scholarly journals Effect of Rifaximin and a Multi-Strain Probiotic on the Intestinal Microbiome and Cardiovascular Risk Indicators in Patients with Coronary Heart Disease

2019 ◽  
Vol 29 (4) ◽  
pp. 38-49
Author(s):  
E. A. Kashukh ◽  
E. A. Poluektova ◽  
A. V. Kudryavtseva ◽  
G. S. Krasnov ◽  
V. I. Kazey ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Bifidobacterium Longum ◽  
Lactobacillus Rhamnosus ◽  
Fecal Microbiota ◽  
Bifidobacterium Bifidum ◽  
Intestinal Microbiome ◽  
Group 4 ◽  
Fecal Microflora ◽  
Group 1

Aim. To assess the effect of rifaximin and a multi-strain probiotic on the intestinal microbiome and the indicators of cardiovascular risk in patients with coronary heart disease (CHD).Materials and methods. A study conducted during the 2016–2019 period included 120 people over 50 years old divided into 3 groups. Group 1 comprised patients with coronary heart disease receiving standard treatment. Group 2 comprised patients with coronary heart disease receiving additionally a probiotic (Bifidobacterium bifidum no less than 1x109 CFU; Bifidobacterium longum no less than 1x109 CFU; Bifidobacterium infantis no less than 1x109 CFU; Lactobacillus rhamnosus no less than 1x109 CFU) within 28 days. Group 3 comprised CHD patients receiving rifaximin for 7 days followed by addition of the multi-strain probiotic under test for 21 days. Group 4 consisted of healthy individuals, comparable in age and sex with the examined CHD patients. In group 4, blood and stool tests were performed once to provide a comparison with group 1. TMAO concentration was determined using liquid chromatography–mass spectrometry. To study the composition of fecal microflora, 16S sequencing was used followed by a graphical representation of the results. The results were analysed using the IBM SPSS 22.0 statistical data processing software.Results. An additional administration of the probiotic (Bifidobacterium bifidum no less than 1x109 CFU; Bifidobacterium longum no less than 1x109 CFU; Bifidobacterium infantis no less than 1x109 CFU; Lactobacillus rhamnosus no less than 1x109 CFU) is found to have no effect on the lipid profile and the platelet aggregation rate. Rifaximin therapy reduced the amount of total cholesterol, low density lipoproteins (LDL), very low density (VLDL) lipoproteins and triglycerides (p <0.05), although not affecting the level of high density lipoproteins (HDL). TMAO showed a statistically insignificant (p>0.05) downward trend in all groups. The composition of the fecal microbiota, at the end of administration of the probiotic, showed an increase in the proportion of bacteria of the Streptococcaceae, Lactobacillaceae, Enterobacteriaceae families and a decrease in the Ruminococcaceae family (p>0.05). After rifaximin therapy, a decrease in the proportion of bacteria of the Clostridiaceae (p <0.05) and Peptostreptococcaceae (p <0.05) families, a decrease in Enterobacteriaceae (p > 0.05) family and a decrease in the Clostridium and Escherichia/Shigella (p > 0.05) genera was observed. The use of the probiotic after a course of treatment with rifaximin did not have a significant effect on the composition of the microflora. In general, the high variability of fecal microbiota between different patients (significantly superior to intergroup differences) does not allow us to draw unambiguous conclusions.Conclusions. The use of a multi-strain probiotic as an additional therapy in patients with coronary heart disease within 28 days did not have a significant effect on lipid metabolism, TMAO level and the composition of fecal microflora. The consecutive use of rifaximin and the probiotic had a beneficial effect on such factors as lipid metabolism (decrease in the level of total cholesterol, LDL, VLDL, triglycerides), but did not affect the concentration of TMAO and the composition of the intestinal microflora in patients with coronary heart disease.

scholarly journals Prevalence of Metabolic Syndrome and of Cardiovascular Risk Factors

