scholarly journals Oral verrucous carcinoma: a 24-year epidemiological study and case report

2021 ◽  
Vol 10 (6) ◽  
pp. 975-978
Author(s):  
Iago Demétrio da Silva ◽  
Elen de Souza Tolentino ◽  
Camila Camarini ◽  
Eloise Girondi Berlin ◽  
Vanessa Cristina Veltrini ◽  
...  
Keyword(s):  
Medical Records ◽  
Verrucous Carcinoma ◽  
Anatomical Location ◽  
Referral Service ◽  
Exophytic Tumor ◽  
Rare Lesion ◽  
Caucasian Patients ◽  
Caucasian Women ◽  
Early Diagnose ◽  
Metastatic Variant

Introduction: Verrucous carcinoma is a non-metastatic variant of squamous cell carcinoma. It was first reported by Ackerman in 1948. It is a verrucous exophytic tumor and, although it is a rare lesion, it mainly affects the oral cavity, with slow growth and can be locally invasive. Objective: To report a case and present an observational and retrospective analysis of medical records containing biopsy data from patients diagnosed with oral verrucous carcinoma (OVC) in an oral diagnostic referral service for a period of 24 years. Material and methods: The following data were collected: age, sex, ethnicity, anatomical location and management. Result: Eight cases of OVC were found, all in Caucasian patients (n = 8, 100%), aged between 57 and 102 years. 62% of the injuries affected women. The most affected region was the jugal mucosa (n = 4, 50%). In addition, Smoking patients were not found. In all cases, incisional biopsy was performed and referral to the head and neck surgeon. Conclusion: Caucasian women in the sixth and seventh decades of life were the most affected by OVC. The absence of smoking patients corroborates the literature, which reports that cigarettes appear to be unrelated to this injury. The dentist's role is to recognize the disease early, diagnose it and refer it for medical treatment.

Distress screening, intervention, and follow-up outcomes among Hispanic and Caucasian women with newly diagnosed breast cancer.

2018 ◽  
Vol 36 (7_suppl) ◽  
pp. 163-163
Author(s):  
Rebecca C. Shay ◽  
Gregory Joseph Britt
Keyword(s):  
Breast Cancer ◽  
Female Breast Cancer ◽  
Phone Call ◽  
Newly Diagnosed ◽  
Distress Screening ◽  
Hispanic Patients ◽  
Caucasian Patients ◽  
English Speaking ◽  
Caucasian Women

163 Background: We describe acceptance and impact of mental health (MH) interventions provided to an English speaking Caucasian and Spanish speaking Hispanic female breast cancer (BC) population reporting symptoms of depression and anxiety. Methods: Records of 170 women with newly diagnosed BC at Cancer Centers of Colorado at SCL Health/Saint Joseph Hospital in 2015 were retrospectively assessed for record of a distress screening questionnaire (DSQ), administered in each patients’ native language. Among patients who reported psychosocial distress (PD), records were reviewed for an outreach phone call and visit with social work (SW) or MH, new antidepressant or anxiolytic prescription, and completion of a second DSQ. SCL Health IRB approval obtained. Results: Of 170 subjects, 94 (68% (n = 64) Caucasian, 19% (n = 18) Hispanic, 13% (n = 12) other) completed an initial DSQ. Scores reflecting PD were seen in 57 DSQs; 15 were high-grade PD (HPD). Nearly half (49%; n = 28) of those with PD had been called by MH or SW; 93% (n = 14) with HPD were called. Anxiety scores (AS) improved in 78% (n = 18) and depression scores (DS) in 74% (n = 17) of subjects called. AS and DS improved in 67% (n = 8) and 75% (n = 9), respectively, of Caucasian patients and in 89% (n = 8) and 67% (n = 6) of Hispanic patients called. Of 35 patients who completed follow-up DSQ, 17 visited with MH or SW. AS and DS improved in 65% (n = 11) of these. Improved AS and DS were seen in 38% (n = 3) and 63% (n = 5) of Caucasian patients, respectively, and 88% (n = 7) and 63% (n = 5) of Hispanic patients who had a visit. An antidepressant or anxiolytic was prescribed for 7 patients; AS and DS improved for 33% (n = 1) of Caucasian patients and 67% (n = 2) of Hispanic patients given prescriptions. Conclusions: Outreach to patients with PD and HPD correlated with improved AS and DS. Hispanics were more likely than Caucasians to accept a visit from MH or SW and were more likely to improve AS and DS following a visit with these services or antidepressant or anxiolytic prescription, demonstrating the importance of intervention in this group. This study does not account for patients’ initial staging, progression or regression, therapy pursued, nor presence of other psychosocial concern.

