scholarly journals Impact of Donation Physicians on Deceased Organ Donation: A Systematic Review

2020 ◽  
Author(s):  
Janet Squires ◽  
Laura D Aloisio ◽  
Wilmer John Santos ◽  
Danielle Cho-Young ◽  
Monica Taljaard ◽  
...  
Keyword(s):  
Systematic Review ◽  
Organ Donation ◽  
Data Extraction ◽  
Interrupted Time Series ◽  
Deceased Donor ◽  
Organ Donors ◽  
Consent Rate ◽  
Team Members ◽  
Study Selection ◽  
Deceased Organ Donation

Abstract Background: An emerging strategy to increase deceased organ donation is to use dedicated donation physicians to champion organ donation. We sought to conduct a systematic review of the effectiveness of donation physicians in improving organ donation outcomes.Data Sources: A systematic review was conducted following Cochrane principles. MEDLINE, Embase, and CINHAL databases were searched from inception to March 26, 2020. Study Selection: Quantitative studies examining the effects of donation physicians on all deceased organ donation outcomes were considered for inclusion. Review articles, editorials and opinion articles, and case studies were excluded. Study selection was completed independently by two team members; all discrepancies were resolved by consensus.Data Extraction: Two team members independently extracted data from studies. Data Synthesis: A total of 1,017 studies were screened, and 12 met inclusion criteria. Included studies were published between 1994 and 2019. Half used an interrupted time series design (n = 6; 50%), three (25%) were cohort studies, and three (25%) used a before-and-after study design. Outcomes (reported in greater than 50% of included articles) included consent/refusal rate (n = 8; 67%), number of potential donors (n = 7; 58%), and number of actual donors (n = 7; 58%). Across studies and design types, there was an increase in potential organ donors ranging from 8 to 143% (Mdn = 33%), an increase in actual organ donors from 15 to 113% (Mdn = 27%), an increase in donor consent rate from -3 to 258% (Mdn = 12%) and an increase in deceased donor transplants from 13 to 24% (Mdn = 19%) following the introduction of donation physicians.Conclusions: Donation physicians have the potential to significantly improve deceased organ donation. Further implementation and evaluation of donation physician programs is warranted. However, implementation should be undertaken with a clear plan for a methodologically rigorous evaluation of outcomes.

scholarly journals Impact of Donation Physicians on Deceased Organ Donation: A Systematic Review

2021 ◽  
Author(s):  
Janet E. Squires ◽  
Laura D. Aloisio ◽  
Wilmer John Santos ◽  
Danielle Cho-Young ◽  
Monica Taljaard ◽  
...  
Keyword(s):  
Systematic Review ◽  
Organ Donation ◽  
Interrupted Time Series ◽  
Deceased Donor ◽  
Organ Donors ◽  
Consent Rate ◽  
Team Members ◽  
Study Selection ◽  
Before And After ◽  
Deceased Organ Donation

Abstract Background: An emerging strategy to increase deceased organ donation is to use dedicated donation physicians to champion organ donation. We sought to conduct a systematic review of the effectiveness of donation physicians in improving organ donation outcomes.Methods: A systematic review was conducted following Cochrane principles. MEDLINE, Embase, and CINHAL databases were searched from inception to March 26, 2020. Quantitative studies examining the effects of donation physicians on all deceased organ donation outcomes were considered for inclusion. Review articles, editorials and opinion articles, and case studies were excluded. Study selection was completed independently by two team members; all discrepancies were resolved by consensus. Two team members independently extracted data from studies. Results: A total of 1,017 studies were screened, and 12 met inclusion criteria. Included studies were published between 1994 and 2019. Half used an interrupted time series design (n = 6; 50%), three (25%) were cohort studies, and three (25%) used a before-and-after study design. Outcomes (reported in greater than 50% of included articles) included consent/refusal rate (n = 8; 67%), number of potential donors (n = 7; 58%), and number of actual donors (n = 7; 58%). Across studies and design types, there was an increase in potential organ donors ranging from 8 to 143% (Mdn = 33%), an increase in actual organ donors from 15 to 113% (Mdn = 27%), an increase in donor consent rate from -3 to 258% (Mdn = 12%) and an increase in deceased donor transplants from 13 to 24% (Mdn = 19%) following the introduction of donation physicians.Conclusions: Donation physicians have the potential to significantly improve deceased organ donation. Further implementation and evaluation of donation physician programs is warranted. However, implementation should be undertaken with a clear plan for a methodologically rigorous evaluation of outcomes.

