scholarly journals Electrospun Hybrid Microfibers of Polylactic Acid with Plasma Polypyrrole Particles with Ultrahydrophobic Surface for Biomedical Applications

2021 ◽  
Author(s):  
Fernando G. Flores-Nava ◽  
Guillermo J. Cruz ◽  
Elena Colín-Orozco ◽  
J. Cuauhtémoc Palacios ◽  
Ricardo Valdivia-Barrientos ◽  
...  
Keyword(s):  
Polylactic Acid ◽  
Biomedical Applications ◽  
Chloroform Solution ◽  
Contact Angles ◽  
Electrospun Fibers ◽  
Mass Ratio ◽  
Saline Solutions ◽  
Phosphate Buffered Saline ◽  
Human Fluids ◽  
Nm Range

Abstract This work presents a study on the formation of hybrid electrospun fibers of polylactic acid (PLA) with insoluble polypyrrole (PPy) particles inside with the objective to prepare ultrahydrophobic fibers for biomedical applications. Krebs-Ringer and phosphate-buffered saline solutions were used as test solutions of human fluids. The PPy particles were synthesized by plasma with diameter in the 60-1000 nm range and were suspended in a PLA-chloroform solution with a PPy/PLA = 0.027 mass ratio. PLA fibers with PPy particles inside were formed electrospinning this suspension obtaining diameters in the 0.12-9.0 µm range with average between 1.65 and 1.85 µm. Contact angles of the fibers with the test solutions were measured in the 113°-147° interval, most of them in the ultrahydrophobic (120°-150°) region. The lowest angles were obtained with particles synthesized at the lowest power (20 W) and were like those obtained on PLA fibers. The highest angles were measured on the fibers with the particles synthesized at the highest synthesis power (100 W), with difference up to 15°. This difference in the angles was correlated with the resonant ≈ C ≈ groups of the particles through the fiber ultraviolet absorption.

scholarly journals Topographical and Biomechanical Guidance of Electrospun Fibers for Biomedical Applications

Polymers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 2896
Author(s):  
Sara Ferraris ◽  
Silvia Spriano ◽  
Alessandro Calogero Scalia ◽  
Andrea Cochis ◽  
Lia Rimondini ◽  
...  
Keyword(s):  
Surface Modification ◽  
Biomedical Applications ◽  
Biomedical Application ◽  
Electrospun Fibers ◽  
Natural Polymers ◽  
Polymeric Fibers ◽  
Biological Phenomena ◽  
Proper Design ◽  
Synthetic And Natural Polymers ◽  
Selection Of

Electrospinning is gaining increasing interest in the biomedical field as an eco-friendly and economic technique for production of random and oriented polymeric fibers. The aim of this review was to give an overview of electrospinning potentialities in the production of fibers for biomedical applications with a focus on the possibility to combine biomechanical and topographical stimuli. In fact, selection of the polymer and the eventual surface modification of the fibers allow selection of the proper chemical/biological signal to be administered to the cells. Moreover, a proper design of fiber orientation, dimension, and topography can give the opportunity to drive cell growth also from a spatial standpoint. At this purpose, the review contains a first introduction on potentialities of electrospinning for the obtainment of random and oriented fibers both with synthetic and natural polymers. The biological phenomena which can be guided and promoted by fibers composition and topography are in depth investigated and discussed in the second section of the paper. Finally, the recent strategies developed in the scientific community for the realization of electrospun fibers and for their surface modification for biomedical application are presented and discussed in the last section.

Effect of Thermal Processing on the Dynamic/Isothermal Crystallization and Cytocompatibility of Polylactic Acid for Biomedical Applications

2021 ◽  
pp. 2100274
Author(s):  
Sandra C. Cifuentes ◽  
Laura Saldaña ◽  
José Luis Gónzalez‐Carrasco ◽  
Rosario Benavente ◽  
Alberto García‐Peñas
Keyword(s):  
Polylactic Acid ◽  
Thermal Processing ◽  
Isothermal Crystallization ◽  
Biomedical Applications

Surface Modification of Ti-30Ta Alloy by Electrospun PCL Deposition

2016 ◽  
Vol 869 ◽  
pp. 930-934
Author(s):  
Cristiane Mayumi Wada ◽  
André Luiz Reis Rangel ◽  
Marisa Aparecida de Souza ◽  
Rosemeire dos Santos Almeida ◽  
Marcos Akira D’Ávila ◽  
...  
Keyword(s):  
Contact Angle ◽  
Plasma Treatment ◽  
Biomedical Applications ◽  
Plasma Reactor ◽  
Melting Furnace ◽  
Argon Atmosphere ◽  
Electrospun Fibers ◽  
X Rays ◽  
Arc Melting ◽  
Hydrophilic Behavior

