An Overview of Recent Patents and Patented Technology Platforms based on Co-processed Excipients

2021 ◽  
Vol 14 ◽  
Author(s):  
Deepak Kaushik ◽  
Etisha Goel ◽  
Ravinder Verma ◽  
Parijat Pandey ◽  
Deepika Purohit ◽  
...  
Keyword(s):  
Dosage Form ◽  
Active Pharmaceutical Ingredient ◽  
Future Trend ◽  
Single Step ◽  
Pharmaceutical Manufacturing ◽  
Dry Coating ◽  
Technology Platforms ◽  
Pharmaceutical Industries ◽  
Novel Concept ◽  
A Current

Background: There is no single-component excipient that fulfils all the requisite performance to allow an active pharmaceutical ingredient to be formulated into a specific dosage form. Co-processing is a novel concept that incorporates combination of two or more excipients which is advantageous and cannot be achieved using a physical admixture. Objective: This review provides an overview of co-processed excipients, recent patents granted and filed in this field and the commercial patented technology platforms based on these excipients. Methods: Various online patent databases were used for collecting the information on recent patents and patented co processed excipient technologies. The recent patents such as single-step co-processing by dry coating, novel co-processed excipients for oily drugs and novel silica-coated compositions have been discussed. Results: Co-processed excipients are evolving as a current and future trend of excipient technology in pharmaceutical manufacturing which is evident by increasing number of patents based on these excipients. Among various techniques, the maximum number of patents is based on spray drying technique. Conclusion: In this work, the authors have focussed on recent patents and commercial technologies on co-processed excipient. A better understanding of this will help researchers and pharmaceutical industries to select the appropriate platform, or to develop new innovative co-processed excipients with improved tableting characteristics.

scholarly journals A REVIEW ON CO-PROCESSED EXCIPIENTS: CURRENT AND FUTURE TREND OF EXCIPIENT TECHNOLOGY

2019 ◽  
Vol 11 (1) ◽  
pp. 1
Author(s):  
Liew Kai Bin ◽  
Anand Gaurav ◽  
Uttam Kumar Mandal
Keyword(s):  
Active Pharmaceutical Ingredient ◽  
Future Trend ◽  
Pharmaceutical Manufacturing ◽  
Direct Compression ◽  
Future Trends ◽  
Formulation Development ◽  
Compression Method ◽  
Novel Concept ◽  
Tablet Preparation ◽  
A Current

There is no single-component excipient fulfills all the requisite performance to allow an active pharmaceutical ingredient to be formulated into a specific dosage form. Co-processed excipient has received much more attention in the formulation development of various dosage forms, specially for tablet preparation by direct compression method. The objective of this review is to discuss the emergence of co-processed excipients as a current and future trend of excipient technology in pharmaceutical manufacturing. Co-processing is a novel concept of combining two or more excipients that possess specific advantages that cannot be achieved using a physical admixture of the same combination of excipients. This review article discusses the advantages of co-processing, the need of co-processed excipient, general steps in developing co-processed excipient, limitation of co-processed excipient, technologies used in developing co-processing excipients, co-processed excipients in the literature, marketed products and future trends. With advantages offered by the upcoming newer combination of excipients and newer methods of co-processing, co-processed excipients are for sure going to gain attraction both from academia and pharmaceutical industry. Furthermore, it opens the opportunity for development and use of single multifunctional excipient rather than multiple excipients in the formulation.

Development of Innovative Orally Fast Disintegrating Film Dosage Forms: A Review

2012 ◽  
Vol 5 (2) ◽  
pp. 1666-1674 ◽  
Author(s):  
Bibhu Prasad Panda ◽  
N.S Dey ◽  
M.E.B. Rao
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Dosage Form ◽  
Geriatric Patients ◽  
Dosage Forms ◽  
Delivery Systems ◽  
Design And Development ◽  
Innovative Drug ◽  
Potential Benefits ◽  
Pharmaceutical Industries

