Voltammetric Sensors Based on Various Nanomaterials for the Determination of Sulfonamides

2019 ◽  
Vol 15 (2) ◽  
pp. 124-130
Author(s):  
Hana Beigizadeh ◽  
Mohammad Reza Ganjali ◽  
Parviz Norouzi
Keyword(s):  
Human Health ◽  
Metallic Nanoparticles ◽  
Antimicrobial Agents ◽  
Modified Electrodes ◽  
The Body ◽  
The Poor ◽  
Voltammetric Sensors ◽  
Sensitivity And Selectivity ◽  
History Of

Background: The widespread applications of sulphonamides, as antibacterial or antimicrobial agents, and their mechanism of actions in the body, have changed their determination to an important issue in the area of human health. Objective: Here, history of developing voltammetric sensors based on nanomaterials for the detection of sulfonamides including sulfadiazine, sulfamethoxazole, sulfacetamide, sulfadimethoxine, sulfathiazole, sulfamethiazole and sulfamerazine is reviewed. Modified electrodes based on various nanomaterials (carbonaceous nanomaterials, Metallic Nanoparticles (MNPs), conducting nanopolymers) have been reported, and studies showed that nanomaterials have been mostly used to overcome problems like the poor sensitivity and selectivity of bare electrodes. The study covers the properties of each sensor in detail, and reports and compares the linear ranges, Limits of Detection (LODs), reproducibility, and reusability of the electrodes reported so far.

scholarly journals Medical geochemical investigations in taking precautionary measures against diseases. Protection and human health

2013 ◽  
Vol 14 (4) ◽  
pp. 505-515
Keyword(s):  
Pregnant Women ◽  
Human Health ◽  
Behavioral Problems ◽  
The Body ◽  
Term Delivery ◽  
Brain Neurotransmitter ◽  
Precautionary Measures ◽  
Geochemical Studies

A considerable number of diseases are directly related to environmental impact. Toxic metals such as Hg, Pb, Cd, and As may damage significantly the human health when they exceed certain levels in the body. For example specific precautions should be taken for the diet of pregnant women and the children. Lead concentrations exceeding the safe values can cause severe damage to the development of central nervous system, as well as a general developmental delay of fetuses and young children, interfering with the functioning of almost every brain neurotransmitter. In particular for the pregnant women, it has been found that the exposure of the fetus on high lead values may cause, apart from neurological and behavioral problems, low birth weight, pre-term delivery, spontaneous abortion and stillbirth. Organic mercury (methyl mercury) is the most dangerous form of mercury, because it is the most easily absorbed orally and crosses into the brain and fetus so readily. Populations exposed to chemical compounds containing As, Ni, Cr, Cd, etc. are considered of high-risk in developing cancer. Environmental geochemical studies can help in assessing the quality of the environment as well as the determination of the sources of pollutants, their behaviour and other characteristics. This knowledge is necessary in any application of remediation methodologies and waste management for the prevention of pollutants in getting into the food chain. It is also used in determining safe criteria regarding the quality of soils, drinking water, construction of schools, playgrounds etc. In this work the importance of environmental geochemical research and its applications towards the protection of human health is demonstrated.

scholarly journals DETERMINATION OF PERSONAL AND SITUATION DETERMINANTS LAZINESS

2019 ◽  
Vol 42 (4) ◽  
pp. 115-119
Author(s):  
S. M. MAXIMETS
Keyword(s):  
Self Regulation ◽  
External Pressure ◽  
The Body ◽  
Situational Factors ◽  
Psychological State ◽  
Self Assessment ◽  
Household Chores ◽  
The Poor ◽  
Inner World

This article contains the result of the theoretical and empirical study of personality and situational factors of laziness among young people and the presence of gender differences in the concept of laziness. Laziness is synonymous with a lack of motivation, unwillingness to do anything. Situational laziness is more of a temporary nature of the lack of desire to do something. Personal laziness is a set of determined human characteristics that attend it throughout life. Analysis of the results of self-assessment of laziness found that only 20% of respondents consider themselves to be a lazy person, while the other 80% consider themselves as hardworking. The most important personal determinant of laziness (in 83% of persons) were features of physical and psychological state. Namely: tiredness, desire to rest, drowsiness, no mood, the poor state of feeling, boredom, etc. Other determinants such as lack of opportunities, lack of interest, external pressure are less important and cause personal laziness in single cases. The personal and situational determinants of the laziness that have been investigated have different nature and manifestations. We believe that the features of the body condition can not be included in the group of personal determinants of laziness. Opportunity deficits (lack of perseverance, lack of skills and time, difficult task, other distracting problems) can be attributed to the personal determinants of laziness. Areas of maximum demonstration of laziness are (in descending order): professional (educational) activities, household chores, cases under pressure, and lack cases. Based on the analysis of the results of the study of self-regulation of laziness, we can speak about differences in the concept of laziness between men and women."Male laziness" is perceived as a feeling of unwillingness, apathy, inaction, and focused on the inner world and feelings. "Female laziness" is conditioned by the situation. More demonstrated as outward orientation, responsibility, feelings of guilt. Based on the results, it is planned to develop a program of correctional work based on a differentiated approach to people, taking into account factors that influence the manifestation of laziness.

