scholarly journals Микроскопия с многофотонным возбуждением для идентификации и оперативного контроля компонентов внеклеточного матрикса тканей организма

2020 ◽  
Vol 128 (6) ◽  
pp. 790
Author(s):  
Ю.В. Кистенев ◽  
В.В. Николаев ◽  
А.В. Борисов ◽  
О.Б. Заева ◽  
А.И. Князькова ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Cell Membrane ◽  
Process Parameters ◽  
Multiphoton Microscopy ◽  
Optimal Process ◽  
Operational Monitoring ◽  
Basic Proteins ◽  
Cell Matrix

The process of extraction of the extracellular matrix (ECM) requires operational monitoring since with non-optimal process parameters there is a risk of destruction of the basic proteins of the cell-matrix. Using multiphoton microscopy, the structure of collagen, the integrity of the cell membrane and the content of elastin in the process of isolation of ECM from various tissues of the rat organism (brain, dermis, muscle) were studied. It has been shown that multiphoton microscopy is an effective tool for monitoring the quality of ECM extraction.

scholarly journals Research on the Molding Design and Optimization of the Molding Process Parameters of the Automobile Trunk Trim Panel

2020 ◽  
Vol 2020 ◽  
pp. 1-19
Author(s):  
Youmin Wang ◽  
Zhaozhe Zhu ◽  
Lingfeng Tang ◽  
Qinshuai Jiang
Keyword(s):  
Process Parameters ◽  
Heating Temperature ◽  
Process Parameter ◽  
Shrinkage Rate ◽  
Optimal Process ◽  
Molding Process ◽  
Rate Maximum ◽  
Thinning Rate ◽  
Trim Panel

In order to put forward the theoretical calculation formula for the compression force of the compression mold of the trunk trim panel, obtain the influence trend of the process parameters on the molding quality of the trunk trim panel, and obtain the optimal process parameters combination for the compression molding of the trunk trim panel, four process parameters, the heating temperature, time, compression pressure, and holding time, which affected the compression molding, were selected as the level factors; the maximum thinning rate, maximum thickening rate, and shrinkage rate of the trunk trim panel were selected as evaluation indicators and orthogonal experiments were designed and completed; the comprehensive weighted scoring method was used to obtain the comprehensive score results and obtain the comprehensive evaluation indicators of the best combination of process parameters of trunk trim panel; BP neural network and genetic algorithm were used to study the change trend of the evaluation indicators of trunk trim panel with the changes of process parameters; based on the optimal process parameter combination and the established neural network’s prediction function, the maximum thinning rate, maximum thickening rate, and shrinkage rate under a single process parameter change could be predicted, and the influence of a single process parameter on the maximum thinning rate, maximum thickening rate, and shrinkage rate could be obtained; the process parameters were optimized, and a maximum thinning rate of 28%, a maximum thickening rate of 4.3%, and a shrinkage rate of 0.8% were obtained; the optimal molding process parameters of the trunk trim panel were heating temperature of 209°C, heating time of 62 s, molding pressure of 14 kPa, and holding pressure time of 49 s; after optimization, the maximum shrinkage rate was 28.0880%, the maximum thickening rate was 44.3264%, and the shrinkage rate was 0.8901%; according to the optimal process parameters, the quality of the trunk trim panel was very good, which met the production quality requirements.

scholarly journals Study on Adding Ammonium Hydrogen Fluoride to Improve Manganese Leaching Efficiency of Ammonia Leaching Low-Grade Rhodochrosite

Metals ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 1496
Author(s):  
Peng Yang ◽  
Xiaoping Liang ◽  
Chengbo Wu ◽  
Tengfei Cui ◽  
Yu Wang
Keyword(s):  
Experimental Study ◽  
Hydrogen Fluoride ◽  
Process Parameters ◽  
Ammonia Concentration ◽  
Low Grade ◽  
Optimal Process ◽  
Ammonium Hydrogen ◽  
Ammonia Leaching ◽  
Leaching Efficiency

The ammonia leaching method for treating low-grade rhodochrosite has the advantages of a good impurity removal effect and low environmental pollution. In this paper, aiming at the low leaching efficiency of low-grade rhodochrosite treated by the ammonia leaching method, studies on enhancing the leaching efficiency of manganese by using ammonium hydrogen fluoride as an additive are carried out. The effects of different ammonia concentrations, leaching temperatures, leaching times, liquid-solid ratios, stirring rates, and the addition of ammonium hydrogen fluoride on the leaching efficiency of manganese with and without ammonium hydrogen fluoride as an additive were comparatively studied, and the parameters of ammonia concentration, ammonia leaching temperature, and ammonium hydrogen fluoride dosage were optimized in the experimental study. The results indicated that ammonium hydrogen fluoride as an additive in the treatment of low-grade rhodochrosite by the ammonia leaching method could effectively increase the leaching efficiency of manganese, and the optimal process parameters were obtained. Meanwhile, the addition of ammonium hydrogen fluoride didn’t affect the quality of the steamed ammonia product.

