scholarly journals NEUROPROTECTIVE EFFECTS OF AQUEOUS EXTRACT OF HYDROCOTYLE JAVANICA IN AMELIORATING NEUROBEHAVIORAL ALTERATION INDUCED BY MERCURY

2019 ◽  
Vol 12 (1) ◽  
pp. 374
Author(s):  
Pankaj Phukan ◽  
Sanjit Namasudra ◽  
Meenakshi Bawari ◽  
Mahuya Sengupta
Keyword(s):  
Locomotor Activity ◽  
Aqueous Extract ◽  
Mercuric Chloride ◽  
Path Length ◽  
Low Dose ◽  
Escape Latency ◽  
Learning Ability ◽  
High Dose ◽  
Neuroprotective Effects ◽  
Group I

Objective: This study aims to assess the effects of the aqueous extract of Hydrocotyle javanica (HJ) in ameliorating mercury-induced neurobehavioral toxicity.Methods: For the study, 36 adult male Swiss albino mice of 25–30 g in weight were taken. They were equally divided into six groups. Group I was treated with distilled water, Group II was treated with mercuric chloride (1.5 mg/kg), Group III was treated with HJ extract low dose (100 mg/kg), Group IV was treated with HJ extract high dose (200 mg/kg), Group V was treated with mercuric chloride plus HJ extract low dose, and Group VI was treated with mercuric chloride plus TB extract high dose. In all the groups, the doses were administered orally through oral gavage tube and the treatment lasted for 14 days. The behavioral effects evaluated were locomotor activity in the open field test, immobility in forced swimming test and anxiety in elevated plus maze test, spatial learning ability, and memory in the Morris water maze test.Results: The present study showed that mercury exposure significantly decreased the locomotor activity (p<0.001), number of annulus crossovers (p<0.001), number of open arm entries (p<0.01), time spent in open arms (p<0.001), and increased escape latency (p<0.01), path length (p<0.001), and immobility (p<0.001) in mice. The aqueous extract of HJ significantly alleviated the neurotoxic effects of mercury. The aqueous extract of HJ showed to increase the locomotor activity (p<0.01), number of annulus crossovers (p<0.001), number of open arm entries (p<0.05), and time spent in open arms (p<0.05), which was decreased in mercury-exposed mice. The HJ extract also showed to decrease the immobility (p<0.001), escape latency (p<0.05), and path length (p<0.001) in mercury-exposed mice.Conclusion: The result of the study shows that neurobehavioral changes induced by mercuric chloride were significantly reversed by the aqueous extract of HJ. Thus, base on the present study, it is concluded that HJ is effective in ameliorating the neurobehavioral deficits induced by mercury.

scholarly journals NEUROPROTECTIVE EFFECTS OF AQUEOUS EXTRACT OF HYDROCOTYLE JAVANICA IN AMELIORATING NEUROBEHAVIORAL ALTERATION INDUCED BY MERCURY

2019 ◽  
Vol 12 (1) ◽  
pp. 374
Author(s):  
Pankaj Phukan ◽  
Sanjit Namasudra ◽  
Meenakshi Bawari ◽  
Mahuya Sengupta
Keyword(s):  
Locomotor Activity ◽  
Aqueous Extract ◽  
Mercuric Chloride ◽  
Path Length ◽  
Low Dose ◽  
Escape Latency ◽  
Learning Ability ◽  
High Dose ◽  
Neuroprotective Effects ◽  
Group I

Objective: This study aims to assess the effects of the aqueous extract of Hydrocotyle javanica (HJ) in ameliorating mercury-induced neurobehavioral toxicity.Methods: For the study, 36 adult male Swiss albino mice of 25–30 g in weight were taken. They were equally divided into six groups. Group I was treated with distilled water, Group II was treated with mercuric chloride (1.5 mg/kg), Group III was treated with HJ extract low dose (100 mg/kg), Group IV was treated with HJ extract high dose (200 mg/kg), Group V was treated with mercuric chloride plus HJ extract low dose, and Group VI was treated with mercuric chloride plus TB extract high dose. In all the groups, the doses were administered orally through oral gavage tube and the treatment lasted for 14 days. The behavioral effects evaluated were locomotor activity in the open field test, immobility in forced swimming test and anxiety in elevated plus maze test, spatial learning ability, and memory in the Morris water maze test.Results: The present study showed that mercury exposure significantly decreased the locomotor activity (p<0.001), number of annulus crossovers (p<0.001), number of open arm entries (p<0.01), time spent in open arms (p<0.001), and increased escape latency (p<0.01), path length (p<0.001), and immobility (p<0.001) in mice. The aqueous extract of HJ significantly alleviated the neurotoxic effects of mercury. The aqueous extract of HJ showed to increase the locomotor activity (p<0.01), number of annulus crossovers (p<0.001), number of open arm entries (p<0.05), and time spent in open arms (p<0.05), which was decreased in mercury-exposed mice. The HJ extract also showed to decrease the immobility (p<0.001), escape latency (p<0.05), and path length (p<0.001) in mercury-exposed mice.Conclusion: The result of the study shows that neurobehavioral changes induced by mercuric chloride were significantly reversed by the aqueous extract of HJ. Thus, base on the present study, it is concluded that HJ is effective in ameliorating the neurobehavioral deficits induced by mercury.