scholarly journals Sensitive and Selective Voltammetric Sensors for the Simultaneous Quantification of Natural Phenolic Antioxidants in Cognac and Brandy

2021 ◽  
Vol 5 (1) ◽  
pp. 1
Author(s):  
Guzel Ziyatdinova ◽  
Ekaterina Guss
Keyword(s):  
Modified Electrodes ◽  
Phenolic Antioxidants ◽  
Pyrocatechol Violet ◽  
Simultaneous Quantification ◽  
Voltammetric Sensors ◽  
Quality Markers ◽  
Sensitive Determination ◽  
Polymerization Conditions ◽  
Distilled Beverages

Aged distilled beverages (cognac and brandy) contain phenolic antioxidants as their quality markers. Voltammetric sensors based on the carbon nanotubes and electropolymerized pyrocatechol violet (PCV) or p-aminobenzoic acid (ABA) were developed for the simultaneous determination of the phenolic antioxidants in cognac and brandy. The polymerization conditions of PCV and ABA were optimized. Sensors allow for the simultaneous sensitive determination of gallic and ellagic acids as well as syringaldehyde and vanillin. The analytical characteristics are improved vs. other modified electrodes. The sensors show selectivity in the presence of typical interferences and other natural phenolics. The sensors that were developed were tested on cognac and brandy samples.

The role of the main ingredients of chocolate in the formation of its beneficial properties for the consumer

2021 ◽  
pp. 582-587
Author(s):  
I.V. Goloviznin ◽  
A.V. Ryzhakova
Keyword(s):  
Human Health ◽  
Complete Information ◽  
The Body ◽  
Specific Product ◽  
Regular Process ◽  
The World ◽  
The Impact ◽  
Confectionery Product

Chocolate is the most staple and consumed confectionery product in Russia and the world. The determination of the beneficial properties of such a product as chocolate is an important and regular process of food institutions in every country, since new lines of already well-known manufacturers and new manufacturers with an innovative assortment are added to the retail assortment. Today, it is very relevant and important to understand the impact of new products on human health. In this regard, in order to provide complete information on a specific product, it is necessary to know its composition, ingredients and their effect on the body separately and within the framework of a specific product. Along with its beneficial properties, chocolate can also affect health negatively. It is necessary to understand the mechanism of the effect of chocolate on human health when consumed and to assess the risks that may arise subsequently after its active consumption.

Pure Metal Nanoparticles for Selective Electrochemical Sensor of Organic Substances

2016 ◽  
Vol 683 ◽  
pp. 288-294
Author(s):  
Anastasiia V. Shabalina ◽  
Kceniya Belova
Keyword(s):  
Ascorbic Acid ◽  
Electrode Surface ◽  
Metallic Nanoparticles ◽  
Modified Electrodes ◽  
Pure Metal ◽  
Electrochemical Analysis ◽  
Stabilizing Agents ◽  
Sensitivity And Selectivity ◽  
Electro Oxidation ◽  
Surface Increase

The field of application of electrochemical analysis has been significantly widened after modified electrodes appeared. Metallic nanoparticles are ones of the most common used modifiers of the electrode surface to increase the sensitivity and selectivity of the analysis. Increasing of selectivity is extremely important in cases when two or more analyts have electro-chemical signals at nearly the same values of electrode potential. Dopamine and ascorbic acid are an example of such case. In present work Au, Pt, Pd, and Ni “pure” nanoparticles obtained by laser ablation without stabilizing agents were used to modify the surface of a glassy carbon electrode. Modified electrodes were tested in solutions of ascorbic acid and dopamine at their simultaneous electro-oxidation. It was shown that Au, Pt, and Ni nanoparticles on the electrode surface increase the selectivity of analysis giving two separate peaks of analyts.

scholarly journals Novyi Mishor – first country-style resort on the South Coast of Crimea (1898-1920): reconstruction of sociocultural history

2020 ◽  
pp. 103-127
Author(s):  
Andrey Vasil'evich Karagodin ◽  
Mariya Mikhailovna Petrova
Keyword(s):  
The Body ◽  
South Coast ◽  
Russian Society ◽  
The South ◽  
Historical Sources ◽  
Starting Point ◽  
History Of ◽  
The Subject ◽  
First Time