2018 ◽  
Vol 15 (5) ◽  
pp. 35-42
Author(s):  
Manta Andrei ◽  
Maștaleru Alexandra ◽  
Oancea Andra ◽  
Anghel Razvan Constantin ◽  
Roca Mihai ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Public Health Problem ◽  
Left Ventricular ◽  
Lifestyle Changes ◽  
Therapeutic Success ◽  
The Metabolic Syndrome ◽  
Group 2 ◽  
Group 1

AbstractObesity, a component of the metabolic syndrome, is a rising public health problem, continuously increasing in the European countries. The therapeutic success of the patient with metabolic syndrome requires a multidisciplinary approach to lifestyle changes, weight loss, continuous and dynamic dietary improvement, sedentary reduction, normalization of blood pressure, glycemia and lipid parameters. We performed a retrospective study that was conducted in the Clinical Rehabilitation Hospital in Iasi, with 4627 patients that were admitted in the Cardiovascular Rehabilitation Clinic from January 2011 to December 2015 with the diagnosis of metabolic syndrome according to WHO definition (Group 1) or with other comorbidities (Group 2). In the first group were included 1064 patients diagnosed with metabolic syndrome. This group has predominantly smoking female patients. Also, in group 1 were diagnosed more patients with left ventricular hypertrophy and coronary heart disease compared to group 2. Most of the patients with inflammatory syndrome were included in the group without metabolic syndrome (group 2). The results of our study confirm that metabolic syndrome is a cluster of abnormalities whose evolution determines the development of coronary heart disease. All this would advocate for treating metabolic syndrome as the primary method of preventing cardiovascular disease.

scholarly journals Longitudinal Effect of Hemoglobin Concentration With Incident Ischemic Heart Disease According to Hepatic Steatosis Status Among Koreans

2021 ◽  
Vol 8 ◽  
Author(s):  
Dong Hyuk Jung ◽  
Yong Jae Lee ◽  
Byoungjin Park
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Hepatic Steatosis ◽  
Reference Group ◽  
Ischemic Heart ◽  
Group 4 ◽  
Group 3 ◽  
Group 5 ◽  
Group 2 ◽  
Group 1

Background: An increased hemoglobin (Hb) level may have detrimental effects on hepatic steatosis (HS) as well as cardiovascular disease (CVD). We investigated Hb's effect on incident ischemic heart disease (IHD) risk in the context of hepatic steatosis (HS).Methods: We assessed 17,521 non-diabetic participants and retrospectively screened for IHD using the Korea National Health Insurance data. High Hb was defined as Hb levels ≥16.3 g/dL in men and 13.9 g/dL in women (&gt;75th percentile). The participants were divided into five groups: reference (group 1), mild HS only (group 2), mild HS and high Hb (group 3), severe HS only (group 4), and severe HS and high Hb (group 5). We assessed hazard ratios (HRs) with 95% confidence intervals (CIs) for IHD using multivariate Cox proportional hazards regression models over 50 months from the baseline survey.Results: During the follow-up period, 330 (1.9%) participants developed IHD (310 angina pectoris and 20 myocardial infarction). Compared with the reference group (group 1), the HRs for IHD were 1.04 (95% CI, 0.75–1.46) in group 2, 1.14 (95% CI, 0.70–1.85) in group 3, 1.58 (95% CI, 1.08–2.32) in group 4, and 1.79 (95% CI, 1.15–2.80) in group 5, after adjusting for IHD risk factors.Conclusions: We found the combined effect of HS and Hb levels on the incidence of IHD.

scholarly journals Otsenka vliyaniya priverzhennosti rekomendatsiyampo profilaktike osteoporoza na mineral'nuyuplotnost' kostey predplech'ya i chastotu komorbidnoypatologii v lechenii osteoporoza

2008 ◽  
Vol 12 (1) ◽  
pp. 23-26
Author(s):  
A. A. Popov ◽  
N. V. Izmozherova ◽  
M. I. Fominykh
Keyword(s):  
Heart Failure ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Chronic Heart Failure ◽  
Glucose Metabolism Disorders ◽  
X Ray ◽  
Comorbid Diseases ◽  
Group 2 ◽  
Mineral Bone Density ◽  
Group 1