scholarly journals Willingness to Become Deceased Organ Donors among Post-graduate Students in Selected Colleges in Kathmandu Valley, Nepal

2019 ◽  
Vol 3 (1) ◽  
pp. 47-58 ◽  
Author(s):  
Pragya Paneru ◽  
Samyog Uprety ◽  
Shyam S. Budhathoki ◽  
Birendra K. Yadav ◽  
Suman L. Bhandari
Keyword(s):  
Graduate Students ◽  
Organ Donation ◽  
Organ Transplantation ◽  
Mass Communication ◽  
Living Donor ◽  
Deceased Donor ◽  
World Health ◽  
Organ Donors ◽  
Post Graduate ◽  
Deceased Organ Donation

Introduction: Globally, there is a discrepancy between demand and availability of organs for transplantation. Transplantation is done from a living donor as well as a brain-dead/deceased donor. However, the World Health Organization (WHO) encourages deceased donor transplantation, since there is no risk to the donor. Although, the Transplant Act of Nepal 2016 opened the doors for deceased donor organ transplantation, the rate of transplantation from deceased donors is very low. Thus, this study assesses factors associated with willingness for deceased organ donation among post-graduate students of law, medicine, and mass communication streams. Methods: A total of 9 colleges, 3 from each specialty were selected via lottery method. The total sample size calculated was 440. Self- administered questionnaire was used to collect the data. 170, 140 and 130 forms were distributed in law, medicine and mass communication respectively via convenient sampling. Multivariate analysis among the variables that had p- value <0.05 in bivariate analysis was carried out to find out the strongest predictors of willingness to be deceased organ donors. Results: In all, 53.2% were willing to become deceased organ donors. Family permission in one's wish to donate organs, having someone in family with chronic disease, having attended any conference or general talk on organ donation, knowing a live organ donor and knowing that body will not be left disfigured after organ extraction were found to be the strongest predictors for willingness to be deceased organ donors; while lack of awareness was reported as the main barrier for the same reason. Conclusion: There is a need for extensive awareness programs and new strategies to motivate individuals and family members for organ donation. Key words: • Deceased Organ Donation • Willingness • Kathmandu • Nepal • Organ Transplantation • Living Donor • Deceased Donor   Copyright © 2019 Paneru et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals An exploration of the relationship between families of deceased organ donors and transplant recipients: A systematic review and qualitative synthesis

2018 ◽  
Vol 5 (1) ◽  
pp. 205510291878217 ◽  
Author(s):  
Sean Glenton Dicks ◽  
Holly Northam ◽  
Frank MP van Haren ◽  
Douglas P Boer
Keyword(s):  
Systematic Review ◽  
Identity Development ◽  
Dynamic System ◽  
Organ Donation ◽  
Organ Donors ◽  
Transplant Recipients ◽  
Qualitative Synthesis ◽  
Deceased Organ Donation ◽  
Points Of View ◽  
The Relationship

Following deceased organ donation and transplantation, the narratives of families of donors and organ recipients become connected. This is acknowledged when parties receive anonymous information from donation agencies and transplant centres, when they exchange correspondence or when they meet in person. This article reviews literature describing the experience from the points of view of donor families, recipients, and other stakeholders to explore the dynamic system that evolves around this relationship. Findings highlight a link between identity development and ongoing adjustment and will assist those supporting donor families and recipients to make decisions that fit meaningfully.

scholarly journals Epidemiology of hepatitis E virus infection in animals in Africa: a systematic review and meta-analysis

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Abdou Fatawou Modiyinji ◽  
Jean Joel Bigna ◽  
Sebastien Kenmoe ◽  
Fredy Brice N. Simo ◽  
Marie A. Amougou ◽  
...  
Keyword(s):  
Systematic Review ◽  
Hepatitis E Virus ◽  
Data Extraction ◽  
Meta Analysis ◽  
Hepatitis E ◽  
Epidemiological Studies ◽  
Cross Sectional ◽  
Resource Limited ◽  
Study Selection ◽  
Language Restriction

