scholarly journals The Macroeconomic Determinants of COVID19 Mortality Rate and the Role of Post Subprime Crisis Decisions

2020 ◽  
Author(s):  
Stephane Goutte ◽  
Olivier Damette
Keyword(s):  
Mortality Rate ◽  
Subprime Crisis ◽  
Macroeconomic Determinants

Treatment of ebola and other infectious diseases: melatonin “goes viral”

2020 ◽  
Vol 3 (1) ◽  
pp. 43-57 ◽  
Author(s):  
Russel J Reiter ◽  
Qiang Ma ◽  
Ramaswamy Sharma
Keyword(s):  
Mortality Rate ◽  
Infectious Diseases ◽  
Hemorrhagic Shock ◽  
Safety Profile ◽  
Ebola Virus ◽  
Viral Infections ◽  
Virus Disease ◽  
Attractive Potential ◽  
Potential Treatment

This review summarizes published reports on the utility of melatonin as a treatment for virus-mediated diseases. Of special note are the data related to the role of melatonin in influencing Ebola virus disease. This infection and deadly condition has no effective treatment and the published works documenting the ability of melatonin to attenuate the severity of viral infections generally and Ebola infection specifically are considered. The capacity of melatonin to prevent one of the major complications of an Ebola infection, i.e., the hemorrhagic shock syndrome, which often contributes to the high mortality rate, is noteworthy. Considering the high safety profile of melatonin, the fact that it is easily produced, inexpensive and can be self-administered makes it an attractive potential treatment for Ebola virus pathology.  

scholarly journals The Role of Place of Delivery in Preventing Neonatal and Infant Mortality Rate in India

Geographies ◽  
2021 ◽  
Vol 1 (1) ◽  
pp. 47-62
Author(s):  
Ujjwal Das ◽  
Barkha Chaplot ◽  
Hazi Mohammad Azamathulla
Keyword(s):  
Mortality Rate ◽  
Infant Mortality ◽  
Neonatal Mortality ◽  
Public Hospitals ◽  
Infant Mortality Rate ◽  
Private Institutions ◽  
Public And Private ◽  
Place Of Delivery ◽  
At Home

Skilled birth attendance and institutional delivery have been advocated for reducing maternal, neonatal mortality and infant mortality (NMR and IMR). This paper examines the role of place of delivery with respect to neo-natal and infant mortality in India using four rounds of the Indian National Family Health Survey conducted in 2015–2016. The place of birth has been categorized as “at home” or “public and private institution.” The role of place of delivery on neo-natal and infant mortality was examined by using multivariate hazard regression models adjusted for clus-tering and relevant maternal, socio-economic, pregnancy and new-born characteristics. There were 141,028 deliveries recorded in public institutions and 54,338 in private institutions. The esti-mated neonatal mortality rate in public and private institutions during this period was 27 and 26 per 1000 live births respectively. The study shows that when the mother delivers child at home, the chances of neonatal mortality risks are higher than the mortality among children born at the health facility centers. Regression analysis also indicates that a professionally qualified provider′s antenatal treatment and assistance greatly decreases the risks of neonatal mortality. The results of the study illustrate the importance of the provision of institutional facilities and proper pregnancy in the prevention of neonatal and infant deaths. To improve the quality of care during and imme-diately after delivery in health facilities, particularly in public hospitals and in rural areas, accel-erated strengthening is required.

scholarly journals Mortality rate in rheumatoid arthritis-related interstitial lung disease: the role of radiographic patterns

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Maria A. Nieto ◽  
Maria J. Rodriguez-Nieto ◽  
Olga Sanchez-Pernaute ◽  
Fredeswinda Romero-Bueno ◽  
Leticia Leon ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Interstitial Lung Disease ◽  
Mortality Rate ◽  
General Population ◽  
Lung Disease ◽  
Interstitial Pneumonia ◽  
Usual Interstitial Pneumonia ◽  
Multiple Regression Model ◽  
Multicentric Study

