A Case-Control Study on the Relationship Between Cholecystectomy and Cholangiocarcinoma in China

Abstract Aims: The present study aimed to explore the correlation between cholecystectomy and cholangiocarcinoma, and to provide preliminary clinical basis for precise cholecystectomy in China.Methods: We conducted a retrospective analysis of 9744 patients with cholangiocarcinoma, colon cancer, pancreatic cancer, femoral fracture, and hepatic hemangioma diagnosed in Xijing hospital from August 2008 to August 2018. They were divided into three groups: case group (1749 cases of cholangiocarcinoma), positive control group (3137 cases of colon cancer and 1950 cases of pancreatic cancer), negative control group (1794 cases of femoral fracture and 1114 cases of hepatic hemangioma). We collected the general information (gender, age), past medical history, cholecystectomy history from the patients, and these data were analyzed by chi-square test and logistic regression analysis. Results: The cholecystectomy rate of the case group was significantly higher than that of the positive control group and the negative control group by chi-square test (p<0.025). The cholecystectomy rate and the history of cholecystolithiasis were analyzed by logistic multivariate regression analysis. The OR values of cholecystectomy rate were 1.553 (95%CI: 1.311-1.840) and 3.181 (95%CI: 2.561-3.951), respectively, and the difference was statistically significant (p<0.000). The OR values of the history of cholecystolithiasis were 2.460 (95%CI: 2.093-2.890) and 5.426 (95%CI: 4.325-6.809), respectively, and the difference was statistically significant (p<0.000). In case group, the difference between cholecystectomy and cholecystolithiasis was statistically significant (p<0.000) by chi-square test. Conclusions: In conclusion, cholecystectomy is one of the risk factors of cholangiocarcinoma and the patients who undergo cholecystectomy have a higher risk of cholangiocarcinoma than the control groups. Cholecystectomy should be conducted with caution and the precise surgical treatment of gallbladder diseases is advocated.

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UJI EFEK ANALGESIK EKSTRAK ETANOL DAUN GEDI (Abelmoschus manihot (L.) Medik) PADA MENCIT (Mus musculus)

Jurnal e-Biomedik ◽

10.35790/ebm.1.1.2013.4601 ◽

2013 ◽

Vol 1 (1) ◽

Author(s):

Ristanti Pratiwi ◽

Jimmy Posangi ◽

Fatimawali .

Keyword(s):

Analgesic Effect ◽

Ethanol Extract ◽

Negative Control Group ◽

Positive Control ◽

Negative Control ◽

Maximum Effect ◽

Control Group ◽

Hot Plate ◽

Thermal Pain ◽

The Difference

Abstract: The objectives of the research were to find out the analgesic effect of giving Gedi (Abelmoschus manihot (L.) Medik) leaf ethanol extract orally on the number of writhing after thermal pain induction of mice. This research using 15 mice which is divided into 5 groups consisted of 1 negative control group given by the aquades, 1 positive control group given by the tramadol, and 3 experiment groups. Experiment group given by Gedi (Abelmoschus manihot (L.) Medik) leaf ethanol extract with the doses which different each other, that is 30 mg/30 g BW, 60 mg/30 g BW and 120 mg/30 g BW. Thermal pain induction was done by placing the mice on hot plate constant temperature of 550C. The mice gave respond in the way of lick its foot or even jumping. The data was collected using table, graphic and analyzed using one direction ANOVA model and it was continued with LSD test to find out the difference every treatment group. The result of analysis showed that gedi’s leaf ethanol extract have the analgesic effect and the maximum effect presented at gedi leaf ethanol extract dosage 60 mg/30 g BW. Keywords: Gedi’s leaf, analgesic effect Abstrak: Tujuan penelitan ini yaitu menemukan efek analgesik dari pemberian ekstrak etanol daun gedi (Abelmoschus manihot (L.) Medik) peroral pada mencit yang kemudian diamati jumlah geliatnya setelah diinduksi panas. Penelitian ini menggunakan 15 ekor mencit yang dibagi 5 kelompok yang terdiri dari 1 kelompok kontrol negatif yang diberi aquades, 1 kelompok kontrol positif yang diberi tramadol, dan 3 kelompok eksperimen. Kelompok eksperimen diberi ekstrak etanol daun gedi dengan dosis yang berbeda-beda, yaitu 30 mg/30 g BB, 60 mg/30 g BB, dan 120 mg/30 g BB. Induksi nyeri berupa panas dilakukan dengan meletakkan mencit pada hot plate dengan suhu 550C . Mencit memberi respon berupa menjilat kaki dan atau melompat. Data disajikan berupa tabel, grafik dan menggunakan analisis statistik ANOVA yang dilanjutkan dengan LSD untuk menemukan perbedaan dari setiap kelompok. Hasil analisis menunjukkan bahwa ekstrak etanol daun gedi memiliki efek analgesik dan efek maksimumnya didapatkan pada dosis 60 mg/30 g BB. Kata kunci: Daun gedi, efek analgesik

