scholarly journals EFFECT OF PHARMACOLOGICAL DOSES OF GARLIC AND OMEGA 3 ON GASTRIC LESIONS INDUCED BY ETHANOL IN MICE

2016 ◽  
Vol 9 (5) ◽  
pp. 153
Author(s):  
Ausama Ayoob Jaccob
Keyword(s):  
Gastric Ulcer ◽  
Gastric Ulceration ◽  
Gastric Lesions ◽  
Omega 3 ◽  
Control Groups ◽  
Ulcer Index ◽  
Once Daily ◽  
Garlic Oil ◽  
Induction Process ◽  
Area Increase

ABSTRACTObjective: This work was designed to investigate and compare the possible protective effect of pharmacological doses of garlic and omega 3 againstgastric lesions induced by ethanol in mice.Methods: A total of 30 mice involved in the study were divided into five groups with 6 mice for each. Groups 1 (ulcer control) and 2 (normal control),Groups 3 (positive ulcer control treated with ranitidine 50 mg/kg), Groups 4 and 5 treated with garlic oil and omega 3 oil at doses 200 and 150 mg/kg,respectively. All groups treated orally by gastric gavage once daily for 14 days before starting gastric ulcer (GU) induction process by absolute ethanoladministration.Results: A treatment with garlic and omega 3 ameliorated the severity of gastric ulceration evidenced by reduced ulcer index area, increase %gastroprotection, increase mucus content, reduced erosions, and necrosis.Conclusion: Oral administration of pharmacological doses of garlic oil and omega 3 oil shows significant gastroprotection against GU models inducedby absolute ethanol confirmed by biochemical and histological data.Keywords: Gastric ulcer, Garlic, Omega 3, Gastroprotection.

scholarly journals Gastroprotective Effect of Symplocos Racemosa Whole Plant Methanolic Extract Against Experimentally Induced Gastric Ulcer in Rat

2019 ◽  
Vol 7 (2) ◽  
pp. 59-61
Author(s):  
R. K. Gupta ◽  
Ravi Vishwakarma ◽  
Yashwant Giri ◽  
Varinder Singh
Keyword(s):  
Gastric Ulcer ◽  
Methanol Extract ◽  
Methanolic Extract ◽  
Gastric Volume ◽  
Gastric Ulceration ◽  
Antiulcer Activity ◽  
Free Acidity ◽  
Ulcer Index ◽  
Whole Plant ◽  
Symplocos Racemosa

Peptic ulcer is a condition which results from an imbalance between offensive and defensive factors of gastrointestinal system. The investigation was designed to evaluate the antiulcer activity of Symplocos racemosa whole plant methanol extract (MESR) in rat model of indomethacininduced gastric ulceration. The total acidity, gastric volume, pH and free acidity were measured to determine the anti-ulcer activity of MESR. Pretreatment with MESR (125-500 mg/kg) markedly reduced the indomethacin-induced increase in gastric ulcer index and score. These results revealed that antisecretory effects MESR were responsible for antiulcer activity of MESR.

scholarly journals A preli­minary study of endoscopic diagnosis of gastric ulcer in Egyptian donkeys (Equus asinus) pa­ra­sitised by Gasterophilus intestinalis (Diptera: Oestridae)

2021 ◽  
Vol 24 (2) ◽  
pp. 268-277
Author(s):  
M. Abuowarda ◽  
M. Amer ◽  
A. Shamaa ◽  
G. Shehab ◽  
A. Abdallah ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Diagnostic Tool ◽  
Histopathological Examination ◽  
Gastric Ulceration ◽  
Economic Losses ◽  
Morphological Identification ◽  
Parasitic Infestation ◽  
Gastric Lesions ◽  
Gastroscopic Examination ◽  
Equus Asinus