Abstract Background Hepatitis E virus (HEV) is a major cause of acute hepatitis in humans worldwide and have high burden in the resource-limited countries. Better knowledge of the epidemiology of hepatitis in animals in Africa can help to understand the epidemiology among humans. The objective of this study was to summarize the prevalence of HEV infection and distribution of HEV genotypes among animals in Africa. Methods In this systematic review and meta-analysis, we comprehensively searched PubMed, EMBASE, African Journals Online, and Africa Index Medicus from January 1st, 2000 to March 22th, 2020 without any language restriction. We considered cross-sectional studies of HEV infection in animals in Africa. Study selection, data extraction, and methodological quality of included studies were done independently by two investigators. Prevalence data were pooled using the random-effects meta-analysis. This review was registered in PROSPERO, CRD42018087684. Results Twenty-five studies (13 species and 6983 animals) were included. The prevalence (antibodies or ribonucleic acid [RNA]) of HEV infection in animals varied widely depending on biological markers of HEV infection measured: 23.4% (95% confidence interval; 12.0–37.2) for anti-HEV immunoglobulins G, 13.1% (3.1–28.3) for anti-HEV immunoglobulins M, and 1.8% (0.2–4.3) for RNA; with substantial heterogeneity. In subgroup analysis, the immunoglobulins G seroprevalence was higher among pigs 37.8% (13.9–65.4). The following HEV genotypes were reported in animals: Rat-HEV genotype 1 (rats and horses), HEV-3 (pigs), HEV-7 (dromedaries), and Bat hepeviruses (bats). Conclusions We found a high prevalence of HEV infection in animals in Africa and HEV genotypes close to that of humans. Some animals in Africa could be the reservoir of HEV, highlighting the need of molecular epidemiological studies for investigating zoonotic transmission.

scholarly journals Prioritising recommendations following analyses of adverse events in healthcare: a systematic review

2020 ◽  
Vol 9 (4) ◽  
pp. e000843
Author(s):  
Kelly Bos ◽  
Maarten J van der Laan ◽  
Dave A Dongelmans
Keyword(s):  
Systematic Review ◽  
Adverse Events ◽  
Data Extraction ◽  
Data Sources ◽  
Cochrane Library ◽  
High Quality ◽  
Data Synthesis ◽  
Study Selection ◽  
Personal Opinion ◽  
User Friendly

PurposeThe purpose of this systematic review was to identify an appropriate method—a user-friendly and validated method—that prioritises recommendations following analyses of adverse events (AEs) based on objective features.Data sourcesThe electronic databases PubMed/MEDLINE, Embase (Ovid), Cochrane Library, PsycINFO (Ovid) and ERIC (Ovid) were searched.Study selectionStudies were considered eligible when reporting on methods to prioritise recommendations.Data extractionTwo teams of reviewers performed the data extraction which was defined prior to this phase.Results of data synthesisEleven methods were identified that are designed to prioritise recommendations. After completing the data extraction, none of the methods met all the predefined criteria. Nine methods were considered user-friendly. One study validated the developed method. Five methods prioritised recommendations based on objective features, not affected by personal opinion or knowledge and expected to be reproducible by different users.ConclusionThere are several methods available to prioritise recommendations following analyses of AEs. All these methods can be used to discuss and select recommendations for implementation. None of the methods is a user-friendly and validated method that prioritises recommendations based on objective features. Although there are possibilities to further improve their features, the ‘Typology of safety functions’ by de Dianous and Fiévez, and the ‘Hierarchy of hazard controls’ by McCaughan have the most potential to select high-quality recommendations as they have only a few clearly defined categories in a well-arranged ordinal sequence.

Methodological systematic review of studies on social inequalities in smoking among young adults: A field coming of age?

