scholarly journals Ischemic stroke as a consequence of coagulopathy in coronavirus disease

2021 ◽  
Vol 17 (2) ◽  
pp. 25-30
Author(s):  
H.S. Trepet ◽  
L.M. Trepet ◽  
Ya.A. Havryliuk
Keyword(s):  
Ischemic Stroke ◽  
Neurological Status ◽  
Speech Disorders ◽  
Coagulation System ◽  
Significance Level ◽  
Group I ◽  
Prothrombin Index ◽  
Group Ii ◽  
Cerebral Ischemic ◽  
D Dimer

Objective: to compare the state of the coagulation system in patients with ischemic stroke and coronavirus disease in those with ischemic stroke without coronavirus disease. Materials and methods. We examined 40 patients in the acute period of cerebral ischemic stroke, aged from 69 to 87 years (average age of 77.30 ± 2.08 years). They were divided into two groups: group I — SARS-CoV-2-positive, group II — SARS-CoV-2-negative. Group I consisted of 20 individuals (9 women and 11 men) aged 69 to 84 years (average age of 76.9 ± 3.0 years). Group II included 20 patients (10 women and 10 men) aged 72 to 87 years (average age of 78.5 ± 2.5 years). Results. Twelve (60 %) patients of group I had a moderate disease severity, 8 (40 %) — severe. The severity of neurologic deficits on the National Institutes of Health Stroke Scale did not differ significantly in patients of both clinical groups: in group I it was 14.0 ± 0.7 points, in group II — 10.00 ± ± 1.37 points, which corresponded to moderate stroke, the significance level p = 0.05. In the neurological status, motor and sensory deficits were observed in both groups in combination with speech disorders and ataxia. The average level of prothrombin index in group I was 101 ± 6 %, in II — 83 ± 2 %, p = 0.01. The level of fibrinogen in group I was 401.0 ± 18.6 mg/dl, in group II — 250 ± ± 12 mg/dl, which can lead to temporary hypercoagulation and the development of thromboembolism (p < 0.05). In group I, the level of D-dimer was 465 ± 8 ng/ml, in group II — 175 ± 4 ng/ml (p < 0.05). Conclusions. The data suggest that SARS-CoV-2-posi-tive patients with ischemic stroke compared to SARS-CoV-2-ne-gative ones with ischemic stroke are characterized by the presence of coagulopathy, as evidenced by significantly higher levels of fibrinogen, prothrombin index, D-dimer and moderate thrombocytopenia, as well as significantly higher levels of C-reactive protein that indicates the presence of an acute inflammatory process, which also causes thrombosis.

scholarly journals The prognostic role of inflammatory markers in COVID 19 patients – A retrospective analysis.

2021 ◽  
Author(s):  
Shivkumar Gopalakrishnan ◽  
sangeetha kandasamy ◽  
S.Malini ◽  
S.Peer Mohamed ◽  
k.velmurugan
Keyword(s):  
Inflammatory Markers ◽  
Severe Disease ◽  
Radiation Hazard ◽  
P Value ◽  
Binary Logistic Regression Analysis ◽  
Group Iii ◽  
Group I ◽  
Group Ii ◽  
D Dimer

