scholarly journals INFECTIOUS EXACERBATION OF BRONCHIECTASIS SUCCESSFULLY TREATED WITH CEFTRIAXONE/SULBACTAM/DISODIUM EDETATE-1034 (ELORES™)

2017 ◽  
Vol 10 (2) ◽  
pp. 407
Author(s):  
Ninik Mudjihartini
Keyword(s):  
Brain Tissue ◽  
Hemorrhagic Stroke ◽  
Hypoxic Condition ◽  
Normal Subjects ◽  
The Elderly ◽  
Health Concern ◽  
Stroke Patients ◽  
Significant Difference ◽  
Hypoxia Ischemia ◽  
The Brain

Objective: Strokes remain a significant health concern and are the highest cause of mortality and physical or mental disability in productive and the elderly hospitalized patients in Indonesia. Neuroglobin (Ngb) mostly located in the central and peripheral nervous system, predicted enhanced neuronal survival under hypoxic condition, such as in a stroke. The aim of this study is to observe the response of the brain tissue of hemorrhagic stroke patients against hypoxic/ischemic conditions. The objectives are to recognize the pattern of Ngb expression in the brain tissue and plasma of hemorrhagic stroke patients, and furthermore, to compare the level of Ngb in the brain tissue and plasma of hemorrhagic stroke patients.Methods: This is an observational study with consecutive sampling methods using cerebral cortex and the blood of hemorrhagic stroke patients, who underwent craniotomies to evacuate hematomas at Cipto Mangunkusumo Hospital (RSCM) and other hospitals in Jakarta. Ngb expression was measured in brain tissue and blood using real time reverse transcription polymerase chain reaction, while the ELISA method was adopted to measure Ngb protein in plasma.Results: Hypoxia/ischemia in the brain tissue of hemorrhagic stroke patients increased the expression of Ngb in brain tissue compared to the blood. The level of Ngb protein in plasma of hemorrhagic stroke patients increased significantly compared to normal subjects; however, there is no significant difference between the plasma and brain tissue of hemorrhagic stroke patients.Conclusion: Hypoxia/ischemia in hemorrhagic stroke patients increases the expression of Ngb mRNA and protein level.Keywords: Neuroglobin, Hypoxia, Hemorrhagic stroke.

scholarly journals Comparison of Tryglicerides Levels and Total Cholesterol in Ischemic Stroke and Haemorrhagic Stroke Patients

2020 ◽  
Vol 1 (2) ◽  
pp. 49
Author(s):  
Hijriyah Putri Tarmizi Hasibuan ◽  
Isra Thristy
Keyword(s):  
Ischemic Stroke ◽  
Total Cholesterol ◽  
Large Scale ◽  
Hemorrhagic Stroke ◽  
Total Cholesterol Level ◽  
Haemorrhagic Stroke ◽  
Total Sample ◽  
Stroke Patients ◽  
Average Value ◽  
Significant Difference

Background: Stroke is the second largest cause of death in the world. Stroke is classified based on its etiology as ischemic stroke and hemorrhagic stroke. Most large-scale studies on the risk of total cholesterol and triglyceride levels in stroke are not distinguished between ischemic and hemorrhagic strokes. Purposes: The purpose of this study was to determine the comparison of triglyceride and total cholesterol levels in ischemic stroke patients with hemorrhagic stroke. Method: Descriptive analytic study using medical records of patients at Medan Haji General Hospital in 2018-2019. The number of ischemic stroke patients is 28 patients and hemorrhagic stroke 28 patients with a total sample of 56 patients. Results: In ischemic stroke patients, the average value of triglyceride levels was 144.75 mg/dL and the average value of total cholesterol was 250.93 mg/dL. In hemorrhagic stroke patients, the average value of triglyceride levels is 126.93 mg/dL and the average total cholesterol level is 174.25 mg/dL. Conclusion: From this study we found a significant difference in total cholesterol between ischemic and hemorrhagic strokes. No significant difference was found in triglycerides between ischemic and hemorrhagic strokes.

scholarly journals Repeatability of the Evaluation of Perception of Dyspnea in Normal Subjects Assessed Through Inspiratory Resistive Loads