Equine gastric ulcer syndrome (EGUS) is a communal broad problem in equines but in donkeys, the disease is a subclinical disorder which leads to economic losses. Gasterophilus intestinalis larvae are the most predominant parasitic infestation in donkeys. The present study was planned to facilitate the early and efficient diagnosis of gastric ulceration in donkeys through gastroscopic examination. The study was conducted on 120 adult Egyptian donkeys (Equus asinus) from both sexes after a one-month acclimatisation period. Gastroscopic examination was used to evaluate the presence of gastric lesions. In the majority of infested donkeys, G. intestinalis larvae were in the non-glandular part of the stomach. The prevalence of Gastrophilus larvae in animals reached 96.66%. The infestation percentage among jennets (97.5%) was slightly higher than that among jacks (96.25%). After morphological identification of the 3rd instar of larvae, all donkeys were found to be infested by G. intestinalis larvae. The histopathological examination of the affected stomach revealed severe necrosis of the gastric mucosa. Gastroscopic examination is the main diagnostic tool for examination of gastric lesions in the donkeys, so it is necessary as a routine diagnostic tool in donkeys’ examinations.

scholarly journals The preventive effect of Nigella sativa seed on gastric ulcer induced by indomethacin in rat

2020 ◽  
Vol 9 (1) ◽  
pp. 12-19
Author(s):  
Maryam Paseban ◽  
Saeed Niazmand ◽  
Mohammad Soukhtanloo ◽  
Naser Tayyebi Meybodi
Keyword(s):  
Gastric Ulcer ◽  
Acid Secretion ◽  
Protein Content ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Nigella Sativa ◽  
Gastric Ulceration ◽  
Gastric Mucus ◽  
Ulcer Index ◽  
Nigella Sativa Seed

Introduction: Nonsteroidal anti-inflammatory drugs (NSAIDs) are considered as one of the most administrated groups of medications worldwide. Due to the role of NSAIDs in inducing gastric ulceration, their clinical applications are still challenging. Nigella sativa seed is widely used as an herbal medication against gastrointestinal complications. The present experiment was carried out to investigate the impact of N. sativa seed hydro-alcoholic extract on gastric ulcer induced by indomethacin (IND) and to evaluate its possible mechanisms in rat. Methods: This study was performed on 48 male Wistar rats. Acute gastric ulceration was induced by IND (35 mg/kg). N. sativa seed extract (100, 200, 400 mg/kg) and ranitidine (50 mg/kg) were administered orally for five days before the induction ulcer. Ulcer index, gastric acid secretion, gastric mucus content, glutathione (GSH), malondialdehyde (MDA), total hexose, gastric juice protein content were determined on the fifth day. Results: The ulcer index in all groups of N. sativa seed was significantly lower than that of the IND group. N sativa seed considerably decreased MDA and protein content, but increased total thiol, total hexose, and mucus content compared to the IND group. N. sativa seed did not affect gastric acid secretion. Conclusion: These findings were indicative of the gastroprotective effect of N. sativa seed against the IND-induced ulcer, suggesting that it can mainly be exerted through the anti-oxidant activity of the extract as well as its role in stimulating gastric mucus secretion and increasing total hexose in the gastric mucosa.

scholarly journals Omega-3 Self-Nanoemulsion Role in Gastroprotection against Indomethacin-Induced Gastric Injury in Rats

Pharmaceutics ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 140 ◽  
Author(s):  
Osama A. A. Ahmed ◽  
Usama A. Fahmy ◽  
Rana Bakhaidar ◽  
Mohamed A. El-Moselhy ◽  
Solomon Z. Okbazghi ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Gastric Injury ◽  
Tween 20 ◽  
Protective Effects ◽  
Omega 3 ◽  
Ulcer Index ◽  
Ulcer Disease ◽  
Mucosal Defect ◽  
Protection Efficacy ◽  
Mixture Experimental Design

Peptic ulcer disease is an injury of the alimentary tract that leads to a mucosal defect reaching the submucosa. This study aimed to formulate and optimize omega-3 oil as a self-nanoemulsifying drug delivery system (SNEDDS) to achieve oil dispersion in the nano-range in the stomach to augment omega-3 oil gastric ulcer protection efficacy. Three SNEDDS components were selected as the design factors: the concentrations of the oil omega-3 (X1, 10–30%), the surfactant tween 20 and Kolliphor mixture (X2, 20–40%), and the cosurfactant transcutol (X3, 40–60%). The mixture experimental design proposed twenty-three formulations with varying omega-3 SNEDDS formulation component percentages. The optimized omega-3 SNEDDS formula was investigated for gastric ulcer protective effects by evaluating the ulcer index and by the determination of gastric mucosa oxidative stress parameters. Results revealed that optimized omega-3-SNEDDS achieved significant improvement in the gastric ulcer index in comparison with pure omega-3 oil. Histopathological findings confirmed the protective effect of the formulated optimized omega-3 SNEDDS in comparison with omega-3 oil. These findings suggest that formulation of omega-3 in the form of a SNEDDS would be more effective in gastric ulcer protection than the administration of omega-3 as a crude oil.