Aim: to assess compliance to osteoporosis (OP) prophylaxis recommendations and its influence on mineral bone density (BMD) and development of comorbid diseases in postmenopause. Methods: prospective cohort study included 404 postmenopausal women aged from 47 to 59 with OP risk factors. BMD was assessed by distant forearm X-ray absorptiometry. Comorbid diseases were registered. Compliance to recommendations was assessed by questionnaire.. Results. Group 1 consisted of 276 non-compliant women. Group 2 (128 persons) changed their lifestyle and consumed recommended amount of daily calcium and vitamin D. Group 1 demonstrated significant increase of coronary heart disease, chronic heart failure and a fraction of persons in whom BMD decreased during 2 years of survey(x2 = 6.986; P = 0.017).. Relative risk of arterial hypertension, coronary heart disease, chronic heart failure and glucose metabolism disorders significantly decreased in group 2. Comclusion: constant co-operation between doctors and patients is necessary to keep the patient compliant and to obtain clinically relevant results in OP prophylaxis.

scholarly journals The efficacy of secondary prevention programs with remote support in coronary heart disease patients with abdominal obesity

Kardiologiia ◽  
2019 ◽  
Vol 59 (11) ◽  
pp. 21-30 ◽  
Author(s):  
N. V. Pogosova ◽  
A. O. Salbieva ◽  
O. Y. Sokolova ◽  
A. K. Ausheva ◽  
A. V. Karpova ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Secondary Prevention ◽  
Dietary Patterns ◽  
Prevention Programs ◽  
P Values ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Background Long-term secondary preventive programs in coronary heart disease (CHD) are of highest efficacy but numerous logistical problems often compromise their implementation. Contemporary remote technologies have a potential to overcome these barriers. Aim: To assess  the impact of 2 preventive counselling programs with subsequent remote support in CHD patients with concomitant obesity. Methods: A prospective randomized parallel-group study in 120 stable CHD patients hospitalized for elective coronary revascularization who were from 40 to 65 years old and had concomitant obesity. Patients were randomized (1:1:1) into 3 groups (n=40 each). Before discharge, Groups 1 and 2 received a single-session comprehensive counselling with focus on diet followed by remote counselling by phone (Group 1) or via text messages (Group 2). Remote counselling was delivered weekly (Months 1-3) and then monthly (Months 4-6). Group 3 received only standard advice from their attending physicians. The patients were followed for 12 months with assessment of adiposity measures, self-reported dietary patterns, physical activity (IPAQ questionnaire), smoking status, blood pressure (BP), fasting blood glucose, lipids and C-reactive protein (CRP) levels, as well as of clinical events. Results: At 1 year of follow-up, the patients from both intervention groups showed a marked improvement of several risk factors including obesity: the body mass index was reduced by 1.48±0.13 kg/m² in Group 1 and by 1.53±0.18 kg/m² in Group 2; the waist circumference went down by 7.62±0.49 and by 7.41±0.74 cm, respectively; the height-normalized fat mass decreased by 4.66±0.40 kg and 5.98±0.63 kg, respectively (all P values are <0.01 vs corresponding changes in the control group). These changes were coupled with more healthy dietary patterns and less sedentary lifestyles in both intervention groups: the proportion of patients with low activity level fell from 87.5% to 2.5% in Group 1 and from 80% to 10% in Group 2 (both p values <0.01 vs control). In Group 1, BP decreased by 18.08±2.20 mmHg (systolic) and 8.56±1.61 mmHg (diastolic); both р values <0.01 vs Group 3. In Group 2 systolic BP dropped by only 11.95±2.50 mmHg (non-significant) and diastolic BP by 6.33±1.52 mmHg (р<0.05 vs control). The proportion of smokers went down from 30% to 5% in Group 1 and from 22.5% to 0% in Group 2 (both p values <0.01 vs control). The fasting glucose levels decreased by 0.21±0.20 mmol/L in Group 1 and by 0.48±0.25 mmol/L in Group 2 (<0.01 vs control, both), but there were no meaningful improvements in blood lipids or CRP. Conclusion: Long-term (6 months) secondary prevention programs incorporating remote support technologies result into sustained improvement of key secondary prevention indicators in obese CHD patients, irrespective of the support modality (by phone or via electronic messaging).

