The Value of Neuroimaging Techniques in the Translation and Transdiagnostic Validation of Psychiatric Diagnoses - Selective Review

2020 ◽  
Vol 20 (7) ◽  
pp. 540-553 ◽  
Author(s):  
Anna Todeva-Radneva ◽  
Rositsa Paunova ◽  
Sevdalina Kandilarova ◽  
Drozdstoy St. Stoyanov
Keyword(s):  
Psychiatric Disorders ◽  
Psychiatric Symptoms ◽  
Medical Science ◽  
Self Report ◽  
Current Status ◽  
Diagnostic Tools ◽  
Main Concept ◽  
Directional Change ◽  
The Mind ◽  
Neuroimaging Techniques

: Psychiatric diagnosis has long been perceived as more of an art than a science since its foundations lie within the observation, and the self-report of the patients themselves and objective diagnostic biomarkers are lacking. Furthermore, the diagnostic tools in use not only stray away from the conventional medical framework but also remain invalidated with evidence-based concepts. However, neuroscience, as a source of valid objective knowledge has initiated the process of a paradigm shift underlined by the main concept of psychiatric disorders being “brain disorders”. It is also a bridge closing the explanatory gap among the different fields of medicine via the translation of the knowledge within a multidisciplinary framework. : The contemporary neuroimaging methods, such as fMRI provide researchers with an entirely new set of tools to reform the current status quo by creating an opportunity to define and validate objective biomarkers that can be translated into clinical practice. Combining multiple neuroimaging techniques with the knowledge of the role of genetic factors, neurochemical imbalance and neuroinflammatory processes in the etiopathophysiology of psychiatric disorders is a step towards a comprehensive biological explanation of psychiatric disorders and a final differentiation of psychiatry as a well-founded medical science. : In addition, the neuroscientific knowledge gained thus far suggests a necessity for directional change to exploring multidisciplinary concepts, such as multiple causality and dimensionality of psychiatric symptoms and disorders. A concomitant viewpoint transition of the notion of validity in psychiatry with a focus on an integrative validatory approach may facilitate the building of a collaborative bridge above the wall existing between the scientific fields analyzing the mind and those studying the brain.

Diagnosing psychiatric disorders in people with intellectual disabilities: issues and achievements

2015 ◽  
Vol 9 (5) ◽  
pp. 230-242 ◽  
Author(s):  
Marco O. Bertelli ◽  
Michele Rossi ◽  
Daniela Scuticchio ◽  
Annamaria Bianco
Keyword(s):  
Psychiatric Disorders ◽  
Psychiatric Symptoms ◽  
Evidence Base ◽  
Current Status ◽  
Diagnostic Tools ◽  
Diagnostic Process ◽  
Content Type ◽  
People With Intellectual Disabilities ◽  
Assessment Procedures ◽  
Source Of Information

Purpose – Diagnosing psychiatric disorders (PD) in adults with Intellectual Disability (ID) presents several issues and need specific skills and tools. The purpose of this paper is to provide a detailed description of the current status of art through a systematic mapping of the literature. Design/methodology/approach – The authors reviewed the international literature on the basis of the following questions: what are the issues in the psychiatric diagnostic process for adults with ID? What methods and procedures have been used for psychiatric assessment in ID? To date, is it possible to identify some most effective procedures? Findings – The analysis of the literature indicates that main issues of the psychiatric diagnostic process in adults with ID are the following: identification of psychiatric symptoms, behavioural equivalents, diagnostic criteria, setting, source of information, screening, and diagnostic tools. The evidence base is only emerging and although many relevant achievements have been reached in the last two decades, no definitive guideline has been produced. Most recent acquisition also allowed to identify some assessment procedures that are currently considered the most effective. Individualised assessment remains the best way to meet the needs of this heterogeneous and variable patient group. Originality/value – This paper offers a comprehensive and updated description of current achievements and issues towards the assessment of PD in people with ID.