2014 ◽  
Vol 8 (1) ◽  
pp. 41-47 ◽  
Author(s):  
Andréia K Fernandes ◽  
Bruna Ziegler ◽  
Glauco L Konzen ◽  
Paulo R.S Sanches ◽  
André F Müller ◽  
...  
Keyword(s):  
Normal Subjects ◽  
Cross Sectional Study ◽  
Resistive Load ◽  
Cross Sectional ◽  
Intra Class Correlation ◽  
Significant Difference ◽  
Loading System ◽  
Resistive Loads ◽  
The Brain ◽  
Intra Class Correlation Coefficient

Purpose: Study the repeatability of the evaluation of the perception of dyspnea using an inspiratory resistive loading system in healthy subjects. Methods: We designed a cross sectional study conducted in individuals aged 18 years and older. Perception of dyspnea was assessed using an inspiratory resistive load system. Dyspnea was assessed during ventilation at rest and at increasing resistive loads (0.6, 6.7, 15, 25, 46.7, 67, 78 and returning to 0.6 cm H2O/L/s). After breathing in at each level of resistive load for two minutes, the subject rated the dyspnea using the Borg scale. Subjects were tested twice (intervals from 2 to 7 days). Results: Testing included 16 Caucasian individuals (8 male and 8 female, mean age: 36 years). The median scores for dyspnea rating in the first test were 0 at resting ventilation and 0, 2, 3, 4, 5, 7, 7 and 1 point, respectively, with increasing loads. The median scores in the second test were 0 at resting and 0, 0, 2, 2, 3, 4, 4 and 0.5 points, respectively. The intra-class correlation coefficient was 0.57, 0.80, 0.74, 0.80, 0.83, 0.86, 0.91, and 0.92 for each resistive load, respectively. In a generalized linear model analysis, there was a statistically significant difference between the levels of resistive loads (p<0.001) and between tests (p=0.003). Dyspnea scores were significantly lower in the second test. Conclusion: The agreement between the two tests of the perception of dyspnea was only moderate and dyspnea scores were lower in the second test. These findings suggest a learning effect or an effect that could be at least partly attributed to desensitization of dyspnea sensation in the brain.

scholarly journals CT Imaging and Spontaneous Behavior Analysis After Osmotic Blood-Brain Barrier Opening in Wistar Rat

2014 ◽  
pp. S529-S534 ◽  
Author(s):  
P. KOZLER ◽  
V. RILJAK ◽  
K. JANDOVÁ ◽  
J. POKORNÝ
Keyword(s):  
Locomotor Activity ◽  
Brain Edema ◽  
Brain Tissue ◽  
Blood Brain Barrier ◽  
Spontaneous Locomotor Activity ◽  
Brain Barrier ◽  
Male Rats ◽  
Blood Brain ◽  
Significant Difference ◽  
The Brain

In our previous experiments we demonstrated that osmotic opening of the blood brain barrier (BBB) in rats by administration of mannitol into the internal carotid artery leads to cerebral edema. The aim of this study was to confirm objectively the development of brain edema and determine whether it affects spontaneous locomotor activity in rats (SLA). Brain edema was verified by computer tomography (CT) examination of the brain and SLA was observed during open field test. Twenty four adult male rats were divided into four groups of six: (1) control animals (C), (2) controls with anesthesia (CA), (3) controls with sham surgery (CS), (4) experimental – osmotic opening of the BBB (MA). Osmotic BBB disruption manifested by reducing the density of brain tissue (hypodensity), suggesting a higher water content in the brain tissue. SLA was compared between C, CA, CS and MA groups and between MA and CA groups. Significant difference was found only between the control group and MA group. In the first 30 min of the examination, rats after the mannitol administration revealed a marked limitation of spontaneous locomotor activity. Experimental results demonstrated reduction of spontaneous locomotor activity in rats with induced brain edema.

scholarly journals Histological Evaluation of Brain Tissue in Dyslipidemic Rats Treated with Dietary Supplements Based on Amazonian Fruits