Abstract Background. Approximately 5% of COVID-19 patients suffer near fatal disease. Clinical and radiologic features may predict severe disease albeit with limited specificity and radiation hazard. Laboratory biomarkers are eyed as simple, specific and point of care triage tools to optimize management decisions.This study aimed to study the role of inflammatory markers in prognosticating COVID-19 patients.Methodology. A hospital based retrospective study was conducted on COVID-19 adult inpatients classified into three groups as mild disease-recovered [Group I], severe disease-recovered [Group II] and dead [Group III]. Categorical outcomes were compared using Chi square test. Univariate binary logistic regression analysis was performed to test the association between the explanatory and outcome variables. Unadjusted OR along with 95% CI was calculated. The utility of lab parameters (Ferritin, LDH, D dimer, N/L ratio and PLT/L ratio) in predicting severity of COVID-19 was assessed by Receiver Operative Curve (ROC) analysis. P value < 0.05 was considered statistically significant.Results. The mean age was 49.32 +/- 17.1 years. Among study population, 378 were Group I, 66 Group II, and 56 Group III. Median levels of Ferritin among the 3 groups were 62ng/mL, 388.50 ng/mL and 1199.50 ng/mL. Median value of LDH were 95U/L, 720 and 982.50(p <0.001). D-dimer values of 3 groups were 23.20ng/mL, 104.30 ng/mL and 197.10 ng/mL (p <0.001). CRP done qualitatively was positive in 2 (0.53%), 30 (45.45%) and 53 (94.64%) of patients. The odds of patients suffering severe COVID-19 rose with rising values of ferritin, LDH and D-dimer [unadjusted OR 1.007, 1.004 &1.020]Conclusion. One time measurement of serum ferritin, LDH, D-dimer and CRP is promising to predict outcomes for COVID 19 inpatients. Single qualitative CRP was equally good but more cost effective than quantitative CRP. The most specific combination was NLR, Lymphocyte percentage and D-dimer levels done between 7th – 10th day of symptoms.

scholarly journals PERBANDINGAN LAJU NADI PADA AKHIR INTUBASI YANG MENGGUNAKAN PREMEDIKASI FENTANIL ANTARA 1μg/kgBB DENGAN 2μg/kgBB PADA ANESTESIA UMUM

e-CliniC ◽  
2014 ◽  
Vol 2 (2) ◽  
Author(s):  
Kasman Ibrahim
Keyword(s):  
Endotracheal Intubation ◽  
Pulse Rate ◽  
Cardiovascular Response ◽  
T Test ◽  
Significance Level ◽  
Group I ◽  
Minute Post ◽  
The Mean ◽  
Group Ii ◽  
Post Intubation

Abstract : Endotracheal intubation is an act that many use in general anesthesia. This intubation can cause excessive sympathetic and sympathoadrenalreflex which can increase heart rate, blood pressure, pulse, and dysrhythmia. Fentanyl is one medicine that decrease the cardiovascular response. This research aims to determine the differences on pulse rate in giving the fentanyl 1μg/kgBB with 2μg/kgBB post intubation. This was a prospective analytic study, with a sample size of 30 patients, divided into two groups, each of 15 patient. Group I received 1μg/kgBB intravenously and group II fentanyl 2μg/kgBB intravenously. Pulse rate were recorded before and 1, 2, 3, 5 minutes after intubation. The data is analyzed with T-test significance level p < 0,15. The results showed that the mean of the pulse rate before intubation in group I 86,80 beats/minute, group II 91,73 beats/minute. One minute post intubation group I 98,40 beats/minute, group II 99,80 beats/minute. Two minutes post intubation group I 95,33 beats/minute, group II 93,27 beats/minute. Three minutes post intubation group I 89,93 beats/minute, group II 89,40 beats/minute. Five minutes post intubation group I 91,13 beats/minute, group II 85,27 beats/minute. Conclusion: Premedication fentanyl 2μg/kgBB intravenously is faster to stabilize the response to cardiovascular (pulse rate) in endotracheal intubation compared to 1μg/kgBB dose intravenously.Keywords : fentanyl, endotracheal intubation, pulse rateAbstrak : Intubasi endotrakeal merupakan tindakan yang banyak dilakukan pada anestesia umum. Tindakan intubasi ini sering menimbulkan refleks simpatis dan simpatoadrenal yang berlebihan yang dapat meningkatkan laju jantung, tekanan darah, nadi, dan disritmia.Fentanil merupakan salah satu obat untuk mengurangi respon kardiovaskular.Penelitian ini bertujuan untuk mengetahui perbedaan laju nadi pada pemberian fentanil 1μg/kgBB dengan 2μg/kgBB pasca intubasi. Penelitian ini merupakan studi analitik prospektif, dengan jumlah sampel 30 pasien yang dibagi menjadi dua kelompok, masing- masing 15 pasien. Kelompok I diberikan fentanil 1μg/kgBB intravena dan kelompok II fentanil 2μg/kgBB intravena. Laju nadi dicatat sebelum dan 1, 2, 3, 5 menit setelah intubasi. Data di analisis dengan T-test derajat kemaknaan p< 0,15. Hasil penelitian memperlihatkan nilai rata-rata laju nadi sebelum intubasi pada kelompok I 86,80 kali/menit, kelompok II 91,73 kali/menit. Satu menit pasca intubasi kelompok I 98,40 kali/menit, kelompok II 99,80 kali/menit.Dua menit pasca intubasi kelompok I 95,33 kali/menit, kelompok II 93,27 kali/menit.Tiga menit pasca intubasi kelompok I, 89,93 kali/menit kelompok II 89,40 kali/menit.Lima menit pasca intubasi kelompok I 91,13 kali/menit, kelompok II 85,27 kali/menit. Simpulan: Premedikasi fentanil 2μg/kgBB intravena lebih cepat menstabilkan respon terhadap kardiovaskuler (laju nadi) pada tindakan intubasi endotrakeal dibandingkan dosis 1μg/kgBB intravena.Kata kunci : fentanil, intubasi endotrakeal, laju nadi

