Corrigendum

2021 ◽  
Vol 21 (17) ◽  
pp. 2464-2464
Keyword(s):  
Science And Technology ◽  
Scientific Research ◽  
Uttar Pradesh ◽  
Research Project ◽  
Hpv E6 ◽  
Cycle Arrest ◽  
Anti Cancer ◽  
Cervical Cancer Cells ◽  
E6 And E7 ◽  
Funding Information

Minor changes are required in the Funding information and the acknowledgement for the article entitled “Organosulphur Compounds Induce Apoptosis and Cell Cycle Arrest in Cervical Cancer Cells via Downregulation of HPV E6 and E7 Oncogenes” in “Anti-Cancer Agents in Medicinal Chemistry, 2021, Vol. 21, No. 3, pp. 393-405.” The correct Funding information and Acknowledgement is given below: FUNDING: This project was funded by the Council of Science and Technology (CST), Lucknow, Uttar Pradesh, India (Sanction No. CST/374). The financial support during this research was also provided by the Deanship of Scientific Research, King Khalid University, Abha, Saudia Arabia through the General Research Project under grant number R.G.P. 01/48/42. ACKNOWLEDGEMENT: IAA is greatly thankful to the Council of Science and Technology (CST), Uttar Pradesh, India, for providing him project as a Principal Investigator. Authors would also like to acknowledge the support of the King Khalid University through the General Research Project under grant number R.G.P. 01/48/42. under the Deanship of Scientific Research, King Khalid University, Abha, Saudia Arabia

scholarly journals management of scientific research projects in local universities

2016 ◽  
Vol 4 (11) ◽  
pp. 68-72
Author(s):  
Li Fangzheng ◽  
Xiaoyun Zhang
Keyword(s):  
Local Governments ◽  
Science And Technology ◽  
Scientific Research ◽  
Research Projects ◽  
Research Project ◽  
Innovative Management ◽  
State And Local

With the increasing development of science and technology, and state and local governments paying more attention to the power of science and technology, many local universities are faced with a series of innovative management environment, such as, the growing amount of scientific research projects substantially, the improving level, the wide areas involved, which put forward some new requests in projects management for local universities. According to this question ,the scientific research projects management in local universities are ought to make the thinking correct, the essential captured , the supervision strengthen, the distinguishing feature stand out .And local universities should, in the links of research project application, project initation, project inspection, projiect accepting and the use of funds strengthen the management, improving the quality projects management, enhancing the comprehensive strength of scientific research.

scholarly journals E6-mediated activation of JNK drives EGFR signalling to promote proliferation and viral oncoprotein expression in cervical cancer

2020 ◽  
Author(s):  
Ethan L. Morgan ◽  
James A. Scarth ◽  
Molly R. Patterson ◽  
Christopher W. Wasson ◽  
Georgia C. Hemingway ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cell Proliferation ◽  
Cancer Cells ◽  
Human Papillomaviruses ◽  
Signalling Pathway ◽  
Viral Oncoprotein ◽  
Hpv E6 ◽  
Cervical Cancer Cells ◽  
E6 And E7 ◽  
Novel Therapeutic

AbstractHuman papillomaviruses (HPV) are a major cause of malignancy worldwide, contributing to ~5% of all human cancers including almost all cases of cervical cancer and a growing number of ano-genital and oral cancers. HPV-induced malignancy is primarily driven by the viral oncogenes, E6 and E7, which manipulate host cellular pathways to increase cell proliferation and enhance cell survival, ultimately predisposing infected cells to malignant transformation. Consequently, a more detailed understanding of viral-host interactions in HPV-associated disease offers the potential to identify novel therapeutic targets. Here, we identify that the c-Jun N-terminal kinase (JNK) signalling pathway is activated in cervical disease and in cervical cancer. The HPV E6 oncogene induces JNK1/2 phosphorylation in a manner that requires the E6 PDZ binding motif. We show that blockade of JNK1/2 signalling using small molecule inhibitors, or knockdown of the canonical JNK substrate c-Jun, reduces cell proliferation and induces apoptosis in cervical cancer cells. We further demonstrate that this phenotype is at least partially driven by JNK-dependent activation of EGFR signalling via increased expression of EGFR and the EGFR ligands EGF and HB-EGF. JNK/c-Jun signalling promoted the invasive potential of cervical cancer cells and was required for the expression of the epithelial to mesenchymal transition (EMT)-associated transcription factor Slug and the mesenchymal marker Vimentin. Furthermore, JNK/c-Jun signalling is required for the constitutive expression of HPV E6 and E7, which are essential for cervical cancer cell growth and survival. Together, these data demonstrate a positive feedback loop between the EGFR signalling pathway and HPV E6/E7 expression, identifying a regulatory mechanism in which HPV drives EGFR signalling to promote proliferation, survival and EMT. Thus, our study has identified a novel therapeutic target that may be beneficial for the treatment of cervical cancer.