Primary Intraosseous Verrucous Carcinoma Developing from a Maxillary Odontogenic Cyst: Case Report

2001 ◽  
Vol 87 (6) ◽  
pp. 444-446 ◽  
Author(s):  
Eraldo Pomatto ◽  
Vincenzo Carbone ◽  
Davide Giangrandi ◽  
Vittorio Falco
Keyword(s):  
Case Report ◽  
Single Case ◽  
Verrucous Carcinoma ◽  
Odontogenic Cyst ◽  
Epithelial Rests Of Malassez ◽  
Short Survey ◽  
Rare Lesion ◽  
Intraosseous Carcinoma

Primary intraosseous carcinoma (PIOC) is an extremely rare lesion, almost always occurring in cranial bones. The origin of this tumor, specific to the maxillae, is associated with the cells of the epithelial rests of Malassez. Among the histotypes which can be included in these neoplasms, verrucous carcinoma is of particular interest due to its rarity: only a single case has been reported to date. After a short survey of the literature, the authors describe a directly observed case of verrucous carcinoma arising from a maxillary odontogenic cyst.

scholarly journals Verrucous Carcinoma of the Vulva: A Case Report

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Ioannis Boutas ◽  
Chrisostomos Sofoudis ◽  
Emmanouil Kalampokas ◽  
Christos Anastasopoulos ◽  
Theodoros Kalampokas ◽  
...  
Keyword(s):  
Case Report ◽  
Postmenopausal Women ◽  
Genital Tract ◽  
Verrucous Carcinoma ◽  
Female Genital Tract ◽  
University Hospital ◽  
Specialist Doctor ◽  
Rare Lesion ◽  
Female Genital

Verrucous carcinoma of the female genital tract is a rare lesion, primarily affecting postmenopausal women. We present a 78-year-old patient with verrucous carcinoma of the vulva, who was admitted to the “Aretaieion” Athens University Hospital. She had complained of vulvar itching during the last two years without visiting a specialist doctor.

scholarly journals Odontogenic keratocysts: a 22-year epidemiological study and case report

2019 ◽  
Vol 60 (2) ◽  
pp. 43-52
Author(s):  
Fernanda Chiguti Yamashita ◽  
Gustavo Nascimento de Souza Pinto ◽  
Elen De Souza Tolentino ◽  
Mariliani Chicarelli ◽  
Liogi Iwaki Filho ◽  
...  
Keyword(s):  
Medical Records ◽  
Wide Spectrum ◽  
Dentigerous Cyst ◽  
Treatment Options ◽  
Histopathological Diagnosis ◽  
Oral Lesions ◽  
The Third ◽  
Referral Service ◽  
Osseointegrated Implant ◽  
The Mean

Odontogenic Keratocyst (OKC) is a cyst that presents local aggression and a high recurrence; thus, a better understanding of its clinical characteristics and treatment options is required. The aim of this study is to report a case and describe the epidemiology and characteristics of OKCs diagnosed at a referral service for patients with oral lesions. Patients with histopathological diagnosis of OKC were included in the sample over 22 years. The study highlights the demographic and clinical-radiological characteristics, as well as the treatment options. In addition, a case of an extensive OKC in the mandible is reported. 3064 medical records were analyzed and 16 cases of OKC (0.52%) were found, with two recurrences (12.5%). The mean age of the patients was 33.19 years, being the third decade of life more affected (31.25%), with equal prevalence for both sexes. The mandible was more affected (68.75%), mainly its body. The differential diagnosis included the dentigerous cyst (11.54%) and the ameloblastoma (11.54%). The most frequent treatment was the curettage enucleation (50%). In the reported case, enucleation associated with cryotherapy was performed, followed by rehabilitation with xenogen graft and osseointegrated implant. OKC presents a wide spectrum of differential diagnoses due to its non-specific clinical-radiographic characteristics. The case reported shows that treatments such as enucleation may be efficient when accompanied by adjuvant techniques.

