scholarly journals Vitex trifolia: AN ETHNOBOTANICAL AND PHARMACOLOGICAL REVIEW

2018 ◽  
Vol 11 ◽  
Author(s):  
Suchitra M,
Keyword(s):  
Amino Acids ◽  
Secondary Metabolites ◽  
Plant Species ◽  
Plant Extracts ◽  
Clinical Studies ◽  
Clinical Relevance ◽  
Polyphenolic Compounds ◽  
Rich Source ◽  
Medicinal Uses ◽  
Anti Inflammatory

Objective: The perspective of this review is the list of activities carried out or studied along with description, habitat macro-microscopy, phytoconstituents, medicinal uses, clinical studies, and toxicology on the plant Vitex trifolia. Methods: A large number of the species of the Genus Vitex are widely employed in Indian traditional systems of medicine. A total of 270 plant species of genus Vitex have been identified worldwide. V. trifolia is used in Ayurveda and Unani. These species are rich source of secondary metabolites such as polyphenolic compounds, terpenoids, phytosterols, protein and amino acids, tannins, and saponins.Results: The results of various studies V. trifolia possess larvicidal, analgesic, anti-inflammatory, antimicrobial, antioxidant, hepatoprotective, antihistaminic, and antiasthmatic properties.Conclusion: The review on V. trifolia explains that there is a need for detailed study on its clinical relevance and safety of plant extracts.

scholarly journals Meroterpenoids: A Comprehensive Update Insight on Structural Diversity and Biology

Biomolecules ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 957
Author(s):  
Mamona Nazir ◽  
Muhammad Saleem ◽  
Muhammad Imran Tousif ◽  
Muhammad Aijaz Anwar ◽  
Frank Surup ◽  
...  
Keyword(s):  
Amino Acids ◽  
Secondary Metabolites ◽  
Biological Effects ◽  
Structural Diversity ◽  
Chemical Diversity ◽  
Biosynthetic Pathways ◽  
Natural Sources ◽  
Hybrid Compounds ◽  
Anti Inflammatory

Meroterpenoids are secondary metabolites formed due to mixed biosynthetic pathways which are produced in part from a terpenoid co-substrate. These mixed biosynthetically hybrid compounds are widely produced by bacteria, algae, plants, and animals. Notably amazing chemical diversity is generated among meroterpenoids via a combination of terpenoid scaffolds with polyketides, alkaloids, phenols, and amino acids. This review deals with the isolation, chemical diversity, and biological effects of 452 new meroterpenoids reported from natural sources from January 2016 to December 2020. Most of the meroterpenoids possess antimicrobial, cytotoxic, antioxidant, anti-inflammatory, antiviral, enzyme inhibitory, and immunosupressive effects.

scholarly journals Antinociceptive, Anti-Inflammatory, and Antipyretic Activity of Mangrove Plants: A Mini Review

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
J. A. Shilpi ◽  
M. E. Islam ◽  
M. Billah ◽  
K. M. D. Islam ◽  
F. Sabrin ◽  
...  
Keyword(s):  
Natural Products ◽  
Biological Activity ◽  
Plant Species ◽  
Active Compound ◽  
Medicinal Uses ◽  
Antipyretic Activity ◽  
Mangrove Plants ◽  
The World ◽  
Anti Inflammatory ◽  
The Web

Mangrove plants are specialised plants that grow in the tidal coasts of tropic and subtropic regions of the world. Their unique ecology and traditional medicinal uses of mangrove plants have attracted the attention of researchers over the years, and as a result, reports on biological activity of mangrove plants have increased significantly in recent years. This review has been set out to compile and appraise the results on antinociceptive, anti-inflammatory, and antipyretic activity of mangrove plants. While the Web of Knowledge, Google Scholar, and PubMed were the starting points to gather information, other pieces of relevant published literature were also adequately explored for this purpose. A total of 29 reports on 17 plant species have been found to report such activities. While 19 reports were on the biological activity of the crude extracts, 10 reports identified the active compound(s) of various chemical classes of natural products including terpenes, steroids, and flavonoids. This review finds that antinociceptive, anti-inflammatory, and antipyretic activity appears to be widespread in mangrove plants.

scholarly journals The Anti-Inflammatory and Antimicrobial Potential of Selected Ethnomedicinal Plants from Sri Lanka

Molecules ◽  
2020 ◽  
Vol 25 (8) ◽  
pp. 1894
Author(s):  
Mayuri Napagoda ◽  
Jana Gerstmeier ◽  
Hannah Butschek ◽  
Sudhara De Soyza ◽  
Simona Pace ◽  
...  
Keyword(s):  
Sri Lanka ◽  
Secondary Metabolites ◽  
Medicinal Plant ◽  
Plant Species ◽  
Medicinal Plant Species ◽  
Human Neutrophils ◽  
Scavenging Activity ◽  
Garcinia Cambogia ◽  
Ms Analysis ◽  
Anti Inflammatory

