ACE2 as a key target for treatment of COVID-19 related cardiovascular diseases: current progress and prospect

2021 ◽  
Vol 22 ◽  
Author(s):  
Shuainan Li ◽  
Benzhi Cai ◽  
Wenya Ma ◽  
Fan Yang ◽  
Yan Xu ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Diseases ◽  
Clinical Research ◽  
Protective Factor ◽  
Organ Damage ◽  
Negative Regulator ◽  
Recent Outbreak ◽  
Heart Injury ◽  
The Relationship ◽  
Entry Receptor

: ACE2 has long been known as an injury protective protein, it can protect a variety of organ damage such as heart, liver, kidney and lung. Especially in cardiovascular diseases, ACE2, as a negative regulator of RAAS, is an extremely important protective factor that mainly plays a role by converting Ang Ⅱ to Ang-(1-7). Nevertheless, with the recent outbreak of COVID-19, it was exposed that another identity of ACE2 is the entry receptor for SARS-CoV-2, which previously served as the entry receptor for SARS. With the in-depth clinical research, it was found that the severity and susceptibility of COVID-19 are related to cardiovascular disease, and SARS-CoV-2 binding to ACE2 receptor is also potentially associated with heart injury symptoms. Therefore, in this article, we mainly review the relationship between ACE2, COVID-19 and cardiovascular system diseases/heart injury.

Hypothyroidism and cardiovascular system

2016 ◽  
Vol 94 (7) ◽  
pp. 497-503 ◽  
Author(s):  
A. F. Verbovoy ◽  
Lyudmila A. Sharonova ◽  
O. V. Kosareva ◽  
N. I. Verbovaya ◽  
Yu. A. Dolgikh
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Cardiovascular Diseases ◽  
Vitamin D3 ◽  
Thyroid Dysfunction ◽  
Myocardial Remodeling ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
The Relationship

The article presents data on the relationship between thyroid dysfunction and cardiovascular diseases. The role of dyslipidemia, adipokines (adiponectin, leptin, resistin), C-reactive protein, deficiency of vitamin D3 in the development of cardiovascular disease in hypothyroidism is discussed. The article describes characteristics of myocardial remodeling, its dysfunction and their correlation with risk factors of cardiovascular diseases in patients with hypothyroidism.

scholarly journals The Biological Role of Klotho Protein in the Development of Cardiovascular Diseases

2018 ◽  
Vol 2018 ◽  
pp. 1-17 ◽  
Author(s):  
Agnieszka Olejnik ◽  
Aleksandra Franczak ◽  
Anna Krzywonos-Zawadzka ◽  
Marta Kałużna-Oleksy ◽  
Iwona Bil-Lula
Keyword(s):  
Cardiovascular Disease ◽  
Growth Factor ◽  
Protective Factor ◽  
Endocrine System ◽  
Left Ventricular ◽  
Proper Function ◽  
Vascular Protection ◽  
Age Related ◽  
Klotho Protein ◽  
Heart Injury

Klotho is a membrane-bound or soluble antiaging protein, whose protective activity is essential for a proper function of many organs. In 1997, an accidental insertion of a transgene led to creation of transgenic mice with several age-related disorders. In Klotho-deficient mice, the inherited phenotypes closely resemble human aging, while in an animal model of Klotho overexpression, the lifespan is extended. Klotho protein is detected mainly in the kidneys and brain. It is a coreceptor for fibroblast growth factor and hence is involved in maintaining endocrine system homeostasis. Furthermore, an inhibition of insulin/insulin-like growth factor-1 signaling pathway by Klotho regulates oxidative stress and reduces cell death. The association between serum Klotho and the classic risk factors, as well as the clinical history of cardiovascular disease, was also shown. There are a lot of evidences that Klotho deficiency correlates with the occurrence and development of coronary artery disease, atherosclerosis, myocardial infarction, and left ventricular hypertrophy. Therefore, an involvement of Klotho in the signaling pathways and in regulation of a proper cell metabolism could be a crucial factor in the cardiac and vascular protection. It is also well established that Klotho protein enhances the antioxidative response via augmented production of superoxide dismutase and reduced generation of reactive oxygen species. Recent studies have proven an expression of Klotho in cardiomyocytes and its increased expression in stress-related heart injury. Thus, the antioxidative and antiapoptotic activity of Klotho could be considered as the novel protective factor in cardiovascular disease and heart injury.

scholarly journals Can body shape index indicate obesity-associated inflammation and cardiovascular diseases in stage 3-4 chronic kidney disease patients?

