scholarly journals TAMERON (SODIUM AMINODIGYROPHTHALAZINEDIONE) AS A POTENT IAL COMPLEX DRUG FOR THE TREATMENT OF CORONAVIRUS INFECTION COVID-19

2020 ◽  
Vol 6 (3) ◽  
pp. 67-75
Author(s):  
A. M. Ermakov ◽  
E. A. Tzar’kova ◽  
O. N. Ermakova ◽  
A. N. Tzar’kov
Keyword(s):  
Side Effects ◽  
Specific Immunotherapy ◽  
Mortality Rates ◽  
Confined Spaces ◽  
Global Pandemic ◽  
Coronavirus Infection ◽  
Immunomodulatory Properties ◽  
The Military ◽  
Potential Complex ◽  
Complex Drug

Coronavirus infection has caused a global pandemic with high mortality rates among the population of different countries. Drugs for non-specific immunotherapy of this infection based on sodium aminodihydrophthalazinedione (in particular, Tameron) were not considered for this purpose. It has immunomodulatory properties, and its use is not accompanied by side effects. Tameron can become a potential complex drug for the treatment of coronavirus infection COVID-19 and its use is especially important in confined spaces on ships and vessels of the military and civilian fleets.

FEATURES OF THE COURSE AND TACTICS OF MANAGING CHILDREN WITH KIDNEYS AND URINARY TRACT DISEASES DURING THE PANDEMIC OF NEW CORONAVIRUS INFECTION COVID-19

2021 ◽  
Vol 100 (4) ◽  
pp. 74-79
Author(s):  
I.M. Kagantsov ◽  
◽  
V.V. Sizonov ◽  
V.G. Svarich ◽  
K.P. Piskunov ◽  
...  
Keyword(s):  
Age Groups ◽  
Clinical Manifestations ◽  
Routine Care ◽  
The Novel ◽  
Urinary System ◽  
Death Rates ◽  
Global Pandemic ◽  
Coronavirus Infection ◽  
Novel Coronavirus ◽  
Significant Health

The novel coronavirus infection (SARS-CoV-2), which first appeared in Wuhan, China in December 2019, has been declared a global pandemic by WHO. COVID-19 affects people of all age groups. The disease in children is usually asymptomatic or mild compared to adults, and with a significantly lower death rates. Data on kidney damage in children with COVID-19, as well as the effect of coronavirus infection on the course of diseases of the genitourinary system, are limited, the risks of contracting a new coronavirus infection in children with significant health problems, including those with chronic kidney disease, remain uncertain. The pandemic has affected the activities of surgeons treating diseases of the urinary system in children. Since the prospects for the end of the pandemic are vague, it is necessary to formulate criteria for selecting patients who can and should be provided with routine care in the pandemic. The purpose of this review is to highlight the features of the clinical manifestations and treatment of children with COVID-19, occurring against the background of previous renal pathology or complicating its course.

scholarly journals Plasmapheresis in the treatment of myasthenia gravis: retrospective study of 26 patients

2004 ◽  
Vol 62 (2b) ◽  
pp. 391-395 ◽  
Author(s):  
Rosana Carandina-Maffeis ◽  
Anamarli Nucci ◽  
José F.C. Marques Jr ◽  
Eduardo G. Roveri ◽  
Beatriz H.M. Pfeilsticker ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Side Effects ◽  
Myasthenia Gravis ◽  
Plasma Exchange ◽  
Mortality Rates ◽  
Motor Deficit ◽  
Myasthenic Crisis ◽  
Clinical Hospital ◽  
The Mean ◽  
Mean Time

