scholarly journals Correlation between echocardiographic findings and biochemical markers in term newborns with moderate to severe perinatal asphyxia

2021 ◽  
pp. 12-12
Author(s):  
Milena Vasiljevic ◽  
Dejan Nesic ◽  
Stasa Krasic ◽  
Sanja Ninic ◽  
Sergej Prijic ◽  
...  
Keyword(s):  
Gas Exchange ◽  
Biochemical Markers ◽  
Perinatal Asphyxia ◽  
Serum Lactate ◽  
Strong Positive Correlation ◽  
Multinomial Regression ◽  
Positive Correlation ◽  
Echocardiographic Parameters ◽  
Term Newborns ◽  
Echocardiographic Findings

Perinatal asphyxia (PA) is a condition characterized by a gas exchange disorder due to a lack of blood flow or gas exchange, with potential multiorgan dysfunction. Our study aimed to determine the correlation between biochemical markers and echocardiography findings in a group of asphyxiated newborns. The prospective cohort study included 120 neonates (52/120 with PA) treated at a tertial referral pediatric center, from 2012 to 2014. A moderate-strong positive correlation was recorded between the transtricuspid pressure gradient (TRPG) and serum lactate, and between TRPG and NT-proBNP in the PA group (P<0.001) on the 1st day of life. A moderate positive correlation was found between NT-proBNP, lactate and troponins on one side, and TRPG on the other in the PA group after the 2nd measurement. Multinomial regression analysis showed that the lactate level was an independent factor for survival on the 1st (odds ratio (OR) 41.3, 95%confidence interval (CI) 2.14-797.1) and 3rd (OR 136.4, 95% CI 2.27-8206.7) days. Our research confirmed a significant correlation between echocardiographic and biochemical parameters of the myocardial lesion and cardiac function. Due to their complementarity, the use of the biochemical and echocardiographic parameters may be conditioned by their availability.

scholarly journals Serum lactate as a potential biomarker of meningioma malignancy and preoperative treatment effect

2015 ◽  
Vol 42 (S1) ◽  
pp. S46-S46
Author(s):  
Y Meng ◽  
S Bharadwaj ◽  
J Ebinu ◽  
L Venkatraghavan ◽  
G Zadeh
Keyword(s):  
Brain Tumors ◽  
Aerobic Glycolysis ◽  
Serum Lactate ◽  
Preoperative Treatment ◽  
Strong Positive Correlation ◽  
Metastatic Brain Tumors ◽  
Who Grade ◽  
Positive Correlation ◽  
Potential Biomarker ◽  
Lactate Levels

Introduction: Serum lactate levels are useful indicators of illness severity such as sepsis. Previous investigations have shown that lactate is a potential biomarker for glioma malignancy; mechanism of which may be related to Warburg effect - accelerated lactate production when tumors uniquely undergo aerobic glycolysis. Our study reveals a correlation between serum lactate and meningioma WHO grade. We also observed a relationship between radiation effect on metastatic brain tumors and lactate levels. Methods: Data was collected from the charts of 14 patients with grade I meningiomas, 6 grade II meningiomas, and 9 metastatic brain tumors who underwent resection at our institution from 2013-2014. T test and ANCOVA were carried using R software controlling for base deficit. Results: The mean age was 53 years, with 75% females. There was a statistically significant change in intra- and post-operative lactate during meningioma resections, which had a strong positive correlation with grade (p<0.005). Interestingly, the lactate rise was not significant for metastatic brain tumors (p=0.13), but had a positive correlation with tumors that received pre-operative radiation (p<0.05). Conclusion: Lactate is a potential non-invasive biomarker for brain tumor malignancy, as demonstrated in gliomas and meningiomas. Identifying metabolic biomarkers and their relationship to tumor pathology is important to understanding disease processes and improving patient care.

scholarly journals A study of correlation of foot length and new Ballard score in determining the gestational age of newborns

2021 ◽  
Vol 8 (10) ◽  
pp. 1713
Author(s):  
Bijli Pathiyil ◽  
Anuradha Varadhan ◽  
Balachandar B. Varadhan
Keyword(s):  
Standard Deviation ◽  
Diagnostic Accuracy ◽  
Gestational Age ◽  
Cost Effective ◽  
Vital Role ◽  
Preterm Neonates ◽  
Strong Positive Correlation ◽  
Positive Correlation ◽  
Foot Length ◽  
Term Newborns

