scholarly journals Tools of the Trade: How Do You Perform and Interpret an Exercise Test?

2019 ◽  
Vol 18 (2) ◽  
pp. 47-55
Author(s):  
Franz P. Rischard ◽  
Barry A. Borlaug
Keyword(s):  
Cardiopulmonary Exercise Testing ◽  
Response To Therapy ◽  
Pulmonary Vascular Disease ◽  
Clear Understanding ◽  
Valuable Insight ◽  
Adaptation To Stress ◽  
The Individual ◽  
Cardiopulmonary System ◽  
Insight Into ◽  
Minute Walk

Background: Most pulmonary vascular disease (PVD) is poorly modifiable and incurable even with effective therapy. Therefore, adaptation to stress, the reserve of the cardiopulmonary system, is important for assessment of patient function and prognosis. Methods that assess the adaptation to stress, especially exercise, provide valuable insight into diagnosis, prognosis, and response to therapy. Implications for Clinicians: We provide a comprehensive review of the indications, methodology, and interpretation, as well as practical information of the forms of provocative testing in PVD. We include 6-minute walk testing, noninvasive cardiopulmonary exercise testing (CPET), invasive CPET, and additional forms, including volume loading. Conclusions: Through a clear understanding of the methodology in the assessment of PVD, the clinician can determine which of these “tools of the trade” are best suited to the individual patient and situation.

scholarly journals Meteorological Impacts on Commercial Aviation Delays and Cancellations in the Continental United States

2019 ◽  
Vol 58 (3) ◽  
pp. 479-494 ◽  
Author(s):  
Christopher J. Goodman ◽  
Jennifer D. Small Griswold
Keyword(s):  
Extreme Weather Events ◽  
Valuable Insight ◽  
National Airspace System ◽  
Safety Hazards ◽  
Commercial Aviation ◽  
Weather Events ◽  
The Individual ◽  
Causes Of Delays ◽  
Weather’S Impact ◽  
Insight Into

AbstractWeather creates numerous operational and safety hazards within the National Airspace System (NAS). In 2014, extreme weather events attributed 4.3% to the total number of delay minutes recorded by the Bureau of Transportation Statistics. When factoring weather’s impact on the NAS delays and aircraft arriving late delays, weather was responsible for 32.6% of the total number of delay minutes recorded. Hourly surface meteorological aviation routine weather reports (METARs) at major airports can be used to provide valuable insight into the likely causes of weather delays at individual airports. When combined with the Federal Aviation Administration’s (FAA’s) Operations Network (OPSNET) delay data, METARs can be used to identify the major causes of delays and to create delay climatologies for a specific airport. Also, patterns for delays and cancellations for the study period of 2003–15 can be identified for the individual airports included in this study. These patterns can be useful for operators and airport planners to optimize performance in the future.

scholarly journals HDXmodeller: an online webserver for high-resolution HDX-MS with auto-validation

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Ramin Ekhteiari Salmas ◽  
Antoni James Borysik
Keyword(s):  
High Resolution ◽  
Exchange Rates ◽  
Valuable Insight ◽  
Proteolytic Digestion ◽  
Folding Dynamics ◽  
Hydrogen Deuterium ◽  
Exchange Rate Models ◽  
The Individual ◽  
Hdx Ms ◽  
Insight Into

AbstractThe extent to which proteins are protected from hydrogen deuterium exchange (HDX) provides valuable insight into their folding, dynamics and interactions. Characterised by mass spectrometry (MS), HDX benefits from negligible mass restrictions and exceptional throughput and sensitivity but at the expense of resolution. Exchange mechanisms which naturally transpire for individual residues cannot be accurately located or understood because amino acids are characterised in differently sized groups depending on the extent of proteolytic digestion. Here we report HDXmodeller, the world’s first online webserver for high-resolution HDX-MS. HDXmodeller accepts low-resolution HDX-MS input data and returns high-resolution exchange rates quantified for each residue. Crucially, HDXmodeller also returns a set of unique statistics that can correctly validate exchange rate models to an accuracy of 99%. Remarkably, these statistics are derived without any prior knowledge of the individual exchange rates and facilitate unparallel user confidence and the capacity to evaluate different data optimisation strategies.

The Revista Ştiinţifică “Vasile Adamachi” and its role in forming national and international scientific awareness of Greater Romania, 1910–1933

2021 ◽  
pp. 007327532110549
Author(s):  
Alexandra Chiriac
Keyword(s):  
National Identity ◽  
Communication Channel ◽  
Continuous Process ◽  
The Self ◽  
Valuable Insight ◽  
National Consciousness ◽  
Slow Progress ◽  
State Of Research ◽  
The Individual ◽  
Insight Into