Altered Endothelial Cells Properties and Platelets Activity in Treatment NaïVe Patients with Multiple Myeloma (MM ) and Non-Hodgkin Lymphoma (nHL): Association with Thromboembolic Complications

Blood ◽  
2016 ◽  
Vol 128 (22) ◽  
pp. 5649-5649
Author(s):  
Lidia Usnarska-Zubkiewicz ◽  
Maria Podolak-Dawidziak ◽  
Urszula Zaleska-Dorobisz ◽  
Magdalena Olszewska-Szopa ◽  
Iwona Prajs ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Endothelial Cells ◽  
Venous Thrombosis ◽  
Ultrasound Examination ◽  
Non Hodgkin Lymphoma ◽  
Group I ◽  
Elevated Activity ◽  
The Mean ◽  
Group Ii ◽  
D Dimer

Abstract Multiple myeloma and non-Hodgkin lymphoma and its treatment are frequently associated with increased tromboembolic risk, particularly venous trromboembolism (VTE), cerebrovascular ischemic events and myocardial infarction. The incidence of thrombotic complications dramatically raise after highly prothrombotic therapeutic regimens e.g. thalidomide and lenalidomide in MM. The current study was designed to examine whether procoagulant microparticles (MPs) derived from endothelial cells (EMPs) and platelets (PMPs) constitute an enhanced risk for venous thrombosis in MM and nHL patients (pts). We studied 39 pts without history of VTE, 17/22 F/M, aged 24-84 years (mean=60,23±13,45). There were 25 MM pts (15 cases of IgG, 3 of IgA, 1 IgM, 2 non secretory MM, 3 LCD) and 14 nHL (6 cases of DLBCL, 2 anaplastic T cell lymphoma, 2 FL, 4 MCL). All patients underwent routine coagulation tests. Flow-cytometry was used for quantification of endothelial cell (CD133+) microparticles (EMPs) and platelet (CD61+) microparticles (PMPs). In all pts ultrasound examination of venous system of lower extremities was performed. Deep and superficial veins of both limbs were evaluated. Conventional and Doppler imagination, as well as elastography and options to detect microcalcifications (micropure) were used. The ultrasound examination revealed the presence of vein thrombosis in 18 pts (group I, n =18). 11 out of 18 pts with bilateral lesions in VSM (vena saphena magna, great saphenous vein) and lower leg veins or bilateral in VSM only comprised subgroup Ia. 7 pts with unilateral blood clots in VSM formed group Ib. Thrombosis was observed in 11 pts with MM and 7 with nHL, and bilateral thrombotic lesions were demonstrated in 6 MM and 5 nHL pts. The remaining 21 pts showed no thrombosis (group II). The most frequently thrombosis was observed in IgA-MM (3/3 pts), followed by IgG-MM. In nHL patients thrombosis was found the most frequently in DLBCL. Patients were divided into two groups according to the age: > 60 yrs and <60 yrs. Both in MM and nHL, thrombosis was more frequent in older patients. The mean percentage of EMPs (CD133+) was 1,44±1,22 (median 0,95, IQR 0,47-2,31), and it did not differ (p=0,83) between thrombotic (group I) (1,48±1,16) and non-thrombotic pts (group II) (1,46±1,31), however the greatest value was assessed in the subgroup Ia (1,74±1,26, p=0,3467). Also, there was a trend marked that EMP percentage was lower in MM patients (1,25±1,31) in comparison to nHL patients (1,76±1,04), p=0,0671 (UM-W test). EMP percentage did not differ according to sex and age. The percentage of PMPs (CD61+) was 12,06 ± 6,31 (median 10,88, IQR 8,35-15,90), and higher in group I (12,65±3,25) vs. group II (10,93±7,68), p=0,0459 (UM-W test), including subgroup Ia (13,05±3,66), p=0,0885 (UM-W test). The mean PMPs percentage was similar in MM (12,27±7,18) vs. nHL (11,70±4,71), and as EMPs percentage, did not differ according to sex and age. Mean plasma fibrinogen (FBG) concentration was 3,95±1,82 g/L and did not significantly differ in MM and nHL patients with and without thrombosis (3,84±1,68 vs. 4,10±2,06 g/L), also it has similar level in subgroup Ia (4,06±1,97 g/L). Mean D-dimer level was 2,29±4,15 mg/L (median 1,30, IQR 0,54-2,35), and there was not significantly different in patients with and without thrombosis (2,95±5,29 vs. 1,34±1,25 mg/L), moreover it was not elevated in subgroup Ia (1,96±1,02 mg/L). Type of the disease, sex as well as age did not influenced FBG and D-dimer levels. Venous thrombosis was confirmed in nearly half of patients with newly diagnosed patients with MM and n-HL. In patients with many thrombotic lesions elevated activity of platelets (PMPs) was observed, as well as a trend towards elevated activity of endothelial cells (EMPs). Disclosures Robak: MorphoSys AG: Research Funding.