scholarly journals Intervention Effect of Probiotics in Gastric Cancer Patients with Complications of Coronary Heart Disease and Heart Failure

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Hui Yu ◽  
Anqin Dong ◽  
Luosha Zhao ◽  
Ping Li ◽  
Qiujun Zhang ◽  
...  
Keyword(s):  
Heart Failure ◽  
Gastric Cancer ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Control Group ◽  
Observation Group ◽  
Group A ◽  
Group 2 ◽  
Gastric Cancer Patients ◽  
Group 1

Objective. To investigate the characteristics of intestinal flora in patients with gastric cancer complicated by coronary heart disease and heart failure and the guiding value of probiotics intervention for clinical treatment. Methods. (1) One hundred and sixty-eight gastric cancer patients with complications of coronary heart disease and heart failure from August 2017 to December 2020 were selected as the observation group. A total of 125 patients with coronary heart disease treated at the same time were selected as control group 1, and 89 healthy subjects were selected as control group 2. Fecal samples were retained to extract the total RNA, and high-throughput sequencing was applied to complete the analysis of microbial diversity and structure differences, so as to obtain the biological species information of the specimens. (2) Patients in the observation group were randomly divided into two equal groups of 84 patients, namely, group A and group B. Group A was treated with conventional methods, and group B was combined with probiotics intervention on the basis of group A; then, the differences in the intestinal mucosal barrier between the two groups were compared. Results. The Chao, ACE, and Simpson index in the observation group were lower than those in control group 1 ( P < 0.05 ), and the Shannon index was higher than that in control group 1 ( P < 0.05 ). The Chao, ACE, and Shannon index in control group 1 were lower than those in control group 2 ( P < 0.05 ), whereas the Simpson index was higher than in control group 2 ( P < 0.05 ). The abundance of Bacteroidetes in the observation group was lower than that in control group 1 and control group 2 ( P < 0.05 ). The abundance of Firmicutes was higher than that of control group 1 and control group 2 ( P < 0.05 ). Four weeks after treatment, the levels of ET, D-lactic acid, and PCT in the group B were (0.10 ± 0.01), (3.99 ± 0.32), and (0.41 ± 0.10), respectively, which were lower than those in group A (0.19 ± 0.03), (4.51 ± 0.46), and (0.81 0.13). Conclusion. Gastric cancer patients with complications of coronary heart disease and heart failure are associated with intestinal flora disorder, which may be involved in the occurrence and development of the disease. Probiotics intervention is helpful to repair the intestinal mucosal barrier in patients, which is worthy of popularization and application.

Abstract 3652: Coronary Heart Disease Prevention in Women: The Prognostic Significance of Subclinical Atherosclerosis by Carotid Ultrasound

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Kwame O Akosah ◽  
Vicki L McHugh ◽  
Michelle A Mathiason
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Carotid Atherosclerosis ◽  
Prognostic Significance ◽  
Main Body ◽  
Carotid Ultrasound ◽  
Event Free Survival ◽  
Free Survival ◽  
Group 2 ◽  
Group 1