2021 ◽  
pp. 60-66
Author(s):  
Gulsah Sasak ◽  
Banu Isbilen Basok ◽  
Semih Basci ◽  
Abdulkadir Kocanoglu ◽  
Ali Bakan ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Chronic Kidney Disease ◽  
Cardiovascular Diseases ◽  
Kidney Disease ◽  
Body Shape ◽  
Shape Index ◽  
Group I ◽  
The Mean ◽  
Group Ii ◽  
The Relationship

The incidence and prevalence of obesity are increasing rapidly throughout the world. Various methods have been developed to evaluate obesity. A body shape index (aBSI) is based on waist circumference adjusted for height and weight. High BSI values have been found to be associated with early mortality. It is known that obesity is associated with inflammation and cardiovascular diseases. In this study, we examined the relationship between aBSI, inflammatory markers such as C-reactive protein and interleukin-6 and cardiovascular disease in patients with stage 3-4 chronic kidney disease. Methods. One hundred twenty patients were enrolled in this cross-sectional observational study. The mean aBSI value was 0.0870. Patients were divided into 2 groups according to the mean value of aBSI as there is no currently defined cut-off value for BSI. Those with aBSI ≤ 0.087 were allocated to group I, and those with aBSI> 0.0870 to group II. Results. Patients in group II had more cardiovascular disease than in group I. In partial Spearman correlation analysis, the presence of cardiovascular disease was correlated with aBSI (r = 0.36, p = 0.0001). aBSI higher than 0.0986 predicted cardiovascular disease in our cohort: the area under the curve (CI 95%) for aBSI was 0.715 (0.602-0.829). Conclusions. The relationship between aBSI and inflammation could not be shown. But we found that high aBSI is associated with increased cardiovascular disease. Further studies are needed to recommend the routine clinical use of aBSI as a cardiovascular disease marker.

Erectile dysfunction – a cardiologist’s point of view

2021 ◽  
Vol 14 (1) ◽  
pp. 32-35
Author(s):  
Artur Mamcarz ◽  
Marcin Wełnicki
Keyword(s):  
Cardiovascular Disease ◽  
Erectile Dysfunction ◽  
Cardiovascular Diseases ◽  
Arterial Hypertension ◽  
Cardiovascular System ◽  
Side Effect ◽  
Point Of View ◽  
Common Phenomenon ◽  
The Relationship

Cardiovascular disease is a common phenomenon, just like obesity, arterial hypertension and diabetes. Those diseases negatively affect all spheres of our life, including our sex life. The best known currently is the relationship between the occurrence of erectile dysfunction and diseases of the cardiovascular system. Erectile dysfunction may not only be a late consequence cardiovascular diseases, but also their early revelator. However, they can also be a side effect of some cardiac medications. Cardiosexology deals with these issues. Perhaps, however, an even more important issue is the safety of treating erectile dysfunction in patients with cardiovascular diseases.

scholarly journals Protective Effects of Caesalpinia sappan Linn. and Its Bioactive Compounds on Cardiovascular Organs

2021 ◽  
Vol 12 ◽  
Author(s):  
Mas Rizky AA Syamsunarno ◽  
Ratu Safitri ◽  
Yusof Kamisah
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Diseases ◽  
Bioactive Compounds ◽  
Heart Function ◽  
Blood Stasis ◽  
Organ Damage ◽  
Protective Effects ◽  
Cardiac Damage ◽  
Caesalpinia Sappan ◽  
Tropical Asia

