scholarly journals Drug Delivery Nanosystems in Glioblastoma Multiforme Treatment: Current State of the Art

2020 ◽  
Vol 18 ◽  
Author(s):  
Leonardo Delello Di Filippo ◽  
Jonatas Lobato Duarte ◽  
Marcela Tavares Luiz ◽  
Jennifer Thayane Cavalcante de Araújo ◽  
Marlus Chorilli
Keyword(s):  
Drug Delivery ◽  
Glioblastoma Multiforme ◽  
State Of The Art ◽  
Biological Effects ◽  
Tumor Resection ◽  
Inorganic Nanoparticles ◽  
Future Perspectives ◽  
Central Nervous System Cancer ◽  
Current State ◽  
Biopharmaceutical Properties

: Glioblastoma multiforme (GBM) is the most common primary malignant Central Nervous System cancer, responsible for about 4% of all deaths associated with neoplasia, characterized as one of the most fatal human cancers. Tumor resection does not possess curative character, thereby radio and/or chemotherapy are often necessary for the treatment of GBM. However, drugs used in GBM chemotherapy present some limitations, such as side effects associated with nonspecific drug biodistribution as well as limited bioavailability, which limits their clinical use. To attenuate the systemic toxicity and overcome the poor bioavailability, a very attractive approach is drug encapsulation in drug delivery nanosystems. The main focus of this review is to explore the actual cancer global problem, enunciate barriers to overcome in the pharmacological treatment of GBM, as well as the most updated drug delivery nanosystems for GBM treatment and how they influence biopharmaceutical properties of anti-GBM drugs. The discussion will approach lipid-based and polymeric nanosystems, as well as inorganic nanoparticles, regarding their technical aspects as well as biological effects in GBM treatment. Furthermore, the current state of the art, challenges to overcome and future perspectives in GBM treatment will be discussed.

scholarly journals Brain organoids and insights on human evolution

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 760 ◽  
Author(s):  
Alysson R. Muotri
Keyword(s):  
Stem Cells ◽  
Human Brain ◽  
Human Health ◽  
Human Evolution ◽  
Pluripotent Stem Cells ◽  
Disease Modeling ◽  
State Of The Art ◽  
Future Perspectives ◽  
Promising Technique ◽  
Current State

Human brain organoids, generated from pluripotent stem cells, have emerged as a promising technique for modeling early stages of human neurodevelopment in controlled laboratory conditions. Although the applications for disease modeling in a dish have become routine, the use of these brain organoids as evolutionary tools is only now getting momentum. Here, we will review the current state of the art on the use of brain organoids from different species and the molecular and cellular insights generated from these studies. Besides, we will discuss how this model might be beneficial for human health and the limitations and future perspectives of this technology.

scholarly journals Polymer Clay Nano-Composites

Polymers ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 1445
Author(s):  
Stefano Leporatti
Keyword(s):  
Drug Delivery ◽  
Composite Materials ◽  
Polymer Composite ◽  
State Of The Art ◽  
Environmental Water ◽  
Water Remediation ◽  
Nano Composites ◽  
Special Issue ◽  
Current State ◽  
Exciting Area

Clay–polymer composite materials is an exciting area of research and this Special Issue aims to address the current state-of-the-art of “Polymer Clay Nano-Composites” for several applications, among them antibacterial, environmental, water remediation, dental, drug delivery and others [...]

scholarly journals Molecular Targets and Nanoparticulate Systems Designed for the Improved Therapeutic Intervention in Glioblastoma Multiforme

Drug Research ◽  
2020 ◽  
Author(s):  
Md. Habban Akhter ◽  
Md. Rizwanullah ◽  
Javed Ahmad ◽  
Saima Amin ◽  
Mohammad Zaki Ahmad ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Glioblastoma Multiforme ◽  
Targeted Delivery ◽  
Inorganic Nanoparticles ◽  
Therapeutic Approaches ◽  
The Stability ◽  
And Control ◽  
Plasma Half Life ◽  
Nanoparticulate Systems ◽  
Proteins And Peptides

AbstractGlioblastoma multiforme (GBM) is the most aggressive and fatal CNS related tumors, which is responsible for about 4% of cancer-related deaths. Current GBM therapy includes surgery, radiation, and chemotherapy. The effective chemotherapy of GBM is compromised by two barriers, i. e., the blood-brain barrier (BBB) and the blood tumor barrier (BTB). Therefore, novel therapeutic approaches are needed. Nanoparticles are one of the highly efficient drug delivery systems for a variety of chemotherapeutics that have gained massive attention from the last three decades. Perfectly designed nanoparticles have the ability to cross BBB and BTB and precisely deliver the chemotherapeutics to GBM tissue/cells. Nanoparticles can encapsulate both hydrophilic and lipophilic drugs, genes, proteins, and peptides, increase the stability of drugs by protecting them from degradation, improve plasma half-life, reduce adverse effects and control the release of drugs/genes at the desired site. This review focussed on the different signaling pathways altered in GBM cells to understand the rationale behind selecting new therapeutic targets, challenges in the drug delivery to the GBM, various transport routes in brain delivery, and recent advances in targeted delivery of different drug and gene loaded various lipidic, polymeric and inorganic nanoparticles in the effective management of GBM.

scholarly journals Calcium-Ion Batteries: Current State-of-the-Art and Future Perspectives

2018 ◽  
Vol 30 (39) ◽  
pp. 1801702 ◽  
Author(s):  
Rosalind J. Gummow ◽  
George Vamvounis ◽  
M. Bobby Kannan ◽  
Yinghe He
Keyword(s):  
Calcium Ion ◽  
State Of The Art ◽  
Future Perspectives ◽  
Current State

Female fertility preservation strategies: cryopreservation and ovarian tissuein vitroculture, current state of the art and future perspectives

