scholarly journals A Path Analysis To Investigate The Interaction Between Serum, Urinary And Demographic Factors Influencing Urine Calcium In Kidney Stone Formers

Author(s):  
Fatemeh Taheri ◽  
Maryam Taheri ◽  
Tavasoli Sanaz ◽  
Borumandnia Nasrin ◽  
Basiri Abbas

Abstract Background: Hypercalciuria is one of the most important urinary risk factors in kidney stone formers. This study aimed to delineate the interaction of some demographic, serum, and urinary risk factors influencing 24-hour urinary (24-U) calcium excretion.Methods: This study was secondary data analysis, using data from 593 kidney stone patients referred to the Labbafinejad kidney stone prevention clinic from March 2015 to May 2019. The study considered serum, urinary and demographic factors that interact to influence 24-U calcium using path analysis.Results: The results showed that age and weight had an indirect effect on 24-U calcium. Among serum variables, PTH and creatinine had a significant direct effect on 24-U calcium. In comparison, 25-hydroxy vitamin D (25(OH)D) and phosphorus appeared to influence 24-U calcium through serum parathormone. Regarding 24-U metabolites, 24-U sodium, 24-U Urea, and 24-U citrate had a significant direct effect on 24-U calcium. Moreover, 24-U creatinine has a significant direct and indirect effect on 24-U calcium through 24-U citrate and 24-U Urea as mediating variables. 24-U citrate had the most effect on 24-U calcium, following 24-U creatinine, 24-U Urea, 24-U sodium, serum creatinine, and weight.Conclusion: Except for serum calcium, all other predictors had direct and/or indirect effects on 24-U calcium. Serum 25(OH)D had a negligible indirect effect on 24-U calcium. Controlling dietary intake of protein and sodium and bodyweight seems very important in kidney stone formers with hypercalciuria.

2021 ◽  
Author(s):  
Fatemeh Taheri ◽  
Maryam Taheri ◽  
Sanaz Tavasoli ◽  
Nasrin Borumandnia ◽  
Abbas Basiri

Abstract Background: Hypercalciuria is one of the most important urinary risk factors in kidney stone formers. This study aimed to delineate the interaction of some demographic, serum, and urinary risk factors influencing 24-hour urinary (24-U) calcium excretion.Methods: This study was secondary data analysis, using data from 593 kidney stone patients referred to the Labbafinejad kidney stone prevention clinic from March 2015 to May 2019. The study considered serum, urinary and demographic factors that interact to influence 24-U calcium using path analysis.Results: The results showed that age and weight had an indirect effect on 24-U calcium. Among serum variables, PTH and creatinine had a significant direct effect on 24-U calcium. In comparison, 25-hydroxy vitamin D (25(OH)D) and phosphorus appeared to influence 24-U calcium through serum parathormone. Regarding 24-U metabolites, 24-U sodium, 24-U Urea, and 24-U citrate had a significant direct effect on 24-U calcium. Moreover, 24-U creatinine has a significant direct and indirect effect on 24-U calcium through 24-U citrate and 24-U Urea as mediating variables. 24-U citrate had the most effect on 24-U calcium, following 24-U creatinine, 24-U Urea, 24-U sodium, serum creatinine, and weight.Conclusion: Except for serum calcium, all other predictors had direct and/or indirect effects on 24-U calcium. Serum 25(OH)D had a negligible indirect effect on 24-U calcium. Controlling dietary intake of protein and sodium and bodyweight seems very important in kidney stone formers with hypercalciuria.