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Sealing Ability of Mineral Trioxide Aggregate, Biodentine and Glass Ionomer as Root-End Materials: A Question of Choice

Acta Medica Academica ◽

10.5644/ama2006-124.312 ◽

2021 ◽

Vol 49 (3) ◽

pp. 232

Author(s):

Aida Džanković ◽

Naida Hadžiabdić ◽

Samra Korać ◽

Irmina Tahmiščija ◽

Alma Konjhodžić ◽

...

Keyword(s):

Mineral Trioxide Aggregate ◽

Negative Control Group ◽

Positive Control ◽

Negative Control ◽

Control Group ◽

Dye Penetration ◽

Anterior Teeth ◽

Sealing Ability ◽

Significant Difference ◽

The Difference

Objectives. The goal of this study was to determine the sealing ability of MTA, Biodentine, and Fuji IX as root-end materials after ultrasonic retrograde preparation using a dye penetration method. Materials and Methods. Seventy permanent anterior teeth were used in this study. Root canals were prepared using rotary endodontic files, and obturated using the lateral condensation technique. The resection of the root apices was performed perpendicularly to the long axis, and 3 mm deep retrocavities were made by ultrasonic tips. The samples were randomly divided into three experimental groups (N=20) and two control groups (N=5). The root-end cavities were filled with mineral-trioxide aggregate (Rootdent MTA, TehnoDent, Russia) in Group 1, Biodentine (Septodont, Saint Maur des Fossés, France) in Group 2 and Fuji IX GP (GC Corporation, Tokyo, Japan) in Group 3. The retrocavities of the positive control group were left unfilled, while retrocavities in the negative control group were sealed using a flowable composite material. The samples were made transparent, and dye penetration was assessed under a stereomicroscope (x10). The data were analyzed with the Kruskal-Wallis test and the Mann-Whitney U-test. Results. The Biodentine group had a lower mean leakage value than the MTA and Fuji IX groups, and the difference was statistically significant (P<0.01). No statistical difference in apical microleakage was found between the MTA and Fuji IX groups (P>0.05). Conclusion. Within the limitations of this study, it was concluded that Biodentine provides better sealing ability as a root-end material than MTA and Fuji IX. There was no statistically significant difference between the sealing ability of MTA and Fuji IX as root-end materials.

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PERBEDAAN POLA MAKAN PADA BALITA STUNTING DAN TIDAK STUNTING DI KECAMATAN TEON NILA SERUA (TNS) KABUPATEN MALUKU TENGAH

VISIKES: Jurnal Kesehatan Masyarakat ◽

10.33633/visikes.v20i1.3596 ◽

2021 ◽

Vol 20 (1) ◽

Author(s):

Trixie Leunupun ◽

Ani Margawati ◽

Annastasia Ediati

Keyword(s):