Background: Gestational age (GA) estimation plays a vital role in obstetric, perinatal and neonatal care. Foot length (FL) measurement can serve as a simple, easy and cost effective parameter for estimating GA. The aim of this study was to determine correlation between foot length of new born and GA by new Ballard score and forming a percentile chart if a positive correlation was found.Methods: GA assessment of newborns born in our hospital was done by new Ballard score within 24 hours of life. FL was measured using vernier caliper. Neonates were classified as pre term, term and post term and also grouped as small for GA (SGA), appropriate for GA (AGA) and large for GA (LGA).Results: FL measurement was strongly correlating with GA assessment by new Ballard score, with overall correlation coefficient r=0.897 (p<0.001). FL increased as GA increased. Strong positive correlation was seen in pre term and term newborns. The cut-off foot lengths for identifying preterm and early preterm neonates were 73.14 mm (diagnostic accuracy 88.4%) and 68.49 mm (diagnostic accuracy 95.3%), respectively.Conclusions: Strong positive correlation of foot length with GA by new Ballard score was obtained and a percentile chart of foot length for each GA was formed, with mean and standard deviation. This can serve as a simple and quick tool, requiring less expertise for GA assessment.

The Strong Positive Correlation between Factor VII Clotting Activity Using Bovine Thromboplastin and the Activated Factor VII Level

1995 ◽  
Vol 73 (03) ◽  
pp. 429-434 ◽  
Author(s):  
Kazuomi Kario ◽  
Takefumi Matsuo ◽  
Reiko Asada ◽  
Toshiyuki Sakata ◽  
Hisao Kato ◽  
...  
Keyword(s):  
Risk Factor ◽  
Bovine Brain ◽  
Factor Vii ◽  
Rabbit Brain ◽  
Strong Positive Correlation ◽  
Chromogenic Substrate ◽  
Moderate Correlation ◽  
Positive Correlation ◽  
Activated Factor Vii

SummaryWe compared factor VII clotting activity (FVIIc) assays using different thromboplastins to determine which is the most sensitive for activated FVII (FVIIa) or for FVII antigen (FVIIag). FVIIc levels were measured using thromboplastins derived from bovine brain (FVIIc Bov), human placenta (FVIIc Hum), and rabbit brain (FVIIc Rab). FVIIa levels were measured by fluorogenic assays using human soluble tissue factor (rsTF) or bovine rsTF. We also measured FVII activity by an amidolytic assay (FVIIc:am Hum) using human thromboplastin and a chromogenic substrate for thrombin. FVIIag levels were determined by ELISA. In the FVIIa assay, the reaction time obtained from using bovine rsTF was shorter than that with human rsTF, suggesting that the interaction of plasma FVIIa with bovine rsTF was stronger than with human rsTF. The plasma FVIIa levels measured using human rsTF and bovine rsTF were almost the same (r=0.947, p<0.0001). Among the three FVIIc assays, FVIIc Bov had the strongest positive correlation with the plasma FVIIa level (r=0.886, p<0.000l), but had no correlation with FVIIag. An increase of 1 ng/ml in the plasma FVIIa level yielded a 27.9% increase of FVIIc Bov. Plasma FVIIc Hum and FVIIc:am Hum showed moderate correlations with both FVIIa (r=0.520, p<0.02 and r=0.569, p<0.01, respectively) and FVIIag (r=0.438, p<0.05 and r=0.468, p<0.05, respectively). FVIIc Rab had the lowest correlation with FVIIa (r=0.367, p<0.1), but had a moderate correlation with FVIIag (r=0.436, p<0.05). After in vitro cold activation, FVIIc Bov levels increased the most and FVIIc:am levels showed the least change. These findings indicate that consideration of the thromboplastin used for assay is necessary when assessing the clinical significance of FVII activity as a cardiovascular risk factor.

scholarly journals Microsatellite Variation and Recombination Rate in the Human Genome

Genetics ◽  
2000 ◽  
Vol 156 (3) ◽  
pp. 1285-1298 ◽  
Author(s):  
Bret A Payseur ◽  
Michael W Nachman
Keyword(s):  
Recombination Rate ◽  
Microsatellite Polymorphism ◽  
Published Data ◽  
Strong Positive Correlation ◽  
Background Selection ◽  
Recombination Rates ◽  
Microsatellite Variation ◽  
Positive Correlation ◽  
Genome Recombination ◽  
Neutral Mutations