Zygote ◽  
2016 ◽  
Vol 24 (5) ◽  
pp. 635-653 ◽  
Author(s):  
M.A. Filatov ◽  
Y.V. Khramova ◽  
M.V. Kiseleva ◽  
I.V. Malinova ◽  
E.V. Komarova ◽  
...  
Keyword(s):  
Fertility Preservation ◽  
State Of The Art ◽  
Ovarian Tissue ◽  
Female Fertility ◽  
Ovarian Tissue Cryopreservation ◽  
Future Perspectives ◽  
Current State ◽  
Female Fertility Preservation ◽  
Tissue Cryopreservation

SummaryIn the present review, the main strategies of female fertility preservation are covered. Procedures of fertility preservation are necessary for women who suffer from diseases whose treatment requires the use of aggressive therapies, such as chemotherapy and radiotherapy. These kinds of therapy negatively influence the health of gametes and their progenitors. The most commonly used method of female fertility preservation is ovarian tissue cryopreservation, followed by the retransplantation of thawed tissue. Another approach to female fertility preservation that has been actively developed lately is the ovarian tissuein vitroculture. The principal methods, advantages and drawbacks of these two strategies are discussed in this article.

scholarly journals Nanoarchitectonics: Complexes and Conjugates of Platinum Drugs with Silicon Containing Nanocarriers. An Overview

2021 ◽  
Vol 22 (17) ◽  
pp. 9264
Author(s):  
Kinga Piorecka ◽  
Jan Kurjata ◽  
Wlodzimierz A. Stanczyk
Keyword(s):  
Drug Delivery ◽  
Driving Force ◽  
State Of The Art ◽  
Platinum Drugs ◽  
Research Groups ◽  
Current State ◽  
Delivery Platform ◽  
Silicon Based ◽  
Intensive Search

The development in the area of novel anticancer prodrugs (conjugates and complexes) has attracted growing attention from many research groups. The dangerous side effects of currently used anticancer drugs, including cisplatin and other platinum based drugs, as well their systemic toxicity is a driving force for intensive search and presents a safer way in delivery platform of active molecules. Silicon based nanocarriers play an important role in achieving the goal of synthesis of the more effective prodrugs. It is worth to underline that silicon based platform including silica and silsesquioxane nanocarriers offers higher stability, biocompatibility of such the materials and pro-longed release of active platinum drugs. Silicon nanomaterials themselves are well-known for improving drug delivery, being themselves non-toxic, and versatile, and tailored surface chemistry. This review summarizes the current state-of-the-art within constructs of silicon-containing nano-carriers conjugated and complexed with platinum based drugs. Contrary to a number of other reviews, it stresses the role of nano-chemistry as a primary tool in the development of novel prodrugs.

scholarly journals Magnetic Resonance-Guided Laser Induced Thermal Therapy for Glioblastoma Multiforme: A Review

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Sarah E. Norred ◽  
Jacqueline Anne Johnson
Keyword(s):  
Glioblastoma Multiforme ◽  
Magnetic Resonance ◽  
Tumor Tissue ◽  
State Of The Art ◽  
Invasive Approach ◽  
Temperature Imaging ◽  
Current State ◽  
Clinical Challenge ◽  
Potential Applications ◽  
Magnetic Resonance Temperature Imaging

Magnetic resonance-guided laser induced thermotherapy (MRgLITT) has become an increasingly relevant therapy for tumor ablation due to its minimally invasive approach and broad applicability across many tissue types. The current state of the art applies laser irradiation via cooled optical fiber applicators in order to generate ablative heat and necrosis in tumor tissue. Magnetic resonance temperature imaging (MRTI) is used concurrently with this therapy to plan treatments and visualize tumor necrosis. Though application in neurosurgery remains in its infancy, MRgLITT has been found to be a promising therapy for many types of brain tumors. This review examines the current use of MRgLITT with regard to the special clinical challenge of glioblastoma multiforme and examines the potential applications of next-generation nanotherapy specific to the treatment of glioblastoma.

Delving Deeper into Dermal and Transdermal Drug Delivery: Factors and Mechanisms Associated with Nanocarrier-mediated Strategies

2018 ◽  
Vol 24 (27) ◽  
pp. 3210-3222 ◽  
Author(s):  
Jyothsna Manikkath ◽  
TK Sumathy ◽  
Aparna Manikkath ◽  
Srinivas Mutalik
Keyword(s):  
Drug Delivery ◽  
Transdermal Delivery ◽  
Transdermal Drug Delivery ◽  
Dispersion Medium ◽  
State Of The Art ◽  
Particle Engineering ◽  
Key Factors ◽  
Current State ◽  
Routes Of Drug Administration ◽  
Drug And Gene Delivery

Background: Advances in material science and particle engineering have led to the development of a rapidly growing number of nanoparticulate carriers for drug and gene delivery. These carriers are increasingly being investigated in dermal and transdermal routes of drug administration. Objective: To critically examine and summarize the primary factors and mechanisms involved in nanocarriermediated dermal and transdermal delivery of drugs. Method: Thorough literature search was undertaken, spanning the early development of nanocarrier-mediated dermal and transdermal drug delivery approaches, to the current state of the art, using online search tools. Results: Physicochemical, formulation, experimental and morphological factors, such as, material of construction or type of nanoparticle (NP), surface chemistry, particle size, particle shape, surface charge, dispersion medium, duration of exposure of skin to NPs, combination of NPs with physical agents, and aspects related to skin were identified and discussed. Conclusion: The key factors and mechanisms which influence NPs-skin interactions in dermal and transdermal drug delivery are discussed in this article in-line with the current advances in the field.

Sign in / Sign up

Export Citation Format

Share Document