1393-P: Residential Inequality and Birth Outcomes of Gestational Diabetes

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1393-P
Author(s):  
LEELA THOMAS ◽  
MITCHELL R. FAWCETT ◽  
CLAUDINE JURKOVITZ ◽  
JAMES LENHARD
Keyword(s):  
Gestational Diabetes ◽  
Birth Outcomes ◽  
Residential Inequality

scholarly journals Childhood maltreatment and inflammation among pregnant women with gestational diabetes mellitus: A pilot study

2017 ◽  
Vol 10 (3) ◽  
pp. 120-124 ◽  
Author(s):  
Margaret Bublitz ◽  
Suzanne De La Monte ◽  
Susan Martin ◽  
Lucia Larson ◽  
Ghada Bourjeily
Keyword(s):  
Diabetes Mellitus ◽  
Pilot Study ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Birth Outcomes ◽  
Childhood Maltreatment ◽  
Secondary Data ◽  
Past Research ◽  
Increased Risk

Background Women with childhood maltreatment histories are at increased risk for adverse birth outcomes. Mechanisms explaining this link are poorly understood. Past research is limited by sampling pregnant women at low risk for adverse maternal and neonatal outcomes. Methods This pilot study was a secondary data analysis of 24 women with gestational diabetes mellitus; 17% of the sample also reported a maltreatment history. Women provided a blood sample to measure inflammatory cytokines and insulin resistance, and saliva samples to measure diurnal cortisol. Birth outcomes for past and current pregnancies were recorded. Results Histories of maltreatment were associated with elevated interleukin-15 and a marginally greater incidence of preterm delivery in current and past pregnancies. Conclusions This pilot study was the first to demonstrate an association between childhood maltreatment history and inflammatory cytokine levels in pregnant women diagnosed with gestational diabetes mellitus.

scholarly journals Thyroid Dysfunction and Autoantibodies in Early Pregnancy Are Associated with Increased Risk of Gestational Diabetes and Adverse Birth Outcomes

2012 ◽  
Vol 97 (12) ◽  
pp. 4464-4472 ◽  
Author(s):  
Polyxeni Karakosta ◽  
Dimitris Alegakis ◽  
Vaggelis Georgiou ◽  
Theano Roumeliotaki ◽  
Eleni Fthenou ◽  
...  
Keyword(s):  
Gestational Diabetes ◽  
Birth Outcomes ◽  
Early Pregnancy ◽  
Thyroid Dysfunction ◽  
Adverse Birth Outcomes ◽  
Increased Risk

scholarly journals Population-based study on birth outcomes among women with hypertensive disorders of pregnancy and gestational diabetes mellitus

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ya-Wen Lin ◽  
Ming-Hung Lin ◽  
Lee-Wen Pai ◽  
Jen-Wei Fang ◽  
Chih-Hsin Mou ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Birth Outcomes ◽  
Ductus Arteriosus ◽  
Adverse Outcomes ◽  
Neonatal Outcomes ◽  
Hypertensive Disorders Of Pregnancy ◽  
Hypertensive Disorders ◽  
Adverse Neonatal Outcomes

AbstractTo evaluate birth outcomes in women with hypertensive disorders of pregnancy (HDP) and gestational diabetes mellitus (GDM), we used insurance data of Taiwan to evaluate 11 adverse neonatal outcomes of infants born to women with HDP (N = 7775) and with both HDP and GDM (HDP/GDM) (N = 1946), comparing to women with neither disorder (N = 19,442), matched by age. The impacts of preeclampsia/eclampsia were also evaluated. Results showed that Caesarean section delivery was near 1.7-fold greater in the HDP/GDM and HDP groups than in comparisons. The preterm delivery rates were more than threefold greater in HDP/GDM group and HDP group than in comparisons with adjusted odds ratios (aORs) of 4.84 (95% confidence interval (CI) 4.34–5.40) and 3.92 (95% CI 3.65–4.21), respectively, followed by jaundice (aORs 2.95 (95% CI 2.63–3.33) and 1.90 (95% CI 1.76–2.06)), and small gestation age (SGA) (aORs 6.57 (95% CI 5.56–7.75) and 5.81 (95% CI 5.15–6.55)). Incidence rates of birth trauma, patent ductus arteriosus, atrial septal defect, respiratory distress syndrome, and neonatal hypoglycemia were also higher in the HDP/GDM and HDP groups than in the comparison group. Most adverse outcomes increased further in women with preeclampsia or eclampsia. In conclusion, women with HDP are at elevated risks of adverse neonatal outcomes. Risks of most adverse outcomes increase further for women with both HDP and GDM. Preeclampsia or eclampsia may also contribute to these outcomes to higher risk levels. Every pregnant woman with these conditions deserves specialized prenatal care.

