scholarly journals Effeciency of Initial-I Stage Generalized Periodontitis Treatment Among Medical University Students According to Indicators of Oral Cavity Prooxidant-antioxidant System

2019 ◽  
Vol 25 (1) ◽  
Author(s):  
Tetiana Pavliuk ◽  
Mykola Rozhko
Keyword(s):  
Oral Cavity ◽  
Antioxidant System ◽  
Periodontal Diseases ◽  
Advanced Treatment ◽  
Control Group ◽  
Sod Activity ◽  
Diene Conjugates ◽  
Adequate Treatment ◽  
Periodontal Tissues ◽  
Medical University

Periodontal diseases are one of the most important problems in dentistry, due to its very high dissemination. Inflammatory processes in periodontal tissues are more common among young people, which, in the future, without adequate treatment lead to irreversible changes in structure of cellular bone. This causes development of new effective therapeutic complexes aimed at eliminating etiopathogenetic factors development of periodontal tissues inflammatory diseases and the targeted influence on the pathological processes in these tissues. The objective of the study was to analyze the efficiency of suggested initial-I stage generalized periodontitis treatment among second-year students of medical university. Materials and methods. To achieve this goal, we examined and treated 50 students with initial-I stage of generalized periodontitis without somatic pathology, which were divided into two groups, depending on treatment method. First group included 25 students who received advanced treatment; second group included 25 students, who received usual treatment. Control group consisted of 20 clinically healthy students. The state of oral cavity prooxidant-antioxidant system was determined by the level of malone dialdehyde (MDA), diene conjugates (DK), superoxide dismutase (SOD) activity, glutathione-S-transferase (G-ST), and the activity of glutathione peroxidase (GPO). Results and discussion. Periodontal diseases, namely, initial-I stage of GP, are accompanied by an imbalance of oral cavity prooxidant-antioxidant system indicators. This is confirmed by an increase number of MDA and DK (p<0.001), and a decrease in SOD, G-ST, GPO (p<0.001) compared to clinically healthy students. Conclusions. The results of GP treatment in first group were significantly better in relation to the second one (p<0.05), indicating the effectiveness of the proposed advanced treatment of initial-I stage of GP.

scholarly journals CONDITION OF PERIODONTAL TISSUES IN PATIENTS WITH DERMATOSES

2018 ◽  
Vol 14 (4) ◽  
pp. 54-57
Author(s):  
Н. Чернышева ◽  
N. Chernyshova ◽  
Сергей Чуйкин ◽  
Sergey Chuykin ◽  
Гузель Акмалова ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Periodontal Disease ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Periodontal Diseases ◽  
Complex Treatment ◽  
Adequate Treatment ◽  
Periodontal Tissues ◽  
Periodontal Index ◽  
Oral Lichen

Background. Periodontal disease is one of the most common and complex pathologies in dentistry. It is known frequently damage to the tissues of the periodontal complex with dermatoses. The most relevant among the dermatoses of the mucous membrane of the mouth and the red border of the lips is oral lichen planus. Among the six clinical forms of red flat oral lichen planus and the red border of the lips, the exudative-hyperemic and erosive-ulcerous forms occur most often. Atypical form is much less common than other forms and is often diagnosed by dentists as an inflammatory periodontal disease. At the same time, the pathogenetic mechanisms of inflammatory processes in the gums, which are different in oral lichen planus, are not taken into account, which, accordingly, complicates adequate treatment. Objectives. The aim of the study was to analyze the periodontal status in patients with exudative-hyperemic, erosive-ulcerative and atypical forms of oral lichen planus. Methods. Under our supervision there were 181 patients with oral lichen planus, in whom a simplified Green-Vermillion hygiene index was determined. To assess the state of periodontal used periodontal index according to Russell. Results. When assessing the hygienic condition of the oral cavity, high values were observed in individuals with severe forms of the disease: erosive-ulcerative, exudative-hyperemic. The highest values of the periodontal index were found in patients with atypical, erosive and ulcerative forms of oral lichen planus. Conclusions. The results of the clinical examination of patients with oral lichen planus dictate, first of all, to include in the scheme of complex treatment of it the sanitization of oral cavity and complex treatment of inflammatory periodontal diseases as well.

