scholarly journals Hand Sanitizer With Natural Ingredients Exhibits Enhanced Antimicrobial Efficacy

Author(s):  
Ajay Rana ◽  
Srijana Mukhia ◽  
Raksak Acharya ◽  
Sanjay Kumar

Abstract Hand sanitizers are amongst the foremost preventive defence against coronavirus. Ever since the outbreak of this virus in late 2019 the hand sanitizers has become an essential part of our day-to-day life in fight against this contagious disease. The global demand for hand sanitizers has suddenly peaks and reaches record high with ever-increasing market. However, the regular and excessive usage of hand sanitizers, which contains chemical additives and synthetic fragrances, do have serious health and environmental hazards. Thus, due to the evident role of natural phytoconstituents and essential oils against various infectious microorganisms including viruses, they appeared as prospective and viable option for toxic and hazardous chemicals frequently used in hand sanitizers. Here we have developed an alcohol based hand sanitizer formulation supplemented with natural and sustainable ingredients like tea extract and lemon grass essential oil enriched with phenolics and natural flavours respectively. The antimicrobial efficacy of developed hand sanitizer was evaluated and compared with alcohol based hand sanitizers and commercial hand sanitizers. The results of well diffusion assay method and time-kill test have clearly revealed the enhanced effectiveness of hand sanitizer with natural ingredients compared to commercial sample and World Health Organization recommended formulation. Moreover, the herbal origin of these ingredients is very significant since the left over residues on hands after repeated usage might not have any toxicity issues. Hence, it has established that usage of tea extract and lemon grass essential oil in alcoholic hand sanitizer formulation may have positive effects on health and environment.

Author(s):  
Gilberto Schwartsmann

Overview: Cancer is now the second leading cause of death in Brazil (after cardiovascular diseases) and a public health problem, with around 500,000 new cases in 2012. Excluding nonmelanoma skin cancer, lung cancer is the second most incident cancer type in men, with 17,210 expected new cases. In women, it is the fifth most incident cancer, with 10,110 expected new cases. The estimated age-adjusted lung cancer mortality rate is about 13/100,000 for men and 5.4/100,000 for women. Lung cancer rates in men increased until the early 1990s and decreased thereafter, especially in the younger population. In contrast, a steady upward trend was observed for women. The positive effects in men were probably due to the successful anti-tobacco campaign conducted in Brazil over the last decades, which led to a decrease in the adult smoking population, from 32% in the early 1980s to 17% in the 2000s. Although the Brazilian National Cancer Institute is strongly committed to providing excellence in multimodality care to cancer patients, limitations in availability and adequate geographic distribution of specialists and well-equipped cancer centers are evident. Major disparities in patient access to proper staging and state-of-the-art treatment still exist. Considering that World Health Organization (WHO) officials estimate that cancer will become the number one cause of death in most developing countries, including Brazil, in the next decades, it is highly recommended for government authorities to implement firm actions to face this tremendous challenge.


Agronomy ◽  
2019 ◽  
Vol 9 (5) ◽  
pp. 260 ◽  
Author(s):  
Alessandro Calamai ◽  
Enrico Palchetti ◽  
Alberto Masoni ◽  
Lorenzo Marini ◽  
David Chiaramonti ◽  
...  

In recent years, biochar has generated global interest in the areas of sustainable agriculture and climate adaptation. The main positive effects of biochar were observed to be the most remarkable when nutrient-rich feedstock was used as the initial pyrolysis material (i.e., anaerobic digestate). In this study, the influence of solid anaerobic digestate and biochar that was produced by the slow pyrolysis of solid digestate was evaluated by comparing the differences in the crop growth performances of Pelargonium graveolens. The experiment was conducted in a greenhouse while using three different growth media (i.e., solid digestate, biochar, and vermiculite). The results indicated that: (i) the pyrolysis of solid digestate caused a reduction in the bulk density (−52%) and an increase in the pH (+16%) and electrical conductivity (+9.5%) in the derived biochar; (ii) the best crop performances (number of leaves, number of total branches, and plant dry weight) were found using biochar, particularly for plant dry weight (+11.4%) and essential oil content (+9.4%); (iii) the essential oil quality was slightly affected by the growth media; however, the main chemical components were found within the acceptable range that was set by international standard trade; and, iv) biochar induced the presence of leaf chlorosis in Pelargonium graveolens.


