The Relation of the Viral Structure of SARS-CoV2, High-Risk Condition, and Plasma Levels of IL-4, IL-10, and IL-15 in COVID-19 Patients compared to SARS and MERS Infections

2021 ◽  
Vol 21 ◽  
Author(s):  
Leila Mousavizadeh ◽  
Ramin Soltani ◽  
Kosar Abedini ◽  
Sorayya Ghasemi
Keyword(s):  
Risk Factors ◽  
Immune System ◽  
High Risk ◽  
Nonstructural Proteins ◽  
Virus Structure ◽  
Viral Structure ◽  
Risk Condition ◽  
The Relationship ◽  
Different Levels ◽  
Coronavirus Infections

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) has high mortality due to the widespread infection and the strong immune system reaction. Interleukins (ILs) are among the main immune factors contributing to the deterioration of the immune response and the formation of cytokine storms in coronavirus disease 2019 (COVID-19) infections. Introduction: This review article investigated the relationship between virus structure, risk factors, and patient plasma interleukin levels in infections caused by the coronavirus family. Method: The keywords "interleukin," "coronavirus structure," "plasma," and "risk factors" were the main words searched to find a relationship among different interleukins, coronavirus structures, and risk factors in ISI, PUBMED, SCOPUS, and Google Scholar databases. Results: Patients with high-risk conditions with independent panels of immune system markers are more susceptible to death caused by SARS-CoV2. IL-4, IL-10, and IL-15 are probably secreted at different levels in patients with coronavirus infections despite the similarity of inflammatory markers during coronavirus infections. SARS-CoV2 and SARS-CoV increase the secretion of IL-4 in the Middle East respiratory syndrome coronavirus (MERS-CoV) infection, while it remains unchanged in MERS-CoV infection. MERS-CoV infection demonstrates increased IL-10 levels. However, IL-10 levels increase during SARS-CoV infection, and different levels are recorded in SARS-CoV2. MERS-CoV increases IL-15 secretion while its levels remain unchanged in SARS-CoV2. Conclusion: In conclusion, the different structures of SARS-CoV2, such as length of spike or nonstructural proteins (NSPs), and susceptibility of patients based on their risk factors may lead to differences in immune marker secretion and pathogenicity. Therefore, identifying and controlling interleukin levels can play a significant role in controlling the symptoms and the development of individual-specific treatments.

Carnitine Deficiency in Epilepsy: Risk Factors and Treatment

1995 ◽  
Vol 10 (2_suppl) ◽  
pp. 2S32-2S39 ◽  
Author(s):  
David L. Coulter
Keyword(s):  
Risk Factors ◽  
High Risk ◽  
Preliminary Data ◽  
Metabolic Diseases ◽  
Drug Effects ◽  
Carnitine Deficiency ◽  
Free Carnitine ◽  
Specific Drug ◽  
Asymptomatic Patients ◽  
The Relationship

Numerous studies have shown that plasma carnitine levels are significantly lower in patients taking valproate than in controls. Free carnitine deficiency is not uncommon in these patients and also occurs in newborns with seizures and in patients taking other anticonvulsant drugs. Carnitine deficiency in epilepsy results from a variety of etiologic factors including underlying metabolic diseases, nutritional inadequacy, and specific drug effects. The relationship between carnitine deficiency and valproate-induced hepatotoxicity is unclear. Carnitine treatment does not always prevent the emergence of serious hepatotoxicity, but it does alleviate valproate-induced hyperammonemia. These studies suggest that specific risk factors for carnitine deficiency can be identified. Preliminary data suggest that carnitine treatment may benefit high-risk, symptomatic patients and those with free carnitine deficiency. Carnitine treatment is not likely to benefit low-risk, asymptomatic patients and those with normal carnitine levels. (J Child Neurol 1995;10(Suppl):2S32-2S39).

The relationship of “high risk” mammographic patterns to histological risk factors for development of cancer in the human breast

1990 ◽  
Vol 63 (755) ◽  
pp. 845-849 ◽  
Author(s):  
Justine E. Arthur ◽  
I. O. Ellis ◽  
C. Flowers ◽  
E. Roebuck ◽  
C. W. Elston ◽  
...  
Keyword(s):  
Risk Factors ◽  
High Risk ◽  
Human Breast ◽  
Relationship Of ◽  
The Relationship ◽  
Mammographic Patterns

Breast artery calcium noted on screening mammography is predictive of high risk coronary calcium in asymptomatic women: a case control study

