Co-Delivery Nanosystems for Cancer Treatment: A Review

2019 ◽  
Vol 7 (2) ◽  
pp. 90-112 ◽  
Author(s):  
Reza Baradaran Eftekhari ◽  
Niloufar Maghsoudnia ◽  
Shabnam Samimi ◽  
Ali Zamzami ◽  
Farid Abedin Dorkoosh
Keyword(s):  
Drug Delivery Systems ◽  
Therapeutic Agents ◽  
General Concept ◽  
Delivery Systems ◽  
Cancer Growth ◽  
Massive Data ◽  
Biological Complexity ◽  
Single Drug ◽  
Or Gene ◽  
Main Ideas

Massive data available on cancer therapy more than ever lead our mind to the general concept that there is no perfect treatment for cancer. Indeed, the biological complexity of this disease is too excessive to be treated by a single therapeutic approach. Current delivery systems containing a specific drug or gene have their particular opportunities and restrictions. It is worth noting that a considerable number of studies suggest that single- drug delivery systems result in insufficient suppression of cancer growth. Therefore, one of the main ideas of co-delivery system designing is to enhance the intended response or to achieve the synergistic/combined effect compared to the single drug strategy. This review focuses on various strategies for co-delivery of therapeutic agents in the treatment of cancer. The primary approaches within the script are categorized into co-delivery of conventional chemotherapeutics, gene-based molecules, and plant-derived materials. Each one is explained in examples with the recent researches. In the end, a brief summary is provided to conclude the gist of the review.

Advanced Technologies in DNA-based Nanomedicine

2021 ◽  
Vol 15 ◽  
Author(s):  
Ameneh Mohammadi ◽  
Pooria Gill ◽  
Pedram Ebrahimnejad ◽  
Said Abediankenari ◽  
Zahra Kashi
Keyword(s):  
Drug Delivery ◽  
Gene Therapy ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Dna Nanostructures ◽  
Medical Sciences ◽  
Rational Engineering ◽  
Advanced Technologies ◽  
Wide Range ◽  
Or Gene

: The application of nanotechnology in medicine and pharmaceutical purpose suggested a novel procedure in the nanotechnology terminology as nanomedicine. There is a wide range of applications for nanotechnology in medicine, such as the use of nanocarriers in drug delivery systems. Recently a remarkable attention to DNA has been made through its amazing functionality and its nature as a nanomaterial in biological systems. Since DNA is a biocompatible, the use of DNA as a nanomaterial in medicine has shown a great perspective of rational engineering of DNA nanostructures. According to new approaches in treatment of diseases in gene levels, gene therapy, using DNA as a nanomedicine possesses an important role in the medical sciences as the researchers published enormous papers and patents in the fields, for instance, the applications of DNA and DNA-based nanostructures as drug or gene nanocarriers, DNA-based diagnostics and DNA nanovasccines. Here, some examples of DNA-based nanomedicine in the patent frame were reviewed.

scholarly journals Recent trends on hydrogel based drug delivery systems for infectious diseases

2016 ◽  
Vol 4 (11) ◽  
pp. 1535-1553 ◽  
Author(s):  
Arti Vashist ◽  
Ajeet Kaushik ◽  
Atul Vashist ◽  
Rahul Dev Jayant ◽  
Asahi Tomitaka ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Infectious Diseases ◽  
Targeted Drug Delivery ◽  
Drug Delivery Systems ◽  
Therapeutic Agents ◽  
Delivery Systems ◽  
Recent Trends ◽  
Targeted Drug ◽  
Targeted Drug Delivery Systems

Hydrogel based drug delivery systems owe excellent potential as targeted drug delivery systems for the delivery of therapeutic agents and diagnostics for major infectious diseases.

scholarly journals СУЧАСНІ ПІДХОДИ ДО РОЗРОБКИ НАНОСИСТЕМ ДОСТАВКИ ЛІКІВ

World Science ◽  
2020 ◽  
Vol 1 (6(58)) ◽  
pp. 32-37 ◽  
Author(s):  
Olga Bilan ◽  
Iryna Brubaker ◽  
Kateryna Marchenko-Tolsta
Keyword(s):  
Drug Delivery ◽  
Interdisciplinary Research ◽  
Drug Delivery Systems ◽  
Therapeutic Agents ◽  
Delivery Systems ◽  
The Body ◽  
Target Orientation ◽  
Fast Growing ◽  
Modern Drug ◽  
Effective Drugs

The review investigates the latest developments in the field of application of nanotechnologies in the transportation of therapeutic agents, features and the advantages of using nanoscale drug delivery systems for the treatment of diseases, as well as further prospects of using this field in medicine. Modern drug delivery systems are characterized by target orientation, rapid response to the environment and the use of biocompatible and biodegradable nanomaterials which allow for the development of the next generation of more effective drugs. Interdisciplinary research in this fast-growing field provides opportunities to design and develop multifunctional devices that can accurately target and successfully administer the release and distribution of active ingredients in the body.

scholarly journals Nanosized Minicells Generated by Lactic Acid Bacteria for Drug Delivery

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Huu Ngoc Nguyen ◽  
Santa Romero Jovel ◽  
Tu Hoang Khue Nguyen
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Lactic Acid Bacteria ◽  
Drug Delivery Systems ◽  
Therapeutic Agents ◽  
Delivery Systems ◽  
The Body ◽  
Inorganic Nanoparticles ◽  
Microbial Infection ◽  
Clinical Stages