Child Growth ◽

The Body ◽

Control Group ◽

Case Group ◽

Research Subjects ◽

Chi Square ◽

Significant Difference ◽

Chi Square Test ◽

Good Energy ◽

The Difference

Stunting is a condition that describes the growth of children due to long-term malnutrition. Stunting according to WHO is based on the index of the body length compared to age (PB/U) or height compared to the age (TB/U) with the Z-score limit of less than-2 SD. The age of toddlers is an age where child growth and development happens very quickly. In that age toddlers often experience health problems especially nutritional problems. Insufficient nutritional intake can cause stunting and can inhibit children's development. Design of observational analytic research with case-control design in toddlers aged 2-3 years. The population of this research is all toddlers who reside in the working area of Puskesmas Layeni subdistrict of Central Maluku district. Sample research is done using the Lameshow formula. The study used the ratio of 1:1 so that the number of research subjects in the case group was equivalent to the number of research subjects in the control group (i.e. 30 children per group), resulting in a total subject of 60 children. Analysis of the data used to see the difference between variables using the chi-square test. Variable dependent events are stunting and independent dietary variables. The results of the chi-square test show that there is no difference between the diet (the level of energy and protein adequacy) in a stunting toddler and not stunting the value (p > 0.05). The conclusion of the diet (adequacy of energy and protein) respectively in the group of cases is not too much of a significant difference. But in the control group more toddlers with good energy and protein adequacy levels. Keywords: toddler, diet, stunting

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Hubungan antara Frekuensi dan Durasi Diare dengan Kejadian Stunting pada Balita Usia 24-36 Bulan di Desa Kedungrejo Kecamatan Pakis

Journal Of Issues In Midwifery ◽

10.21776/ub.joim.2020.004.03.4 ◽

2020 ◽

Vol 4 (3) ◽

pp. 131-141

Author(s):

Zakiya Miladya Choiroh ◽

◽

Era Nurisa Windari ◽

Astri Proborini ◽

◽

...

Keyword(s):

The Body ◽

Bivariate Analysis ◽

Control Group ◽

Case Group ◽

Validity And Reliability ◽

Chi Square ◽

Group Data ◽

Chi Square Test ◽

History Of ◽

Fluid Levels

Stunting is a condition where there a disruption of growth in body length or height that not by age. A history of infectious diseases are one of the direct factors that can cause this condition. Diarrhea is an infectious disease which if occurs continuously can cause a significant decrease in fluid levels in the body, causing interference in the absorption of nutrients. This study aimed to analyze the relationship between the frequency and duration of diarrhea with the incidence of stunting in children aged 24-36 months. The study used a case control design with the subjects of the case group was stunting toddlers with their mother while the control group was non-stunting toddlers with their mother in Kedungrejo village, District of Pakis with a total of 24 for each group. Data was collected by anthropometric measurements in toddlers and mothers were interviewed using a diarrhea history questionnaire that had been tested for validity and reliability. The bivariate analysis used Chi-Square test. The results showed that from of 48 subjects, the percentage of toddlers aged 24-36 months who had a history of frequent diarrhea frequency was 14,5% (7 children) and the percentage of toddlers who had a mean duration of long diarrhea was 33,3% (16 children). Statistical test results showed that frequency of diarrhea was not significantly related (p = 1,000) but increased the risk of stunting by 1,4 times, while the duration of diarrhea was significantly related (p = 0,030) and increased the risk of stunting by 5,0 times. It can be suggested that counseling is needed to provide information to the public about the first aid of diarrhea in toddlers as to minimize delays in treatment and reduce the risk of stunting.

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Differences of Born Body Length, History of Infectious Diseases, and Development between Stunting and Non-Stunting Toddlers

Jurnal Berkala Epidemiologi ◽

10.20473/jbe.v6i22018.182-191 ◽

2018 ◽

Vol 6 (2) ◽

pp. 182

Author(s):

Dewi Fitria Permatasari ◽

Sri Sumarmi

Keyword(s):