scholarly journals Prospective cohort study of pregnancy complications and birth outcomes in women with asthma

2018 ◽  
Vol 298 (2) ◽  
pp. 279-287
Author(s):  
Nasrin Fazel ◽  
Michael Kundi ◽  
Erika Jensen-Jarolim ◽  
Isabella Pali-Schöll ◽  
Asghar Kazemzadeh ◽  
...  
Keyword(s):  
Cohort Study ◽  
Gestational Diabetes ◽  
Asthma Control ◽  
Birth Outcomes ◽  
Prospective Cohort Study ◽  
Pregnancy Complications ◽  
Prospective Cohort ◽  
Maternal Outcomes ◽  
Total Ige ◽  
In Pregnancy

AbstractBackgroundAsthma is the most common potentially serious medical complication in pregnancy. The purpose of this study was to determine the association between maternal asthma and a spectrum of adverse neonatal and maternal outcomes.MethodsEvents during pregnancy and birth outcome were evaluated in 34 asthmatic as well as 1569 non-asthmatic pregnant women who were enrolled in a prospective cohort study undertaken at the antenatal clinics of Mobini Hospital in Iran. The women were interviewed and classified according to clinical severity and asthma control as per GINA guidelines. Information on asthma symptoms was collected by a questionnaire as well as by spirometry and physical examination. All subjects were followed until delivery, and postpartum charts were reviewed to assess neonatal and maternal outcomes. Eosinophil cells counts were obtained and total IgE was measured by ELISA. Results were assessed by multivariate logistic regression adjusting for maternal age and parity, and for birth outcomes, for gestational diabetes, and hypertension/pre-eclampsia.ResultsThe well-known relationship between family history of asthma and asthma in pregnancy was again supported (p < 0.001). Women with asthma had more bleeding events 3 weeks or more before delivery (OR 3.30, 95% CI 1.41–7.26), more often placenta problems (OR 6.86, 95% CI 1.42–33.02), and gestational diabetes mellitus (OR 3.82, 95% CI 1.06–13.75). No significant differences between asthmatic and non-asthmatic mothers regarding duration of gestation, birthweight, low Apgar scores, or neonatal respiratory difficulties were found. Total IgE antibody levels and eosinophil counts did not differ by asthma control and severity.ConclusionsAsthma in pregnancy poses some risk for pregnancy complications and adverse perinatal outcomes. Managing asthma effectively throughout pregnancy could benefit women and their babies and help to reduce the health burden associated with asthma during pregnancy.

PP003-SUN EFFECT OF PREPREGNANCY OBESITY ON FATTY ACIDS AND BIRTH OUTCOMES IN SUBJECTS WITH GESTATIONAL DIABETES MELLITUS

2012 ◽  
Vol 7 (1) ◽  
pp. 26
Author(s):  
A. Pagán Bernabéu ◽  
J.E. Blanco ◽  
M.T. Prieto Sánchez ◽  
S. Zamora ◽  
J.J. Parrilla ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Fatty Acids ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Birth Outcomes ◽  
Prepregnancy Obesity

scholarly journals Gestational Diabetes Mellitus Is a Risk for Macrosomia: Case- Control Study in Eastern Ethiopia

2018 ◽  
Author(s):  
Elias Bekele Wakwoya ◽  
Tariku Dingeta Amante ◽  
Kassahun Fikadu Tesema
Keyword(s):  
Diabetes Mellitus ◽  
Regression Analysis ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Birth Outcomes ◽  
Case Control Study ◽  
Case Control ◽  
Adverse Birth Outcomes ◽  
Eastern Ethiopia ◽  
Control Study

