scholarly journals Features of clinical symptom and inflammatory marker regression in the use of thermal oxygen-helium mixture in SARS-CoV-2 pneumonia treatment

2022 ◽  
Vol 7 (4) ◽  
pp. 70-74
Author(s):  
V. M. Manuilov ◽  
A. R. Mukhamedzhanova
Keyword(s):  
Medical Records ◽  
Inflammatory Marker ◽  
Severe Disease ◽  
Continuous Process ◽  
Economic Losses ◽  
Disease Treatment ◽  
World Community ◽  
Helium Mixture ◽  
Marker Regression ◽  
Coronavirus Infection

New coronavirus infection is accompanied by high mortality and socio-economic losses in the world community. Despite the continuous process of including new medication with antiviral and anti-inflammatory effects in the disease treatment, the development of complications, primarily of hypoxic origin, and mortality remain high.The aim of the study is to evaluate the effect of the use of thermal oxygen-helium mixture in the therapy on the rate of regression of clinical and laboratory signs of inflammation, as well as the length of patient hospital stay.Material and methods. 59 patient medical records with moderate and severe disease were analyzed. The article summarizes experience of patient management with COVID-19-associated pneumonia who are treated with or without the use of thermal oxygen-helium mixture in one of intensive care units in multi-filed hospital.Results and discussion. It has been proven that the use of a thermal oxygen-helium mixture in the SARS-CoV-2 pneumonia treatment is effective.

scholarly journals Experimental infection of indigenous North African goats with goatpox virus

2021 ◽  
Vol 63 (1) ◽  
Author(s):  
Jihane Hamdi ◽  
Zahra Bamouh ◽  
Mohammed Jazouli ◽  
Meryem Alhyane ◽  
Najet Safini ◽  
...  
Keyword(s):  
Antibody Response ◽  
Experimental Infection ◽  
Subcutaneous Tissue ◽  
Severe Disease ◽  
Clinical Signs ◽  
Economic Losses ◽  
North African ◽  
Cutaneous Lesions ◽  
Viral Dna ◽  
Goatpox Virus

Abstract Background Goatpox is a viral disease caused by infection with goatpox virus (GTPV) of the genus Capripoxvirus, Poxviridae family. Capripoxviruses cause serious disease to livestock and contribute to huge economic losses. Goatpox and sheeppox are endemic to Africa, particularly north of the Equator, the Middle East and many parts of Asia. GTPV and sheeppox virus are considered host-specific; however, both strains can cause clinical disease in either goats or sheep with more severe disease in the homologous species and mild or sub-clinical infection in the other. Goatpox has never been reported in Morocco, Algeria or Tunisia despite the huge population of goats living in proximity with sheep in those countries. To evaluate the susceptibility and pathogenicity of indigenous North African goats to GTPV infection, we experimentally inoculated eight locally bred goats with a virulent Vietnamese isolate of GTPV. Two uninfected goats were kept as controls. Clinical examination was carried out daily and blood was sampled for virology and for investigating the antibody response. After necropsy, tissues were collected and assessed for viral DNA using real-time PCR. Results Following the experimental infection, all inoculated goats displayed clinical signs characteristic of goatpox including varying degrees of hyperthermia, loss of appetite, inactivity and cutaneous lesions. The infection severely affected three of the infected animals while moderate to mild disease was noticed in the remaining goats. A high antibody response was developed. High viral DNA loads were detected in skin crusts and nodules, and subcutaneous tissue at the injection site with cycle threshold (Ct) values ranging from 14.6 to 22.9, while lower viral loads were found in liver and lung (Ct = 35.7 and 35.1). The results confirmed subcutaneous tropism of the virus. Conclusion Clinical signs of goatpox were reproduced in indigenous North African goats and confirmed a high susceptibility of the North African goat breed to GTPV infection. A clinical scoring system is proposed that can be applied in GTPV vaccine efficacy studies.