scholarly journals Molecular analysis of Er:YAG laser irradiation on dentin

2006 ◽  
Vol 17 (1) ◽  
pp. 15-19 ◽  
Author(s):  
Luís Eduardo Silva Soares ◽  
Aldo Brugnera Junior ◽  
Fátima Zanin ◽  
Marcos Tadeu Tavares Pacheco ◽  
Airton A. Martin
Keyword(s):  
Raman Spectroscopy ◽  
Laser Irradiation ◽  
Er:Yag Laser ◽  
Chemical Constituents ◽  
Organic Content ◽  
Control Group ◽  
Significance Level ◽  
Group Iii ◽  
Group I ◽  
Group Ii

The aim of this study was to evaluate by dispersive Raman spectroscopy the mineral and organic components of human dentin before and after laser irradiation and acid etching. The occlusal enamel of six non-carious human third molars was removed providing 6 dentin discs, which were divided in four quadrants each of them receiving a different surface treatment: etching with a 37% phosphoric acid gel (control); irradiation by Er:YAG laser (KaVo Key Laser II) with 80 mJ, 3 Hz, 30 s (group I); 120 mJ, 3 Hz, 30 s (group II); and 180 mJ, 3 Hz, 30 s (group III). The Raman spectra of normal (untreated) and treated dentin were analyzed and the mineral and the organic component were evaluated. Results were submitted to statistical analysis by ANOVA and Tukey's test at 5% significance level. The minerals and organic content were less affected in the control group and group I (p>0.05). Group II presented more reduction in mineral content (p<0.01) whereas in group III the inorganic (p<0.05) and organic (p<0.01) content were more affected. Dispersive Raman spectroscopy provided valid information of dentin chemical constituents with non-chemical sampling preparation.

scholarly journals Cardiovascular Pathology – a Factor of the Adverse Course of Diabetic Polyneuropathy

