scholarly journals Development of A Particle Swarm Optimization-Backpropagation Artificial Neural Network Model And Effects of Age And Gender On Pharmacokinetics Study of Omeprazole Enteric-Coated Tablets In Chinese Population

2021 ◽  
Author(s):  
Yichao Xu ◽  
Jinliang Chen ◽  
Dandan Yang ◽  
Yin Hu ◽  
Bo Jiang ◽  
...  
Keyword(s):  
Chinese Population ◽  
Age Groups ◽  
Pharmacokinetic Data ◽  
Age And Gender ◽  
Pharmacokinetics Study ◽  
High Age ◽  
Enteric Coated ◽  
And Gender ◽  
Chinese Subjects ◽  
Backpropagation Artificial Neural Network

Abstract Background: The effects of age and gender were explored on pharmacokinetics study of omeprazole enteric-coated tablets in Chinese population and a plasma concentration prediction model was developed. All the data (demographic characteristics and results of clinical laboratory tests) were collected from healthy Chinese subjects in pharmacokinetics study using 20 mg omeprazole enteric-coated tablets. A noncompartmental method was used to calculate pharmacokinetic parameters, and 47 subjects were divided into two groups based on the calculation of the median age. Pharmacokinetic data from the low-age and high-age groups or male and female groups were compared by Student t-test. After a total of 12 variables were reconstruct and convert into independent or irrelative variables by principal component analysis, particle swarm optimization (PSO) was used to construct a backpropagation artificial neural network (BPANN) model. Result: The model was fully validated and used to predict the plasma concentration in Chinese population. It was noticed that the Cmax, AUC0-t, AUC0-∞ and t1/2 values have significant differences when omeprazole was administered by low-age groups or high-age groups while there were slight or no significant differences of pharmacokinetic data were found between male and female subjects. The PSO-BPANN model was fully validated and there was 0.000355 for MSE, 0.000133 for the magnitude of the gradient, 50 for the number of validation checks. The correlation coefficient of training, validation, test groups were 0.949, 0.903 and 0.874.Conclusion: It is necessary to pay attention to the age and gender effects on omeprazole and PSO-BPANN model could be used to predict omeprazole concentration in Chinese subjects to minimize the associated morbidity and mortality with peptic ulcer.

The Influence of Age and Gender on Mandibular Indices among the Libyan Population

2019 ◽  
Vol 3 (2) ◽  
Keyword(s):  
Negative Correlation ◽  
Bone Mineralization ◽  
Age Groups ◽  
T Test ◽  
Chi Square ◽  
Age And Gender ◽  
Significant Difference ◽  
Chi Square Test ◽  
And Gender ◽  
Libyan Population

Radiographic Mandibular Indices serve as easy and relatively cheap tools for evaluating bone mineralization. Objectives: To examine the effect of age and gender on three mandibular indices: the panoramic mandibular index (PMI), the mandibular ratio (MR) and the mandibular cortical index (MCI), among Libyan population. Methods: The three indices were measured on 317 digital (OPGs) of adult humans (155 males, 162 females). The sample was divided into six age groups (from 18-25 years through 56-65 years). The measurements were analyzed for interactions with age and sex, using SPSS (Statistical Package for Social Studies) software version no. 22. The tests employed were two way ANOVA, the unpaired T-test and chi-square test. Results: The mean PMI fluctuated between 0.37 s.d. 0.012 and 0.38 s.d. 0.012. among the sixth age groups. One-way ANOVA statistical test revealed no significant of age on PMI. On the other hand gender variation has effect on PMI, since independent sample t-test disclosed that the difference between the male and female PMI means statistically significant. ANOVA test showed that the means of MR among age groups showed a negative correlation i.e. MR mean declined from 3.01 in 18-25 age groups to 2.7 in 55-65 age groups. In contrary, the gender showed no effect on MR according two sample t-test at p> 0.05. In regards with MCI, statistical analysis showed that it affected by age that is C1 was decreasing by age while C2 and C3 were increased by age. Using chi square test the result indicated that there is a significant difference among the different age group and the two genders in MCI readings. Conclusion: PMI was influenced significantly by age but minimally by the gender. MR is not affected by gender but has a negative correlation with age. MCI is affected by both age and gender

Children’s Lives and Deaths in Merovingian Gaul

2020 ◽  
pp. 185-213
Author(s):  
Émilie Perez
Keyword(s):  
Social Identity ◽  
Age Groups ◽  
New Method ◽  
Recent Analysis ◽  
Age And Gender ◽  
The Past ◽  
And Gender ◽  
Grave Goods