VASA ◽  
2013 ◽  
Vol 42 (6) ◽  
pp. 429-433 ◽  
Author(s):  
Martin E. Matsumura ◽  
Crystal Maksimik ◽  
Matthew W. Martinez ◽  
Michael Weiss ◽  
James Newcomb ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
High Risk ◽  
Coronary Artery Calcium ◽  
Screening Mammography ◽  
Artery Disease ◽  
The Relationship ◽  
Asymptomatic Women ◽  
Cad Risk

Background: The relationship between breast artery calcification (BAC) noted on mammography and both coronary artery disease and cardiovascular risk remains controversial. Few studies have examined the clinical significance of BAC in asymptomatic women. In the present study we evaluated the relationship between BAC and coronary artery calcium (CAC) as identified by multi-slice CT scanning (MSCT). Patients and methods: Consecutive women (n = 98) with BAC noted on routine mammography but without known coronary artery disease (CAD) were assessed for CAD risk factors and had assessment of coronary calcium by MSCT. A control cohort of consecutive women who were BAC(-) (n = 104) underwent an identical assessment. Results: Women who were BAC(+) were older than those who were BAC(-); otherwise, there were no differences between the 2 groups with regard to traditional cardiac risk factors. Significantly more BAC(+) vs. BAC(-) women were found to have “high risk” CAC scores, defined as CAC > 400 (11.2 % vs. 1.0 %, p = 0.006). However, the rates of CAC scores of 0 were not different between the two groups (50.0 % vs. 54.8 % for BAC(+) and BAC(-) , respectively, p = 0.586). When examined in a multivariate model including the traditional risk factors of diabetes, increasing age, smoking, hyperlipidemia, and family history of CAD, the presence of BAC remained significantly associated with CAC > 400 (OR = 22.6, 95 % CI = 2.1 - 237.1). Conclusions: The presence of breast artery calcium on screening mammography was a strong independent predictor (odds ratio > 22) of high risk coronary artery calcium scores (defined as CAC > 400). The presence of BAC in those with significant CAD risk factors may warrant further evaluation.

scholarly journals The Investigation of Sex Differences in the Effect of Body Mass Index

2019 ◽  
Vol 2019 ◽  
pp. 1-5 ◽  
Author(s):  
Xiang Xiao ◽  
Weihua Wang ◽  
Rina Sa ◽  
Lin Qiu ◽  
Feng Liu
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Body Mass Index ◽  
Logistic Regression ◽  
Sex Differences ◽  
Multivariable Logistic Regression ◽  
The Mean ◽  
Prevention Of Hypertension ◽  
The Relationship ◽  
Different Levels

Although many researches regarding risk factors for hypertension have been reported, little information is known about the effect of BMI on the prevalence of hypertension considering sex differences. The aim of this study was to examine the sex difference in the prevalence of hypertension with the predicting indicator BMI. A total number of 6330 subjects in Shaanxi were examined using multivariable logistic regression to study the relationship between genders in different levels of BMI and prevalence of hypertension. Overall, females had a higher prevalence of hypertension than males, being 28.36% and 21.55%, respectively. The mean of blood pressure and the prevalence of hypertension increased as BMI getting larger. The result of multivariable logistic regression showed that obese and overweight males had higher risk of getting hypertension than their female counterparts. Further prevention of hypertension should be focused on obese and overweight males more than females and examining the mechanism of how sex differences influence the prevalence of hypertension.

Discrepancies in the relationship of BMI and traditional cardiovascular risk factors in subjects with different levels of obesity

2015 ◽  
Vol 11 (6) ◽  
pp. S75-S76
Author(s):  
Stefanie van Mil ◽  
Astrid van Huisstede ◽  
Boudewijn Klop ◽  
Gert-Jan van de Geijn ◽  
Gert Jan Braunstahl ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Relationship Of ◽  
The Relationship ◽  
Different Levels

scholarly journals Study of Maternal and Fetal Outcomes in High Risk Pregnancies

2020 ◽  
pp. 1-7
Author(s):  
Dr. Ankita Metkari
Keyword(s):  
Risk Factors ◽  
Retrospective Study ◽  
High Risk ◽  
Fetal Outcome ◽  
Risk Pregnancy ◽  
Maternal And Neonatal Outcomes ◽  
Clinical Records ◽  
Relationship Of ◽  
The Relationship ◽  
In Pregnancy

Background: Objectives of the current study were to detect high-risk-risk-risk factors in pregnancy their presentations and to develop a simple scoring system to identify and categorize high-risk pregnancies and to predict the maternal and neonatal outcomes by comparing our results to previous studies. Methods: In this retrospective study, antepartum, intrapartum and neonatal parameters were integrated into the clinical records and the relationship of a risk score to the outcome was evaluated for 346 randomly selected pregnant patients over 7 months. Conclusions: The present study shows that we achieve comparative and better results in high-risk pregnancy, improving both maternal and fetal outcome at our institute.