Background : The difficulty of coronary heart disease (CHD) prevention in women is recognized. Reasons include gender disparities in accuracy rates of current diagnostic tests and clinical presentation. Objective : Assess the utility and prognostic significance of carotid atherosclerosis in predicting CHD in women. Methods : Women (n=140) scheduled for elective coronary angiography underwent carotid ultrasound and fasting lipid analysis. Subjects were excluded for age (≥ 65), prior history of CHD, and anti-lipid therapy. Severe coronary artery disease (CAD) was defined as stenosis ≥ 50%. Carotid atherosclerosis was defined as IMT ≥ 1 mm in the main body or focal plaque in the main body or bulb. Subjects were followed for a median of 50 months. Future cardiovascular events (CVEs) were defined as Major (death, MI, and stroke), and Any event (Major, revascularization, and new onset heart failure). Results: 136 women (mean age 53 ± 8) had all data available. 80% (n=108) of subjects were classified as low risk and 1% (n=2) as intermediate risk per Framingham score, with an additional 19% (n=26) having CHD equivalent conditions. Severe CAD was present in 39 (28%) subjects. Carotid atherosclerosis had a sensitivity of 74%, specificity of 49%, and negative predictive value of 83% for CAD. Subjects were categorized into Group 1 (Carotid atherosclerosis, n=79) and Group 2 (no carotid atherosclerosis, n=57). After median follow-up of 50 months, 6 women experienced Major CVEs (Group 1 n = 5; Group 2 n=1). Major event rate for Group 1 was 6.3% vs. 1.8% for Group 2. For Any event, the rates were 22% for Group 1 compared to 9% for Group 2 (p=0.046). The event rates were similar between high-risk (3.8%) and low-risk (3.7%) for Major and 12% vs. 16 % for Any event. Kaplan-Meier survival analysis reveals that women without diagnosis of carotid atherosclerosis enjoyed significantly better event free survival. Negative predictive values for carotid atherosclerosis in predicting angiographic disease, Major events and Any event were 83%, 91% and 98%, respectively. Conclusion : Carotid atherosclerosis predicts CVEs in young to middle-aged women without high-risk clinical scores. Women without diagnosis of carotid atherosclerosis enjoy excellent long-term event free survival.

The clinical course of atrial fibrillation in patients with coronary heart disease

2016 ◽  
Vol 94 (8) ◽  
pp. 591-595 ◽  
Author(s):  
V. I. Podzolkov ◽  
Aida I. Tarzimanova ◽  
R. G. Gataulin
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Atrial Fibrillation ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Chronic Heart Failure ◽  
Clinical Course ◽  
History Of ◽  
Group 2 ◽  
Group 1

The modern medical literature practically does not contain clinical publications reporting studies of factors responsible for progression of atrial fibrillation (AF) in patients with coronary heart disease (CHD). It accounts for the importance of investigations into evolution of the clinical course of AF in such patients.Aim. To elucidate evolution of the clinical course of AF in patients with CHD in a long-term prospective study.Materials and methods. The study included. 112 patient aged 57-74 (mean 67.44±3.3) years with CHD and paroxysmal form of AF carried outfrom 2011 to 2015. Evolution of the clinical course of AF was evaluated based on the number of arrhythmic attacks during the last 3 months. The appearance ofprolonged persistent AF episodes or permanent AF was regarded as progression of arrhythmia.Results. During the 4 year study, 64 (57,2%) patients (group 1) did not experiencea rise in the frequency and duration of AF attacks. Progression of arrhythmia was documented in 48 (42,8%) of the 112 (100%) patients (group 2). These patients more frequently had the history of myocardial infarction and chronic heart failure than patients of group 1. The latter had the mean values of left ventricular (LV) ejection fraction 61,23±6,24%, i.e. significantly higher than 48,47±8,4% in group 2.47 and 28 % of the patients in group 2and 1 respectively suffered mitral regurgitation (p<0,05). Patients of group 2 had significantly more akineticzones. Intake of nitroglycerin in group 1 resulted in positive dynamics of local LV contractility that did not change in patients of group 2. Conclusion. 42,8% of the patients with CHD and paroxysmal form of AF experienced progression of arrhythmia into a persistent or permanent form. Predictors of AF progression in patients with CHD are the history of myocardial infarction, chronic heart failure, mitral regurgitation, and irreversible changes in local myocardial LV contraction.

scholarly journals Study of Adhesion and Survival of Lactobacilli and Bifidobacteria on Table Olives with the Aim of Formulating a New Probiotic Food