We analyzed the experience of Unicamp Clinical Hospital with plasma exchange (PE) therapy in myasthenia gravis (MG). About 17.8 % of a totality of MG patients had PE performed: 26 cases, 19 women and seven men. The mean age-onset of MG was 28 years, extremes 11 and 69. Minimum deficit observed in the group was graded IIb (O & G) or IIIa (MGFA scale). One patient had prethymectomy PE. In seven the procedures were performed due to myasthenic crisis and in 18 patients due to severe myasthenic symptoms or exacerbation of previous motor deficit. Two patients were also submitted to chronic PE considering refractoriness to other treatments. Twenty-six patients had 44 cycles of PE and 171 sessions. The mean number of sessions was 3.9 (SD ± 1.4) each cycle; median 5, extremes 2 and 6. The mean time by session was 106,5 minutes (SD ± 35.2); median 100.5 (extremes of 55 and 215). The mean volume of plasma exchanged in each session was 2396 ml (SD ± 561); median 2225 (extremes 1512 and 4500). Side effects occurred: reversible hypotension (seven cases), mild tremor or paresthesias (seven cases). Infection and mortality rates due to PE were zero. All patients had immediate benefit of each PE cycle and usually they also received prednisone or other immunosuppressors. Good acceptance of the procedure was observed in 80.7% of patients.

scholarly journals Hypovitaminosis D and COVID-19

2020 ◽  
Vol 14 (4) ◽  
pp. 216-218
Author(s):  
Gabriele A. Vassallo ◽  
Sirio Fiorino ◽  
Simone Mori ◽  
Tommaso Dionisi ◽  
Giuseppe Augello ◽  
...  
Keyword(s):  
Hypovitaminosis D ◽  
Point Of View ◽  
Diagnostic Tools ◽  
Therapeutic Approaches ◽  
Front Line ◽  
New Therapeutic Approaches ◽  
Global Pandemic ◽  
Infection Disease ◽  
Coronavirus Infection ◽  
Second Wave

As the main title ‘COVID-19 revolution: a new challenge for the internist’ states, the global coronavirus infection disease 2019 (COVID-19) pandemic represented a new challenge for the internists. This paper is part of a series of articles written during the difficult period of the ongoing global pandemic and published all together in this fourth issue of the Italian Journal of Medicine, with the aim of sharing the direct experiences of those who were the first to face this severe emergency, expressing each point of view in the management of COVID-19 in relation to other diseases. Each article is therefore the result of many efforts and a joint collaboration between many colleagues from the Departments of Internal Medicine or Emergency Medicine of several Italian hospitals, engaged in the front line during the pandemic. These preliminary studies therefore cover diagnostic tools available to health care personnel, epidemiological reflections, possible new therapeutic approaches, discharge and reintegration procedures to daily life, the involvement of the disease not only in the lung, aspects related to various comorbidities, such as: coagulopathies, vasculitis, vitamin D deficiency, gender differences, etc.. The goal is to offer a perspective, as broad as possible, of everything that has been done to initially face the pandemic in its first phase and provide the tools for an increasingly better approach, in the hope of not arriving unprepared to a possible second wave. This paper in particular deals with hypovitaminosis D and COVID-19.

scholarly journals The Effectiveness of the Vaccine and the Reinfection Wave by Covid-19: What the Reports Shows

2021 ◽  
Vol 5 (10) ◽  
pp. 79-83
Author(s):  
Rivania Beatriz Novais Lima ◽  
Larissa Moreira Torres ◽  
Glauber Magalhães Pires ◽  
Maria Isabel Fernandes Peixoto Furtado ◽  
Ana Emilia Formiga Marques
Keyword(s):  
Passive Immunization ◽  
Mortality Rates ◽  
Epidemiological Studies ◽  
The Real ◽  
Coronavirus Infection

COVID-19 is a disease caused by the new coronavirus designated SARS-COVS2. Discoveries about the particularities of COVID-19 are constant and challenging. Currently, it has been proven that the recurrence of the disease in the same individual is possible due to the variants that the virus has. This new reality has led to discussions about the real effectiveness of the vaccine in controlling the pandemic. Objective: To obtain, through updated and reliable literature, the main data on the effectiveness of the vaccine. This comment reviewed current articles from the year 2020 to 2021, published by journals such as The Lancet, CNN, BCC and others. Further studies were needed to prove the action of passive immunization of the new variants. Recently, epidemiological studies have shown that coronavirus infection and mortality rates are falling as vaccination progresses.