2018 ◽  
Vol 28 (5) ◽  
pp. 566-573 ◽  
Author(s):  
Thierry Gagné ◽  
Joseph G L Lee ◽  
Madeleine Steinmetz-Wood ◽  
Katherine L Frohlich
Keyword(s):  
Systematic Review ◽  
Young Adults ◽  
Social Inequalities ◽  
Coming Of Age ◽  
Data Extraction ◽  
Life Transitions ◽  
Parental Characteristics ◽  
Study Selection ◽  
Study Characteristics ◽  
Measurement Strategies

ObjectiveSocioeconomic circumstances are critically important to addressing smoking. In young adulthood (ages 18–25), dynamic transitions in education, employment, family and housing complicate the measurement of socioeconomic circumstances. To better understand approaches to capturing these circumstances, this methodological systematic review examined how socioeconomic characteristics used to identify social inequalities in smoking among young adults are measured.Data sourcesWe searched PubMed/MEDLINE, Scopus, EMBASE, ERIC and Sociological Abstracts, and used three prior reviews. We updated the search in March 2018.Study selectionTwo reviewers independently screened peer-reviewed records from OECD countries published in English, French, German or Spanish after 1995 whose samples covered at least 1 year between the ages of 18 and 25. We included 89 of 1320 records.Data extractionOne reviewer extracted study characteristics, indicators used to operationalise socioeconomic circumstances and each indicator’s relation to results on smoking (ie, significance and direction). We found 39 indicators of socioeconomic circumstances related to six broad domains. These indicators were used in 425 results.Data synthesisWe descriptively analysed the extracted data using evidence tables. Educational attainment was most common. Evidence of inequalities varied by indicator used. For example, there was inconsistent evidence regarding the role of parental characteristics and transition stages and insufficient evidence regarding personal income on smoking.ConclusionDespite its importance, studies have disproportionally examined inequalities among young adults using traditional indicators. The mismatch between young adults’ life transitions and measurement strategies may attenuate evidence of inequalities. We suggest strategies to improve future measurement.

scholarly journals Aromatherapy for Symptom Relief in Patients with Burn: A Systematic Review and Meta-Analysis

Medicina ◽  
2021 ◽  
Vol 58 (1) ◽  
pp. 1
Author(s):  
Hye Won Lee ◽  
Lin Ang ◽  
Jung Tae Kim ◽  
Myeong Soo Lee
Keyword(s):  
Systematic Review ◽  
Data Extraction ◽  
Meta Analysis ◽  
Symptom Relief ◽  
Routine Care ◽  
Risk Of Bias ◽  
Review Author ◽  
Beneficial Effects ◽  
Study Selection ◽  
Meta Analyses

Background and Objectives: This review aimed to provide an updated review of evidence regarding the effects of aromatherapy in relieving symptoms of burn injuries, focusing on pain and physiological distress. Materials and Methods: Fifteen databases (including five English databases, four Korean medical databases, and four Iranian databases) and trial registries were searched for studies published between their dates of inception and July 2021. Two review authors individually performed study selection, data extraction, and risk of bias assessment, and any discrepancies were solved by a third review author. Results: Eight RCTs met our inclusion criteria and were analyzed in this updated systematic review. Our meta-analyses revealed that inhaled aromatherapy plus routine care showed beneficial effects in relieving pain after dressing, as compared to placebo plus routine care (p < 0.00001) and routine care alone (p = 0.02). Additionally, inhaled aromatherapy plus routine care (p < 0.00001) and aromatherapy massage plus routine care (p < 0.0001) also showed superior effects in calming anxiety, as compared to routine care alone. None of the included studies reported on AEs. Overall, the risk of bias across the studies was concerning. Conclusions: This updated review and synthesis of the studies had brought a more detailed understanding of the potential application of aromatherapy for easing the pain and anxiety of burn patients.

scholarly journals Effects of Composite Attachments on Orthodontic Clear Aligners Therapy: A Systematic Review

Materials ◽  
2022 ◽  
Vol 15 (2) ◽  
pp. 533
Author(s):  
Riccardo Nucera ◽  
Carolina Dolci ◽  
Angela Mirea Bellocchio ◽  
Stefania Costa ◽  
Serena Barbera ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Data Extraction ◽  
Risk Of Bias ◽  
Bias Assessment ◽  
Bodily Movement ◽  
Study Selection ◽  
Medium Risk ◽  
Clear Aligner ◽  
Anterior Root

This systematic review aims to highlight the differences between different clear aligner therapies that differ in the presence of attachments or in attachment configuration. Eight electronic databases were searched up to March 2020. Two authors independently proceeded to study selection, data extraction, and risk of bias assessment. The analysis of the results was carried out examining six groups of movements (mesio-distal tipping/bodily movement; anterior bucco-lingual tipping/root torque; posterior bucco-lingual tipping/expansion; intrusion; extrusion; rotation). Five clinical trials were selected and all of them showed a medium risk of bias. Literature showed that attachments mostly increase the effectiveness of orthodontic treatment with clear aligners, improving anterior root torque, rotation, and mesio-distal (M-D) movement; they are also important to increase posterior anchorage. However, some articles showed contradictory or not statistically significant results. Attachments also seem to improve intrusion, but the evidence about this movement, as well as extrusion, is lacking. No studies evaluated posterior bucco-lingual tipping/expansion. Further clinical trials are strongly suggested to clarify the influence of attachments and their number, size, shape, and position on each orthodontic movement.