scholarly journals On the problem of improving dental care for professional athletes

2017 ◽  
Vol 98 (2) ◽  
pp. 256-260
Author(s):  
Dzh G Gadzhiev
Keyword(s):  
Oral Cavity ◽  
Dental Care ◽  
Periodontal Diseases ◽  
Professional Athletes ◽  
Control Group ◽  
Care Organization ◽  
Orthopaedic Care ◽  
Periodontal Tissues ◽  
High Prevalence ◽  
Mouth Guards

Aim. Assessment of organs and tissues of oral cavity of professional athletes who use protective mouth guards. Methods. Dental examination of 340 professional athletes of Olympic reserve at the age of 18 to 32 years with a duration of sport experience of 9-13 years was performed. We investigated the effect of mouth guards on the condition of the marginal periodontium and microbial contamination. Changes in periodontal tissues were diagnosed by means of traditional methods of inspection, probing of the periodontal grooves, recesses, as well as determining tooth mobility. The control group included 20 athletes not using athletic mouth guards during training. Results. High prevalence of caries (in average, in all examined athletes the rate of carious teeth reaches 32.90%) and fairly high prevalence of severe forms of periodontal diseases in those patients were revealed. Evaluation of the structure of the index of teeth with decay and fillings and removed teeth showed major defects in timely dental care organization for professional boxers: their ratio of filled teeth does not exceed 40.36% in average. A significant number of extracted teeth (more than 23%) indicates that the examined patients require dental orthopaedic care. 30 examined athletes wearing protective mouth guards had the strains of P. gingivalis, A. Actinomycetemcomitans and P. oralis revealed. Conclusion. The study of dental status of professional athletes using protective mouth guards, showed high prevalence of inflammatory periodontal diseases and low level of hygienic state of oral cavity.

scholarly journals Characteristics of dental status of patients with inflammatory periodontal diseases

2017 ◽  
Vol 98 (2) ◽  
pp. 204-210
Author(s):  
N A Vasil’eva ◽  
A I Bulgakova ◽  
E S Soldatova
Keyword(s):  
Oral Cavity ◽  
Soft Tissues ◽  
Periodontal Diseases ◽  
Dental Status ◽  
Control Group ◽  
Periodontal Tissues ◽  
Healthy Donors ◽  
Severe Periodontitis ◽  
Local Trauma ◽  
History Of

Aim. Evaluation of dental status in patients with inflammatory periodontal diseases. Methods. The study of dental status was performed with the use of clinical and historical data from 269 patients with inflammatory periodontal diseases at the age of 18-65 years. Among examined patients there were 75 (27.9%) people with gingivitis, 54 (20.1%) with mild periodontitis, 66 (24.5%) with moderate and 74 (27.5%) with severe periodontitis. Control group consisted of practically healthy donors at the age of 18-52 years (40 people) with sanitized oral cavity. Results. From history and interviewing it was found that 72% of the surveyed patients brush their teeth twice a day, 24% - once a day and 4% of patients do not brush their teeth. Family history of periodontal diseases among parents was recorded by 86% of participants. Dental status was characterized by the increase of the values of all dental indices with increasing disease severity regardless of gender. Need for correction of the depth of the vestibule, lips, cords, and bridles was identified in 51.7% of cases in patients with gingivitis and in 96.6% of cases of periodontal diseases. With increasing severity of periodontitis index (sum) of teeth with decay and fillings and removed teeth was increased by 1.5 times in gingivitis, by 2.2 times in mild periodontitis, by 2.6 times in moderate and by 2.9 times in severe periodontitis compared to control group. Partial adentia in gingivitis is 3 times more prevalent in males than in females and in severe periodontitis is 1.6 times more prevalent in females than in males. Conclusion. Dental status of the patients with inflammatory periodontal diseases was characterized by increased values of all dental indices compared to control group that demonstrates typical course of inflammatory periodontal diseases and decrease of local immunologic resistance of oral cavity and the organism in total; timely correction of local factors (local trauma), anatomical and topographical features of dentofacial system and status of oral soft tissues allows prevention of pathologic processes in periodontal tissues.