NEW CORONOVIRUS INFECTION: CLINICAL AND PATHOGENETIC ASPECTS OF COVID-19 IN PREGNANT WOMEN

2021 ◽  
pp. 57-62
Author(s):  
Allakhyarov D.Z. ◽  
Petrov Yu.A. ◽  
Chernavsky V.V.
Keyword(s):  
Pregnant Women ◽  
The Body ◽  
World Health ◽  
Upper Respiratory Tract ◽  
Global Pandemic ◽  
High Prevalence ◽  
Coronavirus Infection ◽  
The Moment ◽  
Health Organization ◽  
The Impact

This article presents reviews of literature sources on the clinical and pathogenetic aspects of the course of a new coronovirus infection in pregnant women, in order to analyze the features of the course of COVID-19 in pregnant women and to assess the impact of infection on the body of a woman and a fetus. Pregnancy is a special physiological condition, during which a number of changes occur in the body, not only in the hormonal status, but also in the immune system. The urgency of this problem is due to the high prevalence of new coronavirus infection among the population. On March 12, 2020, the World Health Organization (WHO), as a result of the dynamic development of the epidemic in many countries and continents, declared a global pandemic of the contagious disease COVID-19 caused by the SARS-CoV-2 virus. According to available studies, pregnant women are more susceptible to a more severe course of infectious diseases affecting the upper respiratory tract. According to various studies, a new coronavirus infection can lead to premature birth, miscarriage, and preeclampsia. Separate studies show increased mortality in pregnant women diagnosed with COVID-19. The SARS-CoV-2 virus does not have a direct teratogenic effect on the fetus, but it can indirectly lead to harmful effects on the developing organism. Special attention should be paid to the issue of vaccination of pregnant women against a new coronavirus infection, at the moment there is no accurate data on the effect of the vaccine on the body of the pregnant woman and the fetus. In this regard, the question of the impact of a new coronavirus infection on the course of pregnancy has become relevant.

scholarly journals Prevention and treatment system of novel coronavirus infection in medical and health institutions: experience in West China Hospital of Sichuan University

2020 ◽  
Vol 37 (10) ◽  
pp. 639-641
Author(s):  
Qiao Zhou ◽  
He Yu ◽  
Zong-An Liang ◽  
Rong Yao ◽  
Feng-Ming Luo ◽  
...  
Keyword(s):  
Treatment System ◽  
The Novel ◽  
West China Hospital ◽  
West China ◽  
Global Pandemic ◽  
Prevention And Treatment ◽  
Coronavirus Infection ◽  
Health Institutions ◽  
Novel Coronavirus

The novel coronavirus infection broke out in Wuhan, China, in December 2019, and progressed to a global pandemic. We describe the measures taken by West China Hospital of Sichuan University to address the diagnosis, prevention and treatment of the infection.

Election dispute belies Togo's deeper stability risks

2015 ◽  
Keyword(s):  
Public Health ◽  
Child Mortality ◽  
Mortality Rates ◽  
West African ◽  
The Political ◽  
The West ◽  
Content Type ◽  
Franc Zone ◽  
The Military ◽  
Democratic Norms

Subject The political outlook in Togo. Significance On April 28, the Independent National Electoral Commission (CENI) announced that President Faure Gnassingbe had won re-election in the presidential ballot held on April 25, with 58.75% of the vote. His controversial third term will extend his family's rule to nearly 50 years. Opposition candidate Jean-Pierre Fabre secured 34.95% of the vote. His Combat for Political Change (CAP) alliance rejects the result. Impacts Western donors' effectiveness at pushing for democratic norms will wane as Togo, like other African states, accesses new debt sources. Togo's membership of the West African CFA franc zone, which is backed by the French treasury, will ensure currency stability. A Burkina Faso-style ouster of Gnassingbe is unlikely, for now -- he enjoys the support of the military who first installed him. Despite being spared the Ebola crisis, standards of public health will remain poor, with child mortality rates far above global averages.

scholarly journals Nepal’s Response to Contain COVID-19 Infection

2020 ◽  
Vol 18 (1) ◽  
pp. 128-134 ◽  
Author(s):  
Rano Mal Piryani ◽  
Suneel Piryani ◽  
Jay Narayan Shah
Keyword(s):  
Regional Cooperation ◽  
Initial Response ◽  
The Novel ◽  
Comprehensive Plan ◽  
Imported Case ◽  
Global Pandemic ◽  
Before And After ◽  
Global Status ◽  
Coronavirus Infection ◽  
Novel Coronavirus