2021 ◽  
pp. 28-33
Author(s):  
Hennadii Chupryna ◽  
Viktoriia Dubynetska ◽  
Kateryna Kachur
Keyword(s):  
Peripheral Nerves ◽  
Clinical Manifestations ◽  
Diabetic Polyneuropathy ◽  
Neurological Status ◽  
Type I ◽  
Cardiovascular Pathology ◽  
Tibial Arteries ◽  
Group I ◽  
Wide Range ◽  
Group Ii

Diabetic polyneuropathy (DP) and angiopathy are interdependent processes, as disturbances in the microcirculatory system of peripheral nerves lead to increased axonal damage and is a kind of predictor of polyneuropathy progressing [6]. 80% of deaths from diabetes mellitus (DM) are associated with cardiovascular catastrophes, including coronary heart disease (CHD), stroke and peripheral artery disease [3]. The objective: to analyze the most common cardiovascular pathology (CVP) and show its impact on the course of DP in type I and II DM. Materials and methods. Was clinically examined 101 patient with DP. The examined patients were divided into groups: with DP on the background of type 1 DM (group I) (n=54) and with DP on the background of type II DM (group II) (n=47), and also were divided into subgroups: DP on the background of type I and II DM and existing CVP (including diabetic angiopathy) 82 (82%) (subgroup А) and with the DP on the background of DM type I and II without CVP – 19 (19%) (subgroup В). Patients were examined to determine the neurological status, were performed laboratory and instrumental methods of examination. Static calculation was performed in MS Excel 2003 and in the programme STATISTICA 10. Results. Regarding to the patients of subgroup А and В we noted the natural predominance of trophic disorders, changes in the reflex sphere and sensitivity in subgroup А. Patients of group II more often than in group I had pathology of the cardiovascular system. Hypertension (HT) and CHD in both cases were registered with a high frequency. In subgroup А there was a combination of several nosologies: from the respiratory, urinary, gastroenterological system (1%), urinary and gastroenterological (3%), gastroenterological and endocrine (2%), urinary and endocrine (1%). In subgroup В diseases of urinary and gastroenterological pathology were found in (5%), gastroenterological (5%), endocrine (11%). The examined patients from group I and with the concomitant CVP have lower linear velocity of blood flow (LVBF) on both tibial arteries, patients in group II – have marginally higher LVBF. Analysis of the results of duplex scanning of lower extremity arteries showed a high incidence of stenosis, in particular the anterior tibial arteries (ATA) up to 30–40%, posterior tibial arteries (PTA) up to 40–50% and occlusion (PTA and femoral, popliteal, tibial segment) in individuals of group I. Conclusions. In patients with DP on the background of type I and II DM and available CVP (subgroup А), the clinical manifestations of polyneuropathy were quite pronounced, especially in the field of trophic disorders, because CVP enhances the ischemia of the microsaceous channel of the peripheral nerves. In addition, persons with concomitant CVP have a wide range of another comorbid pathology, which accelerates the onset of DM complications.

scholarly journals Association of Serum Triglycerides in Patients with Ischaemic Stroke Admitted in Hospital with type-2 Diabetes Patients

2013 ◽  
Vol 29 (2) ◽  
pp. 98-107
Author(s):  
Nirmalendu Bikash Bhowmik ◽  
Dilruba Alam ◽  
Md Rashedul Islam ◽  
Rumana Habib ◽  
Aminur Rahman ◽  
...  
Keyword(s):  
Risk Factors ◽  
Ischemic Stroke ◽  
Triglyceride Level ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Group I ◽  
Stroke Group ◽  
Group Ii ◽  
Type 2 Diabetic