scholarly journals Chemical Constituents and Antiulcer Activity of n-Hexane Extract of Sanchezia nobilis Hook F. Leaves from Vietnam

2019 ◽  
Vol 31 (9) ◽  
pp. 2125-2132
Author(s):  
Xuan Bui Thi ◽  
Loi Vu Duc ◽  
Tung Bui Thanh ◽  
Ngoc Tran Minh
Keyword(s):  
Mass Spectrometry ◽  
Gastric Ulcer ◽  
Chemical Constituents ◽  
Gastric Ulceration ◽  
Hexane Fraction ◽  
Antiulcer Activity ◽  
Spectroscopic Methods ◽  
Ulcer Index ◽  
Margaric Acid ◽  
First Time

Five compounds (1-5) were isolated from the leaves of Sanchezia nobilis collected in Nam Dinh province by chromatographic methods. These compounds were identified as: mangiferin (1), β-sitosterol (2), margaric acid (3), ursolic acid (4), oleanolic acid (5). Their structures were elucidated by spectroscopic methods, including mass spectrometry and nuclear magnetic resonance. These compounds were isolated from the leaves of Sanchezia nobilis for the first time. Screening of gastric and duodenal antiulcer effects on indomethacin induced gastric ulcer models showed that n-hexane fraction produced the highest antiulcer activity. Percentage inhibition of gastric ulceration of misoprostol was 22.86 %, while that of n-hexane fraction was 28.57 % (p < 0.05). Evaluation of gastric and duodenal antiulcer effects on acysteamine induced gastric ulcer models showed that this fraction was effective against gastric and duodenal ulcer (83.3 %), improved ulcer damage (54.17 %), significantly reduced the number of mean ulcer and ulcer index (2.00 ± 1.28) but it did not change the area of the ulcer.

Investigation of antiulcer activity of Pergularia extensa Linn

2020 ◽  
Vol 9 (2) ◽  
pp. 23-26
Author(s):  
Pavani C H
Keyword(s):  
Cardiac Glycosides ◽  
Methanol Extract ◽  
Methanolic Extract ◽  
Antiulcer Activity ◽  
Acute Oral Toxicity ◽  
Gastric Lesions ◽  
Oral Toxicity ◽  
Control Groups ◽  
Dose Dependent

This study was based on determination of the antiulcer activity from methanol extract was prepared by using barks of pergularia extensa linn.. Priliminary investigations showed presence of saponins, terpenes, cardiac glycosides, alkaloids and sterols. Based on OECD-423 Guidelines, the pharmacology and acute oral toxicity studies were conducted by using methanolic extract. Ulcer development was prevented by Tannins because of their vasoconstriction effects and due to protein precipitation. Similarly, the Methanolic extract of Pergularia extensa Linn shows triterpenoids and saponins. The phytoconstituents are present in the extract and these could be possible agents which are involved in order to prevent gastric lesions induced by aspirin. When compared to ulcerative control groups, this Pergularia extensa Linn., shows a dose dependent curative ratio. The extracts exhibited an inhibition percentage of 27.18, 45.47 and 61.28 at doses of 100, 200 and 400mg/kg doses respectively. 