Infectious Diseases ◽

Body Length ◽

Sampling Technique ◽

Simple Random Sampling ◽

Control Group ◽

Case Group ◽

Chi Square ◽

Chi Square Test ◽

History Of ◽

Inadequate Nutrition

ABSTRACTBackground: Stunting reflects the largely result of inadequate nutrition and attacks recurring infections in the first 1.000 days of life, that cause in develepmental obstacles. Purpose: This study was to analyze the differences born body length, history of infectious diseases, development between stunting, and non stunting children age 24-36 months. Methods: The type of this research was observational analytic with case control study. The sample size was 68 toddlers consist of 34 stunting childrens as case group and 34 non stunting children as control group in the catchment area of Jagir Public Helath Center in Surabaya. Sampling technique using simple random sampling. The observed variabls were born body length, history of infectious diseases, and child development. The data were collected using microtoise, questionnaire, and Denver Developmental Screening Test (DDST) sheets. Data were analyzed using chi square test. Results: This research showed significancy between stunting and non stunting children with difference of born body length (p = 0,01), history of infectious diseases (p = 0,01), and toddlers’ development (p = 0,01). Conclusion: There were difference variables of born body length, history of infectious diseases, and development between stunting and non stunting children age 24-36 months.

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ROLE OF HEPATITIS B AND HEPATITS C VIRUS COINFECTION IN TB DEVELOPMENT

Folia Medica Indonesiana ◽

10.20473/fmi.v52i1.5204 ◽

2017 ◽

Vol 52 (1) ◽

pp. 19

Author(s):

Pudji Lestari ◽

Ivan Rahmatullah ◽

Dwi Susanti

Keyword(s):

Hepatitis C ◽

Hepatitis B ◽

Female Respondent ◽

Control Group ◽

Case Group ◽

Hepatitis C Infection ◽

Chi Square ◽

Chi Square Test ◽

History Of

Tuberculosis developed differently in each individual. The role of HIV in the disease development is widely known unlike the role of Hepatitis B and Hepatitis C infection. Therefore, this study is aimed at to describe the role of those co-infections in the TB development. The study employed observational – case control design with two groups, case and control group. Data collection include TB condition, whether latent or manifest, and history of Hepatitis B and Hepatitis C co-infection. The study successfully recruited the total of 32 respondents in each group. At the case group, the number of male and respondent is 19 and 13. Meanwhile, at the control group the number male respondent is 10 and the female respondent is 22. The study found that 20 and 12 respondents were positive Hepatitis B at the case and the control group. Chi-square test resulted significant different between two groups (P=0.0455 and a =0.05) with odd ratio p=0.479. Meanwhile, the study only tested one respondent with positive Hepatitis C at case group and one at control group. Comparison analysis found no significant different between groups (P=1 and a =0.05). This study reveals that TB patients are more likely to have history of Hepatitis B 2.7 times than those at the control group with the same infection but without TB development. Therefore, the possibility of Hepatitis B co-infection has role in the TB manifestation, but not for Hepatitis C co-infection.

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HUBUNGAN TUNGAU DEBU RUMAH, PAPARAN ASAP ROKOK DAN RIWAYAT PENYAKIT KELUARGA TERHADAP KEJADIAN ASMA BRONKIAL PADA ANAK USIA 5 – 10 TAHUN DI WILAYAH KERJA PUSKESMAS LEMPAKE KOTA SAMARINDA TAHUN 2016

KESMAS UWIGAMA: Jurnal Kesehatan Masyarakat ◽

10.24903/kujkm.v3i1.327 ◽

2018 ◽

Vol 3 (1) ◽

pp. 1

Author(s):

Sri Evi New Yearsi Pangadongan ◽

Agustina Rahyu ◽

Selvy Pasulu

Keyword(s):

Cigarette Smoke ◽

Bronchial Asthma ◽

Sampling Technique ◽

Total Sample ◽

Control Group ◽

Case Group ◽

Chi Square ◽

History Of ◽

Weather Changes ◽

And Gender

Bronchial Asthma generally starts from childhood which is condition where respiration channel experiences constriction because of hyperactivity with some specific stimulation which cause inflammation. Some risk factors are smoking exposure of cigarette smoke, weather changes, mite on house dirt, pet and history of family sickness. The purpose of this research is to know Relation of mite on house dirt, exposure of cigarette smoke and history of family sickness with bronchial asthma incident to child 5 – 10 years old on working area of Puskesmas Lempake Samarinda City in 2016. Method which used was analytic survey with Case Control approaching. The total sample was 36 children which consisted of 18 case group and 18 control group with matching by using age and gender which submitted with Purposive Sampling technique. Data Analysis used Chi Square with wrong degree α = 0,005. The result showed that there was relation of mite of house dirt (p = 0,006), history of family sickness (p = 0,001) and no relation with exposure of cigarette smoke (p = 0,370) with bronchial asthma incident to child 5 – 10 years old on working area of Puskesmas Lempake Samarinda City in 2016.

