scholarly journals Neurorehabilitation: Sanogenetic and pathogenetic foundations of innovative directions

2021 ◽  
Vol 16 (3) ◽  
pp. 159-170
Author(s):  
Lyudmila Tibekina ◽  
◽  
Alexander Shaposhnikov ◽  
Keyword(s):  
Recovery Process ◽  
Maximum Effect ◽  
Self Healing ◽  
Organizational Model ◽  
Endogenous Factors ◽  
Neurological Patients ◽  
Single Complex ◽  
Rehabilitation Measures ◽  
The Relationship ◽  
Theory Of Functional Systems

The processes of sanogenesis and pathogenesis in patients with acute cerebrovascular accident occur simultaneously, starting with the acute period of stroke. In most cases, this is a single process viewed from different perspectives. Modern innovative areas of neurorehabilitation include the use of drug therapy, rehabilitation measures and mechanisms of sanogenesis and self-healing, which can be influenced by the methods used in the course of restoring the health of neurological patients. The organizational model of modern neurorehabilitation is based on an interdisciplinary multistage approach. The analysis of the relationship between patho‑ and sanogenetic reactions is important for the development of this organizational model. Exogenous therapeutic and rehabilitation measures form a single complex with endogenous factors of sanogenesis. These measures achieve the maximum effect only with the conscious active participation of the patient in the recovery process. The theoretical basis of the research is the concept of the theory of functional systems by P. K. Anokhin and the axiomatic theory of human health. The integration of these approaches is considered as the most general self-acting self-healing mechanism, concretized in the form of the concept of sanogenesis. Mechanisms for maintaining homeostasis are activated at all levels when a damaging factor occurs. Pathogenesis develops, becoming an integral part of the processes of sanogenesis.

Desire for Self-healing

2017 ◽  
Vol 12 (1-2) ◽  
pp. 317-335
Author(s):  
Ngar-sze Lau
Keyword(s):  
Theravada Buddhism ◽  
Self Healing ◽  
Core Knowledge ◽  
The Third ◽  
The Core ◽  
Physical Suffering ◽  
Mind And Body ◽  
Core Practice ◽  
The Relationship ◽  
Contemporary Chinese

Abstract This practice report describes how Chinese meditators understand the “four foundations of mindfulness” (satipaṭṭhāna, sinianzhu 四念住) as a remedy for both mental and physical suffering. In the tradition of Theravāda Buddhism, satipaṭṭhāna is particularly recognized as the core knowledge for understanding the relationship between mind and body, and the core practice leading to liberation from suffering. Based on interviews with Chinese meditation practitioners, this study develops three main themes concerning how they have alleviated afflictions through the practice of satipaṭṭhāna. The first theme highlights how practitioners learn to overcome meditation difficulties with “right attitude.” The second theme is about practicing awareness with “six sense doors” open in order to facilitate the balance of the “five faculties.” The third theme explores how practitioners cultivate daily life practice through an understanding of the nature of mind and body as impermanent and as not-self. This paper details how these themes and embodied practices of satipaṭṭhāna constitute ways of self-healing for urban educated Buddhists in the contemporary Chinese context.

Interaction of Concentrated Solar Radiation with Materials

2020 ◽  
pp. 1-3
Author(s):  
Muhammad-Sultanhan Paizullahanov ◽  
◽  
Rasul Akbarov ◽  
Abdurashid Abdurakhim Uglu ◽  
Kholmatov, Muslimbek Mukhsinjon ugli Sobirov ◽  
...  
Keyword(s):  
Dielectric Properties ◽  
Solar Radiation ◽  
Recovery Process ◽  
Solar Furnace ◽  
Structure And Properties ◽  
Technological Parameters ◽  
Fine Grained ◽  
Concentrated Solar Radiation ◽  
The Relationship ◽  
Synthesis Of Materials

The paper analyzes approaches to modeling the processes of interaction of concentrated solar radiation with materials. The experimental results obtained on the synthesis of materials from a melt in a solar furnace are presented. It is shown that when melting in a solar furnace under the influence of concentrated solar radiation of high density due to the acceleration of the recovery process, it is possible to obtain a fine-grained microstructure that gives the material enhanced mechanical and dielectric properties. It is shown that the relationship between the structure and properties of the materials obtained with the technological parameters of melting and cooling in a solar furnace can be used as an approach to modeling the interaction of concentrated solar radiation with materials

scholarly journals Strategy Orientation, Innovation Capacity Endowment, and International R&D Intensity of Listed Companies in China