The role of children in Merovingian society has long been downplayed, and the study of their graves and bones has long been neglected. However, during the past fifteen years, archaeologists have shown growing interest in the place of children in Merovingian society. Nonetheless, this research has not been without challenges linked to the nature of the biological and material remains. Recent analysis of 315 children’s graves from four Merovingian cemeteries in northern Gaul (sixth to seventh centuries) allows us to understand the modalities of burial ritual for children. A new method for classifying children into social age groups shows that the type, quality, quantity, and diversity of grave goods were directly correlated with the age of the deceased. They increased from the age of eight and particularly around the time of puberty. This study discusses the role of age and gender in the construction and expression of social identity during childhood in the Merovingian period.

Age and gender differences in socially aversive (“dark”) personality traits

2021 ◽  
pp. 089020702098843
Author(s):  
Johanna Hartung ◽  
Martina Bader ◽  
Morten Moshagen ◽  
Oliver Wilhelm
Keyword(s):  
Personality Traits ◽  
Structural Equation ◽  
Age Groups ◽  
Dark Triad ◽  
Equation Modeling ◽  
Model Parameters ◽  
Age And Gender ◽  
Measurement Models ◽  
And Gender ◽  
Latent Means

The strong overlap of personality traits discussed under the label of “dark personality” (e.g., psychopathy, spitefulness, moral disengagement) endorses a common framework for socially aversive traits over and beyond the dark triad. Despite the rapidly growing research on socially aversive traits, there is a lack of studies addressing age-associated differences in these traits. In the present study ( N = 12,501), we investigated the structure of the D Factor of Personality across age and gender using local structural equation modeling, thereby expressing the model parameters as a quasi-continuous, nonparametric function of age. Specifically, we evaluated loadings, reliabilities, factor (co-)variances, and means across 35 locally weighted age groups (from 20 to 54 years), separately for females and males. Results indicated that measurement models were highly stable, thereby supporting the conceptualization of the D factor independent of age and gender. Men exhibited uniformly higher latent means than females and all latent means decreased with increasing age. Overall, D and its themes were invariant across age and gender. Therefore, future studies can meaningfully pursue causes of mean differences across age and between genders.

scholarly journals Exploring Impact of Age and Gender on Sentiment Analysis Using Machine Learning

Electronics ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 374 ◽  
Author(s):  
Sudhanshu Kumar ◽  
Monika Gahalawat ◽  
Partha Pratim Roy ◽  
Debi Prosad Dogra ◽  
Byung-Gyu Kim
Keyword(s):  
Machine Learning ◽  
Sentiment Analysis ◽  
Short Term Memory ◽  
Age Groups ◽  
Modern World ◽  
Support Vector ◽  
Digital Information ◽  
Age And Gender ◽  
And Gender ◽  
The Impact

Sentiment analysis is a rapidly growing field of research due to the explosive growth in digital information. In the modern world of artificial intelligence, sentiment analysis is one of the essential tools to extract emotion information from massive data. Sentiment analysis is applied to a variety of user data from customer reviews to social network posts. To the best of our knowledge, there is less work on sentiment analysis based on the categorization of users by demographics. Demographics play an important role in deciding the marketing strategies for different products. In this study, we explore the impact of age and gender in sentiment analysis, as this can help e-commerce retailers to market their products based on specific demographics. The dataset is created by collecting reviews on books from Facebook users by asking them to answer a questionnaire containing questions about their preferences in books, along with their age groups and gender information. Next, the paper analyzes the segmented data for sentiments based on each age group and gender. Finally, sentiment analysis is done using different Machine Learning (ML) approaches including maximum entropy, support vector machine, convolutional neural network, and long short term memory to study the impact of age and gender on user reviews. Experiments have been conducted to identify new insights into the effect of age and gender for sentiment analysis.

scholarly journals A Study of Wideband Energy Reflectance in Patients with Otosclerosis: Data from a Chinese Population

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Suju Wang ◽  
Wenyang Hao ◽  
Chunxiao Xu ◽  
Daofeng Ni ◽  
Zhiqiang Gao ◽  
...  
Keyword(s):  
Resonance Frequency ◽  
Racial Differences ◽  
Chinese Population ◽  
Ambient Pressure ◽  
Control Group ◽  
Age And Gender ◽  
Significant Difference ◽  
And Gender ◽  
And Control ◽  
Peak Pressures