Abstract Background (purifying) selection on deleterious mutations is expected to remove linked neutral mutations from a population, resulting in a positive correlation between recombination rate and levels of neutral genetic variation, even for markers with high mutation rates. We tested this prediction of the background selection model by comparing recombination rate and levels of microsatellite polymorphism in humans. Published data for 28 unrelated Europeans were used to estimate microsatellite polymorphism (number of alleles, heterozygosity, and variance in allele size) for loci throughout the genome. Recombination rates were estimated from comparisons of genetic and physical maps. First, we analyzed 61 loci from chromosome 22, using the complete sequence of this chromosome to provide exact physical locations. These 61 microsatellites showed no correlation between levels of variation and recombination rate. We then used radiation-hybrid and cytogenetic maps to calculate recombination rates throughout the genome. Recombination rates varied by more than one order of magnitude, and most chromosomes showed significant suppression of recombination near the centromere. Genome-wide analyses provided no evidence for a strong positive correlation between recombination rate and polymorphism, although analyses of loci with at least 20 repeats suggested a weak positive correlation. Comparisons of microsatellites in lowest-recombination and highest-recombination regions also revealed no difference in levels of polymorphism. Together, these results indicate that background selection is not a major determinant of microsatellite variation in humans.

scholarly journals Changes in Antioxidative, Oxidoreductive and Detoxification Enzymes during Development of Aphids and Temperature Increase

Antioxidants ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 1181
Author(s):  
Roma Durak ◽  
Jan Dampc ◽  
Monika Kula-Maximenko ◽  
Mateusz Mołoń ◽  
Tomasz Durak
Keyword(s):  
Antioxidant Enzymes ◽  
Enzymatic Activity ◽  
Antioxidant Enzyme ◽  
Temperature Increase ◽  
Enzyme System ◽  
Life Cycles ◽  
Detoxification Enzymes ◽  
Strong Positive Correlation ◽  
Positive Correlation ◽  
Antioxidant Enzyme System

Temperature, being the main factor that has an influence on insects, causes changes in their development, reproduction, winter survival, life cycles, migration timing, and population dynamics. The effects of stress caused by a temperature increase on insects may depend on many factors, such as the frequency, amplitude, duration of the stress, sex, or the developmental stage of the insect. The aim of the study was to determine the differences in the enzymatic activity of nymphs and adult aphids Aphis pomi, Macrosiphum rosae and Cinara cupressi, and changes in their response to a temperature increase from 20 to 28 °C. The activity of enzymatic markers (superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), β-glucosidase, polyphenol oxidase (PPO) and peroxidase (POD)) in aphid tissues was analysed for three constant temperatures. The results of our research showed that the enzymatic activity of aphids (measured as the activity of antioxidant, detoxifying and oxidoreductive enzymes) was mainly determined by the type of morph. We observed a strong positive correlation between the activity of the detoxifying and oxidoreductive enzymes and aphids’ development, and a negative correlation between the activity of the antioxidant enzymes and aphids’ development. Moreover, the study showed that an increase in temperature caused changes in enzyme activity (especially SOD, CAT and β-glucosidase), which was highest at 28 °C, in both nymphs and adults. Additionally, a strong positive correlation between metabolic activity (heat flow measured by microcalorimeter) and longevity was observed, which confirmed the relationship between these characteristics of aphids. The antioxidant enzyme system is more efficient in aphid nymphs, and during aphid development the activity of antioxidant enzymes decreases. The antioxidant enzyme system in aphids appears to deliver effective protection for nymphs and adults under stressful conditions, such as high temperatures.

scholarly journals Vitamin D Status Among Children aged 2 months to 13 years-a Hospital Based Study

2018 ◽  
Vol 3 (1) ◽  
pp. 381-384
Author(s):  
Hem Sagar Rimal ◽  
Shripad J Walavalkar
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Urban Area ◽  
Serum Calcium ◽  
Winter Season ◽  
College Teaching ◽  
Vitamin D Insufficiency ◽  
P Value ◽  
Strong Positive Correlation ◽  
Positive Correlation