2005 ◽  
Vol 71 (8) ◽  
pp. 4233-4240 ◽  
Author(s):  
Paola Lavermicocca ◽  
Francesca Valerio ◽  
Stella Lisa Lonigro ◽  
Maria De Angelis ◽  
Lorenzo Morelli ◽  
...  
Keyword(s):  
Bacterial Species ◽  
Bifidobacterium Longum ◽  
Lactobacillus Rhamnosus ◽  
Bifidobacterium Bifidum ◽  
Good Survival ◽  
Bacterial Cells ◽  
Table Olives ◽  
Species Survival ◽  
High Viability ◽  
Probiotic Food

ABSTRACT With the aim of developing new functional foods, a traditional product, the table olive, was used as a vehicle for incorporating probiotic bacterial species. Survival on table olives of Lactobacillus rhamnosus (three strains), Lactobacillus paracasei (two strains), Bifidobacterium bifidum (one strain), and Bifidobacterium longum (one strain) at room temperature was investigated. The results obtained using a selected olive sample demonstrated that bifidobacteria and one strain of L. rhamnosus (Lactobacillus GG) showed a good survival rate, with a recovery of about 106 CFU g−1 after 30 days. The Lactobacillus GG population remained unvaried until the end of the experiment, while a slight decline (to about 105 CFU g−1) was observed for bifidobacteria. High viability, with more than 107 CFU g−1, was observed throughout the 3-month experiment for L. paracasei IMPC2.1. This strain, selected for its potential probiotic characteristics and for its lengthy survival on olives, was used to validate table olives as a carrier for transporting bacterial cells into the human gastrointestinal tract. L. paracasei IMPC2.1 was recovered from fecal samples in four out of five volunteers fed 10 to 15 olives per day carrying about 109 to 1010 viable cells for 10 days.

scholarly journals Changes of intestinal bacterial microbiota in coronary heart disease complicated with nonalcoholic fatty liver disease

BMC Genomics ◽  
2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Yiwen Zhang ◽  
Jun Xu ◽  
Xuemei Wang ◽  
Xinhua Ren ◽  
Yulan Liu
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Bifidobacterium Longum ◽  
Clinical Information ◽  
Alcoholic Fatty Liver ◽  
Nonalcoholic Fatty Liver ◽  
Bacterial Microbiota

Abstract Background Previous study reported that patients who suffered coronary heart disease (CHD) complicated with non-alcoholic fatty liver disease (NAFLD) had worse cardiac function and clinical outcomes than patients with CHD only. Notably, the mechanism is still unclear. This study aimed to investigate the changes and roles of intestinal bacterial microbiota in CHD-NAFLD patients. Methods and results People were recruited and divided into three groups, including CHD patients (without NAFLD), CHD-NAFLD patients and healthy controls (HCs). Each group contained 24 people. Fecal samples and clinical information were carefully collected. The Illumina sequencing of 16S rRNA was applied to profile the overall structure of the fecal bacterial microbiota and the characteristics of the bacterial microbiota based on the Operational Taxonomic Units. In clinical information, the CHD-NAFLD patients showed an increase in BMI, uric acid and triglyceride. There was a significant reduction in the abundance of Parabacteroides and Collinsella in overall CHD patients (including CHD-NAFLD and CHD patients). The intestinal bacterial microbiota in CHD-NAFLD patients showed an increase in the abundance of Copococcus and Veillonella, and a reduction in the abundance of Parabacteroides, Bacteroides fragilis, Ruminococcus gnavus, Bacteroides dorei, and Bifidobacterium longum subsp infantis. Among them, the abundance of Ruminococcus gnavus and Bacteroides dorei was significantly lower than that in CHD patients. Additionally, BMI positively correlated with the abundance of Copococcus and negatively correlated with the abundance of Bifidobacterium longum subsp infantis. The abundance of Veillonella positively correlated with AST. The abundance of Bacteroides dorei negatively correlated with ALT and AST. It indicates that the abundance of intestinal microbiota was related to the changes in clinical indexes. Conclusions Changes of intestinal bacterial microbiota in CHD-NAFLD patients may be important factors affecting the degree of metabolic disorder, which may be one of the important reasons for the worse clinical outcome and disease progression in CHD-NAFLD patients than in CHD patients.

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