2021 ◽  
pp. 46-58
Author(s):  
Matheus Vinícius de Souza Carneiro ◽  
Ricardo de Queiroz Freitas ◽  
Lucas Baltar Rodrigues ◽  
Wenberger Lanza Daniel de Figueiredo ◽  
Geane Antiques Lourenço ◽  
...  
Keyword(s):  
Brain Tissue ◽  
Neuronal Damage ◽  
Female Rats ◽  
Histological Evaluation ◽  
Control Group ◽  
Neurotoxic Effect ◽  
Significant Difference ◽  
The Mean ◽  
The Brain ◽  
Amazonian Fruits

Aims: By using histological analysis, the study aims to evaluate the effect of a nutraceutical based on the Amazonian fruits of camu-camu (Myrciaria dubia (Kunth) Mc Vaugh), acai (Euterpe precatoria Mart.) and guarana (Paullinia cupana) on the brain tissue (hippocampus) of dyslipidemic rats. Methodology: Preclinical trials were conducted using male and female rats (n=30) of the Wistar strain (Rattus norvegicus) that were randomly divided into five groups (G) (n=6). G1 was control, G2 was induced to obesity with consumption of experimental feed (hypercaloric and hyperlipidic), G3 was induced to obesity with consumption of experimental feed and treated with simvastatin (50 mg/kg/day), and G4 and G5, which were induced to obesity with the consumption of experimental feed and supplemented with 100 mg/kg/day and 200 mg/kg/day of the formulation, respectively. The study period was 72 days, and, for 37 days, induction to obesity was performed with the experimental feed (hypercaloric and hyperlipidic). During the following weeks, for 35 days, after division of the groups, certain groups received, in parallel, treatment with simvastatin (G3) or supplementation with the nutraceutical (G4 and G5). Subsequently, histological slides of the brain tissue stained with violet cresyl were elaborated, photographed and analyzed. Results: No significant differences were observed between the mean of intact neurons among the experimental groups induced to obesity. The neurotoxic effect, evidenced by the significant difference between the mean of intact neurons between the control group and obesity-induced groups, corroborates the findings of neuronal damage and degenerative processes reported in the literature. Conclusion: The nutraceutical based on Amazonian fruits was not able to prevent the neurotoxic effect arising from the hyperlipidic and hypercaloric diet, and therefore did not present a neuroprotective effect in Wistar rats under the conditions established in the experiment.

scholarly journals ELECTROLYTE DISTURBANCE IN HEMORRHAGIC AND NON-HEMORRHAGIC STROKE PATIENTS IN AL-DIWANIYAH TEACHING HOSPITAL

2018 ◽  
Vol 11 (11) ◽  
pp. 456
Author(s):  
Aqeel Raheem Hassan ◽  
Zahraa Adel Aryan
Keyword(s):  
Ischemic Stroke ◽  
Teaching Hospital ◽  
Serum Potassium ◽  
Sodium Level ◽  
Hemorrhagic Stroke ◽  
Control Group ◽  
Stroke Patients ◽  
Cross Sectional ◽  
Electrolyte Disturbance ◽  
Significant Difference

Objectives: Although there are many studies on stroke, few studies on electrolyte disturbance have been done in our country, even on the outside. Our aim in this study is to estimate the level of serum potassium and sodium in acute stroke patients with comparison to patients of the control group.Methods: Our study is a comparative cross-sectional study conducted on patients in the neurological center who suffer from stroke and others in medicine department admitted for any disease other than cerebrovascular accidents (CVA) they consider the control group. All were in AL-Diwaniyah Teaching Hospital from April to July 2018. The level of potassium and sodium from all patients is estimated. Patients with ischemic stroke, hemorrhagic stroke, and transient ischemic attack (TIA) were classified into having Glasgow coma scores (GCS) of 3–8, 9–12, and 13–15, respectively.Result: Significant difference was seen in the distribution of patients according to GCS levels (p=0.014). Mean serum sodium was significantly lowest in hemorrhagic stroke, then ischemic stroke, followed by TIA, and the highest sodium level was seen in the control group (p<0.001). Mean serum potassium was significantly lowest in hemorrhagic stroke, then ischemic stroke, followed by TIA, and the highest sodium level was seen in the control group (p<0.001). Mean serum-to-potassium ratio was significantly highest in hemorrhagic stroke, then TIA, followed by ischemic stroke, and finally, by control group (p<0.001).Conclusion: This study reveals that, in hemorrhagic stroke, the incidence of electrolytes imbalance was more than ischemic and which was mostly hyponatremia and hypokalemia.

scholarly journals “A Study of Electrolyte imbalance in stroke patients”.