Introduction: Vitamin D is an important micronutrient having crucial role in calcium and phosphate homeostasis but there is emerging evidence to suggest its role in prevention of infectious, inflammatory and neoplastic diseases. The vitamin D insufficiency/deficiency is a widely recognized problem among children in developed as well as developing countries.Objective: To find out the prevalence of vitamin D deficiency/insufficiency among children aged 2 months to 13 yrs and its correlation with serum calcium, phosphate and demographic factors.Methodology: Prospective, cross sectional, hospital based study conducted at Birat Medical College Teaching Hospital for a period of one year among children presented to pediatric OPD in whom pediatrician had a suspicion of Vitamin D Insufficiency /Deficiency. Venous blood Samples were taken for the estimation of 25(OH) Vitamin D, Calcium and Phosphate. Statistical analysis was done using SPSS software version 16. Results Among 174 children aged 2 months to 13 years, the prevalence of vitamin D insufficiency at the cutoff of <30ng/ml was 82.75% where as no cases of vitamin D deficiency was noted at cut off level of < 10 ng/ml. Children residing in urban area, samples taken in the winter season had higher prevalence of vitamin D insufficiency (p value <0.05). Serum calcium and phosphate level were found positively correlated with Vitamin D level (p<.05). However the relationship was very strong between Vitamin D and Calcium (r=0.402, p-value <0.001) and weak positive correlation was noted with phosphate(r=0.155, p value <0.05).Conclusion: There is very high prevalence of Vitamin D insufficiency among children. The vitamin D insufficiency was significantly higher in winter season as compared to summer. Children living in the urban area are more prone to Vitamin D insufficiency. Moderately strong positive correlation was observed between Vitamin D level and calcium but weak correlation existed with phosphate. BJHS 2018;3(1)5 : 381-384

scholarly journals Spatial Variation of the Relationship between PM2.5Concentrations and Meteorological Parameters in China

2015 ◽  
Vol 2015 ◽  
pp. 1-15 ◽  
Author(s):  
Gang Lin ◽  
Jingying Fu ◽  
Dong Jiang ◽  
Jianhua Wang ◽  
Qiao Wang ◽  
...  
Keyword(s):  
Negative Correlation ◽  
Meteorological Parameters ◽  
Semiarid Region ◽  
Strong Positive Correlation ◽  
Annual Average ◽  
Strong Negative Correlation ◽  
Positive Correlation ◽  
Humid Region ◽  
The Relationship ◽  
Warm Temperate

Epidemiological studies around the world have reported that fine particulate matter (PM2.5) is closely associated with human health. The distribution of PM2.5concentrations is influenced by multiple geographic and socioeconomic factors. Using a remote-sensing-derived PM2.5dataset, this paper explores the relationship between PM2.5concentrations and meteorological parameters and their spatial variance in China for the period 2001–2010. The spatial variations of the relationships between the annual average PM2.5, the annual average precipitation (AAP), and the annual average temperature (AAT) were evaluated using the Geographically Weighted Regression (GWR) model. The results indicated that PM2.5had a strong and stable correlation with meteorological parameters. In particular, PM2.5had a negative correlation with precipitation and a positive correlation with temperature. In addition, the relationship between the variables changed over space, and the strong negative correlation between PM2.5and the AAP mainly appeared in the warm temperate semihumid region and northern subtropical humid region in 2001 and 2010, with some localized differences. The strong positive correlation between the PM2.5and the AAT mainly occurred in the mid-temperate semiarid region, the humid, semihumid, and semiarid warm temperate regions, and the northern subtropical humid region in 2001 and 2010.

Relationship amongst ResearchGate altmetric indicators and Scopus bibliometric indicators

2015 ◽  
Vol 116 (9/10) ◽  
pp. 564-577 ◽  
Author(s):  
RISHABH SHRIVASTAVA ◽  
Preeti Mahajan
Keyword(s):  
Sample Size ◽  
Correlation Coefficients ◽  
Strong Positive Correlation ◽  
Bibliometric Indicators ◽  
Pearson’S Correlation ◽  
Content Type ◽  
Positive Correlation ◽  
Pearson's Correlation ◽  
Different Characteristics ◽  
The Relationship