Abstract Background To assess mortality rate (MR) and standardized mortality rate (SMR) of rheumatoid arthritis-related interstitial lung disease (RA-ILD) patients and to evaluate the role of radiographic patterns in mortality. Methods A longitudinal multicentric study was conducted in RA-ILD patients from 2005 to 2015 and followed-up until October 2018 in Madrid. Patients were included in the Neumologia-Reumatología y Enfermedades Autoinmunes Registry, from diagnosis of ILD. The main outcome was all-cause mortality. The radiographic pattern at baseline [usual interstitial pneumonia (UIP), nonspecific interstitial pneumonia (NSIP), or others] was the independent variable. Covariables included sociodemographic and clinical data. Survival techniques were used to estimate MR, expressed per 1000 persons-year with their 95% confidence intervals [CI]. Cox multiple regression model was run to examine the influence of radiographic patterns on survival. SMR [CI] was calculated comparing MR obtained with MR expected in the general population of Madrid by indirect age-gender standardization. Results 47 patients were included with a follow-up 242 patients-year. There were 16 (34%) deaths, and most frequent causes were acute ILD exacerbation and pneumonia. MR was 64.3 [39.4–104.9], and 50% of the patients died at 8.3 years from ILD diagnosis. After adjusting for confounders, (UIP compared to NSIP was associated with higher mortality risk. The overall SMR was 2.57 [1.4–4.17]. Women of 60–75 years of age were the group with the highest SMR. Conclusions RA-ILD is associated with an excess of mortality compared to general population. Our results support that UIP increases the risk of mortality in RA-ILD, regardless other factors.

Beta-Blocker Attenuates Cardiotoxicity Related Anthracycline Usage

2021 ◽  
Vol 104 (8) ◽  
pp. 1389-1392
Keyword(s):  
Side Effects ◽  
Cancer Therapy ◽  
Mortality Rate ◽  
Cancer Patients ◽  
Beta Blocker ◽  
The Other ◽  
Large Numbers ◽  
Therapy Effectiveness ◽  
Chemotherapy Agents

To summarize the recent trials and studies of the role of beta-blocker on the treatment for cancer patients treated with anthracycline to decrease morbidity and mortality rate. Good management of cancer will result in large numbers of cancer survivors. On the other hand, cancer therapy also has side effects, one of which is cardiotoxicity. Cardiotoxicity could reduce therapy effectiveness, hence, increase disease progression and mortality rate. Anthracyclines is one of the chemotherapy agents with cardiotoxicity as a side effect. Beta-blocker has the ability to reduce cardiotoxicity due to anthracyclines usage. Keywords: Beta-blocker; Cardiotoxicity; Anthracyclines

Role of clinical predictors in determining the need for mechanical ventilation in patients with acute stroke and their outcome- A Prospective observational study

2021 ◽  
Vol 12 (6) ◽  
pp. 16-22
Author(s):  
Maqsood Ahmad Dar ◽  
Eijaz Ahmad Bhat ◽  
Muzzafer M Mir
Keyword(s):  
Mechanical Ventilation ◽  
Mortality Rate ◽  
Acute Stroke ◽  
Developed Countries ◽  
Loss Of Consciousness ◽  
Motor Score ◽  
Clinical Predictors ◽  
Focal Neurological Deficit ◽  
Ventilator Support