Methyl jasmonate reduces the survival of cervical cancer cells and downregulates HPV E6 and E7, and survivin

2012 ◽  
Vol 319 (1) ◽  
pp. 31-38 ◽  
Author(s):  
Elad Milrot ◽  
Anna Jackman ◽  
Tatiana Kniazhanski ◽  
Pinhas Gonen ◽  
Eliezer Flescher ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Methyl Jasmonate ◽  
Cancer Cells ◽  
Hpv E6 ◽  
Cervical Cancer Cells ◽  
E6 And E7

scholarly journals Leukemia Inhibitory Factor Downregulates Human Papillomavirus-16 Oncogene Expression and Inhibits the Proliferation of Cervical Carcinoma Cells

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Joseph M. Bay ◽  
Bruce K. Patterson ◽  
Nelson N. H. Teng
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
Cancer Cells ◽  
Leukemia Inhibitory Factor ◽  
Inhibitory Factor ◽  
Human Papillomavirus 16 ◽  
Oncogene Expression ◽  
Hpv E6 ◽  
Cervical Cancer Cells ◽  
E6 And E7

The constitutive proliferation and resistance to differentiation and apoptosis of neoplastic cervical cells depend on sustained expression of human papillomavirus oncogenes. Inhibition of these oncogenes is a goal for the prevention of progression of HPV-induced neoplasias to cervical cancer. SiHa cervical cancer cells were transfected with an HPV-16 promoter reporter construct and treated with leukemia inhibitory factor (LIF), a human cytokine of the interleukin 6 superfamily. SiHa and CaSki cervical cancer cells were also assessed for proliferation by MTT precipitation, programmed cell death by flow cytometry, and HPV E6 and E7 expression by real-time PCR. LIF-treated cervical cancer cells showed significantly reduced HPV LCR activation, reduced levels of E6 and E7 mRNA, and reduced proliferation. We report the novel use of LIF to inhibit viral oncogene expression in cervical cancer cells, with concomitant reduction in proliferation suggesting re-engagement of cell-cycle regulation.

scholarly journals In Vitro Anti-proliferative Activity and Mechanism of Action of Anemone nemorosa

2019 ◽  
Vol 20 (5) ◽  
pp. 1217 ◽  
Author(s):  
Bresler Swanepoel ◽  
Luanne Venables ◽  
Octavian Olaru ◽  
George Nitulescu ◽  
Maryna van de Venter
Keyword(s):  
Cell Cycle ◽  
Annexin V ◽  
Positive Control ◽  
Cycle Arrest ◽  
Anti Cancer ◽  
Cervical Cancer Cells ◽  
Anti Oxidant ◽  
Anemone Nemorosa ◽  
Early Mitosis

Anemone nemorosa is part of the Ranunculaceae genus Anemone (order Ranunculales) which comprises more than 150 species. Various parts of the plant have been used for the treatment of numerous medical conditions such as headaches, tertian agues, rheumatic gout, leprosy, lethargy, eye inflammation as well as malignant and corroding ulcers. The Anemone plants have been found to contain various medicinal compounds with anti-cancer, immunomodulatory, anti-inflammatory, anti-oxidant and anti-microbial activities. To date there has been no reported evidence of its use in the treatment of cancer. However, due to the reported abundance of saponins which usually exert anti-cancer activity via cell cycle arrest and the induction of apoptosis, we investigated the mode of cell death induced by an aqueous A. nemorosa extract by using HeLa cervical cancer cells. Cisplatin was used as a positive control. With a 50% inhibitory concentration (IC50) of 20.33 ± 2.480 µg/mL, treatment with A. nemorosa yielded a delay in the early mitosis phase of the cell cycle. Apoptosis was confirmed through fluorescent staining with annexin V-FITC. Apoptosis was more evident with A. nemorosa treatment compared to the positive control after 24 and 48 h. Tetramethylrhodamine ethyl ester staining showed a decrease in mitochondrial membrane potential at 24 and 48 h. The results obtained imply that A. nemorosa may have potential anti-proliferative properties.