Purpose – The purpose of this paper is twofold. First, the study aims to investigate the relationship between the altmetric indicators from ResearchGate (RG) and the bibliometric indicators from the Scopus database. Second, the study seeks to examine the relationship amongst the RG altmetric indicators themselves. RG is a rich source of altmetric indicators such as Citations, RGScore, Impact Points, Profile Views, Publication Views, etc. Design/methodology/approach – For establishing whether RG metrics showed the same results as the established sources of metrics, Pearson’s correlation coefficients were calculated between the metrics provided by RG and the metrics obtained from Scopus. Pearson’s correlation coefficients were also calculated for the metrics provided by RG. The data were collected by visiting the profile pages of all the members who had an account in RG under the Department of Physics, Panjab University, Chandigarh (India). Findings – The study showed that most of the RG metrics showed strong positive correlation with the Scopus metrics, except for RGScore (RG) and Citations (Scopus), which showed moderate positive correlation. It was also found that the RG metrics showed moderate to strong positive correlation amongst each other. Research limitations/implications – The limitation of this study is that more and more scientists and researchers may join RG in the future, therefore the data may change. The study focuses on the members who had an account in RG under the Department of Physics, Panjab University, Chandigarh (India). Perhaps further studies can be conducted by increasing the sample size and by taking a different sample size having different characteristics. Originality/value – Being an emerging field, not much has been conducted in the area of altmetrics. Very few studies have been conducted on the reach of academic social networks like RG and their validity as sources of altmetric indicators like RGScore, Impact Points, etc. The findings offer insights to the question whether RG can be used as an alternative to traditional sources of bibliometric indicators, especially with reference to a rapidly developing country such as India.

scholarly journals Characterization of Black Carbon and Its Correlations with VOCs in the Northern Region of Hangzhou Bay in Shanghai, China

Atmosphere ◽  
2021 ◽  
Vol 12 (7) ◽  
pp. 870
Author(s):  
Fangfang Wang ◽  
Jialuo Xu ◽  
Yinzhi Huang ◽  
Guangli Xiu
Keyword(s):  
Global Warming ◽  
Black Carbon ◽  
Northern Region ◽  
Hangzhou Bay ◽  
Industrial Park ◽  
Strong Positive Correlation ◽  
Incomplete Combustion ◽  
Positive Correlation ◽  
Industrial Parks ◽  
Haze Pollution

Ozone and PM2.5 (all particulate matter with diameter of 2.5 µm or smaller) are currently two disturbing environmental issues in most cities of China. Black carbon (BC), mainly from incomplete combustion, is one of the most important components of PM2.5 because it can absorb light and contribute to haze pollution and global warming. Meanwhile, volatile organic compounds (VOCs) have become a major air pollutant due to their association with haze, ozone (O3), global warming and human health by direct or indirect processes. In this study, one year-long observation campaign of BC, VOCs and other conventional air pollutants was conducted in the Northern Region of the Hangzhou Bay (NRHB) in Shanghai, China. The results indicated that higher concentration of BC mainly occurred in the autumn and winter, especially in December. In December, higher BC concentrations were found when the air mass came from northwest where there is an important local freeway, or southwest where some adjacent southwest chemical industrial parks are located. Different from the characteristics of BC in urban areas reported by previous studies, the diurnal variation of BC exhibited three peaks, two of which coincided with the morning and evening rush hours which are related to the heavy diesel traffic from a nearby freeway, and the third peak was often found late at night, around 2 am, which might be associated with abnormal emissions from an industrial park or marine traffic in the ocean waterway. BC had weakly negative correlation with O3 and NO, and a strongly positive correlation with PM2.5, SO2, NO2 and NOx, which implies that some incomplete combustion sources might occur in the nearby regions. With regard to VOCs, BC had a strong positive correlation with alkane, alkenes, alkynes, aromatic and non-sulfur VOCs, particularly with aromatic organic matter. Unlike the stronger correlation with aromatics in the morning rush hours, a stronger correlation between BC and alkenes and alkynes during the evening rush hour was observed. The relationships between BC and VOCs, particularly with some specific VOCs species related to the neighboring chemical industrial park, demonstrated that the contribution of the surrounding chemical industrial parks to BC should not be neglected.

Leisure Functioning and Offender Rehabilitation

2016 ◽  
Vol 61 (2) ◽  
pp. 150-170 ◽  
Author(s):  
Alison J. Link ◽  
D J Williams
Keyword(s):  
Intrinsic Motivation ◽  
Empirical Evidence ◽  
Offender Rehabilitation ◽  
Strong Positive Correlation ◽  
Statistical Relationship ◽  
Leisure Education ◽  
Positive Correlation ◽  
Independent Variables ◽  
Rehabilitation Strategy

This study examined the statistical relationship between offender rehabilitation and leisure functioning of Oregon prisoners ( N = 281) soon to reenter society. The strong positive correlation between leisure functioning and rehabilitation is an important finding of the study. Perception of freedom and intrinsic motivation in leisure, as independent variables, were significantly related to rehabilitation even when controlling for the influence of demographic and important forensic variables. This study provides initial empirical evidence for the importance of leisure in offender rehabilitation and successful offender reentry. The role of leisure education programming as a supportive offender rehabilitation strategy is also discussed.

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