2018 ◽  
Vol 29 (1) ◽  
pp. 39-42
Author(s):  
Mohammad Zakir Hossain ◽  
Md Soroar Hossain ◽  
Satya Ranjan Sutradhar ◽  
PM Basak ◽  
MN Islam
Keyword(s):  
Prospective Observational Study ◽  
Hemorrhagic Stroke ◽  
Venous Blood ◽  
The Elderly ◽  
Developed Countries ◽  
Electrolyte Imbalance ◽  
Stroke Patients ◽  
Short Term ◽  
Artery Disease ◽  
The Developed Countries

Background: After coronary artery disease and cancer, stroke is the third commonest cause of death in the developed countries. Mortality risk is quite variable among stroke patients. Careful and early risk evaluation of each patient is therefore important. Electrolyte imbalance is a common phenomenon after stroke, particularly in the elderly. This research will provide the information regarding electrolyte imbalance in stroke patients.Objective: To find out prevalence of different type of electrolyte imbalance between ischemic and hemorrhagic stroke patients. Method: This short term prospective observational study was done in Medicine dept. of MMCH. We valuated 50 patients of Stroke admitted in hospital. Venous blood sample was collected for electrolyte. Additional clinical data was recorded including detailed complications of Stroke.Results: Out of 50 patients of Stroke the percentage of hypernatremia, hyponatremia, hypokalemia, hyperchloremia, hypochloremia, metabolic acidosis and metabolic alkalosis were higher in patients with Hemorrhagic stroke (27.3%,18.2%, 9.1%,18.2%, 45.5%, 18.2% and 9.2% respectively) than ischemic stroke patients (3.6%,7.1%, 3.6%, 0%, 3.6%, 0%, and 2.6% respectively).TAJ 2016; 29(1): 39-42

scholarly journals TINJAUAN PENGGUNAAN DAN POTENSI INTERAKSI OBAT ANTIKEJANG DENGAN OBAT LAIN PADA PASIEN STROKE PERDARAHAN RAWAT INAP RSUP PROF. DR. R. D. KANDOU MANADO

PHARMACON ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 239
Author(s):  
Vionita L. Porogoi ◽  
Weny Indayany Wiyono ◽  
Heedy Tjitrosantoso
Keyword(s):  
Drug Interactions ◽  
Medical Records ◽  
Hemorrhagic Stroke ◽  
Scar Tissue ◽  
Retrospective Data ◽  
Inclusion Criteria ◽  
Cerebral Blood Vessels ◽  
Stroke Patients ◽  
Neurological Problem ◽  
The Brain