scholarly journals Enhancing the Surface Quality of Micro Titanium Alloy Specimen in WEDM Process by Adopting TGRA-Based Optimization

Materials ◽  
2020 ◽  
Vol 13 (6) ◽  
pp. 1440 ◽  
Author(s):  
Muthuramalingam Thangaraj ◽  
Ramamurthy Annamalai ◽  
Khaja Moiduddin ◽  
Mohammed Alkindi ◽  
Sundar Ramalingam ◽  
...  
Keyword(s):  
Decision Making ◽  
Surface Quality ◽  
Process Parameters ◽  
Quality Measures ◽  
Machining Process ◽  
Optimal Process ◽  
Input Process ◽  
Process Factors ◽  
Wedm Process

The surface measures of machined titanium alloys as dental materials can be enhanced by adopting a decision-making algorithm in the machining process. The surface quality is normally characterized by more than one quality parameter. Hence, it is very important to establish multi-criteria decision making to compute the optimal process factors. In the present study, Taguchi–Grey analysis-based criteria decision making has been applied to the input process factors in the wire EDM (electric discharge machining) process. The recast layer thickness, wire wear ratio and micro hardness have been chosen to evaluate the quality measures. It was found that the wire electrode selection was the most influential factor on the quality measures in the WEDM process, due to its significance in creating spark energy. The optimal arrangement of the input process parameters has been found using the proposed approach as gap voltage (70 V), discharge current (15 A) and duty factor (0.6). It was proved that the proposed method can enhance the efficacy of the process. Utilizing the computed combination of optimal process parameters in surface quality analysis has significantly contributed to improving the quality of machining surface.

scholarly journals Quality Prediction of Polygonal Helical Curved Tube by Abrasive Flow Precision Machining

2021 ◽  
Author(s):  
Junye Li ◽  
Shangfu Zhu ◽  
Jinbao Zhu ◽  
Chengyu Xu ◽  
Hengfu Zhang ◽  
...  
Keyword(s):  
Experimental Data ◽  
Prediction Model ◽  
Surface Quality ◽  
Process Parameters ◽  
Orthogonal Experimental Design ◽  
Quality Prediction ◽  
Optimal Process ◽  
Curved Tube ◽  
Inner Surface

Abstract Polygonal helical curved tube is the main form of rifling barrel, which surface quality determines the shooting accuracy of gun. Abrasive flow machining (AFM) technology can significantly improve its inner surface quality. In order to study the influence of AFM technical parameters on the inner surface quality of polygonal helical curved tube, orthogonal experimental design (OED) was used as the research method in this paper. By means of analysis of variance (ANOVA) of experimental data, the degree of influence of inlet pressure, abrasive concentration, abrasive particle size and machining time on the inner surface quality of polygonal helical curved tube was determined, and the optimal combination of process parameters was obtained. Under the optimal process parameters, the surface roughness Ra value in the inlet area of polygonal helical curved tube was reduced to 0.098 µm. The surface quality was significantly improved. Based on the regression analysis of experimental data, the quality prediction model of polygonal helical curved tube roughness by AFM was established to realize the effective prediction of surface quality after machining. The fitting value calculated by the model with optimal process parameters is close to the experimental value, which proves the accuracy and validity of the prediction model.

Application Of Cusum Chart In Control Of Paper Quality

GIS Business ◽  
2020 ◽  
Vol 14 (6) ◽  
pp. 1062-1069
Author(s):  
S.Ramesh ◽  
B.A.Vasu
Keyword(s):  
Process Parameters ◽  
Manufacturing Process ◽  
Paper Industry ◽  
Primary Data ◽  
Cusum Chart ◽  
Paper Machine ◽  
Statistical Control ◽  
Operating Characteristics ◽  
Small Shift

This paper is an attempt to assess if the manufacturing process of paper machine is in statistical control thereby improving the quality of paper being produced in a paper industry at the time of process itself. Quality is the foremost criteria for achieving the business target. Therefore, emphasis was made on controlling the quality of paper at the time of manufacturing process itself, rather than checking the finished lots at a later time.  This control on quality will help the industry deduct the small shift in the process parameters and modify the operating characteristics at the time of production itself rather than receiving complaints from customers at a later stage.  This paper describes controlling quality at the time of manufacture itself and helps the industry to concentrate on quality at low cost. The researcher has collected primary data at a leading paper industry during October, 2019.  Though X-bar and Range charges were primarily used, CUSUM charts were used to sense the minor shifts in manufacturing process, to explore the possibility of adjusting process parameters during manufacture of paper.