2020 ◽  
Vol 12 (1) ◽  
pp. 344 ◽  
Author(s):  
Jianhong He ◽  
Hongmin Chen ◽  
Fu-Sheng Tsai
Keyword(s):  
Positive Impact ◽  
Bootstrap Method ◽  
Inhibitory Effect ◽  
Chinese Enterprises ◽  
Mediation Effects ◽  
Endogenous Factors ◽  
Mediating Role ◽  
Innovation Capacity ◽  
Technology Orientation ◽  
The Relationship

Based on the endogenous factors which can affect the strategy of international R&D of China’s enterprises, an analysis is carried out on the relationship between market- and technology-orientation of the strategy and the intensity of international R&D. In addition, the mediation effects of innovation capacity endowment are discussed. On this basis, 254 listed enterprises with overseas R&D institutions approved by the Ministry of Commerce of China were taken as the sample for survey administration. The poisson regression method was adopted to test the hypotheses. Additionally, we utilized the Bootstrap method to confirm the robustness of the regression models. Results show that for Chinese enterprises with significant international R&D strategy intentions, market orientation has a significant inhibitory effect on their international R&D intensity, while the technology orientation has a significant stimulating effect on international R&D. In addition, innovation capacity has a significant positive impact on the intensity of international R&D, and plays a partial mediating role in the relationship between technology orientation and international R&D. Therefore, to promote international R&D strategies in the era of high-quality economic development, Chinese enterprises are suggested to establish an innovation-oriented strategy orientation to promote innovation cultural heritage, and to strengthen the accumulation of innovative resources and capabilities.

Temperature Profile of Microencapsulation for Self-Healing Application

2010 ◽  
Vol 143-144 ◽  
pp. 353-357
Author(s):  
Ting Ting Li ◽  
Xing Liu ◽  
Rui Wang
Keyword(s):  
Temperature Profile ◽  
Shell Thickness ◽  
Urea Formaldehyde ◽  
Life Time ◽  
Self Healing ◽  
Time Service ◽  
Healing Efficiency ◽  
Performance Surface ◽  
The Relationship

Healing agents significantly affect the efficiency of healing microcracks, which produced from life-time service in composites. And microencapsulating 5-ethylidene-2-norbornene (ENB) with Melamine-Urea-Formaldehyde (MUF) shell possessing higher self-healing efficiency is sensitive to the manufacture temperature profile which is difficult to control but crucial to the microcapsule performance and thus the reproducibility. In this paper, we studied the relationship between heating curve (rate, steps and time) and microcapsule performance (surface morphology, thermal stability and shell thickness). It shows that fast-slower heating stage produces the best quality of microcapsule with proper outer and inner surface which can endure 285°C, and the particle size is about 100m with 400-700nm shell thickness.

Influence of Cement Coarse Particle on the Self-Healing Ability of Concrete Based on Ultrasonic Method

2010 ◽  
Vol 177 ◽  
pp. 526-529 ◽  
Author(s):  
Zhi Qiang Li ◽  
Zong Hui Zhou ◽  
Dong Yu Xu ◽  
Jing Hua Yu
Keyword(s):  
Particle Size ◽  
Wave Amplitude ◽  
Ultrasonic Method ◽  
The Self ◽  
Experimental Results ◽  
Coarse Particle ◽  
Head Wave ◽  
Self Healing ◽  
Before And After ◽  
The Relationship

The influences of particle size and mixing content of coarse cement on the self-healing ability of concrete were researched by ultrasonic method. Damaged degree was measured through the decrease of ultrasonic head wave amplitude (UHA) before and after loading. The relationship between damaged degree and self-healing ratio of concrete was built based on the experimental results as well as the relationship between cement diameter and self-healing ratio of concrete. Analyzing results show that UHA can evaluate the damaged degree of concrete clearly. There exists a damaged threshold of the concrete during loading. Under the same mixing content of coarse cement, when the damaged degree is higher than the threshold, the self-healing ratio of concrete decreases with the increase of damaged degree and increases with the increase of coarse cement diameter, however, while the damaged degree is less than the threshold, the self-healing ratio of concrete increases with both the increase of damaged degree and coarse cement diameter.

