scholarly journals EVALUATING OF EFFERVESCENT TABLETS CONTAINING GRAPE SEED (VITIS VINIFERA L.) EXTRACT AS A NUTRACEUTICAL

2017 ◽  
Vol 9 ◽  
pp. 150
Author(s):  
Silvia Surini ◽  
Mutiah Rakhma Wisnu Wardani ◽  
Erny Sagita
Keyword(s):  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Vitis Vinifera L ◽  
Total Phenol Content ◽  
Wet Granulation ◽  
Disintegration Time ◽  
Acceptable Range ◽  
And Control ◽  
Equilibrium Vapor Pressure

Objective: Grape is one of the most well-known fruits. People usually consume only the fruit and the skin; however, the seed is the part of the fruitthat contains important antioxidant rich polyphenol. However, grape seed and its extract have an unpleasant taste. Therefore, this study aimed toformulate effervescent tablets containing grape seed extract (GSE) to overcome the unpleasant taste.Methods: Effervescent tablets of GSE were formulated using three formulas, each with a different percentage of the effervescent mix. The tablets wereprepared using wet granulation method at 40% relative humidity (RH) (the ratio of the partial pressure of water vapor to the equilibrium vapor pressure ofwater) and 25°C temperature. The effervescent granules and the tablets were evaluated for various characteristics in term of granules flowability, moisturecontent, as well as tablets appearance, size and weight uniformity, hardness, friability, effervescence time, pH, and total phenol content. In addition, all threeformulations of the effervescent tablets and solutions were evaluated for appearance, taste, and flavor using the hedonic test that involved 30 panelists.Results: The evaluation of the effervescent granules and tablets showed that they had good characteristics. The disintegration time of the threeformulations was within the acceptable range, between 3.67 minutes and 4.69 minutes. The pH of the effervescent solution was between 5.18 and5.80. Based on the hedonic test, all the effervescent solutions had favorable appearance, taste, and flavor.Conclusions: Clinical Streptococcus salivarius isolates from the dorsum of the tongue had greater potential for inhibiting Enterococcus faecalis growthcompared to the saliva isolates and control bacteria. Therefore, we can conclude that the effervescent tablets containing grape seed extract arepotential be used as a nutraceutical dosage form.

scholarly journals Noise Exposure Decreases the Number of Spermatozoa in Male Mice (Mus musculus L.) Even With Grape Seed Extract (Vitis vinifera L.) Administration

2020 ◽  
Vol 5 (2) ◽  
pp. 70-75
Author(s):  
Ghestiara Siregar
Keyword(s):  
Treatment Group ◽  
Mus Musculus ◽  
Noise Exposure ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Control Group ◽  
Vitis Vinifera L ◽  
Not Given ◽  
Male Mice

  Excessive continuous noises exposure changes the male hormone system which leads to formation of oxidative stress and results in disrupt of semen quality. This condition can be reduced by the use of antioxidants. Grape seed is one of the antioxidants that contains phenol components that have Resveratrol compounds. This research aimed to observe the effect of noise exposure on the number of spermatozoa of male mice given grape seed extract. The method of the research was a post-test only control group design with research subjects of 30 male Mus musculus L. (Swiss Webster) mice divided into 5 groups: group A (treatment control) was not given noise exposure and grape seed extract, group B (negative control) was not given noise exposure and was given grape seed extract, groups C, D, E (treatment group) were given noise exposure with sequential intensities of 65 dB, 85 dB, 105 dB. The treatment was given for 33 days. The results showed that noise exposure with different intensities of 65 dB, 85 dB, 105 dB reduced the spermatozoa count of male Swiss Webster mice even with the administration of grape seed extract. One Way Anova test was used to analyze the data with p-value of 0.001. Conclusion: There were differences in spermatozoa count between the control group and the treatment group. Provision of noise exposure with a value above the threshold limit reduces the number of male Swiss Webster mice spermatozoa given with grape seed extract. Keywords: Number of Spermatozoa, Grape Seed Extract, Noise exposure  

scholarly journals The Effects of the Grape Seed Extract on Streptococcus mutans and Candida albicans: An In Vitro Study

2020 ◽  
Vol 12 (2) ◽  
pp. 35-39
Author(s):  
Masoumeh Aslanimehr ◽  
Ashraf Alizadeh ◽  
Faezeh Azmoudeh
Keyword(s):  
Candida Albicans ◽  
Streptococcus Mutans ◽  
Large Population ◽  
In Vitro Study ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Vitis Vinifera L ◽  
Oral Pathogens