scholarly journals MERCURY-INDUCED NEUROBEHAVIORAL DEFICIT AND ITS AMELIORATING EFFECTS OF AQUEOUS EXTRACT OF TRAPA BISPINOSA

2018 ◽  
Vol 11 (9) ◽  
pp. 420
Author(s):  
Pankaj Phukan ◽  
Sanjit Namasudra ◽  
Meenakshi Bawari ◽  
Mahuya Sengupta
Keyword(s):  
Locomotor Activity ◽  
Aqueous Extract ◽  
Mercuric Chloride ◽  
Path Length ◽  
Low Dose ◽  
Escape Latency ◽  
Morris Water Maze Test ◽  
High Dose ◽  
Maze Test ◽  
Group I

Objective: The aim of this study was to evaluate the effects of aqueous extract of dry fruits of Trapa bispinosa (TB) in alleviating mercury (Hg)-induced neurobehavioral toxicity.Methods: A total of 36 adult male Swiss albino mice weighing 25–30 g were equally divided into six groups, namely I–VI. Group I received distilled water, Group II received mercuric chloride (1.5 mg/kg), Group III received TB extract low dose (150 mg/kg), Group IV received TB extract high dose (300 mg/kg), Group V received mercuric chloride plus TB extract low dose, and Group VI received mercuric chloride plus TB extract high dose. All the groups received doses orally through oral gavage tube and the treatment lasted for 14 days. The behavioral effects were evaluated with locomotor activity in the open field test (OFT), spatial learning ability and memory in the Morris water maze test (MWM), immobility in Forced swimming test (FST) and anxiety in Elevated plus maze test (EPM).Result: In the present study, it was observed that Hg-exposed mice significantly decreased the locomotor activity (p<0.001), time spent in open arms (p<0.001), number of open arm entries (p<0.01), number of annulus crossovers (p<0.001) and increased immobility (p<0.001), escape latency (p<0.01), and path length (p<0.001) in mice. The aqueous extract of TB significantly reduced the neurotoxic effects of Hg. The aqueous extract of TB showed to increase the locomotor activity (p<0.01), time spent in open arms (p<0.01), number of open arm entries (p<0.05), and number of annulus crossovers (p<0.001), which was decreased in Hg-exposed mice. TB extract also showed to decrease the immobility (p<0.001), escape latency (p<0.05), and path length (p<0.001) in Hg-fed mice.Conclusion: On the basis of the results obtained from the behavioral study, the present study indicates that mercuric chloride caused neurobehavioral changes which were significantly reversed by the aqueous extract of TB. Thus, TB was found to be effective in ameliorating the neurobehavioral deficit induced by Hg exposure.

scholarly journals Evaluation of antihyperlipidemic and antioxidant activity of Rubia Cordifolia Linn.

2019 ◽  
Vol 9 (1) ◽  
pp. 211-215
Author(s):  
Priyanka Kumari ◽  
Satish Kumar Sharma ◽  
Snigdha Tiwari
Keyword(s):  
Aqueous Extract ◽  
High Fat Diet ◽  
Low Dose ◽  
Ethanolic Extract ◽  
High Dose ◽  
Root Extract ◽  
High Fat ◽  
Rubia Cordifolia ◽  
Group I ◽  
Aqueous Root Extract