Association between abnormal maternal serum levels of vitamin B12 and preeclampsia: a systematic review and meta-analysis

2020 ◽  
Author(s):  
Farzaneh Mardali ◽  
Somaye Fatahi ◽  
Maryam Alinaghizadeh ◽  
Hamed Kord Varkaneh ◽  
Mohammad Hassan Sohouli ◽  
...  
Keyword(s):  
Systematic Review ◽  
Vitamin B12 ◽  
Pregnant Women ◽  
Data Extraction ◽  
Meta Analysis ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Folic Acid Supplementation ◽  
Maternal Serum ◽  
Study Selection

Abstract Context Some evidence has shown an association between maternal vitamin B12 levels and the development of preeclampsia in pregnant women, but the relationship between preeclampsia and vitamin B12 is not clear. Objective The aim of this systematic review was to compare serum vitamin B12 levels in women with preeclampsia with those in normotensive pregnant women. Data Sources The PubMed/MEDLINE, Scopus, and Web of Science databases were searched up to August 2019, along with the reference lists of included articles. Study Selection The literature was searched for observational studies that investigated vitamin B12 levels in women with preeclampsia. Data Extraction Data were extracted independently by 2 authors. Data were pooled using a random-effects model. Results Vitamin B12 levels in women with preeclampsia were significantly lower than those in healthy women (mean, −15.24 pg/mL; 95%CI, −27.52 to −2.954; P &lt; 0.015), but heterogeneity between studies was high (I2 = 97.8%; P = 0.0103). Subgroup analyses based on folic acid supplementation, homocysteine concentrations, and gestational age at the time of sampling for vitamin B12 assessment did not identify the sources of heterogeneity. Conclusions Women with preeclampsia had significantly lower vitamin B12 concentrations than normotensive pregnant women.

scholarly journals Awareness regarding body and organ donation amongst the population of an urban city in India

2015 ◽  
Vol 05 (04) ◽  
pp. 051-057 ◽  
Author(s):  
Vaishaly K. Bharambe ◽  
Rathod H. ◽  
Paranjape V. M. ◽  
Kanaskar N. ◽  
Shevade S. ◽  
...  
Keyword(s):  
Organ Donation ◽  
Health Care Professionals ◽  
The Body ◽  
Organ Donors ◽  
Urban City ◽  
The People ◽  
Deceased Organ Donation ◽  
Knowledge And Attitude ◽  
End Stage ◽  
Body Donation

Abstract Purpose : Bodies for purpose of dissection and organs for transplantation surgeries are needed for education of medical students and treatment of cases of end-stage organ failure. However deceased organ donation rate in India is very dismal. In the present study the authors assess the knowledge and attitude of the people living in an urban city in India towards organ and body donation. Materials/Methods : A questionnaire was distributed amongst all willing patients and their relatives attending the out-patient Department at our Hospital. This was followed by an awareness session wherein the researchers discussed body and organ donation and its need in India. Information sheet was handed to all and the willing respondents were given eye and body donation forms, and donor cards. Result: 41/65 people consented to participate. 41.5%, 31.7%, 12.2% and 12.2% had obtained knowledge regarding organ donation from newspaper, television, family members and internet respectively. 26.8% claimed that they were imparted knowledge by health care professionals. 78%, 53.7% and 19.5% were aware about eye, kidney and liver donations respectively. 17.1% were aware of body and lung donation each. Awareness of donation of other organs was found to be in the range between 4.9% to 14.6%. 43.9% were willing to be organ donors and 3 persons filled the body donation forms. Conclusion: Newspapers, healthcare professionals could be utilized to further the awareness regarding body and organ donation. Carrying out awareness programmes will help to reach information to each individual, clarifying any myths and increasing understanding and motivation levels among

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