Planta Medica ◽  
2018 ◽  
Vol 84 (09/10) ◽  
pp. 662-673 ◽  
Author(s):  
Ané Orchard ◽  
Alvaro Viljoen ◽  
Sandy van Vuuren

AbstractFoot odour (bromodosis) is an embarrassing and perplexing condition mostly caused by bacteria of the Brevibacterium species. Essential oils are a credible option as an affordable treatment of odour and contribute towards antimicrobial efficacy. Therefore, this study sets out to investigate the antimicrobial activity of essential oil combinations against odour-causing bacteria. The broth microdilution method was used to investigate the antimicrobial activity of 119 essential oil combinations, and the fractional inhibitory index was calculated to determine the interactive profile. Combinations that resulted in synergy in 1 : 1 ratios were further evaluated in different concentrations, and isobolograms were plotted to determine the influence of the ratio on overall activity. Numerous combinations could be identified as having synergistic interactions against the Brevibacterium spp. and no antagonism was observed. The combination of Juniperus virginiana (juniper) and Styrax benzoin (benzoin) demonstrated synergy against all three Brevibacterium spp. tested and J. virginiana was the essential oil responsible for the majority of the synergistic interactions. The results reported here confirm the promising potential of the majority of these oils and selected combinations in treating and controlling bromodosis.


Author(s):  
Danila De Vito ◽  
Antonio Fusco ◽  
Caterina Benincasa ◽  
Luca Laghi ◽  
Francesco M. Ceruso

Background: World Health Organization (WHO) has increasingly improved the guidelines to tackle the spread of Coronavirus Disease 2019 (COVID-19) among the worldwide population. In this context, each country has introduced specific social, healthcare, political and macroeconomic measures to face COVID pandemic locally. Objective: The general aim of this comparative overview is to highlight the most significant effects of COVID-19 pandemic on the main healthcare systems. Also, we critically analyzed the macroeconomic variables and the most promising solutions to improve both healthcare system and its related risk management, taking into specific consideration the most industrialized countries. Method: The main strategy has been built on a renewed concept of the hospital, rebuilding the old concepts of “triage” and “intensive care”. Recently, COVID-19 hospitals have allowed to cater the patients affected by COVID-19. Moreover, the reshaping of several healthcare policies and requirements has led to several positive effects, such as the recruitment of a huge number of human resources in the healthcare systems. Nevertheless, several negative effects have also impacted the communities mostly subjected to infections. Conclusion: Undoubtedly, the national healthcare systems have somehow addressed the people’s needs, trying not to neglect the social, healthcare, economic and political aspects. In our overview, we have reported how the different actions taken in the last months, have resulted in different outcomes.


2002 ◽  
Vol 10 (3) ◽  
pp. 392-400 ◽  
Author(s):  
Rachel Z. Booth

A worldwide shortage of nurses has been acknowledged by the multidisciplinary Global Advisory Group of the World Health Organization. The shortage is caused by an increased demand for nurses, while fewer people are choosing nursing as a profession and the current nurses worldwide are aging. The shortage applies to nurses in practice as well as the nurse faculty who teach students. The inter-country recruitment and migration of nurses from developing countries to developed countries exacerbates the problem. Although public opinion polls identifies the nurse as the person who makes the health care system work for them, the conditions of the work environment in which the nurse functions is unsatisfactory and must change. Numerous studies have shown the positive effects on the nurse of a healthy work environment and the positive relationships between nursing care and patient outcomes. It is important that government officials, insurance companies, and administrators and leaders of health care systems acknowledge and operationalize the value of nurses to the health care system in order to establish and maintain the integrity and viability of that system.