Cardiovascular diseases are the leading cause of death worldwide. The long-term aim of cardiovascular disease therapy is to reduce the mortality rate and decelerate the progression of cardiovascular organ damage. Current therapies focus on recovering heart function and reducing risk factors such as hyperglycemia and dyslipidemia. However, oxidative stress and inflammation are important causes of further damage to cardiovascular organs. Caesalpinia sappan Linn. (Fabaceae), a flowering tree native to tropical Asia, has antioxidant and anti-inflammatory properties. It is used as a natural dye to color food and beverages and as a traditional treatment for diarrhea, diabetes, and blood stasis. The phytochemical compounds in C. sappan, mainly the homoisoflavonoids brazilin, sappanone A, protosappanin, and hematoxylin, can potentially be used to protect cardiovascular organs. This review aims to provide updates on recent developments in research on C. sappan in relation to treatment of cardiovascular diseases. Many studies have reported protective effects of the plant’s bioactive compounds that reduce cardiac damage and enhance vasorelaxation. For example, brazilin and sappanone A have an impact on molecular and cellular changes in cardiovascular disease pathogenesis, mainly by modulating oxidative, inflammatory, and apoptotic signaling pathways. Therefore, bioactive compounds of C. sappan have the potential to be developed as therapeutic agents to combat cardiovascular diseases like myocardial infarction and vascular disease. This review could help further the understanding of the possible modulatory role of the compounds in cardiovascular diseases, thereby facilitating future studies.

scholarly journals Natural Bioactive Compounds As Protectors Of Mitochondrial Dysfunction In Cardiovascular Diseases And Aging

Molecules ◽  
2019 ◽  
Vol 24 (23) ◽  
pp. 4259 ◽  
Author(s):  
Diego Arauna ◽  
María Furrianca ◽  
Yolanda Espinosa-Parrilla ◽  
Eduardo Fuentes ◽  
Marcelo Alarcón ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Diseases ◽  
Bioactive Compounds ◽  
Healthy Aging ◽  
Functional Foods ◽  
Protective Factor ◽  
Mitochondrial Proteins ◽  
Oxygen Species ◽  
Cellular Mechanisms ◽  
Potential Use

Diet, particularly the Mediterranean diet, has been considered as a protective factor against the development of cardiovascular diseases, the main cause of death in the world. Aging is one of the major risk factors for cardiovascular diseases, which have an oxidative pathophysiological component, being the mitochondria one of the key organelles in the regulation of oxidative stress. Certain natural bioactive compounds have the ability to regulate oxidative phosphorylation, the production of reactive oxygen species and the expression of mitochondrial proteins; but their efficacy within the mitochondrial physiopathology of cardiovascular diseases has not been clarified yet. The following review has the purpose of evaluating several natural compounds with evidence of mitochondrial effect in cardiovascular disease models, ascertaining the main cellular mechanisms and their potential use as functional foods for prevention of cardiovascular disease and healthy aging.

The Relationship between Immigration Status and Cardiovascular Disease Risk Factors in United States Adults with Diabetes—A 14-Year Study

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1491-P
Author(s):  
APRILL DAWSON ◽  
EMMA GARACCI ◽  
MUKOSO N. OZIEH ◽  
REBEKAH J. WALKER ◽  
LEONARD E. EGEDE
Keyword(s):  
United States ◽  
Risk Factors ◽  
Cardiovascular Disease ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Cardiovascular Disease Risk Factors ◽  
Immigration Status ◽  
The Relationship

The Dual Use of Religious-Faith in Intimate Partner Abuse Perpetration: Perspectives of Latino Men in a Parish-based Intervention Program

2020 ◽  
Vol 47 (4) ◽  
pp. 71-95
Author(s):  
Maxine Davis ◽  
Melissa Jonson-Reid
Keyword(s):  
Partner Violence ◽  
Intervention Program ◽  
Protective Factor ◽  
Partner Abuse ◽  
Religious Faith ◽  
Gain Control ◽  
Intimate Partner ◽  
Latino Men ◽  
Spiritual Abuse ◽  
The Relationship

Little is known about the role that religious-faith plays in the lives of men who have acted abusively against an intimate partner. Studies report mixed findings about the relationship between religious-faith and intimate partner violence/abuse (IPV/A) perpetration. This study explored the perceptions of Latino men involved in a parish-based partner abuse intervention program (PAIP). Two focus groups were conducted with members of the PAIP (N=18). Two major themes emerged. Participants reported using religious-faith as a mechanism for ending violence. However, participants also reported past misuse of religion in order to gain control over intimate partners. These apparently conflicting roles of religion were further elucidated in several sub-themes. Religious-faith is complex. This study offers insight into how faith may serve as both a risk and protective factor for IPV/A perpetration. Implications for how intervention programs may address participants’ religious-faith during treatment and how religio-spiritual abuse is measured are discussed.