scholarly journals Oral Artesunate Dose-Response Relationship in Acute Falciparum Malaria

2002 ◽  
Vol 46 (3) ◽  
pp. 778-782 ◽  
Author(s):  
Brian J. Angus ◽  
Itaporn Thaiaporn ◽  
Kenechanh Chanthapadith ◽  
Yupin Suputtamongkol ◽  
Nicholas J. White
Keyword(s):  
Falciparum Malaria ◽  
Dose Response ◽  
Parasite Clearance ◽  
Multidrug Resistant ◽  
Maximum Effect ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
To Receive ◽  
The Relationship

ABSTRACT The combination of an oral artemisinin derivative (usually artesunate) and mefloquine has become standard treatment for multidrug-resistant falciparum malaria in several parts of Southeast Asia. The doses of artesunate used in monotherapy and combination treatment have largely been derived empirically. In order to characterize the in vivo dose-response relationship for artesunate and thus rationalize dosing, 47 adult patients with acute uncomplicated falciparum malaria and parasitemia ≥1% were randomized to receive a single oral dose of artesunate varying between 0 and 250 mg together with a curative dose of oral mefloquine. Acceleration of parasite clearance was used as the pharmacodynamic variable. An inhibitory sigmoidal maximum effect (E max) pharmacodynamic model typical of a dose-response curve was fitted to the relationship between dose and shortening of parasite clearance time (PCT). The E max was estimated as 28.6 oral h, and the 50% effective concentration was 1.6 mg/kg of body weight. These results imply that there is no reduction in PCTs with the use of single doses of artesunate higher than 2 mg/kg, and this therefore reflects the average lower limit of the maximally effective dose.

REGIONAL COMPETITIVENESS ANALYSIS AND ITS IMPLICATIONS FOR THE SPATIAL PLANNING OF LATGALE REGION

2019 ◽  
Vol 6 ◽  
pp. 142
Author(s):  
Sandra Ezmale
Keyword(s):  
Quantitative Analysis ◽  
Regional Development ◽  
Significant Role ◽  
Spatial Planning ◽  
Economic Activities ◽  
Regional Competitiveness ◽  
Endogenous Factors ◽  
The Relationship

This paper offers a contribution to contemporary studies of spatial planning. In particular, it focuses on the relationship between competitiveness and spatial planning. In the topical academic debates, there has been a growing interest in raising new paradigms to introduce innovative ways of undertaking long-lasting regional development problems. Territorial assets and spatial qualities have increasingly been regarded as factors for attracting on economic activities and increasing the competitiveness of regions. Spatial and non-spatial policies, planning documents, may have a significant role in enhancing the competitiveness of regions and territories by changing endogenous factors and producing shifts related to positioning and increasing the competitiveness of regions. This paper contains an analysis of competitiveness dimensions in the spatial planning documents of     Latgale planning region (Latvia) by focusing on a quantitative analysis of the specific dimensions of competitiveness.  

Posttraumatic Growth as a Mediator of Self-Blame and Happiness in the Context of Interpersonal Violence

2018 ◽  
Vol 33 (6) ◽  
pp. 1088-1101 ◽  
Author(s):  
Elizabeth A. Moschella ◽  
Sidney Turner ◽  
Victoria L. Banyard
Keyword(s):  
Posttraumatic Growth ◽  
Interpersonal Violence ◽  
Partner Violence ◽  
Recovery Process ◽  
The United States ◽  
Intimate Partner ◽  
Future Research ◽  
Self Blame ◽  
The Impact ◽  
The Relationship

Sexual assault (SA) and intimate partner violence (IPV) occur at alarming rates in the United States. Prior research indicates that victims of traumatic events frequently experience both positive and negative changes as part of their recovery process. The present study aimed to further existing research by examining the relationship between self-blame, posttraumatic growth (PTG), and happiness when controlling for posttraumatic stress and time since victimization. The current study analyzed 357 women who had experienced at least one incident of SA or IPV. We found that PTG partially mediated the relationship between self-blame and happiness, suggesting that PTG only somewhat explains the impact of self-blame on victim happiness. Implications of these findings and directions for future research are discussed.

Relationship between abiraterone exposure, prostate-specific antigen (PSA) kinetics, and overall survival (OS) in patients with metastatic castration-resistant prostate cancer (mCRPC) .