Background: Oral pathogens can affect a large population and the general health of individuals. Based on the evidence, the grape seed extract (GSE) contains herbal compounds that have the ability tosuppress oral pathogens associated with caries and fungal diseases. In this regard, the current studyaimed at evaluating the effect of GSE on Streptococcus mutans and Candida albicans. Methods: The grape (Vitis vinifera L.) seed was used in this in-vitro experimental study. After thepreparation of methanolic GSE, its effect on S. mutans and C. albicans was assessed at 0.25-256 mg/mL concentrations. Then, the minimum inhibitory concentration (MIC) and minimum bactericidalconcentration (MBC) were determined by macro broth dilution methods. Finally, data were analyzedby SPSS, version 20. Results: The results showed that GSE inhibits the growth of S. mutans and C. albicans. In addition, theMIC and MBC of the extract against S. mutans and C. albicans were 2 and 8 mg/mL, as well as 32 and64 mg/mL, respectively. Conclusions: In general, GSE had a significant antimicrobial effect on S. mutans, while it only affected C. albicans at high concentrations.

Evaluation of total phenol content and antioxidant properties of encapsulated grape seed extract in yoghurt

2017 ◽  
Vol 71 (1) ◽  
pp. 96-104 ◽  
Author(s):  
Kanta Yadav ◽  
Rajesh Kumar Bajaj ◽  
Surajit Mandal ◽  
Priti Saha ◽  
Bimlesh Mann
Keyword(s):  
Antioxidant Properties ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Total Phenol ◽  
Total Phenol Content ◽  
Phenol Content

scholarly journals Effect of Adding Different Levels of Grapes (Vitis vinifera L.) Seeds and Leaf Powder or their Extracts on Some Bone Characteristics and Total Ash Content in Broiler Chickens

2021 ◽  
Author(s):  
Rabia J. Abbas ◽  
Taha Hasheem Khauoon
Keyword(s):  
Broiler Chickens ◽  
Leaf Extract ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Ash Content ◽  
Vitis Vinifera L ◽  
Grape Seeds ◽  
Leaf Powder ◽  
Grape Leaf

Background: Some natural sources of polyphenols like grape seed, leaf or extracts, have many benefits in maintaining bone health in animals. This study aimed to investigate the efficacy of grape seeds, grape leaves powder, or their extracts on some bone characteristics and total ash content in broiler chickens. Methods: Three hundred and twenty four one-day-old broilers were allocated to nine treatments with three replicates containing 12 chicks each. Chicks were fed nine experimental diets for 35 days; as a control diet without supplementation (T1), control diets supplemented with 15 and 30 g/kg grape seeds powder (GSP) (T2, T3), 15 and 30 g/kg grape leaf powder (GLP) (T4, T5), grape seed extract (GSE) at levels 2 and 4 ml/l added in drinking water (T6, T7) and with grape leaf extract (GLE ) at levels 2 and 4 ml/l (T8 and T9), respectively. Result: Significant increase (p≤0.05) in the bone length was recorded with GSP (30 g/kg), GLP (15 g/kg), GSE or GLE and calcium percent with GLE as compared with control. Furthermore, significant improvement was recorded in predictive skeletal weight of broilers fed GSE (T6 α T7) as compared to the other treatments. The study concluded that the best results were achieved at the 2 or 4 ml/l of grape seed extract in improving femur length, predicted skeletal weight and from grape leaf extract in improving calcium percentage in broiler bone ash.

Effect of the duration of storage of a fermented milk product with an increased relative biological value on the antioxidant activity

2021 ◽  
pp. 51-53
Author(s):  
Зинаида Семеновна Зобкова ◽  
Екатерина Германовна Лазарева
Keyword(s):  
Heat Treatment ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Fermented Milk ◽  
Seed Extract ◽  
Vitis Vinifera L ◽  
Milk Product ◽  
Biological Value ◽  
Duration Of Storage ◽  
Fermented Milk Product

