Review and comparative analysis of machine learning-based predictors for predicting and analyzing of anti-angiogenic peptides

2021 ◽  
Vol 28 ◽  
Author(s):  
Phasit Charoenkwan ◽  
Wararat Chiangjong ◽  
Md. Mehedi Hasan ◽  
Chanin Nantasenamat ◽  
Watshara Shoombuatong
Keyword(s):  
Machine Learning ◽  
Comparative Analysis ◽  
Causes Of Death ◽  
Cross Validation ◽  
Rapid Screening ◽  
Ongoing Effort ◽  
Anti Cancer ◽  
Common Framework ◽  
Screening And Identification ◽  
The Common

: Cancer is one of the leading causes of death worldwide and underlying this is angiogenesis that represents one of the hallmarks of cancer. Ongoing effort is already under way in the discovery of anti-angiogenic peptides (AAPs) as a promising therapeutic route by tackling the formation of new blood vessels. As such, the identification of AAPs constitutes a viable path for understanding their mechanistic properties pertinent for the discovery of new anti-cancer drugs. In spite of the abundance of peptide sequences in public databases, experimental efforts in the identification of anti-angiogenic peptides have progressed very slowly owing to its high expenditures and laborious nature. Owing to its inherent ability to make sense of large volumes of data, machine learning (ML) represents a lucrative technique that can be harnessed for peptide-based drug discovery. In this review, we conducted a comprehensive and comparative analysis of ML-based AAP predictors in terms of their employed feature descriptors, ML algorithms, cross-validation methods and prediction performance. Moreover, the common framework of these AAP predictors and their inherent weaknesses are also discussed. Particularly, we explore future perspectives for improving the prediction accuracy and model interpretability, which represents an interesting avenue for overcoming some of the inherent weaknesses of existing AAP predictors. We anticipate that this review would assist researchers in the rapid screening and identification of promising AAPs for clinical use.

scholarly journals Comparative Analysis of Machine Learning Classifiers for the Prediction of Malaria Incidence Attributed to Climatic Factors

2020 ◽  
Author(s):  
Pallavi Mohapatra ◽  
N.K. Tripathi ◽  
Indrajit Pal ◽  
Sangam Shrestha
Keyword(s):  
Machine Learning ◽  
Comparative Analysis ◽  
Cross Validation ◽  
Climatic Factors ◽  
Malaria Incidence ◽  
Maximum Temperature ◽  
Suitable Model ◽  
Seasonal Temperature ◽  
Medium Range Weather Forecast ◽  
Fold Cross Validation

Abstract Background: India has a rising rate of malaria as well as a high mortality rate despite awareness and efforts being focused on the issue. Some regions are profoundly affected than others, such as in Odisha, where the prevalence of malaria is nearly a third of the whole country. This study investigated the influence of climate factors on the incidence of malaria in the Sundargarh district in the state of Odisha, India. Methods: Block-wise observed station rainfall data was sourced from the Special Relief Commissioners' (SRC) web portal. Gridded surface maximum temperature and relative humidity data were accessed from the European Center for Medium-range Weather Forecast (ECMWF) reanalysis data archive. Malaria incident data were collected from the Directorate of Public Health, Government of Odisha. WEKA machine learning tool with two classifier techniques, Multi-Layer Perceptron (MLP) and J48 with 10-fold cross-validation, percentile split (66%), and supplied test options, were used for the Malaria prediction. A comparative analysis was carried out on both techniques to ascertain the superior model amongst the two, concerning the prediction accuracy of malaria in the context of a varying climate. Classifier accuracy, Root Mean Square Error (RMSE), Kappa, and ROC scores were the indicators used for the analysis. Results: The results suggested that J48 had exhibited a better skill to MLP and illustrated less error with a positive kappa. In particular, the 10-fold cross-validation method had better performance over the percentile Spilt (66%) and supplied test options. J48 demonstrated less error (RMSE = 0.6), better kappa = 0.63, and higher accuracy = 0.71), suggesting it as most suitable model. Further, seasonal temperature and humidity variation had shown a better association with malaria incidents in comparison to rainfall.Conclusion: The performance of the machine learning methods for Sundargarh was particularly better during the monsoon and post-monsoon when the events are at the peak. The results were encouraging for the utilization of climate forecast for prediction of malaria incidences. It is thus recommended that the J48 classifier machine learning technique could be adopted for the development of malaria early warning system.