Hyperlipidemia is major problem among population those, who have sedentary life style. The effects of ethanolic and aqueous root extract of Rubiacordifoliain experimentally induced hyperlipidemic rats were investigated. 42 wistar rats of both sexes were used for the study. The animals were completely randomized into seven groups comprising 6 animals each. The groups were treated as follows: Group I: normal diet (ND); Group II: HFD ( Vanaspati ghee + coconut oil mixture in ratio of 3:2 at 10 ml/kg/day); Group III: HFD + Atorvastatin (10 mg/kg/day); Group IV: HFD+ ethanolic extract of roots of Rubia cordifolia low dose(200 mg/kg/day); Group V: HFD + ethanolic extract of roots of Rubia cordifolia high dose (400 mg/kg/day); Group VI: HFD + aqueous extract of roots of Rubia cordifolia low dose (200 mg/kg/day); Group VII: HFD + aqueous extract of roots of Rubia cordifolia high dose (400 mg/kg/day). Hypercholesterolemia was induced by feeding the animals with high fat diet for 21 days before administration of the extract. After 21thday of feeding, administration of extract lasted for 14 days. Preliminary phytochemical screening revealed that the ethanolic and aqueous root extract of Rubia cordifolia contains glycosides, triterpenoids, saponins, alkaloids and flavonoids. Overall, findings from the present study suggest that the antihyperlipidemic activity observed with Atorvastatin (10mg/kg oral) and the ethanolic extracts of Rubia cordifolia (400mg/kg) showed better activity thanaqueous extracts of Rubia cordifolia (200mg/kg). Keywords: Rubia cordifolia, body weight, high fat diet, serum lipid, anti-hyperlipidemic activity.

scholarly journals Tamarix dioica (Ghaz) Protective Potential in the Carbon Tetrachloride-Induced Hepatotoxicity Animal Model

2021 ◽  
Vol 35 (3) ◽  
pp. 37-43
Author(s):  
Sumra Komal
Keyword(s):  
Body Weight ◽  
Aqueous Extract ◽  
Liver Damage ◽  
Liver Diseases ◽  
High Dose ◽  
Standard Drug ◽  
Methanolic Extracts ◽  
Hepatic Diseases ◽  
Group I ◽  
Group 2

Introduction: Hepatic diseases remain the leading cause of death worldwide. Despite overall advancements in health care, mortality due to hepatic diseases is constantly growing. More than 2 million people globally are estimated to die each year from liver diseases, and current treatment offers little for its management. Thus, it is essential to find more effective and less toxic pharmaceutical alternatives for the treatment of liver diseases. Aims & Objectives: Tamarix dioica, a shrub broadly used in herbal medicine for the treatment and prevention of various diseases. The current study was designed to analyze the hepatoprotective effect of T. dioica in BALB?cmice against CCl4-induced acute liver damage. Place and duration of study: The study was conducted in NIH, Islamabad, Pakistan, for six months in 2016-2017. Material & Methods: For in vivo evaluation, the animals (n= 42) were randomly divided into seven groups (n=6), three control (i.e. Group, I or normal control, group II or induction control received 0.9% normal saline orally, and Group III or positive control received silymarin 100 mg/kg per oral), and four treatment groups (i.e. IV, V,VI and VII were treated with oral T.dioica 200 mg/kg/day, 300mg/kg/day methanol extract, 200mg/kg/day and 300mg/kg/day of aqueous extracts respectively for six days, followed by intraperitoneal administration of CCl4 on the seventh day. The blood samples were collected for analysis of LFTs, and hepatic tissue was taken for histological analysis. Data was analyzed using SPSS version 16, one-way ANOVA with Duncan’s Multiple Range Test (DMRT). Results: CCl4 induction in Group 2 resulted in severe hepatic derangement manifested as highly elevated mean LFTs (ALT 7245.56, AST 3292.11, ALP 340.09 U/L, bilirubin 4.64 mg/dl) as compared to healthy controls (ALT 38.97, AST 50.20, ALP 57.17 U/L, bilirubin 1.25 mg/dl: (Group 1) levels p<0.001. Pretreatment with different extracts of T.dioica for 6 days before CCl4 administration produced varying degrees of hepatoprotection. 300mg/kg aqueous extract T.dioica (Group7) prevented damage with maximal hepatoprotection, reduced LFTs (ALT: 339.95 , AST: 242.90 , ALP: 116.86 U/L, bilirubin: 1.38 mg/dl) and normalized liver histology as compared to Group 2 and standard drug silymarin 100mg/kg, (ALT: 6483.23, AST: 2567.69, ALP: 272.19 U/L, bilirubin: 2.84 mg/dl: Group 3) p<0.001. Lesser hepatoprotection was provided by T.dioica aqueous extract 200mg/kg (ALT: 439.93, AST: 367.87, ALP: 180.62 U/L bilirubin: 1.53 mg/dl: Group VI) and least by 300mg/kg & 200mg/kg methanolic extracts Groups V & IV (ALT: 6338.06, 6443.91, AST: 2800.81, 3012.34, ALP: 242, 248 U/L & bilirubin: 2.82 & 3.62 mg/dl) respectively. Further, no drug-induced toxicity symptoms were observed 24 hours after administration of the high dose oral T. dioica 2000 mg/kg/body weight aqueous and methanolic extracts were administered. Conclusion: Pretreatment with T. dioica extracts especially 300mg/kg aqueous extract reduced acute CCl4-mediated liver damage, ameliorated histopathological as well as biochemical parameters and was free of toxicity in 2000mg/kg /body weight dose in the mice experimental model. T. dioica has potential in hepatoprotective drug research.