Nanotechnology has the ability to target specific areas of the body, controlling the drug release and significantly increasing the bioavailability of active compounds. Organic and inorganic nanoparticles have been developed for drug delivery systems. Many delivery systems are through clinical stages for development and market. Minicell, a nanosized cell generated by bacteria, is a potential particle for drug delivery because of its size, safety, and biodegradability. Minicells produced by bacteria could drive therapeutic agents against cancer, microbial infection, and other diseases by targeting. In addition, minicells generated by lactic acid bacteria being probiotics are more interesting than others because of their benefits like safety, immunological improvement, and biodegradation. This review aims to highlight the stages of development of nanoparticle for drug delivery and discuss their advantages and limitations to clarify minicells as a new opportunity for the development of potential nanoparticle for drug delivery.

scholarly journals Novel Drug Delivery Systems for Rheumatoid Arthritis: An Approach to Better Patient Compliance

2019 ◽  
Vol 12 (1) ◽  
pp. 157-170 ◽  
Author(s):  
Sangeeta Mohanty ◽  
Sthitapragnya Panda ◽  
Aslesha Bhanja ◽  
Abhisek Pal ◽  
Si Sudam Chandra
Keyword(s):  
Rheumatoid Arthritis ◽  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Human Life ◽  
Therapeutic Agents ◽  
Delivery Systems ◽  
Future Perspectives ◽  
Conventional Drug ◽  
Potential Applications ◽  
Novel Drug

Recent advances in science and technology radically changed the way we detect, treat and prevent different diseases in all aspects of human life. Rheumatoid arthritis (RA) is a chronic, systemic, progressive, autoimmune disease in which the body’s immune system whose major role is to protect the health by attacking foreign bacteria and viruses are mistakenly, attacking the joints resulting in thickened synovium, pannus formation, & destruction of bone, cartilage. Still now researchers are unable to know the exact cause of this disease. However, it is believed that genes and environmental factors play a role in development of RA. In this review, we discuss the Pathophysiology, predictors, & factors involved in pathogenesis of RA. We also discuss the Conventional therapeutic agents for Rheumatoid Arthritis. More importantly, we extensively discuss the emerging novel drug delivery systems (NDDS) like nanoparticles, dendrimers, micelles, microspheres, liposomes, and so on as these are the promising tools having successful applications in overcoming the limitations associated with conventional drug delivery systems. Although several NDDS have been used for various purposes, liposomes have been focused on due to its potential applications in RA diagnosis and therapy. In addition, we discuss the therapeutic effectiveness and challenges for RA by using these novel drug delivery systems. Finally, we conclude by discussing the future perspectives.

scholarly journals Intravitreal Devices for the Treatment of Vitreous Inflammation

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
John B. Christoforidis ◽  
Susie Chang ◽  
Angela Jiang ◽  
Jillian Wang ◽  
Colleen M. Cebulla
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Visual Loss ◽  
Ethylene Vinyl Acetate ◽  
Polyglycolic Acid ◽  
Therapeutic Agents ◽  
Delivery Systems ◽  
Fluocinolone Acetonide ◽  
Implantable Devices ◽  
Investigational Drug

The eye is a well-suited organ for local delivery of therapeutics to treat vitreous inflammation as well as other pathologic conditions that induce visual loss. Several conditions are particularly challenging to treat and often require chronic courses of therapy. The use of implantable intravitreal devices for drug delivery is an emerging field in the treatment of vitreous inflammation as well as other ophthalmologic diseases. There are unique challenges in the design of these devices which include implants, polymers, and micro- and nanoparticles. This paper reviews current and investigational drug delivery systems for treating vitreous inflammation as well as other pathologic conditions that induce visual loss. The use of nonbiodegradable devices such as polyvinyl alcohol-ethylene vinyl acetate polymers and polysulfone capillary fibers, and biodegradable devices such as polylactic acid, polyglycolic acid, and polylactic-co-glycolic acid, polycaprolactones, and polyanhydrides are reviewed. Clinically used implantable devices for therapeutic agents including ganciclovir, fluocinolone acetonide, triamcinolone acetonide, and dexamethasone are described. Finally, recently developed investigational particulate drug delivery systems in the form of liposomes, microspheres, and nanoparticles are examined.

Dual-ligand functionalized carbon nanodots as green fluorescent nanosensors for cellular dual receptor-mediated targeted imaging

The Analyst ◽  
2019 ◽  
Vol 144 (22) ◽  
pp. 6729-6735 ◽  
Author(s):  
Fangfang Du ◽  
Xuewei Zhao ◽  
Wenjing Lu ◽  
Zhonghui Guo ◽  
Shaomin Shuang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Cells ◽  
Drug Delivery Systems ◽  
Therapeutic Agents ◽  
Delivery Systems ◽  
Carbon Nanodots ◽  
Targeted Imaging ◽  
Green Fluorescent

The conjugation of dual-ligands to nanoparticles as drug delivery systems that target specific cells is a promising approach for the delivery of therapeutic agents to tumor cells.

scholarly journals Fabrication of Cell-Derived Biomimetic Drug Delivery System

2019 ◽  
Vol 5 (1) ◽  
pp. 1-18 ◽  
Author(s):  
Yi Zhou ◽  
Hong-Hui Wu ◽  
Yuan Ping ◽  
Jian-Qing Gao
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Therapeutic Agents ◽  
Delivery Systems ◽  
Processing Methods ◽  
Therapeutic Delivery ◽  
Hybrid Delivery ◽  
Functional Biomaterials

Abstract Functional biomaterials that are capable of effectively carrying therapeutic agents and specifically delivering therapeutics to pathological sites have been widely investigated over decades. Recently, cellular carriers and cell derivative-based bio-hybrid delivery systems have drawn extensive attention as a promising branch of therapeutic delivery systems, owing to their low immunogenicity and intriguing biomimetic capabilities. Various approaches for the fabrication of these biomimetic carriers have been developed, and some products have already been commercialized as well. In this review, we summarized various processing methods for engineering cell-derived biomimetic drug delivery systems, and discussed their future outlooks.

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