Objective(s). The purpose of this study was to explore the effectiveness of wideband acoustic immittance (WAI) in the diagnosis of otosclerosis by comparing the differences in the energy reflectance (ER) of WAI between patients with otosclerosis and age- and gender-matched normal hearing controls in the Chinese population. Methods. Twenty surgically confirmed otosclerotic ears were included in the otosclerotic group. The ER of WAI at ambient and peak pressures, resonance frequency, and 226-Hz tympanogram were collected prior to surgery using a Titan hearing test platform (Interacoustics A/S, Middelfart, Denmark). All diagnoses of otosclerosis in the tested ear were confirmed by surgery after the measurements. Thirteen normal adults (26 ears) who were age- and gender-matched with the otosclerotic patients were included as the control group. Results. At peak pressure, the ERs of otosclerotic patients were higher than those of the control group for frequencies less than 4,000Hz and were lower for frequencies greater than 4,000Hz. In addition, within the analyzed frequencies, the differences observed at 2,520Hz was statistically significant (p<0.05/16=0.003, Bonferroni corrected). At ambient pressure, the differences observed at 1,260 and 6,350Hz were statistically significant (p<0.05/16=0.003, Bonferroni corrected). Although the differences between the otosclerotic and control groups exhibited similar trends to those in studies implemented in Caucasian populations, the norms in the present study in the control group were different from those in the Caucasian populations, suggesting racial differences in WAI test results. Regarding the middle ear resonance frequency, no significant difference was observed between the two groups (P>0.05). Conclusion. WAI can provide valuable information for the diagnosis of otosclerosis in the Chinese population. Norms and diagnostic criteria corresponding to the patient’s racial group are necessary to improve the efficiency of WAI in the diagnosis of otosclerosis.

scholarly journals Performance of Children in Phonemic and Semantic Verbal Fluency Tasks

Psico-USF ◽  
2016 ◽  
Vol 21 (2) ◽  
pp. 293-304 ◽  
Author(s):  
Gilmara de Lucena Leite ◽  
Izabel Augusta Hazin Pires ◽  
Laura Carolina Lemos Aragão ◽  
Artemis Paiva de Paula ◽  
Ediana Rossely de Oliveira Gomes ◽  
...  
Keyword(s):  
Explicit Memory ◽  
Verbal Fluency ◽  
Age Groups ◽  
Memory Systems ◽  
Semantic Fluency ◽  
Age And Gender ◽  
Northeast Region ◽  
Semantic Verbal Fluency ◽  
And Gender ◽  
Brazilian Northeast

Abstract This study investigated the performance of children from the Brazilian Northeast region, from 7 to 10 years in phonemic and semantic verbal fluency tasks. The participants were 102 subjects (62 girls and 40 boys) who performed three phonemic and three semantic fluency tasks. The results were submitted to correlational and variance analysis to investigate the influence of the variables age and gender on the subjects performance. There was no effect of gender on the results. Significant contrasts between age groups were found, and better performance was observed on phonemic tasks. Also, the performance in this task changed along development, in contrast to what happened with the semantic fluency. The findings seem to be in accordance to neurodevelopmental aspects, taken into account that explicit memory systems show more precocious maturational course, with earlier consolidation, in comparison to the executive functions and frontal lobes, which go on developing until adult ages.

Reliability Estimates and Age and Gender Comparisons of Expectations of Success in Sex-Typed Activities

1985 ◽  
Vol 7 (4) ◽  
pp. 379-388 ◽  
Author(s):  
Charlotte Sanguinetti ◽  
Amelia M. Lee ◽  
Jack Nelson
Keyword(s):  
Skill Acquisition ◽  
Motor Skill ◽  
Age Groups ◽  
Motor Tasks ◽  
Sex Typing ◽  
Age And Gender ◽  
Motor Skill Acquisition ◽  
Reliability Estimates ◽  
And Gender ◽  
The Stability

The purposes of this study were to determine the stability of estimations of success in masculine, feminine, and gender-neutral motor tasks with subjects of three age groups, and to compare expectancies for success of boys and girls at each of the ages. A total of 90 subjects took part in the study, including 15 males and 15 females randomly selected from the three age groups (grades 1 & 2; grades 6 & 7; and adults). Three activities (football, ballet, and swimming) had been sex-typed in a previous study as masculine, feminine, and neutral, respectively. Subjects were asked to indicate how they would expect to perform on three occasions in all three tasks. Results indicated that all age groups can provide reliable expectations for their success in motor skill acquisition, although the younger children's estimates are slightly less reliable, especially on the first trial. Sex-typing of activities was found to definitely affect the performance estimations in all three age groups. Males' expectancies were higher on the male task and females' expectancies were higher on the female task. The younger children's overall estimates of success were higher than those of the older groups.