ABSTRACK Hemorrhagic stroke is a stroke caused by intra-cerebral hemorrhage or subarachniod hemorrhage due to rupture of cerebral blood vessels in certain areas so that blood fills the brain tissue. Seizures are the most common neurological problem in stroke patients. The occurrence of seizures due to stroke is believed to be the presence of lesions in the brain during a stroke and the formation of scar tissue. This study discusses the use of anti-seizures and the potential of anti-seizure interactions of hemorrhagic stroke patients in inpatient at RSUP Prof. Dr. R. D. Kandou Manado. This study is involved retrospective data on 30 medical records of stroke patients with Hemorrhage in inpatients that met the inclusion criteria. Phenytoin as many as 23 (76,67%), phenytoin combined with Diazepam can occur as many as 4 (13,33%) and Diazepam by 3 (10%). Drug interactions, phenytoin combined with nicardipine which occurs as many as 2 (40%) interactions occur, phenytoin combined with Diazepam can occur as many as 3 (60%) interactions occur. Based on interactions, pharmacokinetic interactions were 5 (100%) occurrences.  Keywords: Hemorrhagic Stroke, anti-seizures, drug interactions ABSTRAK Stroke hemoragik adalah stroke yang disebabkan oleh perdarahan intraserebral atau perdarahan subaraknoid akibat pecahnya pembuluh darah otak di daerah tertentu sehingga darah mengisi jaringan otak. Kejang adalah masalah neurologis yang paling umum pada pasien stroke. Terjadinya kejang akibat stroke dipercayai adanya lesi di otak selama stroke dan pembentukan jaringan parut. Penelitian ini membahas penggunaan anti-kejang dan potensi interaksi anti-kejang pasien stroke hemoragik di rawat inap di RSUP Prof. Dr. R. D. Kandou Manado. Penelitian ini melibatkan data retrospektif pada 30 catatan medis pasien stroke dengan Perdarahan pada pasien rawat inap yang memenuhi kriteria inklusi. Fenitoin sebesar 23 (76,67%), Fenitoin dikombinasikan dengan Diazepam sebesar 4 (13,33%)., dan Diazepam sebesar 3 (10%). Interaksi obat, fenitoin yang dikombinasikan dengan nicardipine yang terjadi sebanyak 2 (40%) interaksi terjadi, fenitoin yang dikombinasikan dengan Diazepam dapat terjadi sebanyak 3 (60%) interaksi terjadi. Berdasarkan interaksi, interaksi farmakokinetik adalah 5 (100%) kejadian.  Kata kunci: Stroke Hemoragik, anti-kejang, interaksi obat

scholarly journals Analisis Kinerja Algoritma Mesin Pembelajaran untuk Klarifikasi Penyakit Stroke Menggunakan Citra CT Scan

2020 ◽  
Vol 7 (4) ◽  
pp. 833
Author(s):  
Nur Sakinah ◽  
Tessy Badriyah ◽  
Iwan Syarif
Keyword(s):  
Deep Learning ◽  
Ct Scan ◽  
Hemorrhagic Stroke ◽  
Image Data ◽  
Machine Learning Algorithms ◽  
Support Vector ◽  
Gray Level ◽  
Stroke Patients ◽  
Occurrence Matrix ◽  
The Brain

<p>Stroke adalah suatu kondisi dimana pasokan darah ke otak terganggu sehingga bagian tubuh yang dikendalikan oleh area otak yang rusak tidak dapat berfungsi dengan baik. Penyebab stroke antara lain adalah terjadinya penyumbatan pada pembuluh darah (stroke iskemik) atau pecahnya pembuluh darah (stroke hemoragik). Pasien yang terkena stroke harus segera ditangani secepatnya karena sel otak dapat mati dalam hitungan menit. Tindakan penanganan stroke secara cepat dan tepat dapat mengurangi resiko kerusakan otak dan mencegah terjadinya komplikasi. Penelitian ini bertujuan untuk mengembangkan perangkat lunak yang dapat membaca dan menganalisis citra CT scan dari otak, dan kemudian secara otomatis memprediksi apakah citra CT scan tersebut stroke iskemik atau stroke hemoragik. Data citra CT scan berasal dari Rumah Sakit Umum Haji Surabaya yang diambil selama periode Januari-Mei 2019 dan berasal dari 102 pasien yang terindikasi stroke. Sebelum data gambar tersebut diolah dengan menggunakan beberapa algoritma mesin pembelajaran, data tersebut melalui tahap pre-processing yang bertujuan untuk meningkatkan kualitas citra meliputi konversi citra, pemotongan citra, penskalaan, greyscaling, penghilangan noise dan augmentasi. Tahap selanjutnya adalah ekstraksi fitur menggunakan metode Gray-Level Co-Occurrence Matrix (GLCM). Penelitian ini juga bertujuan untuk membandingkan kinerja lima algoritma mesin pembelajaran yaitu Naïve Bayes, Logistic Regression, Neural Network, Support Vector Machine dan Deep Learning yang diterapkan untuk memprediksi penyakit stroke. Hasil percobaan menunjukkan bahwa algoritma Deep Learning menghasilkan tingkat performansi paling tinggi yaitu nilai akurasi 96.78%, presisi 97.59% dan recall 95.92%.</p><p> </p><p><em><strong>Abstract</strong></em></p><p><em>Stroke is a condition in which the blood supply to the brain is interrupted so that parts of the body that are controlled by damaged brain areas cannot function properly. Causes of strokes include blockages in blood vessels (ischemic stroke) or rupture of blood vessels (hemorrhagic stroke). Stroke patients must be treated as soon as possible because brain cells can die within minutes. The handling of stroke patients quickly can reduce the risk of brain damage and prevent complications. This study aims to develop software that can read and analyze CT scan images from the brain, and then automatically predict whether the CT scan images are ischemic stroke or hemorrhagic stroke. The CT scan image data came from the Surabaya Hajj General Hospital which was taken during the January-May 2019 period and came from 102 patients who had indicated a stroke. Before the image data is processed using several machine learning algorithms, the data goes through a pre-processing phase which aims to improve image quality including image conversion, image cutting, scaling, greyscaling, noise removal and augmentation. The next step is feature extraction using the Gray-Level Co-Occurrence Matrix (GLCM) method. This study also aims to compare the performance of five machine learning algorithms, namely Naïve Bayes, Logistic Regression, Neural Networks, Support Vector Machines and Deep Learning which are applied to predict stroke. The experimental results show that the deep learning algorithm produces the highest level of performance where the accuracy value is 96.78%, 97.59% precision and 95.92% recall.</em></p><p><em><br /></em></p>