scholarly journals FEATURES OF MICROBIOLOGICAL AND IMMUNE STATE IN PREGNANT WOMEN WITH INFLAMMATORY PERIODONTAL DISEASES AGAINST THE BACKGROUND OF GESTATIONAL DIABETES MELLITUS

2020 ◽  
Vol 75 (3) ◽  
pp. 83-86
Author(s):  
Ye.I. Alexandrov ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Oral Cavity ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Periodontal Diseases ◽  
Main Group ◽  
Control Group ◽  
Periodontal Health ◽  
Periodontal Tissues

90 pregnant women with inflammatory periodontal diseases, aged 27 to 35 years were examined. The main group consisted of 60 pregnant women with gestational diabetes mellitus and the control one consisted of 30 patients with physiological pregnancy. All patients were examined before providing treatment and preventive measures at 14–15 weeks of pregnancy and after them at 37–38 weeks. Studies have shown deterioration in periodontal health, oral hygiene and increase in contamination of the oral cavity in patients of the main group as compared with patients of the control group. The use of the anti-inflammatory succinic acid based preparation is effective for inflammatory periodontal diseases in pregnant women with gestational diabetes. The improvement of periodontal tissues health was confirmed by the posttreatment indices of hygiene, immunoglobulins, microbiocenosis and periodontal indices that promote normalization of the oral cavity.

Comparative analysis of polymorphic variants of IL-17A and MMP-1 genes with the risk of developing chronic periodontitis in petrochemical workers

2020 ◽  
Vol 60 (10) ◽  
pp. 687-693
Author(s):  
Iskander I. Zaidullin ◽  
Denis O. Karimov ◽  
Lilija K. Karimova ◽  
Milyausha F. Kabirova ◽  
Rasima R. Galimova ◽  
...  
Keyword(s):  
Ethylene Oxide ◽  
Chronic Periodontitis ◽  
Periodontal Diseases ◽  
Clinical Manifestations ◽  
Control Group ◽  
Periodontal Tissues ◽  
Dental Examination ◽  
Number Of Patients ◽  
Increased Risk ◽  
Harmful Substances

The susceptibility to the development and progression of inflammatory periodontal diseases, which depends on genetic and external factors (smoking, stress, oral hygiene), varies widely. In the development of these diseases, an important role is played not only by the presence of periodontal pathogenic microorganisms, but also by the presence of congenital or acquired immunodeficiency, immunoregulatory defects. The immune system plays a key role in the physiological and pathological processes of periodontal tissues. In this regard, IL17, produced by CD4+ Th cells, which has both Pro-inflammatory and protective activity, is of particular interest in the pathogenesis of periodontitis. The aim of study was to identify the relationship between polymorphic loci of the IL-17A (rs2275913) and MMP-1 (rs1799750) genes and clinical manifestations of chronic periodontitis in petrochemical workers. Dental examination was performed in 92 ethylene oxide production workers with chronic periodontitis and 74 patients with chronic periodontitis who did not come into contact with chemical factors (control group). Genotyping of polymorphisms rs2275913 of the IL17A gene and rs1799750 of the MMP1 gene was performed by allele-specific real-time polymerase chain reaction (PCR). Hygienic assessment of the degree of air pollution of the working area with harmful substances was carried out by gas chromatography according to the guidelines for the determination of harmful substances in the air № 5098-89, № 3119-84. When comparing the results of studies of both groups, there were no statistically significant differences in the frequency distributions of allelic variants and genotypes of the IL-17A and MMP-1 genes. The AA/AG genotypes of the IL-17A gene were associated with an increased risk of severe disease compared to the GG genotype in workers in the main group (OR=6.1; 95% CI 1.33-28.5; p=0.021) and in the control group (OR=7.26; 95% CI 1.34-39.25; p=0.016). Carriers of the A allele in the control group increased the risk of severe chronic periodontitis by 2.4 times compared to carriers of the G allele (OR=2.41; 95% CI 1.19-4.87; p=0.014). During the dental examination of employees of the ethylene oxide plant, the clinical course of periodontal diseases was more severe in comparison with the control group, and the number of patients with severe periodontitis was twice as high. It was found that the AA/AG genotypes of the IL-17A gene and the carrier of the A allele are associated with increased susceptibility to the development of severe chronic periodontitis. The association between the MMP-1 gene polymorphism and the risk of severe forms of chronic periodontitis has not been established. A risk factor for the development of inflammatory periodontal diseases in employees of the petrochemical complex is a complex of harmful production factors.