2014 ◽  
Vol 32 (4_suppl) ◽  
pp. 39-39 ◽  
Author(s):  
Steven Xu ◽  
Charles J. Ryan ◽  
Kim Stuyckens ◽  
Matthew R. Smith ◽  
Fred Saad ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Overall Survival ◽  
Specific Antigen ◽  
Maximum Effect ◽  
Castration Resistant Prostate Cancer ◽  
Modeling Framework ◽  
Psa Kinetics ◽  
Castration Resistant ◽  
Survival Modeling ◽  
The Relationship

39 Background: Abiraterone, the active metabolite of abiraterone acetate (AA), is an effective androgen biosynthesis inhibitor for patients with metastatic castration-resistant prostate cancer (mCRPC). We conducted a sequential exposure-biomarker-survival modeling analysis to explore the relationship between prostate-specific antigen (PSA) kinetics and overall survival (OS) and to establish the exposure response for PSA kinetics and OS in chemotherapy-naïve and -pretreated patients with mCRPC following AA administration. Methods: The exposure-PSA-survival modeling framework was based on two phase III studies, COU-AA-301 (chemotherapy-pretreated, N = 1184) and COU-AA-302 (chemotherapy-naïve, N = 1081), and included a mixed-effects tumor growth inhibition (TGI) model to describe PSA dynamics in response to AA and a Cox proportional hazards survival model to evaluate the relationship between relative risk of death and PSA dynamic end points. Results: The TGI model best described the longitudinal PSA dynamics following AA treatment. Abiraterone exposure significantly increased PSA decay rate (maximum effect of 2.72, p < 0.0001). The estimated concentration for 50% of the maximum effect (EC50) was 4.75 ng/mL. The abiraterone effect on PSA kinetics was similar in chemotherapy-naïve and -pretreated subjects, and approximately 90% of subjects had a steady-state concentration greater than the EC50. All model-predicted PSA metrics were strongly associated with OS in both populations; model-based post-treatment PSA doubling time showed the strongest association (hazard ratios approximately 0.9 in both populations). Simulations showed that the modeling framework could accurately predict the survival outcome for both studies. Conclusions: The analysis revealed a similar effect of abiraterone on PSA kinetics and association between PSA kinetics and OS in chemotherapy-naïve and -pretreated subjects, providing additional evidence for surrogacy of PSA kinetics and the use of PSA end points to indicate clinical benefit of abiraterone in subjects with mCRPC regardless of prior chemotherapy. Furthermore, the study confirmed that the recommended 1,000 mg/d dose of AA leads to adequate clinical exposure above the effective level. Clinical trial information: NCT00638690, NCT00887198.

The Relationship between the Initial Gas Ratios and the Condensed Phase Composition in the CVD of BxC with BCl3-CH4-H2 Precursors

2011 ◽  
Vol 239-242 ◽  
pp. 1761-1765 ◽  
Author(s):  
Juan Li Deng ◽  
Lai Fei Cheng ◽  
Li Ning Gao ◽  
Ke He Su
Keyword(s):  
Condensed Phase ◽  
Molar Ratio ◽  
Ideal Condition ◽  
Deposition Condition ◽  
Self Healing ◽  
Rich Phase ◽  
Healing Phase ◽  
Temperature And Pressure ◽  
Rich Material ◽  
The Relationship

For the preparation of the self-healing phase BxC with BCl3-CH4-H2precursors, the production has been examined as a function of the initial gas ratios of BCl3/(BCl3+CH4) and H2/(BCl3+CH4) at given temperature and pressure. The results show that the composition of the condensed phase is quite sensitive to the molar ratio of BCl3/(BCl3+CH4) and H2/(BCl3+CH4). The ideal condition for the deposition of BxC is that the ratio of BCl3/(BCl3+CH4) is 0.8 and the H2/(BCl3+CH4) ratio ranges from 10 to 105.2. The carbon or boron-rich material is mainly controlled by the ratios of BCl3/(BCl3+CH4) and H2/(BCl3+CH4). The deposition condition of carbon-rich phase should be in low BCl3/(BCl3+CH4) (0.0~0.8) and H2/(BCl3+CH4) (10-2<102) ratios, whereas that of the boron-rich phase needs high BCl3/(BCl3+CH4) (0.8~1.0) and H2/(BCl3+CH4) (104~105) ratios.

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