CHANGING PROFESSIONAL MOTIVATION AMONG NURSING STAFF IN THE PANDEMIC

2021 ◽  
pp. 72-79
Author(s):  
Elizaveta O. Nechaeva ◽  
Keyword(s):  
Health Care ◽  
Comparative Analysis ◽  
Nursing Staff ◽  
Great Majority ◽  
Practical Skills ◽  
World Community ◽  
Personal Motivation ◽  
Coronavirus Infection ◽  
Entire World ◽  
Almost All

The pandemic of the new coronavirus infection, which swept the entire world community in 2020, has made strong adjustments in almost all spheres of life, but first of all, in health care. The great majority of the medical staff at the onset of the pandemic had no clinical experience with the COVID-19 patients. In addition to the lack of practical skills in treatment for the period of the onset of mass infections, doctors faced great physical and emotional stress. The article provides a comparative analysis of the questionnaires results from among nursing staff in SRC Burnasyan FMBC in 2018 and 2020. The research results show that in the process of treatment and rehabilitation of pa- tients with COVID-19 in the professional motivation of doctors some changes took place towards personal motivation associated with serving and helping people.

scholarly journals PROFILE OF PATIENTS RECEIVING TOTAL KNEE ARTHROPLASTY: A CROSS-SECTIONAL STUDY

2017 ◽  
Vol 25 (5) ◽  
pp. 202-205 ◽  
Author(s):  
MARCELO JOSÉ CORTEZ BEZERRA ◽  
IGOR MAGALHÃES BARBOSA ◽  
THALES GONÇALVES DE SOUSA ◽  
LARISSA MEIRELES FERNANDES ◽  
DIEGO LEONARDO MENEZES MAIA ◽  
...  
Keyword(s):  
Medical Records ◽  
Severe Disease ◽  
Functional Limitation ◽  
Cross Sectional Study ◽  
Level Of Evidence ◽  
Cross Sectional ◽  
Lequesne Index ◽  
Total Knee ◽  
Epidemiological Profile

ABSTRACT Objective: To describe the epidemiological profile, presented deformities, associated comorbidities, and impact on quality of life in patients with knee osteoarthritis. This study was conducted in a philanthropic hospital in Fortaleza from 2014 to 2015. Methods: Data were collected from medical records, epidemiological forms, and by applying the Lequesne index questionnaire, which contains several questions related to pain, discomfort and functional limitation to assess the severity of symptoms. Results: Females were more prevalent (76.7%), as were patients over 65 years of age (61.6%) and non-whites (81.6%). As for comorbidities, 83.3% had hypertension and 31.7% had diabetes. Of the total, 76.5% cases were genu varum, and 23.5% genu valgum. According to the Lequesne index findings, 61.6% cases were “extremely severe,” and women had higher scores. Conclusion: Females were more prevalent and whites were less prevalent. The most frequent comorbidity was hypertension. Female and elderly patients have more severe disease according to Lequesne index score, and these findings were statistically significant. Level of Evidence II, Prospective Study.

A synthetic review of notoedres species mites and mange

Parasitology ◽  
2016 ◽  
Vol 143 (14) ◽  
pp. 1847-1861 ◽  
Author(s):  
J. FOLEY ◽  
L. E. K. SERIEYS ◽  
N. STEPHENSON ◽  
S. RILEY ◽  
C. FOLEY ◽  
...  
Keyword(s):  
Close Contact ◽  
Systemic Disease ◽  
Severe Disease ◽  
Epidemiological Studies ◽  
Host Population ◽  
Disease Treatment ◽  
Notoedres Cati ◽  
Immunological Factors ◽  
Population Treatment ◽  
Notoedric Mange