scholarly journals Clinical and cytological characteristic of a condition of the oral cavity at pregnant women with various types of a diabetes mellitus

2016 ◽  
Vol 65 (6) ◽  
pp. 45-51 ◽  
Author(s):  
Ludmila Yu Orekhova ◽  
Anna A Aleksandrova ◽  
Ludmila A Aleksandrova ◽  
Ramila S Musaeva ◽  
Gulrukhsor Kh Tolibova ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Oral Cavity ◽  
Pregnant Women ◽  
Inflammatory Diseases ◽  
Type I Diabetes ◽  
Periodontal Diseases ◽  
Diabetes Mellitus Type 1 ◽  
Control Group ◽  
Type I ◽  
Liquid Based Cytology

Introduction. More and more researches dedicated to the communication of diseases of the oral cavity of pregnant women with diabetes. It is proved that the intensity of caries and inflammatory periodontal diseases (gingivitis and periodontitis) increase significantly during pregnancy, while the presence of comorbidities, such as diabetes, increase these indexes.Aim. The aim of the work was to study the dental status of pregnant women with diabetes.Materials and methods. The study compared women with gestational diabetes mellitus, type 1 diabetes, and type 2 diabetes, to a control group of pregnant women without diabetes. In addition to clinical research methods, liquid-based cytology of the contents of the gingival sulcus was performed.Results. The results of clinical and laboratory studies have shown that inflammatory diseases of periodontium and teeth within pregnant women with diabetes are more common than within the pregnant women without this disease. It should be noted that the frequency of occurrence and severity of these diseases in the pregnant women with type I diabetes is higher than in the other groups.Conclusion. Pregnant women with diabetes are at risk for dental disease and require more attention from dentists, endocrinologists and obstetricians. The use of liquid-based cytology method helps in the diagnosis of inflammatory periodontal diseases.

scholarly journals CONDITIONS OF THE ORAL CAVITY STATUS IN YOUTH WITH ALIMENTARY-CONSTITUTIONAL FORM OF OBESITY

2019 ◽  
Vol 23 (1-2) ◽  
pp. 17-21
Author(s):  
M. Skrypnyk ◽  
T. Petrushanko ◽  
T. Kryvoruchko ◽  
K. Neporada
Keyword(s):  
Oral Cavity ◽  
Periodontal Disease ◽  
Periodontal Diseases ◽  
Young Patients ◽  
Overweight And Obesity ◽  
Obesity Prevalence ◽  
Periodontal Tissues ◽  
Mild Degree ◽  
Inflammatory Processes ◽  
Second Degree

Obesity prevalence has significantly increased especially in young adults, which is caused by a particular lifestyle, food quality and dietary behavior. Obesity leads to development of huge array of comorbid conditions such as arterial hypertonia, heart stroke, arthritis and other diseases. We conducted standard clinical examination of oral cavity of 154 young patients (18-21 years old) – all of them were students of Ukrainian Medical Stomatological Academy. It has been determined that the majority of patients with BMI >30 kg/cm2 have aggravated family heredity, in 66,2% cases one parent of obese students had obesity and 32,43% patients have both parents with obesity that is significantly higher compared with persons with normal BMI and overweight. There was a high prevalence of periodontal diseases about 74% and carious lesions of teeth - 97.4% among young people despite the age and contingent of examined patients - medical students. In patients with BMI >30 kg/cm2 prevalence of generalized forms of gingivitis and periodontitis was by three times higher compared with individuals with normal BMI. The values of oral hygienic indexes were poor in all examined groups, but their values were slightly lower in patients with normal BMI than in those with overweight and obesity. The prevalence of inflammatory changes in gums was higher in persons with obesity: all of them had a mild degree of lesions in periodontal tissues. Inflammatory processes in the gums were the most intense in patients with the second degree of obesity. According to the results of the study, the presence of the first and the second degree of obesity should be considered as a risk factor triggering periodontal tissues diseases. For persons with BMI >30 kg/cm2 with periodontal disease measures for the secondary prevention of inflammatory and inflammatory dystrophic periodontal diseases should be carried out and in persons without periodontal disease on the background of obesity measures primary prevention should be done.