Background: Stroke is the third leading cause of death in developed countries and the leading cause of long term disability. As the mortality during initial few days depends upon the compression of vital organs in brain stem due to raised intracranial tension and possible herniation, treatment for impending or early herniation requires intubation and mechanical ventilation and up to 10% of patients with acute stroke need mechanical ventilation due to different reasons. Aims and Objective: The aim of the study was to find the role of clinical predictors in determining the need for mechanical ventilation in patients with acute stroke and their outcome. Materials and Methods: This prospective observational cohort study was conducted from September 2017 to march 2019 of patients with acute stroke admitted either through OPD or Emergency/ Triage of Max super specialty hospital, Saket, New Delhi. Patients with acute Stroke defined as the presence of sudden onset of focal neurological deficit and admitted within 24 h of onset of symptoms with Age ≥18 years were included in the study. Patients already on ventilator support at the time of admission were excluded. Results: A total of 165 patients met the inclusion and exclusion criteria and were enrolled for the study. Out of 165 patients included in the study 43 (26.06 %) were put on the mechanical ventilation due to various reasons. Multivariate analysis of statistically significant and most clinically important variables showed the overall predictor accuracy of requirement of mechanical ventilation of 81.2% if the patients had loss of consciousness at the time of onset ( OR = 0.076) and Glasgow Coma Scale (GCS) motor score of ≤ 5 ( OR= 0.000). About 58.62% (17/29) patients who were put on ventilator support were found to have favorable outcome Modified Rankin Scale (MRS score ≤ 2) at discharge compared to 6.90% (2/29) before ventilation. Conclusion: We concluded that loss of consciousness at onset, GCS motor score ≤ 5 (OR= 0.000) were associated with overall predictor accuracy of 81.2% in determining the need for mechanical ventilation. We found overall in-hospital mortality rate of 9.1% whereas mortality rate in patients on mechanical ventilation was 32.55%.

scholarly journals SIR Model for Dengue Disease with Effect of Dengue Vaccination

2018 ◽  
Vol 2018 ◽  
pp. 1-14 ◽  
Author(s):  
Pratchaya Chanprasopchai ◽  
I. Ming Tang ◽  
Puntani Pongsumpun
Keyword(s):  
Mathematical Model ◽  
Mortality Rate ◽  
Dengue Virus ◽  
Numerical Solutions ◽  
Specific Treatment ◽  
Sir Model ◽  
Dengue Vaccine ◽  
Dengue Disease ◽  
Modelling Methods

The dengue disease is caused by dengue virus, and there is no specific treatment. The medical care by experienced physicians and nurses will save life and will lower the mortality rate. A dengue vaccine to control the disease is available in Thailand since late 2016. A mathematical model would be an important way to analyze the effects of the vaccination on the transmission of the disease. We have formulated an SIR (susceptible-infected-recovered) model of the transmission of the disease which includes the effect of vaccination and used standard dynamical modelling methods to analyze the effects. The equilibrium states and their stabilities are investigated. The trajectories of the numerical solutions plotted into the 2D planes and 3D spaces are presented. The main contribution is determining the role of dengue vaccination in the model. From the analysis, we find that there is a significant reduction in the total hospitalization time needed to treat the illness.

scholarly journals Effect of Convalescent Plasma Therapy on Viral Shedding and Survival in Patients With Coronavirus Disease 2019

2020 ◽  
Vol 222 (1) ◽  
pp. 38-43 ◽  
Author(s):  
Qing-Lei Zeng ◽  
Zu-Jiang Yu ◽  
Jian-Jun Gou ◽  
Guang-Ming Li ◽  
Shu-Huan Ma ◽  
...  
Keyword(s):  
Respiratory Failure ◽  
Mortality Rate ◽  
Severe Acute Respiratory Syndrome ◽  
Plasma Treatment ◽  
Critically Ill Patients ◽  
Plasma Therapy ◽  
Viral Shedding ◽  
Almost All ◽  
End Stage

Abstract Currently, coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been reported in almost all countries globally. No effective therapy has been documented for COVID-19, and the role of convalescent plasma therapy is unknown. In the current study, 6 patients with COVID-19 and respiratory failure received convalescent plasma a median of 21.5 days after viral shedding was first detected, all tested negative for SARS-CoV-2 RNA within 3 days after infusion, and 5 eventually died. In conclusion, convalescent plasma treatment can end SARS-CoV-2 shedding but cannot reduce the mortality rate in critically ill patients with end-stage COVID-19, and treatment should be initiated earlier.