Traditional folk medicine in Sri Lanka is mostly based on plants and plant-derived products, however, many of these medicinal plant species are scientifically unexplored. Here, we evaluated the anti-inflammatory and antimicrobial potency of 28 different extracts prepared from seven popular medicinal plant species employed in Sri Lanka. The extracts were subjected to cell-based and cell-free assays of 5-lipoxygenase (5-LO), microsomal prostaglandin E2 synthase (mPGES)-1, and nitric oxide (NO) scavenging activity. Moreover, antibacterial and disinfectant activities were assessed. Characterization of secondary metabolites was achieved by gas chromatography coupled to mass spectrometric (GC-MS) analysis. n-Hexane- and dichloromethane-based extracts of Garcinia cambogia efficiently suppressed 5-LO activity in human neutrophils (IC50 = 0.92 and 1.39 µg/mL), and potently inhibited isolated human 5-LO (IC50 = 0.15 and 0.16 µg/mL) and mPGES-1 (IC50 = 0.29 and 0.49 µg/mL). Lipophilic extracts of Pothos scandens displayed potent inhibition of mPGES-1 only. A methanolic extract of Ophiorrhiza mungos caused significant NO scavenging activity. The lipophilic extracts of G. cambogia exhibited prominent antibacterial and disinfectant activities, and GC-MS analysis revealed the presence of fatty acids, sesquiterpenes and other types of secondary metabolites. Together, our results suggest the prospective utilization of G. cambogia as disinfective agent with potent anti-inflammatory properties.

Verbena officinalis (Common Vervain) – A Review on the Investigations of This Medicinally Important Plant Species

Planta Medica ◽  
2020 ◽  
Vol 86 (17) ◽  
pp. 1241-1257 ◽  
Author(s):  
Paweł Kubica ◽  
Agnieszka Szopa ◽  
Jakub Dominiak ◽  
Maria Luczkiewicz ◽  
Halina Ekiert
Keyword(s):  
Essential Oil ◽  
Plant Species ◽  
Current Knowledge ◽  
Folk Medicine ◽  
In Vivo Studies ◽  
Medicinal Uses ◽  
Phenylpropanoid Glycosides ◽  
Anti Inflammatory

Abstract Verbena officinalis (common vervain) is a medicinal plant species widely distributed in the world and commonly used in folk medicine of different countries, including traditional Chinese medicine. Monographs on “Verbenae herba” have been included in the European Pharmacopoeia since 2008, and in the Chinese Pharmacopoeia since 1995. This work presents botanical characteristics of this species. It reviews the current knowledge of its chemical composition, which is a rich source mostly of iridoids, phenylpropanoid glycosides, phenolic acids, flavonoids, terpenoids, and essential oil. A large part of this article summarizes traditional medicinal uses and professional pharmacological in vitro and in vivo studies that prove new important applications, e.g., antioxidant, antimicrobial, anti-inflammatory, neuroprotective anticancer, analgesic, or anticonvulsant of verbena herb extracts and individual metabolites. Moreover, emphasis is put on the use of V. officinalis in the food and cosmetics industries, especially due to its antioxidant, antibacterial, and anti-inflammatory properties, and the presence of essential oil with an attractive fragrance composition. This paper also presents the state of biotechnological studies of this species.

scholarly journals Ethnopharmacological and toxicological review of Cydonia oblonga M.

2018 ◽  
Vol 64 (02) ◽  
pp. 3-16
Author(s):  
Katerina Cvetkovska ◽  
Biljana Bauer
Keyword(s):  
Secondary Metabolites ◽  
Medicinal Plant ◽  
Organic Acids ◽  
Pharmacological Effects ◽  
Cydonia Oblonga ◽  
Medicinal Uses ◽  
Urinary Infections ◽  
Wide Range ◽  
Anti Inflammatory

Abstract Cydonia oblonga M. is a medicinal plant of family Rosaceae which is used to prevent or treat several ailments such as cancer, diabetes, hepatitis, ulcer, respiratory, and urinary infections, etc. Cydonia oblonga commonly known as quince is rich in useful secondary metabolites such as phenolics, steroids, flavonoids, terpenoids, tannins, organic acids, and glycosides. It shows a wide range of pharmacological effects like antioxidant, antibacterial, antifungal, anti-inflammatory, hepatoprotective, cardiovascular, antidepressant, hypolipidemic, diuretic, etc. The polysaccharide mucus, glucuronoxylane located in the seeds of the quince, is used in the dermatology, for the production of wound patches. The aim of this paper focuses on detailed research on the value of phytochemicals, as pharmacological and attributes of phytomedicine herbs. Keywords: Cydonia oblonga, phytomedicine, pharmacological attributes, folk medicinal uses, quince

Evaluation of different analytical methodologies for the analysis of amino acids in plant extracts

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
M Nasimullah Qureshi ◽  
G Stecher ◽  
MA Hashir ◽  
T Sultana ◽  
G Abel ◽  
...  
Keyword(s):  
Amino Acids ◽  
Plant Extracts