A Database for Counterfeit Electronics and Automatic Defect Detection Based on Image Processing and Machine Learning

2016 ◽  
Author(s):  
Navid Asadizanjani ◽  
Sachin Gattigowda ◽  
Mark Tehranipoor ◽  
Domenic Forte ◽  
Nathan Dunn
Keyword(s):  
Machine Learning ◽  
Image Processing ◽  
Integrated Circuits ◽  
Web Application ◽  
The United States ◽  
Global Market ◽  
Online Database ◽  
Ongoing Effort ◽  
Time Period ◽  
Physical Defects

Abstract Counterfeiting is an increasing concern for businesses and governments as greater numbers of counterfeit integrated circuits (IC) infiltrate the global market. There is an ongoing effort in experimental and national labs inside the United States to detect and prevent such counterfeits in the most efficient time period. However, there is still a missing piece to automatically detect and properly keep record of detected counterfeit ICs. Here, we introduce a web application database that allows users to share previous examples of counterfeits through an online database and to obtain statistics regarding the prevalence of known defects. We also investigate automated techniques based on image processing and machine learning to detect different physical defects and to determine whether or not an IC is counterfeit.

FINANCIAL CONTROLLING IN THE SYSTEM OF FINANCIAL MANAGEMENT

2018 ◽  
Vol 28 (1) ◽  
pp. 137-141
Author(s):  
Petya Yordanova – Dinova
Keyword(s):  
Comparative Analysis ◽  
Financial Management ◽  
Financial Stability ◽  
Business Environment ◽  
Innovative Approach ◽  
Financial Sustainability ◽  
The Common ◽  
The Difference ◽  
Effective Use ◽  
And Control

This paper explores the comparative analysis of the financial controlling, who is a result from the common controlling concept and the financial management. In the specialized literature, financial controlling is seen as an innovative approach to financial management. It is often presented as the most promising instrument of financial diagnostics. Generally speaking, financial controlling is seen as a process of managing the company`s assets which are valued in monetary measures. The difference between the financial management and the financial controlling is that the second covers all functions of management, analysis and control of finances, aiming at maximizing their effective use and increasing the value of the enterprise. Financial controlling is often seen as a function of the common practice of financial management. Its objective is to preserve the financial stability and financial sustainability of enterprises operating in a highly aggressive business environment.

Prediction of K562 Cells Functional Inhibitors Based on Machine Learning Approaches

2020 ◽  
Vol 25 (40) ◽  
pp. 4296-4302 ◽  
Author(s):  
Yuan Zhang ◽  
Zhenyan Han ◽  
Qian Gao ◽  
Xiaoyi Bai ◽  
Chi Zhang ◽  
...  
Keyword(s):  
Machine Learning ◽  
Inclusion Bodies ◽  
Cross Validation ◽  
Independent Set ◽  
K562 Cells ◽  
Machine Learning Algorithms ◽  
Learning Approaches ◽  
Validation Test ◽  
Excess Number ◽  
Fold Cross Validation

Background: β thalassemia is a common monogenic genetic disease that is very harmful to human health. The disease arises is due to the deletion of or defects in β-globin, which reduces synthesis of the β-globin chain, resulting in a relatively excess number of α-chains. The formation of inclusion bodies deposited on the cell membrane causes a decrease in the ability of red blood cells to deform and a group of hereditary haemolytic diseases caused by massive destruction in the spleen. Methods: In this work, machine learning algorithms were employed to build a prediction model for inhibitors against K562 based on 117 inhibitors and 190 non-inhibitors. Results: The overall accuracy (ACC) of a 10-fold cross-validation test and an independent set test using Adaboost were 83.1% and 78.0%, respectively, surpassing Bayes Net, Random Forest, Random Tree, C4.5, SVM, KNN and Bagging. Conclusion: This study indicated that Adaboost could be applied to build a learning model in the prediction of inhibitors against K526 cells.

Identification of Anti-cancer Peptides Based on Multi-classifier System

2020 ◽  
Vol 22 (10) ◽  
pp. 694-704 ◽  
Author(s):  
Wanben Zhong ◽  
Bineng Zhong ◽  
Hongbo Zhang ◽  
Ziyi Chen ◽  
Yan Chen
Keyword(s):  
Machine Learning ◽  
Side Effect ◽  
Learning Models ◽  
Normal Cells ◽  
Classifier System ◽  
Prediction Rate ◽  
Anti Cancer ◽  
Feature Information ◽  
Machine Learning Models ◽  
Better Than

Aim and Objective: Cancer is one of the deadliest diseases, taking the lives of millions every year. Traditional methods of treating cancer are expensive and toxic to normal cells. Fortunately, anti-cancer peptides (ACPs) can eliminate this side effect. However, the identification and development of new anti Materials and Methods: In our study, a multi-classifier system was used, combined with multiple machine learning models, to predict anti-cancer peptides. These individual learners are composed of different feature information and algorithms, and form a multi-classifier system by voting. Results and Conclusion: The experiments show that the overall prediction rate of each individual learner is above 80% and the overall accuracy of multi-classifier system for anti-cancer peptides prediction can reach 95.93%, which is better than the existing prediction model.