Over the past few decades, there has been an increased interest for innovative drug delivery systems to improve safety, efficacy and patient compliance, thereby increasing the product patent life cycle. The discovery and development of new chemical entities is not only an expensive but also time consuming affair. Hence the pharmaceutical industries are focusing on the design and development of innovative drug delivery systems for existing drugs. One such delivery system is the fast disintegrating oral film, which has gained popularity among pediatric and geriatric patients. This fast disintegrating film with many potential benefits of a fast disintegrating tablet but devoid of friability and risk of choking is more acceptable to pediatric and geriatric patients. Formulation of fast disintegrating film can be achieved by various techniques, but common methods of preparation include spraying and casting. These film forming techniques use hydrophilic film former in combination with suitable excipients, which allow the film to disintegrate or dissolve quickly in the mouth within a few seconds without the administration of water. In view of the advantages of the fast disintegrating films over the fast disintegrating tablets and other dosage forms, it has the potential for commercial exploitation. The oral film dosage form not only has certain advantages of other fast disintegrating systems but also satisfies the unmet needs of the market. The present review emphasizes on the potential benefits, design and development of robust, stable, and innovative orally fast- disintegrating films and their future scenarios on a global market as a pharmaceutical dosage form.  

Stability Indicating Photodiode Array Detector Based Estimation of Dapagliflozin Propanediol Monohydrate in API and Tablet Dosage Form by RP-UPLC

2021 ◽  
pp. 4635-4639
Author(s):  
Ashok B. Patel ◽  
Ekta H. Vaghasiya ◽  
Amit R. Dudhatra ◽  
Amitkumar J. Vyas ◽  
Ajay I. Patel ◽  
...  
Keyword(s):  
Dosage Form ◽  
Active Pharmaceutical Ingredient ◽  
Array Detector ◽  
Column Temperature ◽  
Stability Indicating ◽  
Photodiode Array Detector ◽  
Acceptable Method ◽  
Photodiode Array ◽  
Tablet Dosage

Stability indicating RP-UPLC photo diode array detector based method for determination of Dapagliflozin propanediol monohydrate (DPM) in active pharmaceutical ingredient (API) and in tablet dosage form (5mg dapagliflozin) has been developed and validated on Bridge Ethylene Hybride (BEH) C18 column (50mm × 2.1 mm, 1.7µm). Mobile phase composition was water: acetonitrile (60:40 v/v), flow rate 0.5ml/min and detection carried out at 223nm at column temperature 30ºC. Chromatographic separation achieved within 2 min with retention time 0.77 min. Linearity of the method was found over the concentration range of 25-75µg/ml (R2 = 0.9977). The degradation was carried out in five different stress conditions. The developed method was able to resolve peak of API from all generated peaks. Sufficient degradation was achieved in the range of 5.25 to 12.31%. The peak purity is acceptable, Method validation was performed as per ICH guideline Q2(R1).

Recent Developments in Medicated Lozenges: A Promising Dosage Form for the Effective Delivery of Therapeutic Agents

2021 ◽  
Vol 11 ◽  
Author(s):  
Deepak Sharma ◽  
Dinesh Kumar ◽  
Gurmeet Singh
Keyword(s):  
Retention Time ◽  
Drug Targeting ◽  
Dosage Form ◽  
Base Material ◽  
Rapid Onset ◽  
Oral Route ◽  
Therapeutic Agents ◽  
Oral Dosage ◽  
Onset Of Action ◽  
Pharmaceutical Industries

Background: The delivery of therapeutic agents through the oral route remains the most favorable one as compared to other routes of drug administration. However, numerous disadvantages are encountered in conventional formulations such as low bioavailability, first-pass metabolism, gastric irritation, delayed onset of action, bitter taste, low retention time, frequent dosing, and non-localized drug targeting. All these problems encountered guide the various pharmaceutical industries to manufacture and develop a novel solid oral dosage form called lozenges. Lozenges are solid oral dosage forms of medicament, meant to be dissolved within the mouth or pharynx. It may consist of one or more than one medicinal agent contained in a sweetened and flavored base material. Objective: The present review is focused on various types, compositions, methodologies used to prepare the medicated lozenges and on different evaluation parameters that establish its safety and efficacy. It also put a light on different commercially available and reported medicated lozenges formulation. Method: The various review and research articles reported by different researchers were studied extensively by using the databases of Google Scholar, Pubmed, Scopus, Web of Science and various commercial websites that were also investigated for information regarding new products. Results: Lozenges provides various advantages in terms of patient compliance, rapid onset of action, prolonged retention time, enhancement of bioavailability, ease of manufacturing, localized drug targeting, sustained or controlled effect, and reduced dosing frequency. It has also the ability to incorporate the drugs belong to different therapeutic classes for treating various disorders related to oral cavities like gingivitis, dental plaque, mouth ulcers, throat pain, oral thrush, throat infection, periodontitis, and pharyngitis. However, its applicability is not only limited to localized action, but it has also been employed to deliver the drug systemically for the conditions such as cough, decongestion, runny nose, nausea, vomiting, allergy, low immunity, fever, body ache, the killing of worms and smoking cessation. Conclusion: It was concluded that it has been played an important role in the field of drug delivery and will continue to perform in the same way in the future as well.

