common set of measured variables distorts the relationship among the calculated quantities and can lead to incorrect conclusions. This article presents a method of correcting for such distortions in the Pearson correlation coefficient and in the linear regression coefficient for linear calculations involving two measured variables. The errors considered may be either independent of, or proportional to, the value of the variable being measured. Tests to determine whether these popular coefficients have values significantly different from zero are presented. An example from the physiology literature is presented to illustrate these techniques.

Toward a Vortex Breakdown Condition for Swirling Annular Jets

1999 ◽  
Vol 121 (1) ◽  
pp. 102-105 ◽  
Author(s):  
C. F. Stein
Keyword(s):  
Channel Flow ◽  
Vortex Breakdown ◽  
Jet Flows ◽  
Theoretical Discussion ◽  
Cfd Simulations ◽  
Definite Answer ◽  
Significant Phenomenon ◽  
The Common ◽  
Underlying Mechanisms ◽  
Annular Jets

Vortex breakdown is a significant phenomenon in science and technology. In spite of extensive research, the question of the underlying mechanisms for vortex breakdown still lacks a definite answer. The uncertainty of the governing principles for vortex breakdown is revealed by the common use of a variety of different parameters to describe the degree of swirl. In this paper, a theoretical discussion on the suitability of three kinds parameters was conducted, and it was found that one appears to be the natural one if the flow is primarily a swirling channel flow, but if the jet character of the flow is dominant, another one appears to be the most suitable. CFD simulations were performed for a channel with an annular inlet considerably smaller than the channel width. For this case the jet character of the flow should predominate and it was found that the parameter, which theoretically appeared to be best suited for jet flows, indeed was less dependent of the detailed inflow geometry than the others.

scholarly journals OSTEOPOROSIS AND SARCOPENIA: COMMON ETIOPATHOGENETIC FACTORS, PREVENTION AND NON-DRUG TREATMENT

2020 ◽  
Vol 8 (4) ◽  
pp. 466-474
Author(s):  
V.A. Malakhov ◽  
A.K. Tyagniryadko ◽  
Y.A. Isaeva
Keyword(s):  
Drug Treatment ◽  
Age Factors ◽  
The Elderly ◽  
Treatment Of Osteoporosis ◽  
Treatment And Prevention ◽  
Number Of Patients ◽  
Osteosarcopenic Obesity ◽  
Reduced Physical Activity ◽  
The Common ◽  
The Relationship

The problem of osteoporosis and sarcopenia is one of the leading problems in world medicine. There is a significant increase in the number of patients with these pathologies, which is associated with increased life expectancy. Osteoporosis and sarcopenia are among the most common diseases in old age. Moreover, if earlier these pathologies, especially osteoporosis, were observed mainly in the elderly, now these diagnoses have significantly rejuvenated. Thus, early diagnosis, methods of prevention, early treatment and rehabilitation of these diseases become relevant. Equally important is the relationship between these diseases and the commonality of their etiology and pathogenesis, and, accordingly, the identity of methods of prevention and treatment. In the context of medical and preventive care, the commonalities and differences of genetic, biochemical and age factors and nosological units that lead to the development of these pathologies are analyzed. Methods of prevention and non-drug treatment of osteoporosis and sarcopenia are considered in detail. The most effective methods of prevention and non-drug treatment of osteoporosis and sarcopenia have been identified. The common etiopathogenetic factors of sarcopenia and osteoporosis, disorders of fat metabolism and, ultimately, reduced physical activity, suggests the presence of osteosarcopenia and osteosarcopenic obesity. The same commonality leads to almost identical approaches in the treatment and prevention of these diseases.

Induced Root Differentiation in Sycamore Callus

1972 ◽  
Vol 11 (2) ◽  
pp. 319-337
Author(s):  
K. WRIGHT ◽  
D. H. NORTHCOTE
Keyword(s):  
Carbon Source ◽  
Histological Examination ◽  
Growth Medium ◽  
Metabolic Pathway ◽  
Root Hairs ◽  
Physiological Role ◽  
Good Growth ◽  
Active Growth ◽  
Root Differentiation ◽  
The Common

A sycamore callus (S 4) has been isolated and grown on a medium containing salts, vitamins, a casein digest, 2% sucrose and 1 mg/l. NAA. The callus, which would not grow in the absence of the added auxin, was much firmer in texture than a sycamore callus (S 2) isolated in this laboratory in 1958 which has not been induced to differentiate. When kinetin over the range 0.05-0.5 mg/l. was included in the growth medium of S 4 nodules of xylem and phloem were induced within the tissue and roots frequently grew from the surface of the callus. Some roots developed geotropic sensitivity although the majority grew radially outwards from the callus surface. The roots also varied with respect to the number of root hairs they carried. No roots were produced at sucrose concentrations less than 2%, although histological examination revealed extensive xylem and phloem differentiation relative to the amount of growth which had taken place. When sugars other than sucrose were supplied in the medium at a concentration of 3% (w/v) roots were also induced in those calluses where the carbon source had supported good growth. Sucrose, glucose and fructose were identified in the ethanol-soluble extracts of all these calluses. Radioactivity was incorporated into sucrose when S 4 was incubated on a medium containing D-[U-14C]glucose for 24 h. Any sugar which supported growth and differentiation was therefore one which was capable of entering the common metabolic pathway used by the plant for glucose and sucrose. The cells could undergo differentiation so long as the sugar they were supplied with supported active growth and division. The possibility of a physiological role for sucrose is discussed.

Sign in / Sign up

Export Citation Format

Share Document