The Revista Ştiinţifică “Vasile Adamachi” (1910–1948) had aimed since its first edition to disseminate the newest achievements of science to the interested general public with the explicit intention of building national consciousness and solidarity that would forward Romania’s natural powers through science. Even though the editors of the journal had complained constantly that their efforts to promote the national scientific movement were making slow progress, they maintained their openness toward the international state of research by publishing notes and reviews of the main scientific developments worldwide. Caught between those two ideals (that of a Romanian science and of keeping up with the international scientific scene), the journal reflects the struggles, the difficulties, but also the successes of the individual researchers, acting as a two-way communication channel between science producers and consumers. It provides us with a valuable insight into the Self versus Other perception in a time when contact between the Romanian and Western European cultures was beginning to consciously evolve from mere imitation of a dominant power to the incorporation of fragmented foreign categories. It is a perfect example of ‘patchwork’, in which the native and foreign elements coexisted in a continuous process of redefining and reshaping the newly formed national identity.

scholarly journals Chess Not Checkers: Complexities Within the Myeloid Response to the Acute Kidney Injury Syndrome

2021 ◽  
Vol 8 ◽  
Author(s):  
William T. Nash ◽  
Mark D. Okusa
Keyword(s):  
Acute Kidney Injury ◽  
Immune Responses ◽  
Kidney Injury ◽  
Myeloid Cell ◽  
Immune Dysregulation ◽  
Clear Understanding ◽  
Valuable Insight ◽  
Cell Dynamics ◽  
Dynamic Population ◽  
Insight Into

Immune dysregulation in acute kidney injury (AKI) is an area of intense interest which promises to enhance our understanding of the disease and how to manage it. Macrophages are a heterogeneous and dynamic population of immune cells that carry out multiple functions in tissue, ranging from maintenance to inflammation. As key sentinels of their environment and the major immune population in the uninjured kidney, macrophages are poised to play an important role in the establishment and pathogenesis of AKI. These cells have a profound capacity to orchestrate downstream immune responses and likely participate in skewing the kidney environment toward either pathogenic inflammation or injury resolution. A clear understanding of macrophage and myeloid cell dynamics in the development of AKI will provide valuable insight into disease pathogenesis and options for intervention. This review considers evidence in the literature that speaks to the role and regulation of macrophages and myeloid cells in AKI. We also highlight barriers or knowledge gaps that need to be addressed as the field advances.

scholarly journals From Uniaxial Testing of Isolated Layers to a Tri-Layered Arterial Wall: A Novel Constitutive Modelling Framework

2021 ◽  
Author(s):  
Alessandro Giudici ◽  
Ashraf W. Khir ◽  
Jason M. Szafron ◽  
Bart Spronck
Keyword(s):  
Arterial Wall ◽  
Strain Energy Function ◽  
Wall Stress ◽  
Constitutive Modelling ◽  
Valuable Insight ◽  
Modelling Framework ◽  
Uniaxial Testing ◽  
The Individual ◽  
Insight Into

AbstractMechanical testing and constitutive modelling of isolated arterial layers yields insight into the individual layers’ mechanical properties, but per se fails to recapitulate the in vivo loading state, neglecting layer-specific residual stresses. The aim of this study was to develop a testing/modelling framework that integrates layer-specific uniaxial testing data into a three-layered model of the arterial wall, thereby enabling study of layer-specific mechanics under realistic (patho)physiological conditions. Circumferentially and axially oriented strips of pig thoracic aortas (n = 10) were tested uniaxially. Individual arterial layers were then isolated from the wall, tested, and their mechanical behaviour modelled using a hyperelastic strain energy function. Subsequently, the three layers were computationally assembled into a single flat-walled sample, deformed into a cylindrical vessel, and subjected to physiological tension-inflation. At the in vivo axial stretch of 1.10 ± 0.03, average circumferential wall stress was 75 ± 9 kPa at 100 mmHg, which almost doubled to 138 ± 15 kPa at 160 mmHg. A ~ 200% stiffening of the adventitia over the 60 mmHg pressure increase shifted layer-specific load-bearing from the media (65 ± 10% → 61 ± 14%) to the adventitia (28 ± 9% → 32 ± 14%). Our approach provides valuable insight into the (patho)physiological mechanical roles of individual arterial layers at different loading states, and can be implemented conveniently using simple, inexpensive and widely available uniaxial testing equipment.

scholarly journals Techniques for Identifying the Age and Sex of Children at Death

2018 ◽  
Author(s):  
Jo Buckberry
Keyword(s):  
Life Histories ◽  
Skeletal Remains ◽  
Infants And Children ◽  
Dental Development ◽  
Valuable Insight ◽  
Age At Death ◽  
The Past ◽  
The Individual ◽  
Insight Into ◽  
Age And Sex

The skeletal remains of infants and children are a poignant reminder of the perilous nature of childhood in the past, yet they offer valuable insight into the life histories of individuals and into the health of populations. Many osteoarchaeological and bioarchaeological analyses are dependent on two vital pieces of information: the age-at-death and sex of the individual(s) under study. This chapter will outline how age-at-death and sex can be estimated from the skeletal remains and dental development of non-adults, and how these are easier or more difficult to determine than for adults, and will discuss the complexities and controversies surrounding different methods.