The Application of the Cold Atmospheric Plasma-Activated Solutions in Cancer Treatment

2018 ◽  
Vol 18 (6) ◽  
pp. 769-775 ◽  
Author(s):  
Dayun Yan ◽  
Jonathan H. Sherman ◽  
Michael Keidar
Keyword(s):  
Cancer Treatment ◽  
Atmospheric Plasma ◽  
Current Status ◽  
Cold Atmospheric Plasma ◽  
Anti Cancer ◽  
Long Time ◽  
Key Topics ◽  
The Common

Background: Over the past five years, the cold atmospheric plasma-activated solutions (PAS) have shown their promissing application in cancer treatment. Similar as the common direct cold plasma treatment, PAS shows a selective anti-cancer capacity in vitro and in vivo. However, different from the direct cold atmospheric plasma (CAP) treatment, PAS can be stored for a long time and can be used without dependence on a CAP device. The research on PAS is gradually becoming a hot topic in plasma medicine. Objectives: In this review, we gave a concise but comprehensive summary on key topics about PAS including the development, current status, as well as the main conclusions about the anti-cancer mechanism achieved in past years. The approaches to make strong and stable PAS are also summarized.

Comparative Analysis of Machine Learning Techniques Using Predictive Modeling

2020 ◽  
Vol 13 ◽  
Author(s):  
Ritu Khandelwal ◽  
Hemlata Goyal ◽  
Rajveer Singh Shekhawat
Keyword(s):  
Machine Learning ◽  
Comparative Analysis ◽  
Data Science ◽  
Training Data ◽  
Machine Learning Techniques ◽  
Future Trends ◽  
Data Set ◽  
Learning Stage ◽  
Learning Techniques ◽  
Different Types

Introduction: Machine learning is an intelligent technology that works as a bridge between businesses and data science. With the involvement of data science, the business goal focuses on findings to get valuable insights on available data. The large part of Indian Cinema is Bollywood which is a multi-million dollar industry. This paper attempts to predict whether the upcoming Bollywood Movie would be Blockbuster, Superhit, Hit, Average or Flop. For this Machine Learning techniques (classification and prediction) will be applied. To make classifier or prediction model first step is the learning stage in which we need to give the training data set to train the model by applying some technique or algorithm and after that different rules are generated which helps to make a model and predict future trends in different types of organizations. Methods: All the techniques related to classification and Prediction such as Support Vector Machine(SVM), Random Forest, Decision Tree, Naïve Bayes, Logistic Regression, Adaboost, and KNN will be applied and try to find out efficient and effective results. All these functionalities can be applied with GUI Based workflows available with various categories such as data, Visualize, Model, and Evaluate. Result: To make classifier or prediction model first step is learning stage in which we need to give the training data set to train the model by applying some technique or algorithm and after that different rules are generated which helps to make a model and predict future trends in different types of organizations Conclusion: This paper focuses on Comparative Analysis that would be performed based on different parameters such as Accuracy, Confusion Matrix to identify the best possible model for predicting the movie Success. By using Advertisement Propaganda, they can plan for the best time to release the movie according to the predicted success rate to gain higher benefits. Discussion: Data Mining is the process of discovering different patterns from large data sets and from that various relationships are also discovered to solve various problems that come in business and helps to predict the forthcoming trends. This Prediction can help Production Houses for Advertisement Propaganda and also they can plan their costs and by assuring these factors they can make the movie more profitable.

scholarly journals Human Induction in Machine Learning

2021 ◽  
Vol 54 (3) ◽  
pp. 1-18
Author(s):  
Petr Spelda ◽  
Vit Stritecky
Keyword(s):  
Machine Learning ◽  
A Posteriori ◽  
Experimental Paradigm ◽  
Risk Minimisation ◽  
Inductive Risk ◽  
Acceptable Accuracy ◽  
Space And Time ◽  
The Common ◽  
Testing Set

As our epistemic ambitions grow, the common and scientific endeavours are becoming increasingly dependent on Machine Learning (ML). The field rests on a single experimental paradigm, which consists of splitting the available data into a training and testing set and using the latter to measure how well the trained ML model generalises to unseen samples. If the model reaches acceptable accuracy, then an a posteriori contract comes into effect between humans and the model, supposedly allowing its deployment to target environments. Yet the latter part of the contract depends on human inductive predictions or generalisations, which infer a uniformity between the trained ML model and the targets. The article asks how we justify the contract between human and machine learning. It is argued that the justification becomes a pressing issue when we use ML to reach “elsewhere” in space and time or deploy ML models in non-benign environments. The article argues that the only viable version of the contract can be based on optimality (instead of on reliability, which cannot be justified without circularity) and aligns this position with Schurz's optimality justification. It is shown that when dealing with inaccessible/unstable ground-truths (“elsewhere” and non-benign targets), the optimality justification undergoes a slight change, which should reflect critically on our epistemic ambitions. Therefore, the study of ML robustness should involve not only heuristics that lead to acceptable accuracies on testing sets. The justification of human inductive predictions or generalisations about the uniformity between ML models and targets should be included as well. Without it, the assumptions about inductive risk minimisation in ML are not addressed in full.

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