The subject of this research is the history of the first of country-style resort appeared on the South Coast of Crimea at the turn of the XIX – XX centuries on the lands of country estates of New Mishor belonged to Shuvalov-Dolgorukov family. The phenomenon of country-style construction on the South Coast of Crimes, which starting point was the foundation of the Novyi Mishor, is viewed in the context of the processes of economic and sociocultural modernization of Russian society, formation of self-identification mechanisms of the emerging “middle class”, and new urban culture. Special attention is given to the period from 1917 to 1920, when the cultural figures left the capital and resided in the villages of Novyi Mishor. Based on examination the body of historical sources, many of which introduced to the scientific discourse for the first time, the author formed the database of villages and countryside residents of Novyi Mishor. A vast array of archival funds, reference literature, sources of personal provenance (memoirs, correspondence), and visual sources was attracted in the course of research. The novelty of consists in establishment of identities and social status of the residents of country resort of Novyi Mishor, determination of a range of sources for its further research, reconstruction of chronology of the development of this resort, details of everyday life and mentality traits of the residents, among which were the prominent figures of culture and art of Russia of that time – writers, actors, painters, scholars, and philanthropists.

scholarly journals MEDICAL GEOCHEMISTRY A KEY IN THE PRECAUTIONARY MEASURES AGAINST THE DEVELOPMENT OF CANCER AND OTHER DISEASES

2017 ◽  
Vol 43 (1) ◽  
pp. 234 ◽  
Author(s):  
S. Varnavas
Keyword(s):  
Pregnant Women ◽  
Human Health ◽  
Behavioral Problems ◽  
The Body ◽  
Term Delivery ◽  
Brain Neurotransmitter ◽  
Precautionary Measures ◽  
Geochemical Studies

A considerable number of diseases are directly related to environmental impact. Toxic metals such as Hg, Pb, Cd, and As may damage significantly the human health when they exceed certain levels in the body. For example specific precautions should be taken for the diet of pregnant women and the children. Lead concentrations exceeding the safe values can cause severe damage to the development of central nervous system, as well as a general developmental delay of fetuses and young children, interfering with the functioning of almost every brain neurotransmitter. In particular for the pregnant women, it has been found that the exposure of the fetus on high lead values may cause, apart from neurological and behavioral problems, low birth weight, pre-term delivery, spontaneous abortion and stillbirth. Organic mercury (methyl mercury) is the most dangerous form of mercury, because it is the most easily absorbed orally and crosses into the brain and fetus so readily. Populations exposed to chemical compounds containing As, Ni, Cr, Cd, etc. are considered of high-risk in developing cancer. Environmental geochemical studies can help in assessing the quality of the environment as well as the determination of the sources of pollutants, their behaviour and other characteristics. This knowledge is necessary in any application of remediation methodologies and waste management for the prevention of pollutants in getting into the food chain. It is also used in determining safe criteria regarding the quality of soils, drinking water, construction of schools, playgrounds etc. In this work the importance of environmental geochemical research and its applications towards the protection of human health is demonstrated.

scholarly journals Nafion-coated cadmium pentacyanonitrosylferrate-modified glassy carbon electrode for detection of dopamine in biological samples

Bioimpacts ◽  
2017 ◽  
Vol 8 (4) ◽  
pp. 263-270
Author(s):  
Mohammad Johari-Ahar ◽  
Jaleh Barar ◽  
Pari Karami ◽  
Davoud Asgari ◽  
Soodabeh Davaran ◽  
...  
Keyword(s):  
Modified Electrode ◽  
Glassy Carbon ◽  
Biological Samples ◽  
Limit Of Detection ◽  
Biological Fluids ◽  
Modified Electrodes ◽  
Serum Samples ◽  
Selective Determination ◽  
Sensitivity And Selectivity