scholarly journals Gambaran NIHSS pada Pasien Stroke di Ruang Rawat Inap Neurologi RSUP Prof. Dr. R. D. Kandou Manado periode Juli 2014 - Juni 2015

e-CliniC ◽  
2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Yunike M. Arisoy ◽  
Junita Maja PS ◽  
Theresia Runtuwene
Keyword(s):  
Educational Level ◽  
Hemorrhagic Stroke ◽  
Secondary Data ◽  
Measurement Tool ◽  
Stroke Patients ◽  
High School Degree ◽  
Normal Category ◽  
Discharged Patients ◽  
Male Patients ◽  
The Brain

Abstract: Stroke is the interruption of blood flow to the brain that occurs suddenly and persists for more than 24 hours, which can cause disability. NIHSS is a measurement tool assessing the outcomes of stroke. This study aimed to describe NIHSS in stroke patients in the Neurology Departement of Prof. Dr. R. D. Kandou Manado, for the period of July 2014 – June 2015. This is a descriptive retrospective study which used secondary data in the form of inpatients medical record. The result of this study showed that 136 stroke patients who met the criteria used the NIHSS examination with a total of 73 male patients (53,7%) and 63 female patients (46,3%). The largest age group was 41 – 65 years with a total of 96 patients (70,58%) and based on the educational level, most patients had high school degree or equivalent as the latest educational level with a total of 66 patients (48,52%). NIHSS examination in admitted hemorrhagic stroke patients were 28 patients (60%) consisting of 3 patients in the minor category, 16 patients in the moderate category, and 9 patients in the severe category, whereas the discharged patients were 19 patients (40%), consisting of 6 patients in the normal category, 5 patients in the minor category, 6 patients in the moderate category, and 2 patients in the severe category. NIHSS examination in admitted non-hemorrhagic stroke patients were 45 patients (51%), consisting of 3 patients in the minor category, 32 patients in the moderate category, and 10 patients in the severe category, whereas discharged patients were 44 patients (49%) consisting of 6 patients in the normal category, 10 patients in the minor category, 26 patients in the moderate category, and 2 patients in the severe category.Keywords: Stroke Patients, NIHSS Examination Abstrak: Stroke adalah gangguan aliran darah ke otak yang terjadi mendadak dan bertahan dalam waktu lebih dari 24 jam, yang dapat menimbulkan kecacatan. Pemeriksaan NIHSS merupakan alat ukur yang di gunakan menilai luaran stroke. Penelitian ini bertujuan untuk mengetahui gambaran NIHSS pada pasien stroke di ruang rawat inap Neurologi Prof. Dr. R. D. Kandou Manado, periode Juli 2014 - Juni 2015. Penelitian ini bersifat deskriptif retrospektif dengan memanfaatkan data sekunder berupa catatan rekam medik pasien rawat inap. Hasil penelitian ini didapatkan 136 pasien stroke yang memenuhi kriteria menggunakan pemeriksaan NIHSS dengan jumlah pasien laki-laki sebanyak 73 pasien (53,7%) dan perempuan 63 pasien(46,3%). Kelompok umur terbanyak adalah 41-65 tahun dengan jumlah 96 pasien (70,58%) dan kategori pendidikan terakhir paling banyak SMA atau sederajat didapatkan sebanyak 66 pasien (48,52%). Pemeriksaan NIHSS pada stroke hemoragik yang masuk sebanyak 28 pasien (60%) dengan kategori ringan 3 pasien, sedang 16 pasien, dan berat 9 pasien sedangkan pasien keluar sebanyak 19 pasien (40%) dengan kategori normal 6 pasien, ringan 5 pasien, sedang 6 pasien, dan berat 2 pasien. Pemeriksaan NIHSS pada stroke non hemoragik yang masuk sebanyak 45 pasien (51%) dengan kategori ringan 3 pasien, sedang 32 pasien, dan berat 10 pasien sedangkan pasien keluar sebanyak 44 pasien (49%) dengankategori normal 6 pasien, ringan 10 pasien, sedang 26 pasien, dan berat 2 pasien.Kata kunci : Pasien Stroke, Pemeriksaan NIHSS