Application of Mid-Infrared Spectroscopy to the Development and Transfer of a Manufacturing Process for an Active Pharmaceutical Ingredient

2012 ◽  
Vol 66 (5) ◽  
pp. 574-579 ◽  
Author(s):  
Ian M. Clegg ◽  
Adrian M. Daly ◽  
Craig Donnelly ◽  
Ruth Hardy ◽  
Denise Harris ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Chemical Transformation ◽  
Manufacturing Process ◽  
Active Pharmaceutical Ingredient ◽  
Pharmaceutical Manufacturing ◽  
Process Data ◽  
Mid Infrared ◽  
Mid Infrared Spectroscopy ◽  
Whole Process

The use of in situ mid-infrared spectroscopy to support the development of a pharmaceutical manufacturing process is disclosed. Data on this two-stage telescoped reaction from several reaction scales (<50 mL to 1600 liters) and at multiple manufacturing locations is shown. In addition to providing data on both reactions in the telescope, the mid-IR data has been used to monitor an intermediate distillation operation and therefore it has been possible to profile the whole process. Data is also shown on aliquot addition during the first chemical transformation, which is used to check the instrumentation.

scholarly journals Assay of Ampicillin in capsule Dosage Form Manufactured by Different Pharmaceutical Manufacturing Factories available in Iraq.

2019 ◽  
pp. 1-6
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
High Performance ◽  
Dosage Form ◽  
Pharmaceutical Manufacturing ◽  
Reference Standard ◽  
Active Constituent ◽  
Straight Line ◽  
Line Equation ◽  
Liquid Chromatography System

The assay of Ampicillin is carried out by HPLC (High performance liquid chromatography) system to calculate the weight of the active constituent of the drug in this dosage form. In this work we study six samples of Ampicillin 250 mg capsule manufactured by different pharm- aceutical companies available in Iraq to evaluate the content of drug in this dosage form. This has been achieved by making calibration curve of different concentrations of stock solution, using standard ampicillin tri hydrate (Reference Standard Ampicillin) USP, we obtained different reading of the area under the peak (AUP) which followed straight – line equation.

Development and Validation of Stability Indicating UPLC Method for Simultaneous Estimation of Phenylephrine and Fexofenadine in Suspension Dosage Form

2020 ◽  
Vol 13 (5) ◽  
pp. 5069-5074
Author(s):  
Rajitha G ◽  
Geetha Susmita Adepu
Keyword(s):  
Quality Control ◽  
Dosage Form ◽  
Orthophosphoric Acid ◽  
Simultaneous Estimation ◽  
Control Analysis ◽  
Relative Standard ◽  
Pharmaceutical Industries ◽  
Acquity Uplc ◽  
Development And Validation ◽  
Liquid Chromatographic

Phenylephrine and fexofenadine are widely used products for common cold and allergic conditions. In this study, a simple, reliable, sensitive and economical Ultra Performance Liquid Chromatographic (UPLC) method was developed and validated for the simultaneous estimation of phenylephrine and fexofenadine in suspension dosage form. Efficient chromatographic separation was achieved on Acquity UPLC HSS C18 x 1.8μm column with mobile phase consisting of orthophosphoric acid buffer (pH = 2.8) and acetonitrile (55:45% v/v) at a flow rate of 0.3ml.min-1 and 1μl injection volume. TUV detector was used and detection wavelength was 272nm. The retention times of phenylephrine and fexofenadine were found to be 1.347 and 1.536 ± 0.01 mins respectively. The percentage recoveries of phenylephrine and fexofenadine were 99.93% and 99.31% respectively. The relative standard deviation for assay was found to be <2. The detection and quantification limits were found to be 0.04 and 0.13μg/ml for phenylephrine and 0.21 and 0.65μg/ml for fexofenadine respectively. Thus, the developed UPLC method was simple, rapid, sensitive and economical and it can be applied for the routine quality control analysis of combined dosage forms in quality control laboratories and in pharmaceutical industries.