2020 ◽  
Vol 16 (2) ◽  
pp. 184-199
Author(s):  
Novi Mubyarto

Abstract: The purpose of this research was to determine the direct and indirect effect of profitability on firm value using capital structure as a mediator. This involves using panel data from 44 companies listed on LQ45 as of 31st December 2015-2018 and analyzed using the path analysis method including Sobel Test and Bootstrapping technique. The results showed a positive and significant direct effect of profitability on firm value while the indirect effect using capital structure as a mediator between the two variables was found to be negative and significant. Moreover, the direct influence of capital structure on firm value was discovered to be negative and significant while the introduction of profitability variables in the relationship led to a positive and significant influence. Similarly, the direct effect of profitability on firm value using capital structure as the controlling variable was also found to be positive and significant.Keywords: firm value, capital structure, profitabilityPengaruh Profitabilitas Terhadap Nilai Perusahaan dengan Struktur Modal Sebagai MediatorAbstrak: Tujuan dari penelitian ini adalah untuk mengkaji bagaimana pengaruh langsung profitabilitas terhadap nilai perusahaan, dan pengaruh tidak langsung melalui struktur modal sebagai mediator. Menggunakan data panel dari 44 perusahaan yang tercatat di LQ45 per tanggal 31 Desember selama periode 2015 sampai 2018. Metode analisis yang digunakan adalah metode analisis jalur (Path Analysis), dengan Teknik Sobel Test dan Bootsrapping. Hasil riset membuktikan bahwa terdapat pengaruh langsung yang positif dan signifikan antara profitabilitas terhadap nilai perusahaan. Namun, jika dilihat secara tidak langsung pengaruh profitabilitas terhadap nilai perusahaan melalui struktur modal sebagai mediator adalah negatif dan signifikan. Selanjutnya, pengaruh langsung profitabilitas terhadap struktur modal adalah negatif dan signifikan. Sementara ketika dikontrol oleh variabel profitabilitas, pengaruh struktur modal terhadap nilai perusahaan positif dan signifikan. Begitu pula dengan pengaruh langsung profitabilitas terhadap nilai perusahaan dengan mengontrol variabel struktur modal juga positif dan signifikan.Kata kunci: nilai perusahaan, struktur modal, profitabilitas


2020 ◽  
Author(s):  
◽  
Nicole Knapp ◽  

Problem The best outcome for attachment when an infant is born would be a secure attachment, but this is not always the case. Insecure attachments are likely to be formed when the mother has experienced domestic violence given the right environment (Huth-Bocks et al., 2011; Theran et al., 2005). A previous study showed that changes to attachment due to postnatal intervention are based on external behaviors rather than internal though processes (Theran et al., 2005). Because of this, the purpose of this study is to compare therapy categories and each of the observable attachment factors. Method Participants completed a survey which measured the tolerance, acceptance, pleasure in proximity, and competence as a parent in regard to the mother's response to her child(ren) ages zero to six months old, as well demographic information. Data was analyzed using a one-way multivariate analysis of variance (MANOVA), a one-way analysis of variance (ANOVA), post hoc tests, and a path analysis to answer two main research questions and five sub-questions. Results The MANOVA results showed a marginally significant difference among the trauma therapy categories on the dependent variables. Subsequent ANOVA results showed that, individually, trauma therapy had a significant effect on tolerance, pleasure in proximity, and competence as a parent. Bonferroni post hoc analysis showed that not attending therapy significantly differs from attending group therapy in regard to competence as a parent. The hypothesized model was a good fit for the data. This model indicated a weak statistically significant direct effect of childhood abuse on trauma therapy. Race, childhood abuse, and support system all had weak statistically significant direct effect on ATT and trauma therapy had a weak moderately significant direct effect on ATT. Conclusion This study was designed to help understand if various types of trauma therapy could be effective in the formation of a more secure attachment between mother and infant when the mother has had a history of domestic violence. This study also looked to understand if various demographic factors have an effect on the attendance of trauma therapy or on ATT, either directly or as mediated through trauma therapy. Results have indicated that when looking at maternal attachment responses, it may be more beneficial to look at the individual types of trauma therapy and areas of attachment rather than at trauma therapy and attachment as wholes. In regard to demographic factors, there were weak significant direct effects found for both trauma therapy and ATT. This study also offers various implications for future research and professional practice.