scholarly journals DISTURBANCE OF IRON METABOLISM AND ULTRASTRUCTURAL FEATURES OF THE GINGIVA IN PATIENTS WITH Β-THALASSEMIA MAJOR

2018 ◽  
Vol 22 (5) ◽  
pp. 255-261
Author(s):  
Ramida Vaqif qizi Shadlinskaya ◽  
E. K Gasimov ◽  
S. A Israfilova
Keyword(s):  
Iron Metabolism ◽  
Serum Iron ◽  
Binding Capacity ◽  
Periodontal Diseases ◽  
Thalassemia Major ◽  
Control Group ◽  
Periodontal Tissues ◽  
Metabolism Disorder ◽  
Pathogenetic Factor ◽  
Iron Binding Capacity

Introduction: β-thalassemia major is a hereditary blood disease, a main pathogenetic factor of which is the disruption of the synthesis of β-chains of hemoglobin. Inevitable metabolic disorders that occur during regular blood transfusion form an additional risk of damage and cellular modification of organs and tissues, including the oral cavity. Aim: determination of the pathogenetic role of iron metabolism disorder in the development of chronic inflammatory periodontal diseases in patients with β-thalassemia. Material and methods: 12 patients with β - thalassemia major who had periodontal diseases were examined in the Republican Center of Thalassemia in Baku (average age is 18 ± 1.3 years). The control group consisted of 16 somatically healthy individuals with intact gingiva tissues (the average age is 18.0 ± 0.7 years). Serum Iron, ferritin, hepcidin, total iron-binding capacity (TIBC), level of Il2, Il6, Il10, TNFα were measured from peripheral blood samples. To determine the ultra-structural study of the periodontal tissues in patients with β-thalassemia major, the method of electron microscopy studies of gingiva biopsies was used. Results of the study: The study revealed an increase in the level of serum iron and ferritin against the background of a progressively decreasing TIBC in patients with β-thalassemia major. Also activation of pro-inflammatory cytokines - TNFα, Il6, Il10 was observed in homozygous patients. Metabolic indicators are compared with ultrastructural features of cellular elements of a gum. Signs of accumulation of iron in cellular elements both of its own plate and of the epithelial cover were compared. The presence of iron was recorded in immunocompetent cells - macrophages and lymphocytes. Conclusion: Summarizing the data obtained, we can conclude that deproteinization of ferritin cores and their detection both in the cytoplasm and in the nucleoplasm of immunocompotent cells leads to irreversible degenerative changes in cellular elements of the gingiva. The authors link the development of the generalized inflammatory - degenerative process in the periodontium with revealed exchange -structural violations.

scholarly journals Comparative evaluation of expression of VEGF (vascular endothelial growth factors) in periodontal tissues of healthy, chronic and aggressive periodontitis patients: an immunohistochemical study

2020 ◽  
Vol 9 (1) ◽  
pp. 784-788
Keyword(s):  
Growth Factors ◽  
Periodontal Disease ◽  
Chronic Periodontitis ◽  
Periodontal Diseases ◽  
Aggressive Periodontitis ◽  
Control Group ◽  
Vascular Endothelial ◽  
Healthy Controls ◽  
Periodontal Tissues ◽  
Inflammatory Status

