scholarly journals Interactome, Network, and Enrichment Motif Analysis Reveals Possible Linkage Between Human Mental Disorders, Emotions, and Coronavirus: In-Silico Insight

Author(s):  
Peter T. Habib

Abstract The pandemic of COVID-19 has caused a global crisis. Today, everybody focuses on COVID-19 infection prevention, preparation, and discussion of physical health effects issues. It is important to understand, however, that a few will face life-threatening negative effects on physical health, but that all people will face the negative impact of the pandemic on mental health. COVID-19 hospitals are established in different locations to address the physical health implications of the pandemic. However, it is necessary to understand the effects of infections on mental health more effectively to prevent the negative consequences of infection. Here, we try to find out how the infection could affect mental health. We identify motifs in SARS-CoV-2 that are predicted to interact with human transcription factors (TF). Those TFs regulating behavior and mental health. Our results show that SARS-CoV-2 infection may lead to overactivation or inhibition of critical genes already known to affect behavior and mental health. This study is still limited to in silico limits so, clinical investigation needs to be addressed to assess our hypothesis.

2020 ◽  
Author(s):  
Eric Bonetto ◽  
Sylvain Delouvée ◽  
Yara Mahfud ◽  
Jais Adam-Troian

Social distancing and mass quarantines were implemented worldwide in response to the current COVID-19 pandemic. Prior research on the effects of social isolation has shown that such measures bear negative consequences for population health and well-being. Conversely, a growing body of evidence suggests that feeling positively identified with a group is associated with a range of physical and mental health benefits. This effect is referred to as the social cure and generalizes to various identities. In line with these findings, this study tested whether national identification could promote wellbeing and physical health during the COVID-19 pandemic. To do so, we used survey data conducted among 67 countries (N = 46,450) which included measures of wellbeing, national identification, and subjective physical health. Mixed-model analyses revealed that national identity was indeed associated with wellbeing - despite adjustment on social belonging, COVID-19 perceived risk, exposure, and ideology. This effect did not extend to subjective health. These results suggest that the mere feeling of belonging to a national group may have mental health benefits and could be leveraged by governments. We discuss the implications of our findings within the social cure framework and their relevance for population mental health under COVID-19.


Author(s):  
Ben Y. F. Fong ◽  
Martin C. S. Wong ◽  
Vincent T. S. Law ◽  
Man Fung Lo ◽  
Tommy K. C. Ng ◽  
...  

In Hong Kong, social distancing has been adopted in order to minimise the spread of COVID-19. This study aims to examine the changes in physical health, mental health, and social well-being experienced by local residents who were homebound during the pandemic. An online questionnaire in both Chinese and English versions was completed by 590 eligible participants from 24 April to 13 May 2020. The questionnaire found that individuals aged 18 to 25 years spent more time resting and relaxing but experienced more physical strain. Working status was associated with social contact, with participants working full-time jobs scoring higher in “maintaining social communication via electronic means” and “avoiding social activities outside the home”. Additionally, approximately one third of the participants (29.7%) had moderate to severe depression, and participants aged 18 to 25 were found to have higher scores in PHQ-9. Changes in physical health and social contact were significantly associated with developing depressive symptoms. From the results, it is clear that the COVID-19 pandemic has the potential to exert a negative impact on the mental health status of individuals.


2018 ◽  
Vol 122 (5) ◽  
pp. 1600-1617 ◽  
Author(s):  
Steve Thill ◽  
Claude Houssemand ◽  
Anne Pignault

The negative effects of job loss on mental health have been thoroughly described in the literature. However, different fluctuations in mental health during the unemployment period have been noticed. We argue that a coping process takes place in this kind of situation. Therefore, in this study, we investigated the effect of the unemployment normalization process on mental health during various stages of unemployment. Participants ( N = 803) completed the General Health Questionaire-12 and the Unemployment Normalization Questionnaire. Results showed that a negative perception of unemployment had the greatest impact on mental health during the different phases of unemployment. Nevertheless, during the first year, having a positive perception counteracted these negative effects, and after 1 year, the unemployment norm took over the role of buffering against the negative effects on mental health. These results indicate that unemployment is still perceived as negative, but depending on the stage of unemployment, various coping strategies are used to buffer the negative consequences of unemployment.