Verrucous Carcinoma of the Larynx

1998 ◽  
Vol 107 (5) ◽  
pp. 391-395 ◽  
Author(s):  
Thomas V. McCaffrey ◽  
Mark Witte ◽  
M. Troy Ferguson
Keyword(s):  
Residual Disease ◽  
Verrucous Carcinoma ◽  
Statistical Significance ◽  
Clinical Stage ◽  
Surgical Excision ◽  
Laryngeal Function ◽  
Primary Treatment Modality ◽  
Anaplastic Transformation ◽  
Exophytic Tumor ◽  
Carcinoma Of The Larynx

Verrucous carcinoma is a well-differentiated squamous cell carcinoma with minimal cytologic atypia. Characteristically, the surface shows papillary fronds with prominent hyperkeratosis. Its benign appearance makes diagnosis difficult and often delays treatment. This is a review of 52 histologically confirmed cases of verrucous carcinoma of the larynx treated at the Mayo Clinic between 1960 and 1987. The follow-up ranged from 2 to 304 months. The most common primary treatment modality was surgery. Two patients died of laryngeal cancer. In both cases, the recurrence was a high-grade carcinoma histologically distinct from the original verrucous carcinoma. The T stage, clinical stage, and type of surgical excision failed to predict survival. The presence of extensive leukoplakia surrounding the exophytic tumor approached statistical significance (p =.08) in predicting recurrence. Four patients were treated with radiotherapy — in each, to control residual disease. One of these patients developed a local recurrence. None of the irradiated tumors in this series showed anaplastic dedifferentiation, and none of the irradiated patients died of uncontrolled local or regional disease. We conclude that verrucous carcinoma of the larynx should be treated by conservative surgical resection when possible. Radiotherapy can be effectively used for disease that cannot be resected with preservation of laryngeal function. Total laryngectomy should be reserved for recurrent disease or the rare case of anaplastic transformation.

scholarly journals Organ-Sparing Surgery for a Giant Verrucous Carcinoma of the Penile Shaft: A Case Report and Review of the Literature

2019 ◽  
Vol 2019 ◽  
pp. 1-4
Author(s):  
Prodromos Philippou ◽  
Christos Kitsios ◽  
Maria Miliatou ◽  
Christiana Poullou ◽  
Pavlos Konstantinou
Keyword(s):  
Squamous Cell Carcinoma ◽  
Organ Preservation ◽  
Clinical Presentation ◽  
Verrucous Carcinoma ◽  
Dorsal Surface ◽  
Review Of The Literature ◽  
Penile Shaft ◽  
Rare Lesion ◽  
Well Differentiated ◽  
Penile Squamous Cell Carcinoma

Verrucous Carcinoma is a rare but well-differentiated variant of penile squamous cell carcinoma. Its clinical presentation is usually that of an exophytic cauliflower-like lesion with a broad-based growth pattern. We herein report the case of a 61-year-old man who presented with a giant verrucous carcinoma occupying the dorsal surface of the penile shaft. The patient underwent penile-sparing surgery, achieving both disease control and organ preservation. We discuss relevant issues, including clinical features, diagnosis, surgical management, and prognosis and we review the rather sparse literature regarding this rare lesion.

scholarly journals PKCαand ERβAre Associated with Triple-Negative Breast Cancers in African American and Caucasian Patients

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Debra A. Tonetti ◽  
Weihua Gao ◽  
Diana Escarzaga ◽  
Kelly Walters ◽  
April Szafran ◽  
...  
Keyword(s):  
African American ◽  
African American Women ◽  
Triple Negative ◽  
Endocrine Resistance ◽  
Immunohistochemical Analysis ◽  
Tumor Grade ◽  
The United States ◽  
Breast Cancers ◽  
Caucasian Patients ◽  
Caucasian Women

Although the incidence of breast cancer in the United States is higher in Caucasian women compared with African American women, African-American patients have more aggressive disease as characterized by a higher percentage of triple-negative breast cancers (TNBCs), high-grade tumors, and a higher mortality rate. PKCαis a biomarker associated with endocrine resistance and poor prognosis and ERβis emerging as a protective biomarker. Immunohistochemical analysis of ERβand PKCαexpression was performed on 198 formalin-fixed paraffin-embedded primary infiltrating ductal carcinomas from 105 African-American and 93 Caucasian patients. PKCαis positively correlated with TNBC in patients of both races and with high tumor grade in African-American patients. Patients with TNBC express less nuclear ERβcompared with all other subtypes. We find no difference in frequency or intensity of PKCαor ERβexpression between African-American and Caucasian patients. PKCαand ERβare discussed as potential therapeutic targets for the treatment of patients with TNBC.

scholarly journals Epidemiological profile of salivary gland lesions diagnosed in a higher education institution: an observational and retrospective study of 381 cases

2020 ◽  
Vol 42 ◽  
pp. e51032
Author(s):  
Claudio Freire Sesenta Junior ◽  
Camila Camarini ◽  
Isadora Balan ◽  
Lilian Cristina Vessoni Iwaki ◽  
Mariliani Chicarelli da Silva ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Medical Records ◽  
Education Institution ◽  
Malignant Neoplasms ◽  
Anatomical Location ◽  
Benign Neoplasms ◽  
State University ◽  
Neoplastic Lesions ◽  
Epidemiological Profile ◽  
Microscopic Diagnosis