Dominant social frustrating factors and mechanisms of psychological adaptation among women with prolonged paranoid schizophrenia

2011 ◽  
Vol 26 (S2) ◽  
pp. 1489-1489
Author(s):  
P. Bomov ◽  
S. Reyblat
Keyword(s):  
Defense Mechanisms ◽  
Paranoid Schizophrenia ◽  
Medical Science ◽  
Psychological Adaptation ◽  
Self Report ◽  
Current Status ◽  
Occupational Adaptation ◽  
Obsessive Compulsive ◽  
Psychological Defense ◽  
The Social

Given the dominance now in medical science biopsychosocial paradigm of mental disorder becomes relevant to study the social and frustrating factors and psychological defense mechanisms in patients with schizophrenia, particularly in patients with a prolonged course of disease. To study this question have been examined 11 patients with paranoid schizophrenia, a female, being hospitalized, aged 33–59 years with disease duration more than 5 years. Used clinical-psychopathological method objectification of clinical self-report scale (SCL - 90 - R), experimental psychology (questionnaireindex of life style). According to the questionnaire SCL - 90 - R obtained rather higher values on the scales: somatization (2.16), obsessive-compulsive (3.70), interpersonal anxiety (2.41), phobias (4,0), psychotism (2.3), which indicates a bright psychopathology in the current status. In these patients revealed the following psychological defense mechanisms: regression, denial, repression, displacement, which largely prevented adequate social and occupational adaptation of patients. The obtained results reflect the syndromic profile of the examined patients, as well as leading mechanisms of their psychological adaptation, which subsequently will provide an opportunity to more adequately use the methods of pharmacotherapy and psihorehabilitation activities in both inpatient and outpatient in this group of patients.

scholarly journals Measuring Integrated Novel Dimensions in Neurodevelopmental and Stress-related Mental Disorders (MIND-Set): a cross-sectional comorbidity study from an RDoC perspective

2021 ◽  
Author(s):  
Philip van Eijndhoven ◽  
Rose Collard ◽  
Janna M. Vrijsen ◽  
Dirk Geurts ◽  
Alejandro Arias Vasquez ◽  
...  
Keyword(s):  
Mental Disorders ◽  
Data Collection ◽  
Psychiatric Disorders ◽  
Neurodevelopmental Disorder ◽  
Self Report ◽  
System Level ◽  
Cross Sectional ◽  
Related Disorder ◽  
Mind Set ◽  
The Mind

Background: It is widely acknowledged that comorbidity between psychiatric disorders is common. Shared and diverse underpinnings of psychiatric disorders cannot be systematically understood on the basis of symptom-based categories of mental disorders, which map poorly onto pathophysiological mechanisms. In the MIND-Set study, we make use of current concepts of comorbidity that transcend the current diagnostic categories. We test this approach to psychiatric problems in patients with frequently occurring psychiatric disorders and their comorbidities (excluding psychosis). The main objective of the MIND-Set project is to determine the shared and specific mechanisms of neurodevelopmental and stress-related psychiatric disorders at different observational levels. Methods: This is an observational, cross-sectional study. Data from different observational levels as defined in the research domain criteria (RDoC; genetics, physiology, neuropsychology, system level neuroimaging, behavior, self-report and experimental neurocognitive paradigms) are collected over four time points. Included are adult (≥ 18 years), non-psychotic, psychiatric patients with a clinical diagnosis of a stress-related disorder (mood disorder, anxiety disorder and/or addiction disorder) and/or a neurodevelopmental disorder (ASD and/or ADHD). Individuals with no current or past psychiatric diagnosis are included as controls. Data collection started in June 2016 with the aim to include a total of 650 patients and 150 healthy controls by 2021. The data collection procedure includes online questionnaires and three subsequent sessions with 1) Standardized clinical examination, physical examination, and blood sampling; 2) Psychological constructs, neuropsychological tests, and biological marker sampling; 3) Neuroimaging measures. Discussion: The MIND-Set study enables us to investigate the mechanistic underpinnings of non-psychotic psychiatric disorders transdiagnostically. We will identify both shared and disorder-specific markers at different observational levels that can be used as targets for future diagnostic and treatment approaches

scholarly journals Psychiatric Symptoms and Barriers to Care in HIV-Infected Individuals Who Are Lost to Care

2017 ◽  
Vol 16 (5) ◽  
pp. 423-429 ◽  
Author(s):  
Carmen P. McLean ◽  
Natalie G. Gay ◽  
David A. Metzger ◽  
Edna B. Foa ◽  
Keyword(s):  
Viral Load ◽  
Psychiatric Disorders ◽  
Risk Behaviors ◽  
Barriers To Care ◽  
Psychiatric Symptoms ◽  
Self Report ◽  
Hiv Care ◽  
People Living With Hiv ◽  
Blood Draw ◽  
Living With Hiv