In this study, PCL electrospun fibers were deposited on the Ti-30Ta alloy for change the surface properties. Experimental Ti-30Ta alloy was obtained by melting titanium and tantalum in arc melting furnace with argon atmosphere. Ingots were homogenized and bars with 10 mm of diameter were obtained in rotative swagging. PCL fibers were deposited on disks of the alloy by electrospinning. Plasma treatment was carried out for change PCL electrospun superficial energy by using stainless steel plasma reactor. Samples were immersed in mineralization solution for apatite growth. Surfaces were evaluated by using SEM, X-rays diffraction and contact angle. Samples exhibited hydrophilic behavior after plasma treatment and mineralization. Results are very interesting for biomedical applications.

scholarly journals Synthesis and Biological Application of Polylactic Acid

Molecules ◽  
2020 ◽  
Vol 25 (21) ◽  
pp. 5023
Author(s):  
Ge Li ◽  
Menghui Zhao ◽  
Fei Xu ◽  
Bo Yang ◽  
Xiangyu Li ◽  
...  
Keyword(s):  
Physical Properties ◽  
Polylactic Acid ◽  
Biomedical Applications ◽  
Raw Materials ◽  
Raw Material ◽  
Biomedical Materials ◽  
Biomedical Material ◽  
Sugar Fermentation ◽  
Low Toxicity ◽  
Good Biocompatibility

Over the past few decades, with the development of science and technology, the field of biomedicine has rapidly developed, especially with respect to biomedical materials. Low toxicity and good biocompatibility have always been key targets in the development and application of biomedical materials. As a degradable and environmentally friendly polymer, polylactic acid, also known as polylactide, is favored by researchers and has been used as a commercial material in various studies. Lactic acid, as a synthetic raw material of polylactic acid, can only be obtained by sugar fermentation. Good biocompatibility and biodegradability have led it to be approved by the U.S. Food and Drug Administration (FDA) as a biomedical material. Polylactic acid has good physical properties, and its modification can optimize its properties to a certain extent. Polylactic acid blocks and blends play significant roles in drug delivery, implants, and tissue engineering to great effect. This article describes the synthesis of polylactic acid (PLA) and its raw materials, physical properties, degradation, modification, and applications in the field of biomedicine. It aims to contribute to the important knowledge and development of PLA in biomedical applications.

scholarly journals Roughness and Fiber Fraction Dominated Wetting of Electrospun Fiber-Based Porous Meshes

Polymers ◽  
2018 ◽  
Vol 11 (1) ◽  
pp. 34 ◽  
Author(s):  
Piotr Szewczyk ◽  
Daniel Ura ◽  
Sara Metwally ◽  
Joanna Knapczyk-Korczak ◽  
Marcin Gajek ◽  
...  
Keyword(s):  
Contact Angle ◽  
Electrospun Fiber ◽  
Three Dimensional ◽  
Contact Angles ◽  
Electrospun Fibers ◽  
Surface Geometry ◽  
Wetting Contact Angle ◽  
Fiber Fraction ◽  
Significant Difference ◽  
Entrapped Air

Wettability of electrospun fibers is one of the key parameters in the biomedical and filtration industry. Within this comprehensive study of contact angles on three-dimensional (3D) meshes made of electrospun fibers and films, from seven types of polymers, we clearly indicated the importance of roughness analysis. Surface chemistry was analyzed with X-ray photoelectron microscopy (XPS) and it showed no significant difference between fibers and films, confirming that the hydrophobic properties of the surfaces can be enhanced by just roughness without any chemical treatment. The surface geometry was determining factor in wetting contact angle analysis on electrospun meshes. We noted that it was very important how the geometry of electrospun surfaces was validated. The commonly used fiber diameter was not necessarily a convincing parameter unless it was correlated with the surface roughness or fraction of fibers or pores. Importantly, this study provides the guidelines to verify the surface free energy decrease with the fiber fraction for the meshes, to validate the changes in wetting contact angles. Eventually, the analysis suggested that meshes could maintain the entrapped air between fibers, decreasing surface free energies for polymers, which increased the contact angle for liquids with surface tension above the critical Wenzel level to maintain the Cassie-Baxter regime for hydrophobic surfaces.

Electrospinning of Regenerated Silk Fibroin/Polybutylene Terephthalate Blended Mats and their Surface Wettability

2012 ◽  
Vol 531-532 ◽  
pp. 531-534
Author(s):  
Yun Qian Cao ◽  
Qin Fei Ke ◽  
Xiang Yu Jin ◽  
Sha Sha Guo
Keyword(s):  
Silk Fibroin ◽  
Fiber Diameter ◽  
Contact Angles ◽  
Surface Wettability ◽  
Electrospun Fibers ◽  
Average Fiber Diameter ◽  
Polybutylene Terephthalate ◽  
Regenerated Silk Fibroin ◽  
Electrospinning Method ◽  
Nanofiber Membranes

In this paper, regenerated silk fibroin/polybutylene terephthalate blended mats were prepared using electrospinning method with different blending ratios. The influence of regenerated silk fibroin/polybutylene terephthalate ratio on the morphology behaviors, fiber diameter and the surface wettability of the blended mats were studied. The morphology of the electrospun fibers were characterized by SEM. The average fiber diameter and its distribution can be obtained from the SEM pictures using software Image J. The average fiber diameter was 280nm to 486nm and it changed with the blending ratio. The contact angles and penetration times were used to characterize the surface wettability of the nanofiber membranes. It was found that with the increase of regenerated silk fibroin amount, the surface contact angles and penetration times decreased, which meant that the wettability was greatly improved.