Background - Gestational diabetes mellitus is any degree of glucose intolerance at onset or first recognition during pregnancy. A pregnant woman with diabetes and her unborn child are at increased risk of pregnancy complications and adverse neonatal outcomes. The aim of this study was to assess the association of gestational diabetes mellitus and adverse birth outcomes among women who gave birth in Eastern Ethiopia. Method – Unmatched case control study design was conducted in Hiwot Fana Specialized University Hospital and Dilchora Hospital from December 2015 to April 2017. This study involved a total of 1,834 mothers and their babies. A structured and pre-tested questionnaire was used to collect the socio-demographic data. Mothers who had risk factor for gestational diabetes were screened by oral glucose tolerance tests. Adverse birth outcomes were observed and registered after delivery. Multivariate logistic regression analysis was employed to identify predictors of adverse birth outcome. P value less than 0.05 was considered to decide statistical significance. Results: From a total of 1,834 mothers 47 (2.6%) of them were found to have gestational diabetes. In binary logistic regression analysis macrosomia and still were found to have an association with gestational diabetes, COR=11[95% CI = 5.7-21.2] and COR= 2.9[95% CI = 1.02-8.5] respectively. Macrosomia was independently associated with GDM and babies born to mothers with gestational diabetes. Babies born from mothers with gestational diabetes were 8.5 times more likely to have macrosomia than babies born to non-diabetic mothers, AOR = 8.5 [95% CI = 5.7-21.4]. Conclusion: This study revealed that only macrosomia was strongly associated with gestational diabetes and this finding is coherent with studies done at different parts of the world. Early screening and treatment of mothers with GDM can minimize the adverse birth outcomes, therefore routine screening service for pregnant women who are at risk of developing gestational diabetes must exist at all health facilities in Ethiopia.

scholarly journals Comparison of Birth Outcomes by Gestational Diabetes Screening Criteria

2018 ◽  
Vol 08 (04) ◽  
pp. e280-e288 ◽  
Author(s):  
Esa Davis ◽  
Christina Scifres ◽  
Kaleab Abebe ◽  
Tina Costacou ◽  
Diane Comer ◽  
...  
Keyword(s):  
Gestational Diabetes ◽  
Birth Outcomes ◽  
International Association ◽  
Challenge Test ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Singleton Pregnancy ◽  
Screening Criteria ◽  
Iadpsg Criteria ◽  
Normal Glucose

Objectives This study is to examine the association between different diagnostic criteria for gestational diabetes mellitus (GDM) and adverse birth outcomes. Study Design A retrospective cohort study of 5,937 women with a singleton pregnancy was conducted, who completed GDM screening between 24 to 32 weeks gestational age. Four nonoverlapping groups of women defined as: 1) Normal: glucose challenge test (GCT) <130 mg/dL, 2) elevated GCT + normal oral glucose tolerance test (OGTT): abnormal 1 hour GCT + normal 3 hour OGTT, 3) GDM/International Association of Diabetes in Pregnancy Study Group (IADPSG): abnormal 3 hour OGTT by the IADPSG criteria, and 4) GDM/Carpenter-Coustan (CC): diagnosis per CC criteria. We used logistic regression to examine the association between GDM group classification and main outcome of macrosomia and secondary birth outcomes. Results Prevalences were GDM/CC 4.6%, GDM/IADPSG 3.0, and 7.6% overall. GDM/IADPSG group was associated with increased macrosomia (adj OR [odd ratio] 1.87; 95% CI [confidence interval]: 1.08–3.25; p = 0.02), while GDM/CC group was associated with increased preterm birth (adj OR 1.75; 95% CI: 1.05–2.80; p = 0.03). Conclusion Little difference in birth outcomes was found between the two criteria, GDM/CC and GDM/IADPSG. Randomized controlled trials are needed to clarify the risks and benefits of these screening paradigms before their incorporation into clinical practice.