Past studies of barriers to HIV care have not comprehensively assessed psychiatric symptoms, and few have assessed barriers to care among people living with HIV (PLWH) who are lost to care (LTC). We examined psychiatric symptoms, barriers to HIV care, and immune functioning in PLWH who were retained in care (RIC; n = 21) or LTC (n = 21). Participants completed diagnostic interviews for posttraumatic stress disorder (PTSD) and other psychiatric disorders, self-report measures of HIV risk behaviors and psychiatric symptoms, and a blood draw to assess viral load. Compared to RIC participants, LTC participants met criteria for a greater number of psychiatric disorders and reported greater depressive symptoms and more barriers to HIV care. There were no group differences in PTSD severity, risk behaviors, or viral load, suggesting that LTC individuals experience greater psychiatric problems and perceive more barriers to care than RIC participants, but are not less likely to have achieved viral suppression.

Crisis Occurrence and Resolution in Patients with Severe and Persistent Mental Illness

Crisis ◽  
2005 ◽  
Vol 26 (4) ◽  
pp. 160-169 ◽  
Author(s):  
Paul S. Links ◽  
Rahel Eynan ◽  
Jeffrey S. Ball ◽  
Aiala Barr ◽  
Sean Rourke
Keyword(s):  
Mental Illness ◽  
Suicide Ideation ◽  
Rating Scale ◽  
Psychiatric Symptoms ◽  
Self Report ◽  
Community Treatment ◽  
Persistent Mental Illness ◽  
Crisis Events ◽  
Symptom Distress Scale ◽  
Distress Scale

Abstract. Assertive community treatment appears to have limited impact on the risk of suicide in persons with severe and persistent mental illness (SPMI). This exploratory prospective study attempts to understand this observation by studying the contribution of suicidality to the occurrence of crisis events in patients with SPMI. Specifically, an observer-rated measure of the need for hospitalization, the Crisis Triage Rating Scale, was completed at baseline, crisis occurrence, and resolution to determine how much the level of suicidality contributed to the deemed level of crisis. Second, observer-ratings of suicidal ideation, the Modified Scale for Suicide Ideation, and psychopathology and suicidality, Brief Psychiatric Rating Scale, were measured at baseline, crisis occurrence, and resolution. A self-report measure of distress, the Symptom Distress Scale, was completed at baseline, crisis occurrence, and resolution. Finally, the patients' crisis experiences were recorded qualitatively to compare with quantitative measures of suicidality. Almost 40% of the subjects experienced crisis events and more than a quarter of these events were judged to be severe enough to warrant the need for hospitalization. Our findings suggest that elevation of psychiatric symptoms is a major contributor to the crisis occurrences of individuals with SPMI; although the risk of suicide may have to be conceived as somewhat separate from crisis occurrence.

The Blank in the Mind Questionnaire (BIMQ)

2009 ◽  
Vol 25 (2) ◽  
pp. 115-122 ◽  
Author(s):  
Despina Moraitou ◽  
Anastasia Efklides
Keyword(s):  
Negative Affect ◽  
Convergent Validity ◽  
Factor Model ◽  
Self Report ◽  
Younger Adults ◽  
Confirmatory Factor ◽  
Memory Failure ◽  
Temporary Memory ◽  
The Mind ◽  
Lack Of Knowledge

Metacognitive awareness of memory failure may take the form of the “blank in the mind” (BIM) experience. The BIM experience informs the person of a temporary memory failure and takes the form of a disruption in the flow of consciousness, of a moment of no content in awareness. The aim of the present study was to examine the psychometric properties of the Blank in the Mind Questionnaire (BIMQ) designed to tap the BIM experience and differentiate it from other memory-related experiences, such as searching but not having in memory a piece of information (i.e., lack of knowledge). The participants (N = 493) were 249 younger adults (18–30 years old) and 244 older adults (63–89 years old) of both genders. Confirmatory factor analysis applied to the BIMQ confirmed a three-factor model with interrelations between the factors. The first factor represented the experience of lack of knowledge, the second represented the experience of BIM, and the third the person’s negative affective reactions to memory failure. The internal consistency of the three factors ranged from Cronbach’s α = .80 to .88. Convergent validity was shown with correlations of the BIMQ factors with self-report measures of cognitive and memory failures, and to the negative-affect subscale of the Positive and Negative Affect Schedule (PANAS).