Author(s):  
J. Kuokkanen ◽  
A Tiili ◽  
A. Paasivirta

In the spring 2020, the first wave of the coronavirus pandemic quickly spread across Finland, having significant negative consequences for people’s living conditions. On March 16, 2020, the Finnish government declared a state of emergency and imposed several restrictive measures that were in effect until July 16, 2020 [13; 16]. The coronavirus and its aftermath have weakened the resilience of the Finnish welfare state, thereby challenging the welfare state’s ability to protect those most in need of its support. Recent studies have shown that the most vulnerable populations, such as children, are most affected by the negative effects of the pandemic in Finland and worldwide [5; 9; 11; 14; 18]. In autumn 2020, the Central Union for Child Welfare (CUCW) and the National Institute for Health and Welfare (THL) conducted a large-scale survey among the heads of child protection authorities (15.08.—13.10.2020), the aim of which was to find out how the consequences of the coronavirus and government restrictions have affected the well-being of children and their families who are clients of child protection authorities during the fall 2020. This article presents the main results and conclusions of the survey.


2021 ◽  
Vol 9 ◽  
Author(s):  
Mir Nabila Ashraf ◽  
Hannah Jennings ◽  
Nantu Chakma ◽  
Noshin Farzana ◽  
Md. Saimul Islam ◽  
...  

Background: The negative impact of COVID-19 on mental health has been reported by media throughout the world, although this role is not well-understood in low-and middle-income countries (LMIC). We examined the reporting of mental health issues during the COVID-19 pandemic in Bangladesh and initiatives undertaken to support mental health reported from the viewpoint of media.Methods: We reviewed articles published in 10 local newspapers, including seven Bangla and three English newspapers, during the first year of the COVID-19 pandemic. News topics were identified through discussions among the team members, with searches across online newspapers and portals. Data extrapolated from newspapers were documented in an Excel spreadsheet. A mixed-method approach was used following a framework analysis for analyzing data. Recurring issues and commonly emerging topics were generated from the data. Descriptive statistics were applied for analyzing quantitative data.Results: Between March 2020 and March 2021, we have identified 201 reports on mental health issues including 45 reports (22.4%) focused on stress due to the associated financial crisis, unemployment and loneliness, 50 reports (24.9%) of 80 apparent suicides linked to family issues, disharmony in conjugal relationships, harassment, sexual violence, emotional breakdown, financial crisis, and stigma due to COVID-19.There were 77 reports (38.3%) concerning domestic violence during the pandemic. Twenty-nine reports (14.4%) referenced actions taken by different organizations to address mental health issues in response to the pandemic in Bangladesh.Conclusion: News coverage has the scope to highlight important issues that can emerge as a consequence of the COVID-pandemic, such as mental health, in a low resource setting. Capacity building of the media on the way to report mental health issues during emergency situations could be a useful strategy for more credible reporting on mental health issues during the COVID-19 pandemic for raising awareness of the public and policymakers about the negative consequences on mental health of the COVID-19 pandemic in Bangladesh. Adopting policies to support essential mental health care and promoting the local organizations to take timely public health measures will be imperative for averting the negative consequences of mental health due to the COVID-19 pandemic in Bangladesh.


2020 ◽  
Author(s):  
Lisa B Thorell ◽  
Charlotte Borg Skoglund ◽  
Almudena Giménez de la Peña ◽  
Dieter Baeyens ◽  
Anselm Fuermaier ◽  
...  

The aim of the present study was to examine parental experiences of homeschooling during the COVID-19 pandemic in families with or without a child with a mental health condition across Europe. The study included 6720 parents (2002 parents with a child with a mental health condition and 4718 without) from seven European countries: the United Kingdom (n=508), Sweden (n=1436), Spain (n=1491), Belgium (n=508), the Netherlands (n=324), Germany (n=1662) and Italy (n=794). Many parents found homeschooling to be of poor quality, with insufficient support from schools and general negative effects on both children and parents. In most countries, online teaching was uncommon, leaving parents with primary responsibility for managing their child’s schooling. Parents also reported increased levels of stress, worry, social isolation, and domestic conflict. A small number of parents reported increased parental alcohol/drug use. Some differences were found between countries and some effects were more pronounced in families with a child with a mental health condition. However, group differences were generally small, indicating that negative effects were present in many families across countries. It should also be noted that some parents reported positive effects of homeschooling for their child or themselves. The adverse effects of homeschooling will likely have a long-term impact and contribute to increased inequalities. Given that school closures have been argued to be less effective than other social distancing interventions, policymakers need to carefully consider the negative consequences of homeschooling during a possible second wave of the COVID-19 pandemic and future pandemics.


