Exploration of the Two-Way Adjustment Mechanism of Rhei Radix et Rhizoma for Cardiovascular Diseases

2020 ◽  
Vol 23 (10) ◽  
pp. 1100-1112
Author(s):  
Lishan Pei ◽  
Xia Shen ◽  
Kai Qu ◽  
Conge Tan ◽  
Junbo Zou ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Diseases ◽  
Blood Coagulation ◽  
Signaling Pathway ◽  
Blood Circulation ◽  
Human Life ◽  
Receptor Interaction ◽  
Adjustment Mechanism ◽  
Natural Medicine ◽  
Prevention And Treatment

Aim and Objective: Myocardial infarction, cerebral infarction, and other diseases caused by vascular obstruction have always jeopardized human life and health. Several reports indicate that Rhei Radix et Rhizoma has a good clinical effect in the prevention and treatment of cardiovascular diseases. Owing to the complexity of herbal medicine, the pharmacodynamic mechanism of Rhei Radix et Rhizoma is still unclear. The objectives of this study were to explore the two-way adjustment mechanism of Rhei Radix et Rhizoma and provide a new solution for the prevention and treatment of cardiovascular disease. Materials and Methods: This study used data mining, reverse pharmacophore matching, network construction, GO and KEGG Analysis, and molecular docking to investigate the two-way adjustment mechanism of Rhei Radix et Rhizoma. The methods used were based on systems pharmacology and big data analysis technology. Results: The results suggest that Rhei Radix et Rhizoma uses a two-way adjustment of activating blood circulation, as well as blood coagulation in the prevention and treatment of cardiovascular diseases. The components involved in activating blood circulation are mainly anthraquinone components. The corresponding targets are NOS2, NOS3, CALM1, and the corresponding pathways are calcium signaling pathway, VEGF signaling pathway, platelet activation, and the PI3K-Akt signaling pathway. For blood coagulation, the components are mainly tannin components; the corresponding targets are F2, F10, ELANE, and the corresponding pathways are the neuroactive ligand-receptor interaction, complement and coagulation cascades. Conclusion: This study indicated that Rhei Radix et Rhizoma exerts the two-way adjustment of activating blood circulation and blood coagulation in the prevention and treatment of cardiovascular diseases. It can make up for the side effects of the existing blood circulation drugs for cardiovascular disease, only activating blood circulation, and the uncontrollable large-area bleeding due to the long-term use of the drugs. This study provides a material basis for the development of new blood-activating drugs based on natural medicine.

Systematic Investigation of Quercetin for Treating Cardiovascular Disease Based on Network Pharmacology

2019 ◽  
Vol 22 (6) ◽  
pp. 411-420 ◽  
Author(s):  
Xian-Jun Wu ◽  
Xin-Bin Zhou ◽  
Chen Chen ◽  
Wei Mao
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Diseases ◽  
Signaling Pathway ◽  
Kegg Pathway ◽  
Enrichment Analysis ◽  
Network Pharmacology ◽  
Pathway Enrichment Analysis ◽  
Therapeutic Effects ◽  
Pathway Enrichment ◽  
Compound Target

Aim and Objective: Cardiovascular disease is a serious threat to human health because of its high mortality and morbidity rates. At present, there is no effective treatment. In Southeast Asia, traditional Chinese medicine is widely used in the treatment of cardiovascular diseases. Quercetin is a flavonoid extract of Ginkgo biloba leaves. Basic experiments and clinical studies have shown that quercetin has a significant effect on the treatment of cardiovascular diseases. However, its precise mechanism is still unclear. Therefore, it is necessary to exploit the network pharmacological potential effects of quercetin on cardiovascular disease. Materials and Methods: In the present study, a novel network pharmacology strategy based on pharmacokinetic filtering, target fishing, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis, compound-target-pathway network structured was performed to explore the anti- cardiovascular disease mechanism of quercetin. Results:: The outcomes showed that quercetin possesses favorable pharmacokinetic profiles, which have interactions with 47 cardiovascular disease-related targets and 12 KEGG signaling pathways to provide potential synergistic therapeutic effects. Following the construction of Compound-Target-Pathway (C-T-P) network, and the network topological feature calculation, we obtained top 10 core genes in this network which were AKT1, IL1B, TNF, IL6, JUN, CCL2, FOS, VEGFA, CXCL8, and ICAM1. KEGG pathway enrichment analysis. These indicated that quercetin produced the therapeutic effects against cardiovascular disease by systemically and holistically regulating many signaling pathways, including Fluid shear stress and atherosclerosis, AGE-RAGE signaling pathway in diabetic complications, TNF signaling pathway, MAPK signaling pathway, IL-17 signaling pathway and PI3K-Akt signaling pathway.