Chemical Effects and Predictive Factors in Premature Birth

2018 ◽  
Vol 69 (7) ◽  
pp. 1796-1801
Author(s):  
Adrian Neacsu ◽  
Alina Calin ◽  
Anca Daniela Braila ◽  
Dan Navolan ◽  
Mihai Dimitriu ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Premature Birth ◽  
Tissue Concentration ◽  
Premature Labor ◽  
New Born ◽  
Uterine Contractions ◽  
Chemical Effects ◽  
Equal Importance ◽  
Necrosis Factor

Premature birth is considered to be the consequence of independent alterations in the cervix and in the uterus. During labor, for full-term birth, as well as for premature birth, the cervix changes, from firm, long and closed, to soft and pliable, through a biochemical process characterized by the reshaping of the extracellular matrix and a growth of the tissue concentration of inflammatory mediators; the uterus proves an increase in contractility and sensitivity to endogenic hormones, such as oxytocin. Premature labor is associated with the premature activation of the release of cytokines in the decidua (mucosa lining uterus walls) and cervix. Interleukins IL-1 beta, IL-6, IL-8 and the alpha tumoral necrosis factor increase the production and activation of matrix metalloproteinases (MMP-1, MMP-3 and MMP-9) and of cathepsin S, which digests the collagen from the extracellular matrix of the cervix, causing the wiping and softening of the cervix. These cytokines are released by leukocytes in the myometer, leading to the production of prostaglandins and oxytocin, which stimulate uterine contractions. Therefore, the cervical shortening represented by ultrasound is believed to represent premature cervical softening. The obstetrical approach of aspects related to premature birth are based, considerably, on the prognosis expected by the obstetrician regarding the survival of the premature new-born baby, as well as the therapeutic variants to be followed. And not only survival is important, of equal importance is also the quality of life of underweight, immature new-born babies, who are considerably affected both physically, and intellectually.

scholarly journals Effects of Process Parameters on the Color Quality of Anthocyanin-Based Colorants from Conventional and Microwave-Assisted Aqueous Extraction of Sweet Potato (Ipomoea batatas L.) Leaf Varieties

Proceedings ◽  
2020 ◽  
Vol 70 (1) ◽  
pp. 103
Author(s):  
Jin Mark D. G. Pagulayan ◽  
Aprille Suzette V. Mendoza ◽  
Fredelyn S. Gascon ◽  
Jan Carlo C. Aningat ◽  
Abigail S. Rustia ◽  
...  
Keyword(s):  
Sweet Potato ◽  
Process Parameters ◽  
Ipomoea Batatas ◽  
Extraction Methods ◽  
Aqueous Extraction ◽  
Potato Leaf ◽  
Microwave Assisted ◽  
Color Quality ◽  
The Impact

The study aimed to evaluate the effects of process parameters (time and raw material weight (RMW)) of conventional (boiling for 10–45 min) and microwave-assisted (2–8 min) aqueous extraction on the color quality (i.e., lightness (L*), chroma (C*), and hue (H°) of anthocyanin –based colorants of red and Inubi sweet potato (Ipomoea batatas L.) leaves. Using response surface methodology, it was found that RMW and boiling time (BT) and microwave time (MT) generally had a significant (p < 0.05) effect on the color quality of the extract from both extraction methods. The effects were found to vary depending on the extraction method and variety of the leaves used. Both extraction methods produced a brown to brick-red extract from the Inubi variety that turned red-violet to pink when acidified. The red sweet potato leaves produced a deep violet colored extract that also turned red-violet when acidified. It is recommended that the anthocyanin content of the extracts be measured to validate the impact of the methods on the active agent. Nevertheless, the outcomes in this study may serve as baseline data for further studies on the potential of sweet potato leaf colorants (SPLC) as a colorant with functional properties.

scholarly journals Can biomarkers of extracellular matrix remodelling and wound healing be used to identify high risk patients infected with SARS-CoV-2?: lessons learned from pulmonary fibrosis

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
D. J. Leeming ◽  
F. Genovese ◽  
J. M. B. Sand ◽  
D. G. K. Rasmussen ◽  
C. Christiansen ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Extracellular Matrix ◽  
Wound Healing ◽  
Lung Function ◽  
Pulmonary Fibrosis ◽  
Interstitial Lung Diseases ◽  
Lessons Learned ◽  
Lung Function Decline ◽  
Tissue Remodelling

AbstractPulmonary fibrosis has been identified as a main factor leading to pulmonary dysfunction and poor quality of life in post-recovery Severe Acute Respiratory Syndrome (SARS) survivor’s consequent to SARS-Cov-2 infection. Thus there is an urgent medical need for identification of readily available biomarkers that in patients with SARS-Cov-2 infection are able to; (1) identify patients in most need of medical care prior to admittance to an intensive care unit (ICU), and; (2) identify patients post-infection at risk of developing persistent fibrosis of lungs with subsequent impaired quality of life and increased morbidity and mortality. An intense amount of research have focused on wound healing and Extracellular Matrix (ECM) remodelling of the lungs related to lung function decline in pulmonary fibrosis (PF). A range of non-invasive serological biomarkers, reflecting tissue remodelling, and fibrosis have been shown to predict risk of acute exacerbations, lung function decline and mortality in PF and other interstitial lung diseases (Sand et al. in Respir Res 19:82, 2018). We suggest that lessons learned from such PF studies of the pathological processes leading to lung function decline could be used to better identify patients infected with SARS-Co-V2 at most risk of acute deterioration or persistent fibrotic damage of the lung and could consequently be used to guide treatment decisions.

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