Background and Aims: Diabetes mellitus and dyslipidemia, in particular triglyceridemia pose independent risk factors of stroke. Hypertriglyceridemia implicated in the pathogenesis of ischemic stroke by imparting endothelial dysfunction, oxidative stress and lowering fibrinolytic activity. This study was aimed to explore risk incurred by blood triglyceride level for ischemic stroke in type 2 diabetic patients. Materials and Methods: A total number of 80 [50 with acute ischemic stroke and 30 without stroke] type 2 diabetic patients consecutively admitted in the neurology department, during the period of April to September 2012, fulfilling the recruitment criteria were included in the study. Ischemic stroke was confirmed by CT-scan. Informed written consent from the legal attendant of each patient was obtained. Data regarding clinicobiochemical and images studies were retrieved from patient’s record form. Results: Male to female ratio was 1.2:1 of the study subjects. Mean (±SD) age (yrs) was 61.0±10.6 in patients with ischemic stroke (Group I) and 57.0±12.3 in patients without stroke (Group II). Risk factors like BMI, lifestyle, smoking, alcohol intake did not show any statistical significance with incidence of ischemic stroke. Mean (±SD) triglyceride (mg/ dl) was 241±56 and 217±102 in Group I and Group II respectively (p=0.024). Eighty eight percent patients had triglyceride 150 mg/dl in Group I and 70 percent in Group II. Triglyceride level (mean±SD, mg/dl) was significantly higher (335±101) in overweightobese patients (BMI 25 Kg/m2) compared to those (232±68) with normal body weight (BMI<25 Kg/m2). Triglyceride level did not show statistical difference among patients having habit of smoking or not. Mean (±SD) cholesterol (mg/dl, (±SD) was 197±62 and 165±26 in Group I and Group II respectively (p=0.009). Mean (±SD) LDL-c (mg/dl) was 101±45 and 98±42 in Group I (43.8±34.4) compared to Group II (60.2±15.6) (p=0.017). Patients with atherosclerotic changes had significantly higher triglyceride (mean±SD, mg/dl) level (338±155) compared to those without (228±89) (p=0.047). Conclusions: Data concluded that hypertriglyceridemia is relatively common among the diabetic patients even in patients with apparently good glycemic control and possibly incur added risk for ischemic stroke in these patients. However, further studies are needed involving optimum number of patients to substantiate this finding and conclusively comment on the issue and to design effective prevention program to reduce the cerebrovascular morbidity and mortality. Bangladesh Journal of Neuroscience 2013; Vol. 29 (2) : 98-107

Plasma Circulating Levels of Soluble P-Selectin and Thrombospondin-1 (TSP1) Are Elevated in Patients with Cancer and a Shortened Activated Partial Thromboplastin Time (APTT) without Clinical Evidence of Thrombosis: An Inexpensive and Simple Test (APTT) To Be Considered for Its Clinical Value.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 4098-4098
Author(s):  
Fabiola E. Del Carpio-Cano ◽  
Diana Zamora-Rangel ◽  
Miguel A. Rosales-Manoatl ◽  
Maria R. Rivas-Gonzalez ◽  
Eduardo Cervera-Ceballos ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coagulation Factors ◽  
Laboratory Measurements ◽  
Clinical Value ◽  
Group Iii ◽  
Patients With Cancer ◽  
Group I ◽  
Group Ii ◽  
Circulating Levels ◽  
D Dimer