In vitro Action of Gastric Mucosal Lysosomal Enzymes on Intracellular Gastric Glycoproteins

1979 ◽  
Vol 34 (1-2) ◽  
pp. 90-95 ◽  
Author(s):  
Fouad M. Fouad ◽  
D. Waldron-Edward
Keyword(s):  
Cell Wall ◽  
Lysosomal Enzymes ◽  
Gastric Ulceration ◽  
Mucosal Cell ◽  
Gastric Lesions ◽  
Acid Hydrolases ◽  
Gastric Mucosal Cells ◽  
Mucosal Cells ◽  
Specific Increase

Abstract The results show that incubation of gastric mucosal cells from rat at pH ~4.5 or in the presence of aspirin is associated with a specific increase in the activity of some acid-hydrolases. Intracellular glycoproteins, isolated by non-degradative techniques from rat or dog fundic mucosal cells, were found to be potential bio-substrates for these acid-hydrolyses. This may suggest that cleavage of the carbohydrate moieties of the intracellular and mucosal cell wall glycoproteins is a fundamental step in the development of gastric ulceration. A model for gastric lesions is proposed and discussed in the light of the results obtained.

scholarly journals Optimized Self-Nanoemulsifying Delivery System Based on Plant-Derived Oil Augments Alpha-Lipoic Acid Protective Effects Against Experimentally Induced Gastric Lesions

Dose-Response ◽  
2021 ◽  
Vol 19 (1) ◽  
pp. 155932582110012
Author(s):  
Shaimaa M. Badr-Eldin ◽  
Usama A. Fahmy ◽  
Hibah M. Aldawsari ◽  
Osama A. A. Ahmed ◽  
Nabil A. Alhakamy ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Delivery System ◽  
Lipoic Acid ◽  
Tween 80 ◽  
Protective Effects ◽  
Alpha Lipoic Acid ◽  
Ulcer Index ◽  
Ulcer Disease ◽  
Mucosal Defect ◽  
Polyethylene Glycol 200

Peptic ulcer disease is an injury of the alimentary tract that leads to a mucosal defect reaching the submucosa. Alpha-lipoic acid (ALA), a natural potent antioxidant, has been known as a gastroprotective drug yet its low bioavailability may restrict its therapeutic efficacy. This study aimed to formulate and optimize ALA using a self-nanoemulsifying drug delivery system (SNEDDS) with a size of nano-range, enhancing its absorption and augmenting its gastric ulcer protection efficacy. Three SNEDDS components were selected as the design factors: the concentrations of the pumpkin oil (X1, 10–30%), the surfactant tween 80 (X2, 20–50%), and the co-surfactant polyethylene glycol 200 (X3, 30–60%). The experimental design for the proposed mixture produced 16 formulations with varying ALA-SNEDDS formulation component percentages. The optimized ALA-SNEDDS formula was investigated for gastric ulcer protective effects by evaluating the ulcer index and by the determination of gastric mucosa oxidative stress parameters. Results revealed that optimized ALA-SNEDDS achieved significant improvement in gastric ulcer index in comparison with raw ALA. Histopathological findings confirmed the protective effect of the formulated optimized ALASNEDDS in comparison with raw ALA. These findings suggest that formulation of ALA in SNEDDS form would be more effective in gastric ulcer protection compared to pure ALA.

scholarly journals Evaluation of a poly-herbal preparation for the treatment of peptic ulcer

2017 ◽  
Vol 12 (2) ◽  
pp. 11
Author(s):  
Zaman Hayat ◽  
Mueen Ahmad Chaudhry ◽  
. Alamgeer
Keyword(s):  
Peptic Ulcer ◽  
Gastric Ulcer ◽  
Treated Group ◽  
Ulcer Formation ◽  
Ulcer Index ◽  
Herbal Formulation ◽  
High K ◽  
Ulcer Model ◽  
Dose Dependent ◽  
Gross Examination

<p class="Abstract">The aim of this study was to validate the traditional uses of ulcerene, a poly-herbal formulation in ethanol, aspirin and stress-induced gastric ulcer model of rat. The extent of gastric ulcer formation was studied, using ulcer score, ulcer index, percentage cure through gross examination and histopathological evaluation. A significant (p&lt;0.001) dose-dependent anti-ulcerant effect was observed in ulcerene (50 and 100 mg/kg)-treated group with highest effectiveness against ethanol-induced ulcer. The concentration-dependent spasmolytic effect was seen in spontaneously contracting, high K<sup>+</sup> (80 mM) and carbachol (1 µM)-induced jejunum contractions (10, 0.3 and 1 mg/mL), similar to dicyclomine (10, 1 and 3 µM), indicated non-specific spasmolytic mechanism behind the effect. By considering these results, ulcerene can be suggested for the treatment of peptic ulcer.</p>

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