scholarly journals A clinical comparison of high dose and low dose of Suxamethonium

2014 ◽  
Vol 9 (2) ◽  
pp. 1-8
Author(s):  
RK Yadav ◽  
PC Majhi ◽  
D Tiwari
Keyword(s):  
Intraocular Pressure ◽  
Dose Group ◽  
Low Dose ◽  
Cardiovascular Responses ◽  
High Dose ◽  
Clinical Effects ◽  
Duration Of Action ◽  
Group I ◽  
Significant Difference ◽  
Group Ii

Background: Suxamethonium having its rapid onset and short duration of action makes this drug unique amongst the neuromuscular blocking drugs described so far. However, use of suxamethonium is associated with a large number of undesirable side effects. Objective: To evaluate clinical effects of high and low dose of suxamethonium and to determine whether lower dose of suxamethonium can be used for any beneficial effects in terms of its various adverse effects e.g. cardiovascular responses, post-operative muscle pains and intraocular pressure. Methods: A total of 100 patients were included in this prospective study. All these patients on preoperative clinical evaluation were assessed to have adequate airway. All the patients were divided in two groups, low dose group (group I) and High dose group (group II) with 50 patients in each at random. A standard anesthetic technique was adhered to all the patients and following parameters were observed on comparative basis: a. Fasciculation and post operative myalgia. b. Cardiovascular effects, c. Intraocular pressure. Observation: The incidence of post Suxamethonium pain was significantly greater in group II. Increase in heart rate from baseline was significant in both groups. There was no significant difference between the two groups in the diastolic pressure but rise in systolic blood pressure was significant at all assessment times in both groups. This rise from control was statistically significant. Conclusion: Suxamethonium can be used in lower doses (0.5 mg/kg) in elective cases without airway compromise. It gives benefits of reduced muscle pains, cardiovascular responses and intraocular hypertension. Journal of College of Medical Sciences-Nepal, 2013, Vol-9, No-2, 1-8 DOI: http://dx.doi.org/10.3126/jcmsn.v9i2.9677

scholarly journals Effectiveness of low dose versus high dose oxytocin regimen for induction of labour

2021 ◽  
Vol 10 (5) ◽  
pp. 1948
Author(s):  
Paridhi Gupta ◽  
Indu Chawla ◽  
Sonal Gupta
Keyword(s):  
Dose Regimen ◽  
Dose Group ◽  
Low Dose ◽  
Induction Of Labour ◽  
High Dose ◽  
High Dose Regimen ◽  
Nulliparous Women ◽  
Group I ◽  
Significant Difference ◽  
Group Ii

ABSTRACTBackground: Induction of labour is an indispensable part of modern obstetrics and certainly one of the most frequently performed obstetric procedure in the world. Oxytocin, being the most common inducing agent with multiple protocols being practiced, further research is required for the establishment of better protocol with optimal maternal and neonatal outcomes.Methods: Randomized comparative study including 100 term nulliparous women (randomized into high dose, group-I and low dose, group-II with 50 patients in each group) was done. High dose regimen was started with 4mu/min with increment of 4mu/min up to a maximum of 32mu/min and low dose regimen was started with 2mu/min with increment of 2mu/min up to a maximum of 32mu/min. Induction to delivery interval was the primary outcome. Secondary outcomes noted were rate of caesarean section, tachysytole with or without fetal distress, failed induction, maternal outcomes like need for instrumental vaginal delivery, PPH and choriamnionitis, neonatal outcomes like NICU admission, umbilical cord pH and apgar score.Results: There was significant reduction seen in induction to delivery interval among those induced with high dose oxytocin regimen. It was found to be 6.96±3.77 hours in group-I and 9.05±4.65 hours in group-II (p value 0.034). Though incidence of tachysystole was more in high dose regimen, it was not statistically significant. No significant difference was seen in secondary outcomes.Conclusions: On the basis of present study, high dose oxytocin regimen can be considered for induction of labour as it has same effects as that of low dose regimen with lesser induction to delivery interval.