Abstract There is evidence of shortening of the APTT in patients afflicted with and without cancer, and cancer is a well known underlying condition associated with hypercoagulability. Increased levels of coagulation factors such as VIII, IX, XI, II, and fibrinogen have been demonstrated as independent risk factors for venous thromboembolism (VTE). However, there is evidence that high levels of circulating factor VIII levels are not the only determinant for a shortened APTT (Blood2004; 104:3631) and likely the same case for the other factors including fibrinogen levels. A shortened APTT in a patient with cancer with no evidence of a thrombotic event could be of clinical value in particular when the cost of measuring individual coagulation factors previously identified as risk factors for VTE would be very high. A lack of understanding of the underlying mechanism leading to a shortened APTT in the absence of VTE limit its clinical use, particularly for the clinical management of the patient presenting at admission with this phenomenon in association with cancer. In this case-control prospective study, we have investigated a potential mechanism associated with a shortened APTT in patients with cancer without evidence of thrombosis. The rationale for this study was a previous observation supporting a functional role of TSP1 in the generation of thrombin on a cell surface (Thrombosis Research2005; 116: 533). The study was comprised of 69 human subjects subdivided in three separate groups, Group I, was constituted by 23 normal human volunteers, Group II included 23 patients without a shortened APTT and cancer, Group III was comprised of 23 patients with cancer with a shortened APTT (see table). Groups I and II were matched with group III by age and gender. In addition patients in Group II were matched with Group III by the type of cancer. Laboratory measurements included APTT, D-Dimer, soluble E, L, and P-Selectins as well as TSP1. Platelet and neutrophil counts were determined by automated methods. Laboratory measurements demonstrating a significant difference in Group III when compared with Group I and II were P-Selectin and TSP1. These results were independent of the platelet count in Group III. However the significant elevated circulating levels in plasma of P-Selectin in Group III are evidence supporting platelet activation. There was a trend for higher levels of D-Dimer in Group III (P &lt; 0.17) when compared with Group II (P&lt; 0.76), in accordance with previous studies reported in the literature. In summary, this prospective study demonstrates a potential association of a shortened APTT in patients with cancer with elevated circulating levels of soluble P-Selectin and TSP1. Our laboratory is currently investigating in more detail this interesting finding as well as the prospective clinical follow up of patients included in Groups II and III. Plasma Determinations Parameter Group I Group II Group III P Value Normal Range APTT: 24.2–35.3 seconds aPTT 29.3±2.7 28.2±2.3 23±1.0 0.01 sP-Selectin 23.2±4 25.4±9 44.0±11 0.001 TSP1 382±39 871±496 1246±295 0.001

scholarly journals Evaluation of Osteocalcin Levels in Saliva of Periodontitis Patients and Their Correlation with the Disease Severity: A Cross-Sectional Study

2020 ◽  
Vol 14 (03) ◽  
pp. 352-359
Author(s):  
Hamda Shazam ◽  
Fouzia Shaikh ◽  
Zaheer Hussain ◽  
M. Mansoor Majeed ◽  
Saba Khan ◽  
...  
Keyword(s):  
Bone Loss ◽  
Alveolar Bone ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Significance Level ◽  
Group I ◽  
Study Results ◽  
Significant Difference ◽  
Group Ii

Abstract Objectives The present study aimed to investigate osteocalcin levels in saliva of healthy and periodontitis patients and correlate these levels with periodontitis severity. Materials and Methods This cross-sectional study was conducted in a hospital setup. A total of 95 individuals participated in the study with 46 subjects in group I (healthy individuals) and 49 subjects in group II (mild, moderate, and severe chronic periodontitis patients). A detailed assessment of clinical periodontal parameters and alveolar bone loss was made. Unstimulated saliva samples were collected from all study subjects and osteocalcin levels were quantitatively analyzed by sandwich enzyme-linked immunosorbent essay technique. Statistical Analysis One-way analysis of variance, Spearman’s correlation test, and Pearson’s chi-squared test were applied at a significance level of 95%. p-Values less than 0.05 were considered statistically significant. Results The results showed a significant association of qualification with group II (p < 0.02). Bone loss scores were also significantly associated with periodontitis severity (p < 0.01). However, no statistically significant difference was observed between group I and group II in terms of mean salivary osteocalcin levels (p = 0.68). Also, an insignificant correlation was also observed between osteocalcin levels and periodontitis severity (p = 0.13). Conclusion The overall study results showed that there was no significant difference between saliva osteocalcin levels of healthy and periodontitis patients. Also, there was a nonsignificant correlation between osteocalcin levels and periodontitis severity. The findings of the present study support the hypothesis that low osteocalcin levels in saliva might be considered as a poor indicator of periodontal disease progression and severity.

scholarly journals Current role of low molecular weight heparin in the treatment of acute ischemic stroke

2017 ◽  
Vol 4 (6) ◽  
pp. 1599
Author(s):  
Karan Singh
Keyword(s):  
Ischemic Stroke ◽  
Placebo Group ◽  
Acute Ischemic Stroke ◽  
Group Iv ◽  
Control Group ◽  
High Dose ◽  
Mortality And Morbidity ◽  
Group Iii ◽  
Group I ◽  
Group Ii