The aim of this retrospective and observational study was to report the prevalence and characteristics of salivary gland lesions (SGL) in patients treated at the State University of Maringa, between 1995 and 2018. Data from medical records of patients with neoplastic and non-neoplastic SGL concerning to age, sex, ethnicity, anatomical location, microscopic diagnosis and treatment were collected. All SGL with diagnosis confirmed by microscopic examination were considered. Of the 3,127 biopsied lesions, 381 (12.1%) SGL were identified. Caucasian (71%) women (51%) aging from 11 to 20 years (33%) were more affected. 88.5% (n= 337) were non-neoplastic lesions, 7% (n= 27) benign neoplasms and 4.5% (n= 17) malignant neoplasms. Mucocele was the most prevalent lesion (n= 269%), followed by pleomorphic adenoma (n= 25%). Recognition and appropriate management of these lesions is essential, especially because malignant neoplastic lesions of the salivary glands can be very aggressive.

scholarly journals Verrucous carcinoma of vulva associated with lichen sclerosus and condyloma: case report

2021 ◽  
Vol 1 (4) ◽  
pp. 153-159
Author(s):  
Victor Hugo Ribeiro ◽  
Nilma Antas Neves
Keyword(s):  
Verrucous Carcinoma ◽  
Lichen Sclerosus ◽  
Intraepithelial Neoplasia ◽  
Metastatic Potential ◽  
Hpv Infection ◽  
Condyloma Acuminatum ◽  
Vulvar Intraepithelial Neoplasia ◽  
Menopausal Woman ◽  
High Morbidity ◽  
Rare Lesion

Vulvar Verrucous Carcinoma (VVC) is a rare lesion, with few described cases. It has low metastatic potential with high morbidity due to the necessity of extensive resections, although. Previously, VVC was considered a synonym to the Buschke-Lowenstein Tumor (BLT) or Giant Condyloma Acuminatum (GCA). Lichen Sclerosus (LS) is associated with Vulvar Intraepithelial Neoplasia (VIN) and Vulvar Squamous-cell carcinoma (SCC); association with VVC is also described. The case of a 60-year-old menopausal woman is reported; she had chronic itching and an extensive verrucous lesion in vulva, initially diagnosed and treated as condyloma acuminatum; there was recurrence as verrucous carcinoma associated to LS. Excision with margins was performed and clobetasol and imiquimod were used. Patient had complete remission with no further recurrences. Distinction between VVC and BLT can be difficult; current literature considers them different entities. Human papillomavirus (HPV) infection and the presence of LS play a controversial role in these injuries.

Detection of Nucleic Acids in Cells or Tissue Sections Using In situ Polymerase Chain Reaction (PCR)

1996 ◽  
Vol 54 ◽  
pp. 16-17
Author(s):  
J. R. Hully ◽  
K. R. Luehrsen ◽  
K. Aoyagi ◽  
C. Shoemaker ◽  
R. Abramson
Keyword(s):  
Nucleic Acids ◽  
Viral Infections ◽  
Anatomical Location ◽  
Rt Pcr ◽  
Reverse Transcription Pcr ◽  
Cellular Source ◽  
Gene Transcripts ◽  
Initial Description ◽  
In Cells

The development of PCR technology has greatly accelerated medical research at the genetic and molecular levels. Until recently, the inherent sensitivity of this technique has been limited to isolated preparations of nucleic acids which lack or at best have limited morphological information. With the obvious exception of cell lines, traditional PCR or reverse transcription-PCR (RT-PCR) cannot identify the cellular source of the amplified product. In contrast, in situ hybridization (ISH) by definition, defines the anatomical location of a gene and/or it’s product. However, this technique lacks the sensitivity of PCR and cannot routinely detect less than 10 to 20 copies per cell. Consequently, the localization of rare transcripts, latent viral infections, foreign or altered genes cannot be identified by this technique. In situ PCR or in situ RT-PCR is a combination of the two techniques, exploiting the sensitivity of PCR and the anatomical definition provided by ISH. Since it’s initial description considerable advances have been made in the application of in situ PCR, improvements in protocols, and the development of hardware dedicated to in situ PCR using conventional microscope slides. Our understanding of the importance of viral latency or viral burden in regards to HIV, HPV, and KSHV infections has benefited from this technique, enabling detection of single viral copies in cells or tissue otherwise thought to be normal. Clearly, this technique will be useful tool in pathobiology especially carcinogenesis, gene therapy and manipulations, the study of rare gene transcripts, and forensics.

Sign in / Sign up

Export Citation Format

Share Document