Understanding drug release from PCL/gelatin electrospun blends

2016 ◽  
Vol 31 (6) ◽  
pp. 933-949 ◽  
Author(s):  
Hrishikesh R Munj ◽  
John J Lannutti ◽  
David L Tomasko
Keyword(s):  
Drug Release ◽  
Biomedical Applications ◽  
Drug Loading ◽  
Release Mechanism ◽  
Electrospun Fibers ◽  
Electrospun Scaffolds ◽  
Bioactive Properties ◽  
Complex Process ◽  
Rhodamine B Dye ◽  
Polymer Erosion

Electrospinning is one of the efficient processes to fabricate polymeric fibrous scaffolds for several biomedical applications. Several studies have published to demonstrate drug release from electrospun scaffolds. Blends of natural and synthetic electrospun fibers provide excellent platform to combine mechanical and bioactive properties. Drug release from polymer blends is a complex process. Drug release from polymer can be dominated by one or more of following mechanisms: polymer erosion, relaxation, and degradation. In this study, electrospun polycaprolactone (PCL)–gelatin blends are investigated to understand release mechanism of Rhodamine B dye. Also, this article summarizes the effect of high-pressure carbon dioxide on drug loading and release from PCL–gelatin fibers. Results indicate that release media diffusion is a dominant mechanism for PCL–gelatin electrospun fibers. Thickness of electrospun mat becomes critical for blends with gelatin. As gelatin is highly soluble in water and has tendency of gelation, it affects diffusion of release media in and out of scaffold. This article is a key step forward in understanding release from electrospun blends.

Non-woven Membranes Electrospun from Polylactic Acid Incorporating Silver Nanoparticles as Biocide

2012 ◽  
Vol 1376 ◽  
Author(s):  
Haydee Vargas-Villagran ◽  
Elvia Teran-Salgado ◽  
Maraolina Dominguez-Diaz ◽  
Osvaldo Flores ◽  
Bernardo Campillo ◽  
...  
Keyword(s):  
Contact Angle ◽  
Silver Nanoparticles ◽  
Polylactic Acid ◽  
Chloroform Solution ◽  
Average Diameter ◽  
Electrospinning Process ◽  
Water Contact ◽  
X Ray Scattering ◽  
Angle Measurements ◽  
Contact Angle Measurements

ABSTRACTIn this research, we describe the electrospinning processing of polylactic acid (PLA) and the influence of silver nanoparticles on the morphology and microstructure of produced non woven membranes thus produced. The PLA was electrospun from a chloroform solution and a filamentary and granular morphology was obtained, the filaments having an average diameter of 1.25 μm, When silver nanoparticles (of ca. 12 nm size) were incorporated, the filaments diameter was reduced to an average of 0.65 μm, and the density of beads was also reduced. The membranes were rather amorphous, as revealed by X-ray scattering, presumably due to the quenching process associated with the electrospinning process. Water contact angle measurements showed that silver nanoparticles induced significant hidrophobicity in the membranes as neat PLA membrane had a contact angle of 54° and PLA/Ag membrane exhibited an angle of 115°.

scholarly journals An Anti-Inflammatory Poly(PhosphorHydrazone) Dendrimer Capped with AzaBisPhosphonate Groups to Treat Psoriasis

Biomolecules ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 949 ◽  
Author(s):  
Ranime Jebbawi ◽  
Abdelouahd Oukhrib ◽  
Emily Clement ◽  
Muriel Blanzat ◽  
Cédric-Olivier Turrin ◽  
...  
Keyword(s):  
Topical Application ◽  
Therapeutic Efficacy ◽  
Biomedical Applications ◽  
Saline Solution ◽  
Active Pharmaceutical Ingredient ◽  
Systemic Injection ◽  
Human Immune ◽  
Anti Inflammatory ◽  
Phosphate Buffered Saline

Dendrimers are nanosized, arborescent macromolecules synthesized in a stepwise fashion with attractive degrees of functionality and structure definition. This is one of the reasons why they are widely used for biomedical applications. Previously, we have shown that a poly(phosphorhydrazone) (PPH) dendrimer capped with anionic azabisphosphonate groups (so-called ABP dendrimer) has immuno-modulatory and anti-inflammatory properties towards human immune cells in vitro. Thereafter, we have shown that the ABP dendrimer has a promising therapeutic efficacy to treat models of acute and chronic inflammatory disorders in animal models. In these models, the active pharmaceutical ingredient was administered systematically (intravenous and oral administrations), but also loco-regionally in the vitreous tissue. Herein, we assessed the therapeutic efficacy of the ABP dendrimer in the preclinical mouse model of psoriasis induced by imiquimod. The ABP dendrimer was administered in phosphate-buffered saline solution via either systemic injection or topical application. We show that the topical application enabled the control of both the clinical and histopathological scores, and the control of the infiltration of macrophages in the skin of treated mice.

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