SUMMARYNotoedric mange, caused by obligately parasitic sarcoptiform Notoedres mites, is associated with potentially fatal dermatitis with secondary systemic disease in small mammals, felids and procyonids among others, as well as an occasional zoonosis. We describe clinical spectra in non-chiropteran hosts, review risk factors and summarize ecological and epidemiological studies. The genus is disproportionately represented on rodents. Disease in felids and procyonids ranges from very mild to death. Knowledge of the geographical distribution of the mites is highly inadequate, with focal hot spots known for Notoedres cati in domestic cats and bobcats. Predisposing genetic and immunological factors are not known, except that co-infection with other parasites and anticoagulant rodenticide toxicoses may contribute to severe disease. Treatment of individual animals is typically successful with macrocytic lactones such as selamectin, but herd or wildlife population treatment has not been undertaken. Transmission requires close contact and typically is within a host species. Notoedric mange can kill half all individuals in a population and regulate host population below non-diseased density for decades, consistent with frequency-dependent transmission or spillover from other hosts. Epidemics are increasingly identified in various hosts, suggesting global change in suitable environmental conditions or increased reporting bias.

scholarly journals In Vitro Assessment of Biocontrol Effects on Fusarium Head Blight and Deoxynivalenol (DON) Accumulation by DON-Degrading Bacteria

Toxins ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 399
Author(s):  
Hiroyuki Morimura ◽  
Michihiro Ito ◽  
Shigenobu Yoshida ◽  
Motoo Koitabashi ◽  
Seiya Tsushima ◽  
...  
Keyword(s):  
Fusarium Head Blight ◽  
Leaf Growth ◽  
Severe Disease ◽  
Petri Dish ◽  
Inhibitory Effect ◽  
Economic Losses ◽  
Head Blight ◽  
Control Approach ◽  
Degrading Bacteria

Fusarium head blight (FHB) of cereals is a severe disease caused by the Fusarium graminearum species complex. It leads to the accumulation of the mycotoxin deoxynivalenol (DON) in grains and other plant tissues and causes substantial economic losses throughout the world. DON is one of the most troublesome mycotoxins because it is a virulence factor to host plants, including wheat, and exhibits toxicity to plants and animals. To control both FHB and DON accumulation, a biological control approach using DON-degrading bacteria (DDBs) is promising. Here, we performed a disease control assay using an in vitro petri dish test composed of germinated wheat seeds inoculated with F. graminearum (Fg) and DDBs. Determination of both grown leaf lengths and hyphal lesion lengths as a measure of disease severity showed that the inoculation of seeds with the DDBs Devosia sp. strain NKJ1 and Nocardioides spp. strains SS3 or SS4 were protective against the leaf growth inhibition caused by Fg. Furthermore, it was as effective against DON accumulation. The inoculation with strains SS3 or SS4 also reduced the inhibitory effect on leaves treated with 10 µg mL−1 DON solution (without Fg). These results indicate that the DDBs partially suppress the disease by degrading DON.

scholarly journals Apomorphine in the treatment of Parkinson's disease: a review

2018 ◽  
Vol 76 (12) ◽  
pp. 840-848 ◽  
Author(s):  
Renata Ramina Pessoa ◽  
Adriana Moro ◽  
Renato Puppi Munhoz ◽  
Hélio A.G. Teive ◽  
Andrew J. Lees
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rescue Therapy ◽  
Continuous Process ◽  
Subcutaneous Administration ◽  
Historical Background ◽  
Infusion Therapy ◽  
Disease Treatment ◽  
Positive Effects

ABSTRACT Optimizing idiopathic Parkinson's disease treatment is a challenging, multifaceted and continuous process with direct impact on patients’ quality of life. The basic tenet of this task entails tailored therapy, allowing for optimal motor function with the fewest adverse effects. Apomorphine, a dopamine agonist used as rescue therapy for patients with motor fluctuations, with potential positive effects on nonmotor symptoms, is the only antiparkinsonian agent whose capacity to control motor symptoms is comparable to that of levodopa. Subcutaneous administration, either as an intermittent injection or as continuous infusion, appears to be the most effective and tolerable route. This review summarizes the historical background, structure, mechanism of action, indications, contraindications and side effects, compares apomorphine infusion therapy with other treatments, such as oral therapy, deep brain stimulation and continuous enteral infusion of levodopa/carbidopa gel, and gives practical instructions on how to initiate treatment.