scholarly journals Design and Application of Science and Technology Project Management Information System for Educational Institutes

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Jinhua Liu ◽  
Caiping Wang ◽  
Xianchun Xiao
Keyword(s):  
Information System ◽  
Project Management ◽  
Information Management ◽  
Science And Technology ◽  
Scientific Research ◽  
System Level ◽  
Research Project ◽  
Technology Project ◽  
Scientific Research Project ◽  
Science And Technology Project

This paper analyzes the user needs of the scientific research project management system, expounds the feasibility of information system development, and analyzes the business needs combined with the reality of scientific research project management. In the system level design, combined with the demand analysis of the information system function, the system module is developed in a hierarchical way. The whole system is divided into four layers: (i) core business layer; (ii) data access interface layer; (iii) neighborhood object layer; (iv) data platform. The specific functions include three various modules, i.e., scientific research project information management module, research achievement management module, and scientific research information portal module. In the system software part, the attribute encryption method is used to effectively encrypt the information of scientific and technological projects and to protect the safe sharing of scientific and technological information in colleges and universities. Finally, we look at the limitations of conducting high-quality design-science research in the context of the larger information system community. The experimental results show that the system can perform the corresponding functions effectively, and the data reading integrity is high, which can meet the requirements of the university science and technology project information management.

Abstract 679: ABI-231: A novel small molecule suppresses tumor growth and metastatic phenotypes of cervical cancer cells via targeting HPV E6 and E7

2018 ◽  
Author(s):  
Vivek K. Kashyap ◽  
Bilal B. Hafeez ◽  
Qinghai Wang ◽  
Neeraj Chauhan ◽  
Prashanth K. Nagesh ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Tumor Growth ◽  
Cancer Cells ◽  
Small Molecule ◽  
Hpv E6 ◽  
Cervical Cancer Cells ◽  
E6 And E7

Suppression of HPV E6 and E7 expression by BAF53 depletion in cervical cancer cells

2011 ◽  
Vol 412 (2) ◽  
pp. 328-333 ◽  
Author(s):  
Kiwon Lee ◽  
Ah-Young Lee ◽  
Yunhee Kim Kwon ◽  
Hyockman Kwon
Keyword(s):  
Cervical Cancer ◽  
Cancer Cells ◽  
Hpv E6 ◽  
Cervical Cancer Cells ◽  
E6 And E7

Molecular Mechanisms of Thymoquinone as Anticancer agent

2020 ◽  
Vol 23 ◽  
Author(s):  
Fatma Ismail Alhmied ◽  
Ali Hassan Alammar ◽  
Bayan Mohammed Alsultan ◽  
Marooj Alshehri ◽  
Faheem Hyder Pottoo
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Human Breast Cancer ◽  
Phase Cell ◽  
Cycle Phase ◽  
Human Breast ◽  
Cycle Arrest ◽  
Phase Arrest ◽  
Anti Cancer

Abstract:: Thymoquinone (TQ), the bioactive constituent of Nigella Sativa seeds is a well-known natural compound for the management of several types of cancers. The anti-cancer properties of thymoquinone are thought to be operated via intervening with various oncogenic pathways including cell cycle arrest, prevention of inflammation and oxidative stress, induction of invasion, metastasis, inhibition of angiogenesis, and apoptosis. As well as up-regulation and down-regulation of specific tumor suppressor genes and tumor promoting genes, respectively. Proliferation of various tumor cells is inhibited by TQ via induction of cell cycle arrest, disruption of the microtubule organization, and down regulating cell survival protein expression. TQ induces G1 phase cell cycle arrest in human breast cancer, colon cancer and osteosarcoma cells through inhibiting the activation of cyclin E or cyclin D and up-regulating p27and p21 a cyclin dependent kinase (Cdk) inhibitor. TQ concentration is a significant factor in targeting a particular cell cycle phase. While high concentration of TQ induced G2 phase arrest in human breast cancer (MCF-7) cells, low concentration causes S phase arrest. This review article provides mechanistic insights into the anti-cancer properties of thymoquinone.

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