Age- and gender-related normative value of whole-body sagittal alignment based on 584 asymptomatic Chinese adult population from age 20 to 89

2021 ◽  
Author(s):  
Z Hu ◽  
GCW Man ◽  
KH Yeung ◽  
WH Cheung ◽  
WCW Chu ◽  
...  
Keyword(s):  
Lower Limb ◽  
Sagittal Alignment ◽  
Pearson Correlation ◽  
Age Groups ◽  
Whole Body ◽  
Normative Values ◽  
Chinese Adults ◽  
Age And Gender ◽  
Age Related ◽  
And Gender

To establish the age- and sex-related normative values of sagittal alignment in asymptomatic Chinese adults, and to investigate the changes and possible associated compensation mechanisms across age groups. 584 asymptomatic Chinese adults aged 20–89 years were recruited. Subjects were grouped according to age and gender. Whole-body standing radiographs were acquired for evaluating sagittal alignment from spine to lower limb. Sagittal parameters between gender in different age groups were compared via independent t test. Pearson correlation analysis was used to demonstrate relationships between parameters. Thoracic kyphosis (TK) increased steadily while lumbar lordosis decreased gradually in both genders. Pelvic tilt (PT) in male is greater than in female across all age groups with age related gradual increase. There were significant differences between male and female from 20s to 60s in terms of knee flexion angle (KA) and ankle dorsiflexion angle (AA), but the differences were not significant after 60s. T1 pelvic angle (TPA) was significantly correlated with spinal, pelvic and lower-limb alignment. The older group (≥50 years) had a stronger correlation of TPA with PT and KA, whereas the younger (<50 years) had stronger correlation with TK. This study comprehensively presented the normative sagittal alignment based on a large asymptomatic population, which could serve as an age- and gender-specific reference value for spine surgeons when planning for correction surgery. Age can influence the recruitment of compensation mechanism that involve more pelvic and lower limb mechanisms for elderly people.

P5309Age and gender distributions of coronary artery calcium in the Dutch adult population: preliminary results of the ImaLife study

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
C Xia ◽  
M Rook ◽  
G J Pelgrim ◽  
J N Van Bolhuis ◽  
P M A Van Ooijen ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Reference Values ◽  
Coronary Artery Calcium ◽  
Adult Population ◽  
Age Groups ◽  
Population Based ◽  
Imaging Biomarkers ◽  
Dutch Population ◽  
Age And Gender ◽  
And Gender

Abstract Background Coronary artery calcium (CAC) scoring is a promising tool for cardiovascular risk classification. Population-based reference values are important for the clinical interpretation of CAC scores. Purpose To establish standards of CAC distributions by age and gender in an unselected Dutch population, which can be used to determine reference values. Methods ImaLife (Imaging in Lifelines) is a computed tomography (CT) based substudy of the Lifelines cohort, with a primary aim to establish reference values of imaging biomarkers for early stages of coronary artery disease in adults (above 45 years old). In total, 12,000 participants will be enrolled from an unselected adult population in the northern Netherlands for CAC scoring with third generation dual-source CT. CAC is quantified with dedicated commercial software using the Agatston method. Results Included so far were 3,702 participants (57.5% females, mean age 54 years, range 45–82 years). CAC was present in 39.2% of participants, with a higher prevalence of CAC in men (55.3%) than in women (27.3%). CAC scores increased with increasing age in both genders. The percentiles of CAC scores by age and gender groups are summarized in the table. Agatston CAC score percentiles by age and gender Percentiles Women – Age, years Men – Age, years 45–49 50–54 55–59 60–64 65∼ 45–49 50–54 55–59 60–64 65∼ N 505 634 719 260 10 355 473 543 185 18 25th 0 0 0 0 0 0 0 0 1 75 50th 0 0 0 0 4 0 1 6 22 556 75th 0 0 6 33 386 6 21 72 129 751 90th 4 26 77 120 1037 49 154 242 500 1803 Conclusion This preliminary result presents CAC distribution by age and gender in a middle-aged unselected Dutch population. Compared with the Heinz Nixdorf Recall study, CAC scores in our cohort for both genders were lower in the 5-year age groups between 45 and 64 years. Based on the overall data, expected within 2 years, reference values of CAC for the Dutch population can be established.

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