Verification of the mixing processes of the active pharmaceutical ingredient, excipient and lubricant in a pharmaceutical formulation using a resonant acoustic mixing technology

RSC Advances ◽  
2016 ◽  
Vol 6 (90) ◽  
pp. 87049-87057 ◽  
Author(s):  
Ryoma Tanaka ◽  
Naoyuki Takahashi ◽  
Yasuaki Nakamura ◽  
Yusuke Hattori ◽  
Kazuhide Ashizawa ◽  
...  
Keyword(s):  
Chemical Stability ◽  
Pharmaceutical Formulations ◽  
Active Pharmaceutical Ingredient ◽  
Pharmaceutical Formulation ◽  
Pharmaceutical Manufacturing ◽  
High Quality ◽  
Mixing Processes ◽  
Resonant Acoustic Mixing

Mixing processes are important for making high-quality pharmaceutical formulations and are related to dissolution and chemical stability in pharmaceutical manufacturing.

Softwarization of carrier networks

2015 ◽  
Vol 57 (5) ◽  
Author(s):  
Mario Kind ◽  
Róbert Szabó ◽  
Catalin Meirosu ◽  
Fritz-Joachim Westphal
Keyword(s):  
Operation System ◽  
Network Function ◽  
Technology Platforms ◽  
Management Processes ◽  
Related Development ◽  
Network Operation ◽  
Novel Concept ◽  
Development And Management ◽  
Layered Architectures ◽  
Network Function Virtualisation

AbstractCarrier networks are faced with continuous transformations of their technology platforms in order to keep up with the changing customer demands. This paper will show how the transition from stovepipe networks to layered architectures enabled the shift to a future network design based on a network operation system (NetOS) operating the ICT fabric containing merely any kind of resources. Basic, underlying concepts are presented and detailed how they will be integrated in this environment. Software components and related development and management processes are becoming an integrated part of this future carrier environment, representing a softwarization of carrier networks. Key technology enablers are Software Defined Networking and Network Function Virtualisation as well as general availability of compute, storage and networking resources.Existing “Network as a Service” approach benefit from this improvements with virtualization, control plane flexibility and adoption of Operation, Administration and Maintenance (OAM) feature to the latest developments. But carrier services will need additional improvements, resulting in the the presented paradigm of “Generic Resources as a Service”. This novel concept will fulfill most demands for flexible service composition, multi-provider and -domain support, automated deployment and operation.

Toxicity evaluation of herbal pharmaceutical wastewater to the freshwater crustacean Cypris spp.

2011 ◽  
Vol 63 (7) ◽  
pp. 1441-1445 ◽  
Author(s):  
S. R. Sitre ◽  
S. Satyanarayan
Keyword(s):  
Manufacturing Industry ◽  
Herbal Medicines ◽  
Pharmaceutical Manufacturing ◽  
Toxicity Tests ◽  
Toxicity Evaluation ◽  
Pharmaceutical Wastewater ◽  
Complex Type ◽  
Freshwater Crustacean ◽  
Pharmaceutical Industries ◽  
Receiving Water

In India a large number of pharmaceutical industries are manufacturing drugs of complex type subsequently producing huge quantities of wastewaters. The herbal pharmaceutical industries are one of them which manufacture various herbal medicines from natural products and certain chemicals and metal combinations. During their manufacturing process a large number of toxicants enter the watercourse harming the biota of the receiving water bodies. Zooplankton organisms being at the base of the food chain if affected, will subsequently affect the fisheries potential at large, harming the interest of man. Keeping this point in view a herbal pharmaceutical manufacturing industry based at Nagpur was selected for investigation with respect to assessing its toxic effect on the freshwater crustacean Cypris spp. during short duration toxicity tests. This research paper discusses in detail the bioassay evaluation of raw, neutralized and physico-chemically treated herbal pharmaceutical effluent for arriving at a concentration safe for the Cypris spp.

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