Author(s):  
Manuj Kumar Sarkar ◽  
Subhra Dey ◽  
Boudhayan Das Munshi

The first case of SARS-CoV2 admitted on 26th December 2019 in Central Hospital, Wuhan, China. Broncho-alveolar lavage and Polymerase chain reaction of the aspirate showed high abundance of a viral RNA which has 89.1 % nucleotide identity with bat coronavirus previously isolated in China. Soon human to human transmission was observed and the outbreak started spreading. World Health Organisation on 11th March 2020 declared it as pandemic. COVID 19, caused by SARS-CoV-2, a disease we are still struggling to contain. With vaccination drive throughout the world, though the severity in re-infection has come down, but there is still threat by the various variants which are arising from time to time in various countries. The most effective way of preventing the spread of the virus is to keep physical distance from others of at least 1 meter, wearing a well fitted mask, keep hands clean and use hand sanitizer frequently, stay in well ventilated place, avoid crowded place and cough into bent elbow or tissue paper and get vaccinated when once’s turn comes. Therefore, we urge people to follow COVID appropriate behaviour properly. Keywords: COVID 19, SARS-CoV2, COVID appropriate behaviour, Social Distancing


2020 ◽  
Vol 4 (1) ◽  
pp. 137-138
Author(s):  
Syed Alamadar Hussein ◽  
◽  
Raheela Kanwal ◽  
Huma Balqias ◽  
Usman Farooq ◽  
...  

Since the start of 2020, a COVID-19 emerged as a new strain of Coronavirus. Initially, it affected the population of Wuhan, China and after that it outspread all over the world and was declared as a pandemic by World Health Organization on 30th January, 2020.1 It has been identified that COVID-19 can cause mild illness including common cold to more severe condition known as acute respiratory distress syndrome (ARDS), if not treated promptly.2 While people of all ages are susceptible to COVID-19, those over 60 years of age and with cardiovascular diseases along with diabetes have even more chances of becoming seriously ill Whereas children seem to be less affected.3 Currently there is no pharmacological treatment, still some antiviral drugs have been proven to be helpful along with plasma transfusion in which plasma is extracted from the blood of patient who got recovered from COVID-19 an is transfused into the patient still suffering from the said disease.4 Symptoms of respiratory complications due to this disease influence the mind of a Physical Therapist (PT). Though after discussing the maneuvers of respiratory Physical Therapy with fellow professional colleagues as well as clinicians and practically applying it on respective relatives, friends and advice seekers after getting the informed consent from them; those who started to have initial symptoms of COVID-19 before being tested positive and then later got positive. It resulted in great ease for most of them to breathe and did not led to serious respiratory complications that include dyspnea and accumulation of thick and tenacious secretions inside the lungs, which ultimately is a precursor of pneumonia. Following were the PT interventions suggested to the patients showing acute symptoms; Steam inhalation, breathing exercises and postural drainage positions were inculcated in the treatment plan and guided respectively, steam inhalation therapy is normally advised to be used as primary care in acute respiratory diseases.5 It is most commonly used therapy at home and is inexpensive, moreover it promotes self-reliance in the patients; it is used therapeutically by inhaling steam through nose so that it reaches the respiratory system.6-8 Steam inhalation helps in loosening the mucus, it opens the nasal airway passages decreases mucosal inflammation and heat can prevent replication of viruses.9 It helps to relax muscles and relieves coughing by preventing excessive dryness in the mucosal membranes.10 Moreover, breathing exercises have been reported to have beneficial effects in improving symptoms and optimizing pulmonary function in patients. Breathing programs have been reported to have positive effects in alleviating symptoms and optimizing pulmonary function in patients.11 Breathing exercises aim to improve the individuals breathing pattern and increase in lung expansion, they also enhance the performance of respiratory muscles thus leading towards increase in functional residual capacity, and inspiratory reserve volume.12 Breathing exercises reduces breathlessness, increase exercise capacity and improve overall well-being of a person 13,14,15,16 The physiological effect of breathing exercises comprises of increase in intra-bronchial pressure thus preventing the collapse of bronchi and leading towards increase in inspiratory and expiratory flow rate.13,15 It act by stimulating the autonomic system thereby promoting relaxation and in return improves the physiological parameters.16 Furthermore, body positioning improves the efficiency and effectiveness of both primary and accessory muscles of breathing leading to ease in dyspnea and reduction in work of breathing.17 These positions improve the ventilation perfusion ratio and utilize the gravity to remove secretions.18 Positioning decrease the ventilation demand resulting in longer expiratory time thereby preventing hyperinflation and ultimately resolving dyspnea.19 As a healthcare professional and specially a Physical Therapist we would like to ask the imminent researchers to fill this gap by conducting different surveys and trials. Through our experience we’ve found that the manoeuvres we applied have been very effective and improved the overall outcome of the patients suffering from COVID -19.


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