scholarly journals Invasive Monitoring of Intracranial Pressure After Decompressive Craniectomy in Malignant Stroke

Stroke ◽  
2020 ◽  
Author(s):  
Silvia Hernández-Durán ◽  
Leonie Meinen ◽  
Veit Rohde ◽  
Christian von der Brelie
Keyword(s):  
Intracranial Pressure ◽  
Mortality Rate ◽  
Operating Characteristic ◽  
Receiver Operating Characteristic Analysis ◽  
High Specificity ◽  
Invasive Monitoring ◽  
Icp Monitoring ◽  
Characteristic Analysis ◽  
Decompressive Hemicraniectomy

Background and Purpose: The role of decompressive hemicraniectomy (DC) in malignant cerebral infarction (MCI) has clearly been established, but little is known about the course of intracranial pressure (ICP) in patients undergoing this surgical measure. In this study, we investigated the role of invasive ICP monitoring in patients after DC for MCI, postulating that postoperative ICP predicts mortality. Methods: In this retrospective observational study of MCI patients undergoing DC, ICP were recorded continuously in hourly intervals for the first 72 hours after DC. For every hour, mean ICP was calculated, pooling ICP of every patient. A receiver operating characteristic analysis was performed for hourly mean ICP. A subgroup analysis by age (≥60 years and <60 years) was also performed. Results: A total of 111 patients were analyzed, with 29% mortality rate in patients <60 years, and 41% in patients ≥60 years. A threshold of 10 mm Hg within the first 72 postoperative hours was a reliable predictor of mortality in MCI, with an acceptable sensitivity of 70% and high specificity of 97%. Established predictors of mortality failed to predict mortality. Conclusions: Our study suggests the need to reevaluate postoperative ICP after DC in MCI and calls for a redefinition of ICP thresholds in these patients to indicate further therapy.

scholarly journals Investigation of the Role of the Spike Protein in Reversing the Virulence of the Highly Virulent Taiwan Porcine Epidemic Diarrhea Virus Pintung 52 Strains and Its Attenuated Counterpart

Viruses ◽  
2019 ◽  
Vol 12 (1) ◽  
pp. 41 ◽  
Author(s):  
Chi-Fei Kao ◽  
Hui-Wen Chang
Keyword(s):  
Mortality Rate ◽  
Porcine Epidemic Diarrhea Virus ◽  
Rational Design ◽  
Economic Losses ◽  
Diarrhea Virus ◽  
Viral Shedding ◽  
S Gene ◽  
Porcine Epidemic Diarrhea ◽  
Highly Virulent

Porcine epidemic diarrhea virus (PEDV) has continuously caused severe economic losses to the global swine industries; however, no successful vaccine against PEDV has been developed. In this study, we generated four autologous recombinant viruses, including the highly virulent iPEDVPT-P5, attenuated iPEDVPT-P96, and two chimeric viruses (iPEDVPT-P5-96S and iPEDVPT-P96-5S) with the reciprocally exchanged spike (S) gene, to study the role of the S gene in PEDV pathogenesis. A deeper understanding of PEDV attenuation will aid in the rational design of a live attenuated vaccine (LAV) using reverse genetics system. Our results showed that replacing the S gene from the highly virulent iPEDVPT-P5 led to complete restoration of virulence of the attenuated iPEDVPT-P96, with nearly identical viral shedding, diarrhea pattern, and mortality rate as the parental iPEDVPT-P5. In contrast, substitution of the S gene with that from the attenuated iPEDVPT-P96 resulted in partial attenuation of iPEDVPT-P5, exhibiting similar viral shedding and diarrhea patterns as the parental iPEDVPT-P96 with slightly severe histological lesions and higher mortality rate. Collectively, our data confirmed that the attenuation of the PEDVPT-P96 virus is primarily attributed to mutations in the S gene. However, mutation in S gene alone could not fully attenuate the virulence of iPEDVPT-P5. Gene (s) other than S gene might also play a role in determining virulence.

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