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Berat Badan, Panjang Badan dan Faktor Genetik sebagai Prediktor Terjadinya Stunted pada Anak Sekolah

JURNAL NUTRISIA ◽

10.29238/jnutri.v19i2.257 ◽

2017 ◽

Vol 19 (2) ◽

pp. 95

Author(s):

Hetriana Leksananingsih ◽

Slamet Iskandar ◽

Tri Siswati

Keyword(s):

Birth Weight ◽

Nutritional Status ◽

School Children ◽

Genetic Factors ◽

Control Group ◽

Case Group ◽

Normal Birth Weight ◽

Chi Square ◽

Normal Birth ◽

Chi Square Test

Background: Riskesdas in 2013 showed that Yogyakarta (DIY) had a prevalence of stunted new kid in school is less than the national average, which is 14.9% (MOH, 2013). Stunted or short, is a linear growth retardation has been widely used as an indicator to measure the nutritional status of individuals and community groups. Stunted can be influenced by several factors: birth weight, birth length match and genetic factors. Objective: To determine the weight, length of low birth weight and genetic factors as predictors of the occurrence of stunted on elementary school children. Methods: The study was a case control analytic. Research sites in SD Muhammadiyah Ngijon 1 Subdistrict Moyudan. The study was conducted in May and June 2015. The subjects were school children grade 1 to grade 5 the number of cases as many as 47 children and 94 control children. With the inclusion criteria of research subjects willing to become respondents, was present at the time of the study, they have a father and mother, and exclusion criteria have no data BB and PB birth, can not stand upright. The research variables are BBL, PBL, genetic factors and TB / U at this time. Data were analyzed by chi-square test and Odd Ratio (OR) calculation. Results: In case group as much as 91.5% of normal birth weight and length of 80.9% of normal birth weight, most of the height of a normal mother and father as many as 85.1%. In the control group as much as 78.7% of normal birth weight and 61.7% were born normal body length, height mostly normal mom and dad that 96.7% of women and 90.4% normal normal father. Statistical test result is no significant correlation between height mothers with stunted incidence in school children, and the results of chi-square test P = 0.026 with value Odd Ratio (OR) of 3.9 and a range of values from 1.091 to 14.214 Cl95%. Conclusion: High maternal body of mothers can be used as predictors of the occurrence of stunted school children and mothers with stunted nutritional status have 3.9 times the risk of having children with stunted nutritional status.

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The Comparison of Ostecyte in the Pressure area and Tension area on Tooth Movement Because of Hyperbaric Oxygen Therapy

DENTA ◽

10.30649/denta.v12i1.162 ◽

2018 ◽

Vol 12 (1) ◽

pp. 34

Author(s):

Arya Barahmanta ◽

Muhammad Faizal Winaris ◽

Pambudi Raharjo

Keyword(s):