scholarly journals Prevention & Treatment Of Cardiovascular Diseases

2021 ◽  
Vol 03 (06) ◽  
pp. 180-188
Author(s):  
Dr. Imran Aslam ◽  
◽  
Yuldashev Soatboy Jiyanboyevich ◽  
Abdurakhmanova Zamira Ergashboevna ◽  
◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Diseases ◽  
Human Health ◽  
Significant Problem ◽  
Treatment Level ◽  
Medical Institutions ◽  
Prevention And Treatment

Cardiovascular disease is a significant problem that humans have always faced, affecting thousands of people's lives and health and taking the lives of many people. Many medical institutions and researchers have regarded it as a significant problem in overcoming the cardiovascular disease.1 Much attention has been paid, so the prevention and treatment level in this area has also been rapidly improved. However, cardiovascular disease still cannot be prevented or treated fundamentally, and it is still a significant danger to human health. All people still hope for breakthrough results in cardiovascular disease.2 This article analyzes the prevention and treatment of cardiovascular diseases, and has obtained a series of practical and reliable conclusions.

Traditional Chinese Medicine Network Pharmacology in Cardiovascular Precision Medicine

2020 ◽  
Vol 26 ◽  
Author(s):  
Li Gao ◽  
Min Cao ◽  
Jia-qi Li ◽  
Xue-mei Qin ◽  
Jian-song Fang
Keyword(s):  
Cardiovascular Disease ◽  
Chinese Medicine ◽  
Cardiovascular Diseases ◽  
Traditional Chinese Medicine ◽  
Precision Medicine ◽  
Human Health ◽  
Mechanism Of Action ◽  
Network Pharmacology ◽  
Metabolic Characteristics ◽  
Prevention And Treatment

: Cardiovascular disease is a major disease affecting human health, and its pathogenesis is caused by many factors. Through the use of "omics" technology, precision medicine is playing an increasingly important role in the prevention and treatment of cardiovascular diseases. Dialectical treatment with traditional Chinese medicine (TCM）will result in personalized treatment, which is consistent with precision medicine to a certain extent. However, due to the multitarget, multipath, and multistep characteristics of TCM, its mechanism of action is not easy to elucidate. Network pharmacology can be used to predict the mechanism, toxicity and metabolic characteristics of TCM. This review summarizes commonly used bioinformatics resources for cardiovascular diseases and TCM, as well as the opportunities and challenges of TCM in cardiovascular precision medicine, with special emphasis on network pharmacology methods.

scholarly journals The role of potassium and magnesium for prevention and treatment of cardiovascular disease

2020 ◽  
Vol 22 (10) ◽  
pp. 76-79
Author(s):  
Alla V. Pogozheva ◽  
◽  
Alla V. Pogozheva ◽  
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Diseases ◽  
Selection Criteria ◽  
Mineral Status ◽  
High Prevalence ◽  
Prevention And Treatment ◽  
Special Diets

The article provides data on foods rich in potassium and magnesium as well as causes and consequences of their insufficient intake. It shows a high prevalence of their deficiency among the Russia population. The article considers the role of potassium and magnesium in the prevention and treatment of cardiovascular diseases. Ways to increase potassium and magnesium in your diet include the use of special diets, potassium- and magnesium-rich foods. It discusses selection criteria and advantages of using drugs which contain both potassium and magnesium to improve the mineral status of the population.

scholarly journals Nutrition as one of the important factors in prevention and treatment of atherosclerotic cardiovascular diseases

2020 ◽  
Vol 19 (3) ◽  
pp. 2301
Author(s):  
I. V. Rudchenko ◽  
V. V. Tyrenko ◽  
V. A. Kachnov
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Diseases ◽  
Cardiovascular System ◽  
Epidemiological Study ◽  
Modern View ◽  
Prevention And Treatment ◽  
Potential Benefits ◽  
Atherosclerotic Cardiovascular Diseases

The article discusses the issues of nutrition types and related effects on cardiovascular disease, the potential benefits of a particular diet for the cardiovascular system. The problems in studying the nutrition effect on cardiovascular diseases are characterized. Special attention is paid to the plant-based diet and its effect on atherosclerosis. An analysis of PURE (Prospective Urban and Rural Epidemiological) study, which contains a modern view of the diet and the development of cardiovascular diseases, is carried out.

scholarly journals Knowledge and awareness of cardiovascular risk factors among young adults

2020 ◽  
Vol 11 (SPL3) ◽  
pp. 824-830
Author(s):  
Roshan A ◽  
Kavitha S ◽  
Sridevi G ◽  
Vishnu Priya V ◽  
Gayathri R
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Young Adults ◽  
Risk Factor ◽  
Cardiovascular Risk ◽  
Cardiovascular Diseases ◽  
Cardiovascular Risk Factors ◽  
Elevated Blood ◽  
Prevention And Treatment ◽  
Spss Software