scholarly journals THE RELATIONSHIP OF FRAILTY, FEAR OF FALLING, AND DEPRESSION WITH HRQOL IN HIGH-RISK OLDER ADULTS

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S877-S877
Author(s):  
Michelle A McKay ◽  
Linda Copel ◽  
Catherine Todd-Magel
Keyword(s):  
Risk Factors ◽  
Older Adults ◽  
High Risk ◽  
Physical Functioning ◽  
Fear Of Falling ◽  
Well Being ◽  
Community Dwelling ◽  
Mental Functioning ◽  
Community Dwelling Older Adults ◽  
The Relationship

Abstract One in four older adults fall every year. Falls result in negative outcomes including decreased health-related quality of life (HRQoL). Frailty, fear of falling, depression, and HRQoL are not routinely screened in high-risk community-dwelling older adults. Continued study of modifiable fall risk factors is warranted due to varied reported prevalence rates, inconsistent definitions and the persistent high rate of falls resulting in poor HRQoL. The purpose of the study was to determine the relationship between frailty, fear of falling, and depression with physical and mental functioning and well-being measures of HRQoL in community-dwelling older adults 55 years of age and older. A cross-sectional correlational design and chart review were conducted. The sample consisted of 84 primarily African American (81%) nursing home eligible members of the Program for All-Inclusive Care for the Elderly (PACE) program. Data were analyzed with correlational statistics, multiple linear, and hierarchical regression models. Physical functioning and well-being measures were significantly decreased when compared to the general population. Increased frailty, fear of falling, and depression were associated with decreased physical and mental well-being. In the regression model, frailty and fear of falling were significant predictors of decreased physical functioning and well-being, and depression was a significant predictor of decreased mental functioning and well-being. This study provides clarification of the relationship between frailty, fear of falling, and depression with HRQoL in high-risk older adults. Screening for common modifiable risk factors can assist in the development of targeted interventions and treatments to improve HRQoL in high-risk older adults.

MALNUTRITION-INFLAMMATION-ATHEROSCLEROSIS (MIA) SYNDROME IN HEMODIALYSIS PATIENTS

2016 ◽  
pp. 99-104
Author(s):  
Thi Khanh Trang Ngo ◽  
Bui Bao Hoang
Keyword(s):  
Risk Factors ◽  
Peritoneal Dialysis ◽  
High Risk ◽  
Cardiovascular Events ◽  
Inflammatory Marker ◽  
Hemodialysis Patients ◽  
Dialysis Patients ◽  
Number Of Patients ◽  
The Relationship ◽  
Mia Syndrome

Background: Mortality resulting from cardiovascular disease in patients with end-stage renal disease (ESRD) is high. In this study we study characteristics of the malnutrition, inflammation, atherosclerosis (MIA) syndrome; relationship between MIA syndrome and the cardiovascular events in hemodialysis patients. Subjects and methods: A total of 61 hemodialysis patients were enrolled. Inflammatory marker (hs CRP) and nutritional parameters (albumin, prealbumin, BMI) were determined. Carotid atherosclerosis was investigated by ultrasonographically evaluated carotid intima-media thickness (cIMT). Results: -The characteristics of the malnutrition, inflammation, atherosclerosis(MIA) syndrome in in peritoneal dialysis patients: + MIA2-3 group had an average age lower than MIA0 group + MIA2-3 group had lower albumin levels and BMI than MIA0 group. + The prevalence of malnutrition (50.8%), inflammation (27.9%), and atherosclerosis (52.5%); 24 (39.3%) of the patients had one risk factor; 22 (36.1%) of the patients had two risk factors; 4 (6.6%) of the patients had all three risk factors. No signs of either malnutrition, inflammation or atherosclerosis were seen in 11 (18.0%) of patients. Note that a considerable number of patients with malnutrition (23/31 patients) had signs of inflammation or atherosclerosis or both; 12/32 patients with atherosclerosis had signs of inflammation or malnutrition or both. - The relationship between MIA syndrome and the cardiovascular events in peritoneal dialysis patients: We have found the relationship between component M (malnutrition) and the cardiovascular events in syndrome MIA (HR: 4.23 95% CI: 1.89-9.50). Our study suggests that high risk cardiovascular events in patients with 2 or more elements in MIA syndrome (HR: 2.40 95% CI: 1.16-5.00). Conclusion: We had demonstrated an association between malnutrition, inflammation and atherosclerosis; component M (malnutrition) and the cardiovascular events in hemodialysis patients; high risk cardiovascular events in patients with 2 or more elements in MIA syndrome. Key words: Malnutrition-inflammation-atherosclerosis syndrome, hemodialysis

Sign in / Sign up

Export Citation Format

Share Document