Background: Nevertheless, several studies of LMWH in acute ischemic stroke have been neutral with regard to their primary outcomes, and it remains unclear whether these drugs should be used routinely or not. Our present trial endeavors to study the efficacy of LMWH (low and high dose dalteparin) in patients with progressive ischemic stroke in terms of morbidity and mortality as compared to control group and to compare it with AS+CLOP, with respect to these event rates, at the end of treatment.Methods: Our study was performed on 38 patients of acute ischemic stroke admitted to LLR and associated Hospitals, G. S. V. M. Medical College, Kanpur and who were assigned randomly to any of the four treatment groups (0.4ml dalteparin, 0.8ml of dalteparin, O ml of placebo and aspirin +clopidogrel 150+75 mg). The standard error of proportion method and Chi square test was applied.Results: 70% of patients in group I, 62.5% in Group II and 60% Group III presented with stroke in evolution at presentation as compared to only 30% in the placebo group. 75% of patients in group I, 66.66% in group II, 50% in Group III and 33.34% in group IV had a complete recovery. 25% of patients in Group-I, 33.34% in Group-II, 50% in Group III and 66.66% in Group-IV had an incomplete recovery.Conclusions: There is no significant reduction in the mortality and morbidity amongst LMWH groups at the end of treatment and end of trial as compared to the AS+CLOP, or placebo group or even amongst the low and high dose LMWH groups.

Abstract 84: The Effect of Hyperglycemia on Stroke Outcome Depends on Baseline Glycosylated Hemoglobin Levels

Stroke ◽  
2013 ◽  
Vol 44 (suppl_1) ◽  
Author(s):  
Kwang-Yeol Park ◽  
Johanna Helenius ◽  
Ross Avery ◽  
Gyeong-Moon Kim ◽  
Ferdinando S Buonanno ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Plasma Glucose ◽  
Hba1c Level ◽  
Infarct Volume ◽  
Glycosylated Hemoglobin ◽  
Unfavorable Outcome ◽  
Baseline Hba1c ◽  
Group Iii ◽  
Group I ◽  
Group Ii

Background and hypothesis: Patients with diabetes mellitus (DM) are less likely to develop adverse outcomes than are those without DM in response to acute elevations in plasma glucose after stroke. We hypothesized that baseline glycosylated hemoglobin (HbA1c) level, which provides an estimate of long-term plasma glucose concentration, inversely correlated with clinical and tissue outcome in acute ischemic stroke patients presenting with hyperglycemia. Methods: Within the context of an ongoing prospective study (Heart-Brain Interactions Study), we measured plasma glucose and HbA1c levels in 1080 patients with acute ischemic stroke within 72 hours of symptom onset. We classified patients into 3 HbA1c strata based on the American Diabetes Association criteria: group-I (HbA1c <5.7%, n=439), group-II (HbA1c: 5.7 to 6.4%, n=290), group-III (known DM or HbA1c >6.4, n=351). We examined the relationship between admission blood glucose level, acute infarct volume on DWI, and unfavorable outcome (mRS≥3) at 3 months in each HbA1c stratum. Results: The probability of unfavorable outcome decreased by increasing baseline HbA1c level; the OR (95% CI) for unfavorable outcome for every 10 mg/dl increase in glucose level was 1.42 (1.25-1.62) in group-I, 1.19 (1.07-1.33) in group-II, and 1.02 (0.99-1.05) in group-III. When hyperglycemia was defined as ≥144 mg/dl, OR (95% CI) for unfavorable outcome was 6.53 (2.65-16.14) in group-I, 1.56 (0.77-3.15) in group-II, and 1.35 (0.78-2.33) in group-III. Adjusting for age and sex did not change the results. For every 10 ml elevation in plasma glucose, the mean infarct volume increased by 7.45 ml (5.04-9.85) in group-I, 4.96 ml (2.82-7.09) in group-II, and 0.73 ml (-0.24-1.70) in group-III. Conclusions: Chronic hyperglycemia appears to protect from deleterious effects of acute elevations in blood glucose after ischemic stroke. Further research is warranted examining whether baseline HbA1c concentration predicts benefit from interventions for glycemic control in acute stroke.

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