Birth outcomes in women with gestational diabetes managed by lifestyle modification alone: The PANDORA study

2019 ◽  
Vol 157 ◽  
pp. 107876 ◽  
Author(s):  
E. Cheng ◽  
D.K. Longmore ◽  
F. Barzi ◽  
E.L.M. Barr ◽  
I.L. Lee ◽  
...  
Keyword(s):  
Gestational Diabetes ◽  
Birth Outcomes ◽  
Lifestyle Modification

scholarly journals Gestational diabetes using diverse diagnostic criteria, risk factors including dietary intakes, pregnancy outcomes and postpartum glycemic status: a nested case-control study in Ghana

2019 ◽  
Author(s):  
Faith Agbozo ◽  
Abdulai Abubakari ◽  
Francis Zotor ◽  
Albrecht Jahn
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Blood Glucose ◽  
Gestational Diabetes ◽  
Pregnant Women ◽  
Birth Outcomes ◽  
Pregnancy Outcomes ◽  
Birth Asphyxia ◽  
Case Control ◽  
Case Definition

AbstractBackgroundGestational diabetes mellitus (GDM) has risen considerably in recent years. Studies from Africa have investigated the risk factors but reported prevalence is often based on one diagnostic test/cut-off while short-term outcomes have scarcely been explored. This study estimated the prevalence of GDM using diverse diagnostic cut-offs. Associated maternal risk factors, birth outcomes and extent of attainment of euglycemia at 12 weeks postpartum were also assessed.Methods and FindingsThis study was an unmatched case-control nested in a prospective cohort involving 807 pregnant women recruited consecutively from five state-owned hospitals serving rural and peri-urban communities in Ghana. Dietary and obstetric risks were assessed retrospectively while physiologic measurements were repeated throughout pregnancy. Case definition was fasting venous plasma glucose (FPG) ≥5.6 mmol/l and/or single-step 75-g 2-hour oral glucose tolerance test (OGTT) ≥8.5 mmol/l measured between 20-34 gestational weeks for singleton, non-diabetic pregnant women (n=446). Participants whose random blood glucose was ≥11.1 mmol/l and glycated hemoglobin ≥6.5% were excluded. Pregnancy outcomes of 403 women were traced at delivery while 100 could be followed-up at 12 weeks postpartum. Adjusted odds ratio (aOR) for GDM was tested through unconditional logistic regression and Mantel-Haenszel statistic and the association of GDM on pregnancy outcomes was estimated by multiple logistic regression.Prevalence per 2-h OGTT ≥8.5 mmol/l was 9.0% (n=39, 95% confidence interval [CI]; 6.3-11.6) and prevalence per FPG ≥5.6 mmol/l was 10.8% (n=49, 95% CI; 8.1-13.9); 15.9% met the case definition. Independent risk factors included excess intake of high glycemic index foods (aOR:2.91 95% CI]:1.05-8.06), obesity (aOR:2.13 CI:1.12-4.03), previous cesarean delivery (aOR:4.01 CI:1.08-14.76) and antenatal care in a primary facility (aOR:4.951 CI:1.87-3.76). A unit rise in blood glucose significantly increased maternal blood loss and birthweight. Adjusting for covariates, adverse birth outcomes were perineal tear (Aor:2.91 CI:1.08-5.57) and birth asphyxia (aOR:3.24 CI:1.01-10.44). Cesarean section (aOR:1.9 CI:0.97-3.68), large for gestational age (aOR:2.7 CI:0.86-5.05) and newborn resuscitation (aOR:2.91 CI 0.94-9.01) were significant at 10%. At 12 weeks postpartum, 30% of the GDM cases were unable to achieve euglycemia. Different estimates could be obtained if other diagnostic criteria were used.ConclusionsFindings show an increasing prevalence of GDM in peri-urban and rural settings highlighting the need to strengthen primary facilities to test and refer cases for management. Diet and adiposity are key risk factors necessitating lifestyle modification interventions focusing on nutrition education and weight control. GDM-exposed newborn need close monitoring as birth asphyxia which is a key outcome is likely to compromise neonatal survival. Postpartum follow-up of cases is crucial to avert transition of GDM into active diabetes.

Sign in / Sign up

Export Citation Format

Share Document