Cardiovascular diseases (CVD) are becoming a major cause of death worldwide. Understanding the risk factors for CVD could provide important perception towards the etiology, course, prevention, and treatment for this key health problem. Aim of the survey was to create awareness on the cardiovascular risk factors among young adults. A self-administrated questionnaire was prepared and circulated via an online platform. The data were and the results represented as a bar graph. The data were with SPSS software (SPSS). In this survey, about 52% of the young adults were aware of cardiovascular risk factors, about 57.4% of subjects agreed that smoking is a risk factor of cardiovascular disease, but 42% were not aware of it. 65.3% are aware that elevated blood pressure is also a risk factor for CVD. 56.4% knew that obesity increases a person's risk of cardiovascular disease, but 44% did not agree with that. The survey concluded that there was moderate awareness among young adults about the risk factors of cardiovascular disease, and hence more health awareness should be created for common cardiovascular diseases.

scholarly journals Regulation of Mitochondrial Dynamics by Aerobic Exercise in Cardiovascular Diseases

2022 ◽  
Vol 8 ◽  
Author(s):  
Changping Gu ◽  
Jie Yan ◽  
Liang Zhao ◽  
Guanghan Wu ◽  
Yue-lan Wang
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Diseases ◽  
Aerobic Exercise ◽  
Mitochondrial Function ◽  
Cardiovascular Health ◽  
Mitochondrial Dynamics ◽  
Pharmaceutical Intervention ◽  
Prevention And Treatment ◽  
And Function ◽  
Cvd Mortality

Mitochondrial dynamics, including continuous biogenesis, fusion, fission, and autophagy, are crucial to maintain mitochondrial integrity, distribution, size, and function, and play an important role in cardiovascular homeostasis. Cardiovascular health improves with aerobic exercise, a well-recognized non-pharmaceutical intervention for both healthy and ill individuals that reduces overall cardiovascular disease (CVD) mortality. Increasing evidence shows that aerobic exercise can effectively regulate the coordinated circulation of mitochondrial dynamics, thus inhibiting CVD development. This review aims to illustrate the benefits of aerobic exercise in prevention and treatment of cardiovascular disease by modulating mitochondrial function.

scholarly journals Pseudogenes in Cardiovascular Disease

2021 ◽  
Vol 7 ◽  
Author(s):  
Yanyan Qi ◽  
Xi Wang ◽  
Wenbo Li ◽  
Dongchang Chen ◽  
Hua Meng ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Diseases ◽  
Molecular Level ◽  
Human Life ◽  
Therapeutic Approaches ◽  
Sequencing Technology ◽  
Protein Coding ◽  
New Knowledge ◽  
New Biomarkers ◽  
Human Life Span

Cardiovascular disease is the main disease that affects human life span. In recent years, the disease has been increasingly addressed at the molecular levels, for example, pseudogenes are now known to be involved in the pathogenesis and development of cardiovascular diseases. Pseudogenes are non-coding homologs of protein-coding genes and were once called “junk gene.” Since they are highly homologous to their functional parental genes, it is somewhat difficult to distinguish them. With the development of sequencing technology and bioinformatics, pseudogenes have become readily identifiable. Recent studies indicate that pseudogenes are closely related to cardiovascular diseases. This review provides an overview of pseudogenes and their roles in the pathogenesis of cardiovascular diseases. This new knowledge adds to our understanding of cardiovascular disease at the molecular level and will help develop new biomarkers and therapeutic approaches designed to prevent and treat the disease.

NT-PROBNP AND THE CUT-OFF VALUE IN CARDIOVASCULAR DISEASES

2011 ◽  
pp. 5-12
Author(s):  
Anh Tien Hoang ◽  
Van Minh Huynh ◽  
Khanh Hoang ◽  
Huu Dang Tran ◽  
Viet An Tran
Keyword(s):  
Heart Failure ◽  
Cardiovascular Disease ◽  
Pilot Study ◽  
Cardiovascular Diseases ◽  
Clinical Application ◽  
European Society ◽  
The Other ◽  
Cardiac Marker ◽  
Cardiac Biomarker ◽  
European Society Of Cardiology

NT-ProBNP is a high value cardiac biomarker and widely applies in many cardiovascular diseases. The evaluation of concentration of NT-ProBNP needs the concern about age, gender, obesity and especially we need each cut-off point for each cause of cardiovascular disease in evaluation and clinical application. Because NT-ProBNP is a new cardiac marker and has been researched in 5 recent years, the cut-off of NT-ProBNP is still being studied for the clinical application in cardiovascular diseases. Only the cut-off of NT-ProBNP in diagnosis heart failure was guided by European Society of Cardiology. The meaning of introduce cut-off value of value plays an role as pilot study for the other relate study and brings the NT-ProBNP closely approach to clinical application.

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