High-Dose Ascorbic Acid Decreases Cholesterolemic Factors of an Atherogenic Diet in Guinea Pigs

2007 ◽  
Vol 77 (2) ◽  
pp. 125-129
Author(s):  
Filis ◽  
Anastassopoulou ◽  
Sigala ◽  
Theodorou ◽  
Manouras ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Guinea Pigs ◽  
Low Dose ◽  
Plasma Concentrations ◽  
Atherogenic Diet ◽  
High Dose ◽  
Low Density ◽  
Group Iii ◽  
Group I ◽  
Group Ii

Background: The study evaluates the effect of a high supplemental dose of ascorbic acid (AA) on plasma concentrations of total cholesterol (TC), triglycerides (TG), total lipids (TL), and lipoprotein fractions high-density, very-low-density-, and low-density lipoprotein (HDL, VLDL, LDL) in guinea pigs fed with atherogenic diet. Methods: Group I consisted of 5 normally fed guinea pigs plus a low dose of AA (1 mg/100 g/day), group II consisted of 7 guinea pigs fed with food enriched with 2% cholesterol plus a low dose of AA (1 mg/100 g/day), and group III consisted of 7 guinea pigs fed with food enriched with 2% cholesterol plus a high dose of AA (30 mg/100 g/day). Cholesterolemic factors concentrations were determined after nine weeks. Results: Concentrations of TC, TG, TL, LDL, and VLDL were increased in group II compared to group I (p < 0.01 for all differences). Supplementation with a high dose of AA resulted in decreased concentrations of TC (p < 0.01), TG (p < 0.01), TL (p < 0.01), and LDL (p < 0.01) in group III compared to group II. Additionally, concentration of HDL was increased in group III compared to group II (p < 0.01). Conclusion: High-dose AA supplementation to an atherogenic diet decreases concentrations of TC, TG, TL, and LDL and increases concentration of HDL compared to low-dose AA.

scholarly journals Protective Effects of Aqueous Extract ofLuehea divaricataagainst Behavioral and Oxidative Changes Induced by 3-Nitropropionic Acid in Rats

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Aline Alves Courtes ◽  
Letícia Priscila Arantes ◽  
Rômulo Pillon Barcelos ◽  
Ingrid Kich da Silva ◽  
Aline Augusti Boligon ◽  
...  
Keyword(s):  
Locomotor Activity ◽  
Aqueous Extract ◽  
Antioxidant Properties ◽  
Male Rats ◽  
Protective Effects ◽  
Neuroprotective Effects ◽  
Nitropropionic Acid ◽  
3 Nitropropionic Acid

Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease. Accordingly, 3-nitropropionic acid (3-NP) has been found to effectively produce HD-like symptoms.Luehea divaricata(L. divaricata), popularly known in Brazil as “açoita-cavalo,” may act as a neuroprotective agentin vitroandin vivo. We evaluated the hypothesis that the aqueous extract ofL. divaricatacould prevent behavioral and oxidative alterations induced by 3-NP in rats. 25 adult Wistar male rats were divided into 5 groups: (1) control, (2)L. divaricata(1000 mg/kg), (3) 3-NP, (4)L. divaricata(500 mg/kg) + 3-NP, and (5)L. divaricata(1000 mg/kg) + 3-NP. Groups 2, 4, and 5 receivedL. divaricatavia intragastric gavage daily for 10 days. Animals in groups 3, 4, and 5 received 20 mg/kg 3-NP daily from days 8–10. At day 10, parameters of locomotor activity and biochemical evaluations were performed. Indeed, rats treated with 3-NP showed decreased locomotor activity compared to controls. Additionally, 3-NP increased levels of reactive oxygen species and lipid peroxidation and decreased ratio of GSH/GSSG and acetylcholinesterase activity in cortex and/or striatum. Our results suggest that rats pretreated withL. divaricataprior to 3-NP treatment showed neuroprotective effects when compared to 3-NP treated controls, which may be due to its antioxidant properties.