Seizure Medications Effects on Fetus, Neonate, and Lactation

2018 ◽  
Author(s):  
Tara A. Lynch ◽  
J. Christopher Glantz
Keyword(s):  
Seizure Control ◽  
Refractory Epilepsy ◽  
Severe Disease ◽  
Medication Use ◽  
Disease Treatment ◽  
Teratogenic Risk ◽  
Antiepileptic Medications ◽  
Patients With Epilepsy ◽  
In Pregnancy ◽  
The Ideal

Medication use in pregnancy requires a careful balance between the risks of fetal teratogenicity and the maternal benefits of disease treatment. For women with epilepsy, there are many antiepileptic medications available for use in pregnancy. Each varies in their safety profile, risk for fetal anomalies, and effectiveness of seizure control. In most scenarios, the benefits of maternal treatment outweigh the risk of fetal effects, especially in cases of refractory epilepsy or severe disease. Many of the newer anti-epileptic drugs appear to have less teratogenic risk than the older medications. The ideal AED is one that is effective from the woman, is least teratogenic, and used at the lowest possible dose. Overall, a detailed understanding of antiepileptic efficacy, the pharmacologic differences in pregnancy, and the potential adverse fetal effects are required for optimal treatment of pregnant patients with epilepsy.

scholarly journals Physician Awareness of Knee and Hip Pain in the Context of Coronary Heart Disease Treatment

2014 ◽  
Vol 2014 ◽  
pp. 1-5
Author(s):  
Mathias Glehr ◽  
Anna Kaltenbach ◽  
Reinhold Glehr ◽  
Patrick Sadoghi ◽  
Andreas Leithner ◽  
...  
Keyword(s):  
Physical Activity ◽  
Medical Records ◽  
Medical Data ◽  
Hip Pain ◽  
Cvd Risk ◽  
Disease Treatment ◽  
Cross Sectional ◽  
Physician Awareness ◽  
European Society Of Cardiology ◽  
Pain Patients

Background. The benefit of physical activity for the prevention and treatment of cardiovascular disease (CVD) has been well documented. The aim of the present study was to determine the level of awareness among general practitioners (GPs) of knee and hip problems in patients with CVD or CVD risk.Design. Cross-sectional questionnaire survey.Setting and Subjects. Thirty-five Austrian GPs and 1,118 patients were included. The GPs completed an extraction form about the presence or absence of documented evidence of problems related to the knee and/or hip joint within the patient medical data. Patients, in turn, were asked to complete a questionnaire that included the Oxford Knee/Hip Score and the cardiovascular risk-chart established by the European Society of Cardiology.Results. In 748 patients’ data from medical records and questionnaires were available. 40.9% of these patients suffered from serious knee pain and 32.1% from hip pain. However, in the medical records, in only 51.3% (knee) and 48.1% (hip) of these pain-patients the problems were documented.Conclusion. Joint disorders of the knee and hip problems are considerable barriers to effective physical activity and can therefore contribute to the development of CVD. Our data showed that GP awareness of such knee/hip disorders should be improved.

scholarly journals COVID-19 vaccination of pregnant women: state-of-the-art

2021 ◽  
Vol 5 (11) ◽  
pp. 768-772
Author(s):  
A.A. Girina ◽  
◽  
A.L. Zaplatnikov ◽  
V.I. Svintsitskaya ◽  
S.D. Izhogina ◽  
...  
Keyword(s):  
Pregnant Women ◽  
State Of The Art ◽  
Severe Disease ◽  
Perinatal Outcomes ◽  
Professional Associations ◽  
Disease Course ◽  
Complete Control ◽  
Outcome Monitoring ◽  
Coronavirus Infection ◽  
Novel Coronavirus