2019 ◽  
Vol 26 (1) ◽  
pp. 1
Author(s):  
Beny Mahyudi Saputra

The objectives of this study are: 1). Knowing the effect of compensation on employee performance directly. 2). Knowing the effect of compensation on employee performance. 3). Knowing the effect of work performance on employee performance. 4). Knowing the effect of compensation on employee performance through work performance. The population is defined as "the number of families that will be studied", the population used by researchers in this study is the entire work of PT. Nippon Paint Kediri. This research sample was taken by using simple random sampling technique that is sampling technique from the population that was carried out randomly regardless of the strata that existed in the population. simple random sampling is a method of sampling where each element of the population has the same opportunity to be chosen as a member of the sample and the sample is taken using a number table/generator. The technique used is path analysis. Based on the results of the research and the discussion described, conclusions can be drawn as follows: 1). There is a significant direct effect between the variable compensation (X1) on employee performance (X2) of 0.410. 2). There is a significant direct effect between compensation (X1) on employee performance (Y) of 0.561. 3). There is a direct significant between employee work performance (X2) on employee performance (Y) of 0.358. 4). There is an indirect effect between compensation (X1) on employee performance (Y) through employee work performance (X2) of 0.708.


2020 ◽  
Vol 1 (1) ◽  
Author(s):  
Muh. Aripin Nurmantoro ◽  
Dedy Yusuf Aditya ◽  
Dede Irawan

The purpose of this study was to determine the direct effect and indirect influence of a variable. The research data was processed and analyzed using path analysis method. Conclusions are obtained (1) There is a significant direct effect of intelligence numeric on the results of formative tests; (2) There is a significant direct effect of learning discipline on the results of formative tests; (3) There is a significant direct effect of learning motivation on the results of formative tests; (4) There is a significant direct effect of intelligence numeric on learning motivation; (5) There is a significant direct influence of intelligence numericalon learning discipline; (6) There is a significant direct effect of learning discipline on learning motivation; (7) There is no significant indirect effect of intelligence numeric on motivation to learn through learning discipline; (8) There is no significant indirect effect of intelligence numeric on the results of formative tests through learning discipline; (9) There is no significant indirect effect of intelligence numeric on the results of formative tests through learning motivation; and (10) There is no significant indirect effect of intelligence numeric on the results of formative tests through learning discipline and learning motivation.


2021 ◽  
Vol 5 (1) ◽  
pp. 26
Author(s):  
Nuryadi Winra ◽  
Grace Theresia Pontoh ◽  
Grace Theresia Pontoh

This research aimed to find out direct effect of the internal control entities to determining the high of audit fee, and indirect effect of the internal control entities to determining the high of audit fee through the extensive of auditor’s occupation. Data collection in this research used questionnaire which distributed to auditors who working in public accounting in Makassar. Analysis of the data used path analysis. The results of this research provided evidance that the internal control entities (X) had a significant direct effect to determining the high of audit fee (Y), and the internal control intities (X) had a significant indirect effect through the extensive of auditors’ occupation (M) to determining the high of audit fee (Y). The implication is if internal control entities is ineffective, it will be effect the larger of the extensive of auditor’s, so it will be also effect to the highest of amount in determining audit fee.


2017 ◽  
Vol 12 (1) ◽  
pp. 29-44
Author(s):  
I Kade Sanjana Duaja

The study investigated the effect of social economic status, individual modernity, life style towards farmer’s participation in continuation of cultural value. Data on strategy use is gathered through a questionnaire (n=250) and analyzed by using Path Analysis. Results show that there status and farmer’s participation. There is direct effect between individual modernity and farmer’s participation. There is not indirect effect between social economic status through life style and farmer’s participation. There is indirect effect between individual modernity and life style towards participation in continuants of culture value. Economic status, individual modernity and life style are determined factors of cultural value of community.