Observational study on Barium Meal X-Ray in clinically diagnosed cases of Parinama Shoola

2016 ◽  
Vol 1 (2) ◽  
Author(s):  
Dr. Mahamad Yunus ◽  
KM Shailaja Singh ◽  
Suvarna Bhagavat ◽  
Arun Kumar Singh ◽  
Manish Kumar
Keyword(s):  
Medical Science ◽  
Duodenal Bulb ◽  
Barium Meal ◽  
Vital Role ◽  
Question Mark ◽  
X Ray ◽  
System Disease ◽  
Mucosal Erosion ◽  
Meal Time ◽  
The Mind

Parinama Shoola is a disease of Annavaha Srotas (GIT) characterized by pain during digestion of food which tormates the process after every meal time and source of constant discomfort. It is a Pitta Pradhana Tridoshaja Vyadhi. Based on subjective features most of the Ayurvedic scholars considered as peptic ulcer, one of the most common digestive system disease rise due to the faulty diet and habits. Hence in the field of gastroenterology diagnosis and management of shoola plays a vital role. The present era is an era of new inventions and the modern medical science has stuck the mind of all by its day to day developments. It is true that modern medical science has grown up considerably; still it has to face a big question mark in so far as some miserable problems are concerned. The problem selected for this work is one among them. Considering the solemnity and incidence of the disease, the present study was aimed to observe barium meal X-ray findings in clinically diagnosed cases of Parinama Shoola to evaluate objective features for Parinama Shoola. It was observed that among 60 patients of Parinama Shoola, 30% were having deformed duodenal bulb, in 25% duodenal cap is deformed with mucosal erosion and 13.3% had duodenal ulcer found with ulcer crater in upper GI barium meal X-ray.

scholarly journals Incidence of Postpartum Depression and Its Association With Antenatal Psychiatric Symptoms: A Longitudinal Study in 25 Villages of Rural South Karnataka

2021 ◽  
pp. 025371762199106
Author(s):  
Meera George ◽  
Avita Rose Johnson ◽  
Sulekha T.
Keyword(s):  
Longitudinal Study ◽  
Postpartum Depression ◽  
Psychiatric Disorders ◽  
Low Socioeconomic Status ◽  
Rural Women ◽  
Rural Areas ◽  
Psychiatric Symptoms ◽  
Depression Scale ◽  
Newborn Care ◽  
Care Program

Background: Postpartum depression (PPD) is the commonest mental health disorder post-childbirth, yet there is a paucity of data in rural areas regarding the actual incidence of PPD, which excludes pre-existing or antenatal depression. To estimate the incidence of PPD among rural women of south Karnataka and identify predictors of PPD, including antenatal psychiatric disorders. Methods: A longitudinal study in 25 villages in south Karnataka among 150 pregnant women in the third trimester of pregnancy using simple random sampling. Baseline data collected and revised Clinical Interview Schedule used to screen antenatal psychiatric disorders. Participants followed-up 6–8 weeks postpartum, end-line data collected, and Edinburg Postnatal Depression Scale administered. Chi-square and Fischer’s exact tests for association between PPD and covariates. Logistic regression to calculate adjusted odds ratios. Results: Prevalence of antenatal psychiatric disorders was 15.3%. The incidence of PPD was 11%. A significantly higher proportion of PPD was found among women with adverse events in the last year, low socioeconomic status, and perceived lack of care/support at home. Predictors of PPD were antenatal psychiatric disorders (AOR = 4.3, 95% CI = 1.22–5.11; P = 0.028), mothers reporting worry about their infant’s health (AOR = 7.7, 95% CI = 1.22–48.32; P = 0.012) and mothers receiving postpartum care by caregivers other than their own mother (AOR = 4.0, 95% CI = 1.13–8.09; P = 0.030). Conclusions: Our study found that one in ten rural women is developing PPD and there is a strong link between PPD and antenatal psychiatric disorders and family factors. This calls for capacity building of general physicians and village-level workers and strengthening of the Home-Based Newborn Care Program, where weekly postpartum home visits by ASHA are an opportunity for screening and counselling mothers.