Цель данной работы - определить закономерности изменения антиоксидантных свойств обогащенного кисломолочного продукта с повышенной относительной биологической ценностью в процессе хранения. На данном этапе исследования основной задачей являлось определение антирадикальной активности (APA) продукта при хранении в начале и в конце срока годности с учетом коэффициента запаса (1-30-е сут). Кроме того, для выявления влияния термообработки на APA экстракта косточек винограда Vitis Vinifera L. , являющихся обогащающим ингредиентом, при выработке опытных образцов экстракт вносили до и после пастеризации. Полученные данные показали, что продолжительность хранения оказывает значимое влияние на антирадикальную активность продукта, так как она к 30-м суткам снижалась на 30,7-34,2 %. При этом влияние термообработки на АРА вносимого экстракта косточек винограда незначительно. The purpose of this work is to determine the patterns of changes in the antioxidant properties of an enriched fermented milk product with an increased relative biological value during storage. At this stage of the study, the main task was to determine the anti-radical activity (ARA) of the product during storage at the beginning and at the end of the shelf life, taking into account the reserve factor (1-30 days). In addition, to identify the effect of heat treatment on the ARA of grape seed extract Vitis Vinifera L. , which is an enriching ingredient, the extract was added before and after pasteurization during the development of prototypes. The obtained data showed that the duration of storage has a significant effect on the anti-radical activity of the product, since it decreased by 30.7-34.2% by the 30th day, while the effect of heat treatment on the ARA properties of the introduced grape seed extract is insignificant.

Grape Seeds Extract as Brain Food: A Review

2017 ◽  
Vol 9 (1) ◽  
Author(s):  
Souad El Gengaihi ◽  
Doha H. Abou Baker
Keyword(s):  
Antioxidant Activities ◽  
Complex Mixture ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Amyloid Peptide ◽  
Grape Seeds ◽  
Potential Benefits ◽  
Reduced Risk

Interest in the biological role of bioactive compounds present in medicinal herbs has increased over the last years. Of particular interest are plants that have an anti-Alzheimer activities. Several plants can be useful for Alzheimer (AD) management. Such as these which have anti-inflammatory activity, acetylcholinesterase (AChE) inhibitory action, antiapoptotic, slow the aggregation of amyloid peptide and antioxidant activities. Grape seed extract (GSE) is a complex mixture of several compounds, mostly represented by polyphenols and flavonoids. Their consumption is safe and is recognized to exert several health benefits. GS flavonoids have been associated with the reduced risk of chronic diseases, we present some findings on the potential benefits of GSE for the treatment of AD.

Grape Seed Extract Complex (FFM-GS) Inhibits Postmenopausal Symptoms: In Vitro and In Vivo S

2019 ◽  
Vol 48 (3) ◽  
pp. 297-305
Author(s):  
Minhee Lee ◽  
Da-Eun Nam ◽  
Soo-Jeung Park ◽  
Dakyung Kim ◽  
Jeong-Moon Yun ◽  
...  
Keyword(s):  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Postmenopausal Symptoms

scholarly journals Comparative Evaluation of Immediate Bond Strength to Bleached Enamel Following Application of Various Antioxidant Solutions

2017 ◽  
Vol 05 (02) ◽  
pp. 084-089
Author(s):  
Alisha Dhingra ◽  
Ashu Gupta ◽  
Anshu Minocha ◽  
Nayantara Sen
Keyword(s):  
Bond Strength ◽  
Shear Bond Strength ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
The Other ◽  
Sodium Ascorbate ◽  
Group V ◽  
Group I ◽  
Significant Difference

Abstract Aim: The aim of this study was to compare the reversal of shear bond strength of composite to bleached enamel immediately after bleaching followed by application of various antioxidant solutions. Material and Methods: Seventy central incisors were divided into seven groups. Groups I and II served as unbleached and bleached controls respectively. Groups III, IV, V, VI and VII served as the experimental groups and were subjected to 37.5% hydrogen peroxide bleaching followed by 10 min application of 10% sodium ascorbate, 25% alpha-tocopherol, 6.5% grape seed extract, 5% lycopene and 5% green tea extract respectively. Following composite bonding, shear bond strength was determined and the results were analyzed using ANOVA followed by Post Hoc Multiple Comparisons test. Results: The bond strength values for Group I (positive control) were maximum and significantly different than all the other groups except Grape seed extract group (Group V). When compared to Group II (bleached control), all the groups showed significantly higher bond strength. Significant difference in the bond strength values were seen between Group III (10% sodium ascorbate) and Group V. Also values for Group V were significantly different from Group VI (5% lycopene). All the other values showed insignificantly different results. Conclusion: All the antioxidant solutions improved the shear bond strength values after bleaching but only Grape seed extract application reversed the values to the non bleached levels. Lycopene was least effective. Other antioxidants showed comparable results.

Incorporation of grape seed extract towards wound care product development

3 Biotech ◽  
2021 ◽  
Vol 11 (6) ◽  
Author(s):  
Amita Ajit ◽  
A. G. Vishnu ◽  
Prashanth Varkey
Keyword(s):  
Product Development ◽  
Wound Care ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Care Product
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