Author(s):  
Luh Ade Yumita Handriani ◽  
Sudarsana Arka

This study aims to analyze the impact of the BPNT program on household consumption and consumption patterns of BPNT recipient households in Mengwi District, Badung Regency. This research was conducted in Mengwi District, Badung Regency using a questionnaire distributed to respondents with a large sample size of 96 KPM. This study uses path analysis techniques to analyze the direct effect and Sobel test to analyze the indirect effect. Based on path analysis, the results of the study concluded that the BPNT variable had a positive and significant effect on the consumption of BPNT recipient households in Mengwi District, Badung Regency. The BPNT variable has no effect on the consumption pattern of BPNT recipient households in Mengwi District, Badung Regency. The household consumption variable has a negative and significant effect on the consumption pattern of BPNT recipient households in Mengwi District, Badung Regency. The household consumption variable did mediate the effect of the BPNT Program on the consumption pattern of BPNT recipient households in Mengwi District, Badung Regency


Author(s):  
Zuma Nayyir ◽  

This study aims to determine the effect of arm length, hand-eye coordination, and arm-toe coordination on the bowling ability of male cricket athletes in Jakarta. Data collection was carried out in early January 2021, which took place at the campus of the Jakarta State University Cricket Arena. The method of research used in this research is survey method with path analysis technique or path analysis. The sample used in this study amounted to 18 people who came from the male Cricket Athlete in Jakarta. The first test that was carried out was measurement of arm length. Then proceed with a test of eye-eye coordination, arm power and bowling ability for male cricket athletes in DKI Jakarta. The hypothesis testing technique used in this study is to use path analysis techniques. The data that has been obtained aka n through a process of analysis of the data through SPSS. The results of this study are: 1) the direct effect of variable X1 on Y (X1  Y) or (r1y) = -0,245. So the effect of arm length (X1) directly affects bowling ability (Y) of -0.245 or -24.5%. 2) The direct effect of variable X2 on Y (X2 Y) or (r2y) = 0.535. So the effect of eye-hand-foot coordination (X2) directly affects bowling ability (Y) by 0.535 or 53.5%. 3) The direct effect of variable X3 on Y (X3  Y) or (r3y) = 0.457. So the effect of arm power (X3) directly affects the bowling ability (Y) of 0.457 or 45.7%. 4) The direct effect of variable X1 on X3 (X1  X3) or (r13) = 0.552. So the effect of arm length (X1) directly affects arm power (X3) by 0.552 or 55.2%. 5). The direct effect of variable X2 on X3 (X2  X3) or (r23) = 0.407. So the effect of hand-eye coordination (X2) directly affects arm power (X3) by 0.407 or 40.7%. 6) The indirect effect of variable X1 on Y through X3 (X1  X3  Y) or (r13y) = 0.552x0.457 = 0.253. So the effect of arm length (X1) indirectly affects bowling ability (Y) through arm power (X3) by 0.253 or 25.3%. 7) The indirect effect of variable X2 on Y through X3 (X2  X3  Y) or (r23y) = 0.407x0.457 = 0.186. So the effect of hand eye coordination (X2) indirectly affects bowling ability (Y) through arm power (X3) by 0.186 or 18.6%.


2009 ◽  
Vol 297 (4) ◽  
pp. F1017-F1023 ◽  
Author(s):  
Kristin J. Bergsland ◽  
Fredric L. Coe ◽  
Daniel L. Gillen ◽  
Elaine M. Worcester

The process of kidney stone formation depends on an imbalance between excretion of water and insoluble stone-forming salts, leading to high concentrations that supersaturate urine and inner medullary collecting duct (IMCD) fluid. For common calcium-containing stones, a critical mechanism that has been proposed for integrating water and calcium salt excretions is activation of the cell surface calcium-sensing receptor (CaSR) on the apical membranes of IMCD cells. High deliveries of calcium into the IMCD would be predicted to activate CaSR, leading to reduced membrane abundance of aquaporin-2, thereby limiting water conservation and protecting against stone formation. We have tested this hypothesis in 16 idiopathic hypercalciuric calcium stone formers and 14 matched normal men and women in the General Clinical Research Center. Subjects were fed identical diets; we collected 14 urine samples at 1-h intervals during a single study day, and one sample overnight. Hypercalciuria did not increase urine volume, so urine calcium molarity and supersaturation with respect to calcium oxalate and calcium phosphate rose proportionately to calcium excretion. Thus CaSR modulation of urine volume via IMCD CaSR activation does not appear to be an important mechanism of protection against stone formation. The overnight period, one of maximal water conservation, was a time of maximal stone risk and perhaps a target of specific clinical intervention.


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