NT-PROBNP AND THE CUT-OFF VALUE IN CARDIOVASCULAR DISEASES

2011 ◽  
pp. 5-12
Author(s):  
Anh Tien Hoang ◽  
Van Minh Huynh ◽  
Khanh Hoang ◽  
Huu Dang Tran ◽  
Viet An Tran
Keyword(s):  
Heart Failure ◽  
Cardiovascular Disease ◽  
Pilot Study ◽  
Cardiovascular Diseases ◽  
Clinical Application ◽  
European Society ◽  
The Other ◽  
Cardiac Marker ◽  
Cardiac Biomarker ◽  
European Society Of Cardiology

NT-ProBNP is a high value cardiac biomarker and widely applies in many cardiovascular diseases. The evaluation of concentration of NT-ProBNP needs the concern about age, gender, obesity and especially we need each cut-off point for each cause of cardiovascular disease in evaluation and clinical application. Because NT-ProBNP is a new cardiac marker and has been researched in 5 recent years, the cut-off of NT-ProBNP is still being studied for the clinical application in cardiovascular diseases. Only the cut-off of NT-ProBNP in diagnosis heart failure was guided by European Society of Cardiology. The meaning of introduce cut-off value of value plays an role as pilot study for the other relate study and brings the NT-ProBNP closely approach to clinical application.

Prevalence, Biochemical and Clinical Characteristics of Resistant Hypertension

2018 ◽  
Vol 69 (10) ◽  
pp. 2845-2849
Author(s):  
Daniela Gurgus ◽  
Elena Ardeleanu ◽  
Carmen Gadau ◽  
Roxana Folescu ◽  
Ioan Tilea ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Resistant Hypertension ◽  
Clinical Characteristics ◽  
Salt Intake ◽  
Target Organ Damage ◽  
Multivariate Logistic Regression Analysis ◽  
Organ Damage ◽  
Left Ventricular ◽  
High Salt Intake

The objectives of the present study were to evaluate the prevalence of resistant hypertension (RH) in primary care setting and to analyse its biochemical and clinical characteristics. After 3 months of treatment and evaluation, 721 (14.01%) of 5,146 patients with hypertension did not reach target office blood pressure of [ 140/90 mmHg. After exclusion of �white-coat effect� with ambulatory blood pressure, of secondary and pseudo- resistant hypertension, prevalence of RH was 6.74%. Lifestyle factors associated with RH were physical inactivity, obesity, high salt intake, smoking and excessive alcohol ingestion. Compared to controlled hypertension, RH patients presented higher incidence of family history of cardiovascular disease (38.90% vs 25.94%), diabetes mellitus (34.87% vs 19.01%), impaired fasting glucose (21.91% vs 19.07%), target organ damage (29.1% vs 15.95%), and cardiovascular disease (27.09% vs 17.06%). Dyslipidaemia (52.90% vs 42.03%), fasting plasma glucose (116.10�38.9 vs 107.80�37.2), HbA1c (6.41�1.42 vs 5.96�0.94), serum creatinine (1.09�0.27 vs 1.03�0.24) and microalbuminuria (21.90% vs 10.95%) were significantly higher in RH. Predictors of RH, determined by a multivariate logistic regression analysis were left ventricular hypertrophy (OD 2.14, 95% CI 1.32-3.69), renal impairment expressed as eGFR [ 60 ml/min/1.73m2 (OD 1.62, 95% CI 1.21-2.21) and the presence of cardiovascular disease (OD 1.48, 95% CI 1.02-2.16).

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