scholarly journals Comparison of high-dose finasteride (5 mg/day) versus low-dose finasteride (2.5 mg/day) in the treatment of hirsutism

2002 ◽  
pp. 467-471 ◽  
Author(s):  
F Bayram ◽  
M Guven ◽  
F Kelestimur ◽  
Keyword(s):  
Low Dose ◽  
Free Testosterone ◽  
Dehydroepiandrosterone Sulfate ◽  
Blood Chemistry ◽  
Sex Hormone Binding Globulin ◽  
Controlled Clinical Trial ◽  
High Dose ◽  
Group I ◽  
Group Ii ◽  
Estradiol Levels

OBJECTIVE: To compare the clinical efficacy and safety of high-dose (5 mg/day) and low-dose (2.5 mg/day) finasteride in the treatment of hirsutism in women. DESIGN: A prospective, randomized and controlled clinical trial. METHODS: Fifty-six hirsute women with moderate to severe hirsutism were prospectively evaluated to see the effects of low-dose (2.5 mg/day) and high-dose (5 mg/day) finasteride. Patients were randomly divided into two treatment groups. Group I (n=29) received 2.5 mg finasteride/day and group II (n=27) received 5 mg finasteride/day orally for 1 year. Hirsutism score, body mass index and hormonal parameters (FSH, LH, estradiol, androstenedione, testosterone, free testosterone, 17alpha-hydroxyprogesterone, dehydroepiandrosterone sulfate and sex hormone-binding globulin) were measured in all the patients before treatment and repeated at six-monthly intervals. RESULTS: The hirsutism scores decreased significantly at months 6 and 12 from a mean+/-s.d. of 18.4+/-4.6 to 13.3+/-5.2 (P<0.001) and 18.4+/-4.6 to 8.6+/-4.2 (P<0.001) in group I and from 18.7+/-5.2 to 13.9+/-5.3 (P<0.001) and 18.7+/-5.2 to 10.3+/-5.0 (P<0.001) in group II respectively. No significant changes in the blood chemistry and hormonal parameters except estradiol levels were observed. No serious side-effects were seen in the two groups. In group II, estradiol levels increased significantly at 6 and 12 months. CONCLUSIONS: In this study, hirsutism scores decreased significantly at 6 and 12 months in both groups I and II. Low-dose (2.5 mg/day) finasteride is safe and cost effective in the treatment of hirsutism and may be used instead of high-dose finasteride (5 mg/day) therapy.

scholarly journals Preclinical toxicological evaluation of Aloe vera health drinks in wistar rats

2018 ◽  
Vol 1 (1) ◽  
pp. 27-32
Author(s):  
P Sudhakar ◽  
V Vinoth Prabhu ◽  
B Jamuna ◽  
R.S Adithya ◽  
Lakshmi Soman ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Low Dose ◽  
Aloe Vera ◽  
Control Group ◽  
Human Consumption ◽  
High Dose ◽  
Toxicological Evaluation ◽  
Toxicological Effect ◽  
Group I ◽  
Wbc Count

Human consumption of Aloe vera as a beverage has recently increased in popularity. These benefits are controversial with some sources pointing out that the putative effects of aloe are unsupported by clinical studies; it is important that marketed products be tested for toxicities following oral consumption. Hence this study was designed to evaluate the toxicological effect of marketed aloe health drinks. Thirty either sex Wistar rats (200-300gm) were enrolled in this study and are divided into 5 groups. Group I receives Normal saline serves as vehicle control, Group II and III receives Product A- Low dose (0.5 ml twice daily, p.o) and High dose (1.0 ml twice daily, p.o) respectively. Group IV and V receives Product B- Low dose (0.5 ml twice daily, p.o) and High dose (1.0 ml twice daily, p.o) respectively. Weekly body weight and daily feed intake were measured. On 28th day total urine output volume, faecal consistency, Haematological, biochemical, and organ weight were measured to assess the toxicity of aloe health drinks. The result of this study shows that continuous usage of aloe health drinks showed milder weight reduction, significant improvement in erythropoiesis also it increases the WBC count and increases the weight of spleen it may confirm the immune modulatory effect of aloe health drink. At the higher doses, it increased the SGOT, SGPT, serum urea and creatinine it may lead to the hepatotoxicity and nephrotoxicity. In gastrointestinal tract on prolonged uses, it produced few lesions and diarrhoea. It might be concluded that prolonged consumption of unprocessed aloe health drink contains latex, an ingredient which has many health risks associated with it. So it can aggravate health problems.

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