In vitro antibacterial and antibiotic-potentiation activities of five edible plant extracts and mode of action against several MDR Gram-negative phenotypes

2020 ◽  
Vol 4 (1) ◽  
pp. 1-14
Author(s):  
Carine M.N. Ngaffo ◽  
Simplice B. Tankeo ◽  
Michel-Gael F. Guefack ◽  
Brice E. N. Wamba ◽  
Paul Nayim ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Bioactive Compounds ◽  
Plant Extracts ◽  
Theobroma Cacao ◽  
Efflux Pumps ◽  
Phoenix Dactylifera ◽  
Food Plants ◽  
Proton Pumps ◽  
Gram Negative ◽  
E Coli

Abstract Background: Bacterial infections involving the multidrug resistant (MDR) strains are among the top leading causes of death throughout the world. Healthcare system across the globe has been suffering from an extra-ordinary burden in terms of looking for the new and more potent antimicrobial compounds. The aim of the present study was to determine the antibacterial activity of some Cameroonian edible plants (Garcinia lucida bark, Phoenix dactylifera pericarps, Theobroma cacao pod, Solanum macrocarpon leaves and Termitomyces titanicus whole plant) and their antibiotics-potentiation effects against some MDR Gram-negative bacteria phenotypes expressing efflux pumps (Escherichia coli, Enterobacter aerogenes, Klebsiella pneumoniae, Pseudomonas aeruginosa and Providencia stuartii strains). Methods: The antibacterial activities of plant extract alone and in combination with usual antibiotics were carried out using the micro-dilution method. The effects of the most active plant extract (Garcinia lucida bark) on H+-ATPase-mediated proton pumps and on bacterial growth kinetic were performed using experimental protocols, while qualitative reference methods were used to highligh the major groups of secondary metabolites present in the extracts. Results: Qualitative phytochemical screening of plant extracts indicated that all analysed secondary metabolites were present in Theobroma cacao and Termitomyces titanicus while one (saponins) of them was absent in Garcinia lucida and Solanum macrocarpon. Only three of them (polyphenols, flavonoids and saponins) were detected in Phoenix dactylifera. Antibacterial essays showed that G. lucida was the most active plant as it inhibited the growth of all studied bacteria with strong activity (MIC<100 µg/mL) against E. coli ATCC8739, significant activity (100≤MIC≤512 µg/mL) against 80% of bacteria and moderate activity (512<MIC≤2048 µg/mL) against E. coli AG100A and E. aerogenes (EA289 and CM64). It was followed by T. cacao and S. macrocarpon extracts which exhibited an antibacterial potential against 95% and 80% of bacterial strains, respectively. These three extracts exhibited a bactericidal effect on a few bacteria. Extracts from T. titanicus and P. dactylifera were less active as they moderately (512<MIC≤2048 µg/mL) inhibited the growth of 35% and 10% of bacteria. All extracts selectively potentiated the activities of all antibiotics with improvement activity factors (IAF) ranging from 2 to 256. G. lucida, T. cacao and S. macrocarpon potentiated the activities of 100%, 89% and 67% of antibiotics respectively against more than 70%, suggesting that they contain bioactive compounds which could be considered as efflux pumps inhibitors. Whereas T. titanicus and P. dactylifera improved the activities of almost 40% and 20% of antibiotics, respectively. This increase of activities also characterizes synergistic effects between antibiotics and these bioactive compounds. G. lucida extract at all tested concentrations, strongly inhibited the growth of bacterial strain E. coli ATCC8739 and exhibited an inhibitory effect on this bacterial H+-ATPase-mediated proton pumps increasing the pH of the medium. Conclusion: The overall results indicated that food plants among which G. lucida, T. cacao and S. macrocarpon could have a benefit interest in combatting resistant types of bacteria. Keywords: Food plants; infectious diseases; MDR bacteria; efflux pumps; antibiotics; secondary metabolites.

A brief review on the use of cannabis as a treatment option for local inflammation in peripheral tissue01

2020 ◽  
Author(s):  
Lungwani Muungo
Keyword(s):  
Secondary Metabolites ◽  
Treatment Option ◽  
Cell Injury ◽  
Local Inflammation ◽  
Topical Formulations ◽  
Central Effects ◽  
Complex Process ◽  
Anti Inflammatory

Inflammation is a complex process which, ideally, comes about as a “mop up’ response to cell injury. Ithowever occasionally results in undesired effects that should otherwise be prevented or resolvedspeedily. There are available numerous medicines with varied modes of administration commerciallyavailable for the management of inflammation. With the growing evidence of cannabis’ therapeuticeffects, its anti-inflammatory properties being one of them, debates among proponents and opponents ofcannabis use are ever growing. These debates are centered on the undesired central effects of some of theplants secondary metabolites an argument that can be moderated by using the plant in a manner thatsteers clear of these effects. Effective topical formulations could very well be one avenue through whichnature can be allowed to heal with minimal negative repercussions.

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