Periodontitis is a chronic inflammatory disease of the vascularized supporting tissues of the teeth. Angiogenesis (neovascularization) is the budding of new capillaries and is thought to be an essential process in the development of chronic inflammatory diseases. Inflamed tissues (such as gingiva coincident in periodontal disease) have evidence of enhanced expression of inflammatory mediators, many of which can promote angiogenesis. Of the various cytokines and growth factors that are involved in angiogenesis, the most potent agent that acts specifically on vascular epithelium is Vascular Endothelial Growth Factor. Even though angiogenesis is a prominent feature of both inflammation and healing, information about its role in periodontal lesions is limited. Hence the aim of the present study was the immunohistochemical evaluation of the expression of VEGF in the gingival tissues of chronic and aggressive periodontitis patients compared to the healthy controls. The present study was carried out in a total of 45 subjects with age range of 18-55 years, reporting to the Department of Periodontology, Rajarajeswari Dental College and Hospital, Bangalore. Gingival tissue samples were collected from all the 45 subjects and categorized into three groups based on their clinical findings as follows: Group 1 (Healthy), Group II (Chronic Periodontitis), Group III (Aggressive Periodontitis). Following sample collection, immunohistochemical staining of tissues was carried out and evaluation was done to compare the grades of expression of VEGF in the three groups. The expression of VEGF in blood vessels was also quantitatively evaluated. The results were statistically analyzed using Kruskal Wallis ANOVA and Mann Whitney test. There was a statistically significant higher expression of VEGF in both chronic periodontitis and aggressive periodontitis group as compared to the control group. Aggressive periodontitis cases showed higher grades of expression of VEGF compared to the chronic periodontitis cases and healthy controls. However, the difference in expression of VEGF was not statistically significant between the two forms of periodontitis. The presence of VEGF in both chronic and aggressive periodontitis clearly indicates the potent role played by VEGF as an inflammatory agent in the initiation and progression of periodontal diseases. Thus, VEGF might be used as a potential vascular marker for the assessment of severity and inflammatory status in periodontal disease.

scholarly journals Correction of antioxidant protection of cows organism in theperiod of laboratory drugs with content of non-participants of metals

2018 ◽  
Vol 20 (83) ◽  
pp. 204-207
Author(s):  
I.B. Kobilyukh
Keyword(s):  
Antioxidant System ◽  
Free Radical Oxidation ◽  
The Body ◽  
Control Group ◽  
Antioxidant Protection ◽  
Dry Period ◽  
Diene Conjugates ◽  
Radical Oxidation ◽  
Black And White ◽  
White Breed

The enhancement of free radical oxidation, characteristic of inflammatory processes, is accompanied by a violation of the properties of biological membranes, the functioning of cells and damage to surrounding tissues. The purpose and task of the research was to make correction of antioxidant protection of the body of cows during the period of dry preparations containing nanoparticles of metals. To activate the antioxidant system of the body of cows during the dry period, use the vitamin complex «Nanovit». The experiment was conducted on cows of Ukrainian dairy black-and-white breed in Agroprodservice-Invest LLP of the Kozivsky District of the Ternopil Oblast. The experiment was conducted before 35–25 days to the calves birth where the experimental and control groups of cows were formed (n = 10). Cows of the experimental group for 35–25 days to the cattle, intramuscularly injected 5.0 ml vitamin complex «Nanovit» (composition: vitamins A, D, E and nanoparticles Cu, Zn, Mn, Co). Producer of «NVP» LLC «Ecological Capital». Cows of the control group for 35–25 days to the catheter, intramuscularly administered 15.0 ml of the drug Prodevit-tetra (1 ml of the preparation contains vitamin A – 50000 IU, vitamin D – 25000 IU, vitamin E – 20 mg, vitamin F – 6 mg). Manufacturer of Product Ltd. The study found that vitamins A, D, E, and nanoparticles Cu, Zn, Mn, Co, which are part of the drug «Nanovit», activate the antioxidant system of the body of cows during the dry period. So after the application of the drug «Nanovit» in the body of cows there was a decrease of 58.5% (Р ≤ 0.01) of diene conjugates and 95.0% (Р ≤ 0.001) of TBK-active products against the background of an increase of 20.0% (Р ≤ 0.01) activity of catalase. After the application of the drug «Nanovit», the service period of the period from cows decreased by 54 days, and the index of insemination decreased by 0.2 units against the cows fed «Prodevit-tetra», indicating a positive effect of the drug containing the nanoparticles of metals Cu, Zn, Mn, Co and vitamins A, D, E during the post-period period in cows.

Sign in / Sign up

Export Citation Format

Share Document