scholarly journals Oral Care and Prevention of Pneumonia in Hospitalized Patients With Psychiatric Disorders in Japan

2017 ◽  
Vol 8 ◽  
pp. 117967071772040
Author(s):  
Atsushi Hamuro ◽  
Hideki Kawaguchi ◽  
Kazuaki Yamazoe ◽  
Minoru Honda ◽  
Ryuichi Tanaka
Keyword(s):  
Psychiatric Disorders ◽  
Oral Hygiene ◽  
Psychiatric Symptoms ◽  
Univariate Analysis ◽  
Oral Care ◽  
Multivariate Logistic Regression Analysis ◽  
Hospitalized Patients ◽  
Control Group ◽  
Hygiene Intervention ◽  
Time Point

Purpose: Oral care in hospitalized patients with psychiatric disorders is important. However, some patients with psychiatric disorders cannot undergo oral care because of psychiatric symptoms and cognitive decline. The effect of a standardized oral hygiene intervention on the prevention of pneumonia in hospitalized patients with psychiatric disorders was investigated. Method: Patients were divided into 2 groups: control group (N = 259), patients without standardized intervention who were enrolled on April 2014 as the time point of baseline, and intervention group (N = 263), patients with standardized intervention who were enrolled on April 2015 as the time point of baseline. Two end points were evaluated: (1) pneumonia onset within 1 year after the enrollment and (2) no pneumonia for 1 year after the enrollment. The following parameters were compared between the groups: sex, age, psychiatric disorders, past history of diseases of the respiratory system, hypertension, diabetes, hyperlipidemia, heart impairment, and pneumonia. Results: No statistically significant differences were found between the 2 groups in the distributions of characteristics except pneumonia by univariate analysis. The presence of pneumonia was significantly associated with age and the absence of the standardized oral hygiene intervention by multivariate logistic regression analysis. Conclusions: The standardized oral hygiene intervention appears to be effective for preventing pneumonia in patients with psychiatric disorders.

scholarly journals Evolution of psychosocial burden and psychiatric symptoms in patients with psychiatric disorders during the Covid-19 pandemic

2021 ◽  
Author(s):  
Michael Belz ◽  
Philipp Hessmann ◽  
Jonathan Vogelgsang ◽  
Ulrike Schmidt ◽  
Mirjana Ruhleder ◽  
...  
Keyword(s):  
Mental Health ◽  
Mental Disorders ◽  
Psychiatric Disorders ◽  
Stress Responses ◽  
Psychiatric Symptoms ◽  
High Stress ◽  
Specific Treatment ◽  
Time Range ◽  
Long Term Effects ◽  
Psychosocial Burden

AbstractThe Covid-19 pandemic highly impacts mental health worldwide. Patients with psychiatric disorders are a vulnerable risk population for worsening of their condition and relapse of symptoms. This study investigates the pandemic-related course of psychosocial burden in patients with pre-existing mental disorders. With the newly developed Goettingen psychosocial Burden and Symptom Inventory (Goe-BSI) psychosocial burden has been traced retrospectively (1) before the pandemic (beginning of 2020), (2) at its beginning under maximum lockdown conditions (March 2020), and (3) for the current state after maximum lockdown conditions (April/May 2020). The Goe-BSI also integrates the Adjustment Disorder New Module (ADNM-20), assesses general psychiatric symptoms, and resilience. A total of 213 patients covering all major psychiatric disorders (ICD-10 F0-F9) were interviewed once in the time range from April, 24th until May 11th, 2020. Across all diagnoses patients exhibited a distinct pattern with an initial rise followed by a decline of psychosocial burden (p < 0.001, partial η2 = 0.09; Bonferroni-corrected pairwise comparisons between all three time-points: p < 0.05 to 0.001). Female gender and high ADNM-20 scores were identified as risk factors for higher levels and an unfavorable course of psychosocial burden over time. Most psychiatric symptoms remained unchanged. Trajectories of psychosocial burden vary in parallel to local lockdown restrictions and seem to reflect an adaptive stress response. For female patients with pre-existing mental disorders and patients with high-stress responses, timely and specific treatment should be scheduled. With the continuation of the pandemic, monitoring of long-term effects is of major importance, especially when long incubation times for the development of mental health issues are considered.

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