Despite efforts made by the world community to battle the novel coronavirus infection, we are still unable to take complete control of virus spread. One of the causes of this issue is inadequate coverage of vaccination. Meanwhile, disease course in specific populations is associated with the risks of severe complications and lethal outcome. Infection of pregnant women is of particular concern. This paper addresses recent data on vaccination against the COVID-19 infection in pregnant women, including those with risk of severe disease course and unfavorable outcome. Monitoring the health of women infected with SARS-CoV-2 during gestation demonstrates unfavorable effects of the COVID-19 infection on the course and outcome of pregnancy. On the other hand, observational programs have demonstrated that vaccination has no effects on pregnancy course and perinatal outcomes. A view of the WHO and professional associations on the vaccination of pregnant women, particularly those from risk groups of severe COVID-19 course, is discussed. The importance of a personalized and balanced approach to COVID-19 vaccination of pregnant women involving the assessment of risks and benefits for the mother and child is emphasized. KEYWORDS: novel coronavirus infection, COVID-19, vaccination, immunization, pregnant women, risk group. FOR CITATION: Girina A.A., Zaplatnikov A.L., Svintsitskaya V.I., Izhogina S.D. COVID-19 vaccination of pregnant women: state-of-the-art. Russian Medical Inquiry. 2021;5(11):768–772 (in Russ.). DOI: 10.32364/2587-6821-2021-5-11-768-772.

scholarly journals Effect of ZnO nanoparticles in treatment of broilers with Eimeria tenella. experimentally infected.

2021 ◽  
Author(s):  
Sadiya Aziz Anah ◽  
Khadeeja Abees Hmood ◽  
Saad Aziz Anah
Keyword(s):  
Zinc Oxide ◽  
Severe Disease ◽  
Treated Group ◽  
Positive Control ◽  
Negative Control ◽  
Eimeria Tenella ◽  
Positive Control Group ◽  
Economic Losses ◽  
Control Group ◽  
New Treatment

Abstract Coccidiosis is one of the common poultry diseases in Iraq and the world, which causes great economic losses. Therefore, this study aimed to use a new treatment represented by nanoparticles of zinc oxide and compare it with the drug (Amprolium). The Oocysts of Eimeria tenella were isolated from the feces of the briolers received at the Veterinary hospital in Diwaniyah Province and initially diagnosed by compound light microscopy,Then it was confirmed molecularly by PCR technique using the internal transcribed space ITS1 gene with a molecular weight of 409bp. The experiment was carried out on 120 birds of broilers, as the animals were divided into 6 groups with 20 birds per group. The first group(G1) was left as a negative control(uninfected), the second group(G2) was inoculated with 50,000 mature Oocysts and left as a positive control group,the third group(G3) was incubated with 50,000 Oocysts + Amprolium (anticoccidial), the fourth, fifth and sixth groups(G4,G5,G6) were also dosed with 50,000 Oocysts followed by an oral dose of nanoparticles of zinc oxide at a concentration of 20,40,60 mg/kg for each of fourth, fifth and sixth groups respectively. The current results showed that the briolers in G2 suffered from severe disease symptoms and high mortality occurred in the first week of infection, amounting to %10 compared to the anticoccidial (Amprolium group and the groups treated with nanoconcentrations 20,40,60 mg/kg respectively.G6 which was dosed with a concentration of 60 mg /kg, showed a significant decrease in the number of Oocysts excreted compared with the positive control group and the anticoccidial group, in addition to the appearance of mild symptoms and a mortality rate of %0.8,While there was a decrease in the number of Oocysts excreted during the second week in the anticoccidial group and the treated groups with the three nanoconcentrations with a decrease in the mortality rates of birds .The number of Oocysts excreted in the litter significantly decreased in the treated group with a concentration of 60 mg/kg compared to all other groups, and all birds of this group recovered during the second week of infection.

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