Hyperbaric Oxygen ◽

Oxygen Therapy ◽

Tooth Movement ◽

Bone Remodelling ◽

Orthodontic Tooth Movement ◽

Negative Control Group ◽

Positive Control ◽

Negative Control ◽

Control Group ◽

Pressure Area

Background: Orthodontic tooth movement is a interaction prosess of resorption and deposition of bone remodeling. Orthodontic tooth movement by mechanical strength causes changes in alveolar bone. Osteocyte is an essential cell to respond bone remodelling. Hyperbaric Oxygen Therapy affects production of osteocyte because it can release Reactive Oxygen Species (ROS) and Nitrid Oxide (NO). Purpose: To determine the difference number of osteocyte in pressure and tension area during tooth movement by adjuvant of Hyperbaric Oxygen 2,4 ATA during 7 days starting on day 8 to day 14. Materials and Methods: This research used Completery Randomized Control Group Post Test Only Design. 36 cavia cobaya (male) were divided into 3 groups randomly : the negative control groups, positive control group, and treatment group. Preparat staining used Hematoxylin Eosin (HE) and calculated on microscop 1000x with 20 field of view. Data analyses used one way ANOVA and LSD test then compared each area by using paired T test. Result: The data showed that the treatment group (P=10,67) tension area has the highest number of osteocyte than negative control group (K-=3,67), positive control (K+=7,42). In the pressure area showed that negative control group (K-=5,00) has the highest than positive control group (K+=3,83) and treatment (P=3,25). Conclusion: Therapy HBO 2,4 ATA 7 days starting on day 8 to day 14 is could increase osteocyte in the tissue to stimulate process of bone remodelling.<pre> </pre>Keywords: Hyperbaric Oxygen, Tooth movement, Bone remodeling, Osteocyte Correspondence: Arya Brahmanta, Department of Orthodonty, Faculty of Dentistry, Hang Tuah University, Arif Rahman Hakim 150, Surabaya, Phone 031-5945864, Email: <a href="mailto:[email protected]">arya.brahmanta@hangtuah.ac.id</a>

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Efek Ekstrak Etanol Kulit Petai (Parkia speciosa Hassk) Terhadap Penurunan Kadar Glukosa Darah Mencit Jantan

Jurnal Katalisator ◽

10.22216/jk.v3i1.2178 ◽

2018 ◽

Vol 3 (1) ◽

pp. 1

Author(s):

Verawaty Verawaty ◽

Dhea Claudia Novel

Keyword(s):

Blood Glucose ◽

Ethanol Extract ◽

Negative Control Group ◽

Positive Control ◽

Negative Control ◽

Control Group ◽

Male Mice ◽

Glucose Levels ◽

The Third ◽

Blood Glucose Levels

Penelitian ini bertujuan untuk melihat pengaruh pemberian ekstrak etanol kulit petai (Parkia speciosa Hassk) terhadap penurunan kadar glukosa darah mencit jantan yang diinduksi aloksan. Hewan percobaan dibagi atas 5 kelompok diantaranya kelompok kontrol negatif, kelompok kontrol positif,dosis I (280 mg/kgBB mencit), dosis II (560 mg/kg BB mencit), dosis III (840 mg/kg BB mencit). Penelitian dilakukan selama 21 hari. Persentase penurunan kadar glukosa darah mencit jantan setelah diberikan ekstrak etanol kulit petai pada hari ke-21 adalah dosis I (77,52 %) lebih besar dibandingkan dengan dosis II (69,5 %) dan dosis III (73,37 %). Data yang diperoleh dianalisis dengan uji Two Way Anova dengan program SPSS 17. Hasil penelitian ini menunjukkan bahwa pemberian ekstrak etanol kulit petai untuk tiga variasi dosis menyatakan perbedaan yang bermakna secara statistik terhadap penurunan kadar glukosa darah mencit jantan.Petai (Parkia speciosa Hassk) has a compound β-sitosterol and stigmasterol that have efficacy to decreased blood glucose levels. This study aimed to determine the effect of ethanol extract of petai peel for decrease blood glucose levels of male mice induced by alloxan. Experimental animals were divided into 5 groups including negative control group, positive control group, the first dose (280 mg/kg in mice), the second dose (560 mg/kg in mice), the third dose (840 mg/kg in mice). The study was conducted for 21 days. After 21 days, the result found that the percentage of blood glucose levels after the male mice given the ethanol extract of petai peel was, the first dose (77.52%) biger than the second dose (69.5%) and the third dose (73.37%). The data obtained were analyzed by Two Way ANOVA using SPSS 17. The results showed that have signicantly difference between three dose variation of ethanol extract of petai peel in blood glucose levels.

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