Nepal is a landlocked country bordering two most populous countries, India and China. Nepal shares open border with India from three sides, east, south and west. And, in north with China, where the novel coronavirus infection (CVOVID-19) began in late December 2019. The first confirmed imported case in Nepal was reported in 2nd week of January 2020. The initial response of Nepal to COVID-19 were comparably slow but country geared efforts after it was declared a ‘global pandemic’ by WHO on 11 March, 2020. Government of Nepal’s steps from 18 March, 2020 led to partial lock down and countrywide lockdown imposed on 24 March, 2020. Government devised comprehensive plan on 27 March, 2020 for quarantine for peoples who arrived in Nepal from COVID-19 affected countries. This article covers summary of global status, South Asian Association of Regional Cooperation (SAARC) status, and Nepal’s response to contain COVID-19 infection discussed under three headings: Steps taken before and after WHO declared COVID-19 a global pandemic and lab services regarding detection of COVID-19. Nepal has documented five confirmed cases of COVID-19 till the end of March 2020, first in second week of 15 January, 2020 and 2nd case 8-weeks thereafter and 3rd case two days later, 4th on 27 March and 5th on 28 March. Four more cases detected during first week of April. Non-Pharmacological interventions like social distancing and excellent personal habits are widely practiced. Country has to enhance testing and strengthen tracing, isolation and quarantine mechanism and care of COVID-19 patients as Nepal is in risk zone because of comparably weak health system and porous borders with India. The time will tell regarding further outbreak and how it will be tackled.Keywords: COVID-19; lockdown; Nepal; pandemic; response

scholarly journals Application of glucocorticoids in patients with novel coronavirus infection: From bench to bedside

2021 ◽  
pp. 1-14
Author(s):  
Linwei Lu ◽  
Jianhua Huang ◽  
Xiaohong Deng ◽  
Xianjun Sun ◽  
Jingcheng Dong
Keyword(s):  
Drug Resistance ◽  
Side Effects ◽  
Current Literature ◽  
Clinical Applications ◽  
Paper Briefly ◽  
Coronavirus Infection ◽  
Anti Inflammatory ◽  
Novel Coronavirus

Glucocorticoids (GCs) have potential anti-inflammatory and immunosuppressive effects. There is plenty of controversy about the application of glucocorticoids in the treatment of coronavirus disease 2019 (COVID-19). This paper briefly summarizes the mechanism of glucocorticoids and their receptors and clinical applications in COVID-19. Through reviewing the current literature, our aim is to have a deeper understanding of the mechanism of GCs and their clinical applications, so as to find possible ways to enhance their efficacy and reduce drug resistance or side effects.

scholarly journals COVID-19 as a concomitant diagnosis and the emergencies behind COVID-19 mask – a real challenge that requires a multidisciplinary view of the patient

Pharmacia ◽  
2021 ◽  
Vol 68 (3) ◽  
pp. 603-606
Author(s):  
Petar Yordanov Atanasov ◽  
Maria Georgieva Moneva-Sakelarieva ◽  
Yozlem Ali Kobakova ◽  
Stefka Achkova Ivanova ◽  
Danka Petrova Obreshkova ◽  
...  
Keyword(s):  
United States ◽  
Emergency Department ◽  
Distress Syndrome ◽  
The United States ◽  
Global Pandemic ◽  
Number Of Patients ◽  
Severe Respiratory Infection ◽  
Coronavirus Infection ◽  
The Moment ◽  
Real Challenge

The etiological cause of Coronavirus infection, which has captured the attention of almost the whole world at the moment, is SARS-CoV2. The clinical picture of coronavirus infection varies from asymptomatic to severe respiratory infection with manifestations of respiratory failure, the development of respiratory distress syndrome and even death. Already in the first months of the coronavirus pandemic in the United States there was a serious decline in the number of patients seeking medical care in the Emergency Department (49.3%) compared to 2019. There is evidence of increased mortality during the pandemic, which causality cannot be directly or associated with coronavirus infection. Even in the context of a global pandemic, we must not forget all other diagnoses and conditions that exist as comorbidity, and emergency care must be provided without delay and delay.

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