Author(s):  
Katarzyna Piwowar-Sulej ◽  
Dominika Bąk-Grabowska

The purpose of the study is to analyze the correlations between two clearly defined forms of non-standard employment (self-employment and mandate contract) and workers’ health. The study also addressed such variables as gender, age, length of service, and the reason for employment (voluntary vs. non-voluntary). The research was carried out in Poland in 2020 using the CATI method (a telephone interviewing technique), and it covered a sample of 200 workers (100 self-employed and 100 working under a mandate contract). Most of the respondents declared that their form of employment did not affect their health. However, the statistical analysis showed significant differences in health status between the self-employed and those working on a mandate contract. Self-employed respondents experienced mental health impacts more often, whereas those working under a mandate contract more frequently declared that their physical health was affected. The length of service was only important for mental health, having a negative impact on it. The respondents’ age and gender turned out to be statistically insignificant, which is in contradiction to many previous research findings. The inability to choose one’s form of employment resulted in worse physical health. These findings demonstrate the importance of certain variables that were not prioritized in previous studies and emphasize the need to clearly define what non-standard and precarious forms of employment are, as well as revealing new correlations between the studied categories and providing directions for further research.


Author(s):  
Yan Yan ◽  
Hui Liu ◽  
Canfei He

This study takes urbanizing China as the research object, employs data from three follow-up surveys conducted by the Harmonized China Health and Retirement Longitudinal Study, and examines the effects of urban sprawl on public health from physical and mental health perspectives. Although urban sprawl does not necessarily increase the risk of each specific type of disease or psychological feeling, it has a significant impact on overall physical and mental health. Further analysis reveals significant heterogeneity in the effects of urban sprawl on the physical and mental health of different groups. Specifically, urban sprawl is detrimental to the physical health of males and females, but only has negative impact on the mental health of females. Younger groups are more vulnerable to physical and mental health damage from urban sprawl relative to middle-aged and older groups. In addition, urban sprawl has a significant negative impact on the health of the low-education group but a very limited impact on the health of the high-education counterpart. From an income perspective, however, the preference for suburban housing among middle- and high-income groups makes their health more vulnerable to the negative effects of urban sprawl than low-income groups living in urban centers.


2021 ◽  
Vol 12 ◽  
Author(s):  
Laura J. Wright ◽  
Sarah E. Williams ◽  
Jet J. C. S. Veldhuijzen van Zanten

Background: The severity of the Coronavirus pandemic has led to lockdowns in different countries to reduce the spread of the infection. These lockdown restrictions are likely to be detrimental to mental health and well-being in adolescents. Physical activity can be beneficial for mental health and well-being; however, research has yet to examine associations between adolescent physical activity and mental health and well-being during lockdown.Purpose: Examine the effects of adolescent perceived Coronavirus prevalence and fear on mental health and well-being and investigate the extent to which physical activity can be a protective factor against these concerns.Methods: During United Kingdom lockdown restrictions, 165 participants (100 female, aged 13–19) completed an online questionnaire assessing perceived Coronavirus prevalence and fear, physical activity, and indicators of mental health and well-being (stress, anxiety, depression, fatigue, vitality, and perceived health). Separate hierarchical multiple linear regression analyses (with age, gender, perceived Coronavirus prevalence, and fear entered in step 1, and physical activity in step 2) were run to predict each well-being outcome.Results: Regression analyses indicated that in general, while Coronavirus fear was a negative predictor, physical activity was a positive and stronger predictor of enhanced mental health and well-being outcomes.Conclusion: Findings suggest that physical activity during the Coronavirus pandemic can counteract the negative effects of Coronavirus fear on adolescent mental health and well-being. Therefore, physical activity should be promoted during lockdown to support good mental health and well-being.


2020 ◽  
Author(s):  
Reza Jafari Nodoushan ◽  
Hadi alimoradi ◽  
Mahsa Nazari

Abstract Introduction: Stress is one of the effective factors in the occurrence of negative effects during pregnancy that can cause adverse outcomes such as preterm delivery and reduced intrauterine growth of the fetus in pregnant women. Therefore, one of the serious concerns during the COVID-19 Pandemic is the physical health and mental health of pregnant women. This study aimed to evaluate the physical health status with the spiritual and mental health of pregnant women during the COVID-19 Pandemic.Methods: The study is a descriptive study in 2019-2020 and the samples were randomly selected from all pregnant women who referred to hospitals and private maternity centers before and during the COVID-19 Pandemic and performed all pregnancy and fetal health tests. It was performed on 560 pregnant female samples. The mental status of pregnant women was assessed using the DASS Spiritual Health and Stress Questionnaire. Data analysis was performed using SPSS statistical software (version 24).Result: The results of this study showed that preterm birth, height, weight and head circumference of babies and lungs and respiratory status of children with mental health and stress levels of pregnant women during the corona is significant compared to the previous of corona (p<0.05).Conclusion: Increasing stress and decreasing the mental health of pregnant women during COVID-19 Pandemic can increase the influencing factors in preterm delivery and unhealthy birth.


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