Introduction: Dopamine is one of the key neurotransmitters (NTs) in nature, which plays a crucial role in the mammalian central nervous system (CNS). Its selective determination in the biological fluids is an essential need in the field of biomedicine studies. Methods: In this work, an amperometric sensor was developed using Nafion-coated cadmium pentacyanonitrosylferrate (CdPCNF) modified glassy carbon (GC) electrode (Nafion|CdPCNF|GC electrode) as an electrocatalyst to detect dopamine (DA) in human serum samples. To develop this sensor, the surface of bare GC electrode was coated with the film of CdPCNF through an electropolymerization method and then the modified electrode was coated with Nafion to minimize interferences, especially those arising from the presence of anionic compounds. The electrocatalytic behavior of the modified electrodes was studied using the cyclic voltammetry and amperometry, and then the ability of the sensor for the determination of DA in synthetic and biological samples was investigated. Results: The modified electrode was showed a significant electrocatalytic activity for the oxidation of DA at pH 7.4. The limit of detection (LOD) was 0.7 µM and also no interference effects arose from ascorbic acid (AA), uric acid (UA) or the other biological NTs was observed in the DA detection using the modified Nafion|CdPCNF|GC electrode. Conclusion: In comparison with the bare electrode, the Nafion|CdPCNF|GC electrode could determine DA in the biological samples with adequate sensitivity and selectivity. Therefore, we propose that the modified electrode is utilizable as an amperometric DA sensor for the biological sample analysis.

scholarly journals Voltammetric Electronic Tongue for the Simultaneous Determination of Three Benzodiazepines

Sensors ◽  
2019 ◽  
Vol 19 (22) ◽  
pp. 5002 ◽  
Author(s):  
Anna Herrera-Chacón ◽  
Farzad Torabi ◽  
Farnoush Faridbod ◽  
Jahan B. Ghasemi ◽  
Andreu González-Calabuig ◽  
...  
Keyword(s):  
Metallic Nanoparticles ◽  
Simultaneous Detection ◽  
Electronic Tongue ◽  
Principal Component ◽  
Quantitative Model ◽  
Discrete Wavelet ◽  
Composite Electrodes ◽  
Voltammetric Sensors ◽  
Voltammetric Electronic Tongue

The presented manuscript reports the simultaneous detection of a ternary mixture of the benzodiazepines diazepam, lorazepam, and flunitrazepam using an array of voltammetric sensors and the electronic tongue principle. The electrodes used in the array were selected from a set of differently modified graphite epoxy composite electrodes; specifically, six electrodes were used incorporating metallic nanoparticles of Cu and Pt, oxide nanoparticles of CuO and WO3, plus pristine electrodes of epoxy-graphite and metallic Pt disk. Cyclic voltammetry was the technique used to obtain the voltammetric responses. Multivariate examination using Principal Component Analysis (PCA) justified the choice of sensors in order to get the proper discrimination of the benzodiazepines. Next, a quantitative model to predict the concentrations of mixtures of the three benzodiazepines was built employing the set of voltammograms, and was first processed with the Discrete Wavelet Transform, which fed an artificial neural network response model. The developed model successfully predicted the concentration of the three compounds with a normalized root mean square error (NRMSE) of 0.034 and 0.106 for the training and test subsets, respectively, and coefficient of correlation R ≥ 0.938 in the predicted vs. expected concentrations comparison graph.

scholarly journals Atopic Dermatitis and Psoriasis as Overlapping Syndromes

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
A. Bozek ◽  
M. Zajac ◽  
M. Krupka
Keyword(s):  
Atopic Dermatitis ◽  
Family History ◽  
Atopic Disease ◽  
Skin Lesions ◽  
The Body ◽  
T Helper 17 ◽  
Tnf Α ◽  
History Of

Background/Objectives. Cooccurrence of atopic dermatitis (AD) and psoriasis (PS) is not common. However, both diseases are still of interest because of their comprehensive and diverse mechanisms. This study aimed to present the clinical and immunological profiles of patients with concomitant AD and PS and compare them with those of patients with only one of the diseases. Methods. In this observational study, 38 children with concomitant AD and PS with a mean age of 6.5 ± 3.2  yrs were compared with 41 similar patients with AD only ( 5.3 ± 5.1  yrs) and 28 patients with PS only ( 6.4 ± 4.3  yrs). All patients underwent dermatological examinations, including determination of SCORAD and PASI scores. TNF-α, IFN-γ, IL-2, IL-4, IL-5, IL-6, IL-8, IL-12, IL-17, IL-18, IL-22, I:-33, and TARC/CCL17 were measured by ELISA according to the manufacturer’s instructions. Results. Patients with concomitant AD and PS were frequently boys and overweight and had skin lesions equally distributed throughout the body. Children with concomitant AD and PS were more likely to report a family history of atopic disease than children with only AD or PS, and those with AD were more likely to report a family history of atopic disease than those with PS. Significant differences were observed in the concentration of IL-17 between patients with AD and PS and those with only AD or PS: 9.1 ± 3.7  pg/ml vs. 4.8 ± 2.9  pg/ml; and 9.1 ± 3.7  pg/ml vs. 5.2 ± 3.9  pg/ml, respectively (PD vs. AD, p = 0.01 ; PD vs. PS, p = 0.03 ). Conclusions. AD and PS can coexist. The role of T helper 17 cells may be more essential than believed.

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