Abstract W P139: Differential Impact of Preadmission Selective Serotonin Reuptake Inhibitor Treatment on Stroke Outcomes Among Ischemic and Hemorrhagic Stroke Patients? A Nationwide Propensity Score-Matched Follow-Up Study

Stroke ◽  
2014 ◽  
Vol 45 (suppl_1) ◽  
Author(s):  
Janne K Mortensen ◽  
Heidi Larsson ◽  
Grethe Andersen ◽  
Søren P Johnsen
Keyword(s):  
Propensity Score ◽  
Hemorrhagic Stroke ◽  
Conditional Logistic Regression ◽  
Case Fatality ◽  
Stroke Patients ◽  
Severe Stroke ◽  
Risk Of Death ◽  
Follow Up Study ◽  
Significant Difference

Introduction: SSRIs are widely used for treating post-stroke depression and pathological crying and appear to have antithrombotic effects that may increase the risk of bleeding. Increasing evidence further suggests a neuroprotective effect in stroke, however clinical data are sparse. Aim and hypothesis: We aimed to examine the implications of pre-admission SSRI use in patients with ischemic and hemorrhagic stroke. We hypothesized a neuroprotective and antithrombotic effect leading to less severe strokes and decreased 30-day mortality among the ischemic strokes, and a possible reverse effect among the hemorrhagic strokes. Methods: We did a nationwide registry-based follow-up study among ischemic and hemorrhagic stroke patients in Denmark between 2003 and 2011. We identified 4348 pre-admission SSRI users (556 hemorrhagic strokes) and 4348 propensity score-matched non-users in the Danish Stroke Registry. Multiple conditional logistic regression was used to compute odds ratios (OR) of severe stroke (as measured on the Scandinavian Stroke Scale) and death within 30 days after stroke. Analyses were repeated after excluding patients with hemorrhagic stroke. Results: For the stroke types combined, pre-admission SSRI use was associated with a higher risk of severe stroke (adjusted OR, 1.12; CI, 1.00-1.25) and a non-significantly higher risk of death within 30 days (adjusted OR, 1.27; CI, 0.73-2.19). In contrast, no statistically significant difference in risk of severe stroke (adjusted OR, 1.06; CI, 0.92-1.21) or death within 30 days (adjusted OR, 0.81; CI, 0.38-1.77) was found between pre-admission SSRI-users and non-users after excluding patients with hemorrhagic stroke. Conclusion: Our results suggest that pre-admission SSRI use may be associated with a higher risk of severe stroke and case-fatality in patients with hemorrhagic stroke, but not in patients with ischemic stroke. Further studies are warranted to explore the possible neuroprotective and hemorrhagic effects of SSRI treatment in patients admitted with acute stroke.

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