Study of the resistor material of an automotive spark plug by use of the charge-up effect along with elemental mapping in an electron microprobe

1991 ◽  
Vol 49 ◽  
pp. 742-743
Author(s):  
D. R. Liu ◽  
S. S. Shinozaki ◽  
J. S. Park ◽  
B. N. Juterbock
Keyword(s):  
Electron Microprobe ◽  
Present Report ◽  
Coated Sample ◽  
Valuable Insight ◽  
Elemental Mapping ◽  
Spark Plug ◽  
Carbon Coated ◽  
Electron Image ◽  
Electron Imaging ◽  
Insight Into

The electric and thermal properties of the resistor material in an automotive spark plug should be stable during its service lifetime. Containing many elements and many phases, this material has a very complex microstructure. Elemental mapping with an electron microprobe can reveal the distribution of all relevant elements throughout the sample. In this work, it is demonstrated that the charge-up effect, which would distort an electron image and, therefore, is normally to be avoided in an electron imaging work, could be used to advantage to reveal conductive and resistive zones in a sample. Its combination with elemental mapping can provide valuable insight into the underlying conductivity mechanism of the resistor.This work was performed in a CAMECA SX-50 microprobe. The spark plug used in the present report was a commercial product taken from the shelf. It was sectioned to expose the cross section of the resistor. The resistor was known not to contain the precious metal Au as checked on the carbon coated sample. The sample was then stripped of carbon coating and re-coated with Au.

Quantum Mechanical Interpretation of the Ultra-Low Energy Methyl-Rotation Dynamics in Porous Metal-Organic Frameworks Probed by Low-Frequency Vibrational Spectroscopy and ab initio Simulations

2018 ◽  
Author(s):  
Qi Li ◽  
Adam J. Zaczek ◽  
Timothy M. Korter ◽  
J. Axel Zeitler ◽  
Michael T. Ruggiero
Keyword(s):  
Ab Initio ◽  
Metal Organic Frameworks ◽  
Low Frequency ◽  
Rotor Dynamics ◽  
Quantum Mechanical ◽  
Valuable Insight ◽  
Void Space ◽  
Ab Initio Simulations ◽  
Metal Organic ◽  
Insight Into

<div>Understanding the nature of the interatomic interactions present within the pores of metal-organic frameworks</div><div>is critical in order to design and utilize advanced materials</div><div>with desirable applications. In ZIF-8 and its cobalt analogue</div><div>ZIF-67, the imidazolate methyl-groups, which point directly</div><div>into the void space, have been shown to freely rotate - even</div><div>down to cryogenic temperatures. Using a combination of ex-</div><div>perimental terahertz time-domain spectroscopy, low-frequency</div><div>Raman spectroscopy, and state-of-the-art ab initio simulations,</div><div>the methyl-rotor dynamics in ZIF-8 and ZIF-67 are fully charac-</div><div>terized within the context of a quantum-mechanical hindered-</div><div>rotor model. The results lend insight into the fundamental</div><div>origins of the experimentally observed methyl-rotor dynamics,</div><div>and provide valuable insight into the nature of the weak inter-</div><div>actions present within this important class of materials.</div>

A Review of Phytochemical and Pharmacological Studies of Inula Species

2020 ◽  
Vol 16 (5) ◽  
pp. 557-567
Author(s):  
Aparoop Das ◽  
Anshul Shakya ◽  
Surajit Kumar Ghosh ◽  
Udaya P. Singh ◽  
Hans R. Bhat
Keyword(s):  
Bacterial Infections ◽  
Chemical Constituents ◽  
Valuable Insight ◽  
Important Ingredient ◽  
Pharmacological Activities ◽  
Medicinal Uses ◽  
The Family ◽  
Pharmacological Studies ◽  
Perennial Herbs ◽  
Insight Into

Background: Plants of the genus Inula are perennial herbs of the family Asteraceae. This genus includes more than 100 species, widely distributed throughout Europe, Africa and Asia including India. Many of them are indicated in traditional medicine, e.g., in Ayurveda. This review explores chemical constituents, medicinal uses and pharmacological actions of Inula species. Methods: Major databases and research and review articles retrieved through Scopus, Web of Science, and Medline were consulted to obtain information on the pharmacological activities of the genus Inula published from 1994 to 2017. Results: Inula species are used either alone or as an important ingredient of various formulations to cure dysfunctions of the cardiovascular system, respiratory system, urinary system, central nervous system and digestive system, and for the treatment of asthma, diabetes, cancers, skin disorders, hepatic disease, fungal and bacterial infections. A range of phytochemicals including alkaloids, essential and volatile oils, flavonoids, terpenes, and lactones has been isolated from herbs of the genus Inula, which might possibly explain traditional uses of these plants. Conclusion: The present review is focused on chemical constituents, medicinal uses and pharmacological actions of Inula species and provides valuable insight into its medicinal potential.

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